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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to p...

    Authors: Kaku So-Armah, Matthew Freiberg, Debbie Cheng, Joseph K. Lim, Natalia Gnatienko, Gregory Patts, Margaret Doyle, Daniel Fuster, Dmitry Lioznov, Evgeny Krupitsky and Jeffrey Samet

    Citation: BMC Gastroenterology 2019 20:1

    Content type: Research article

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  2. Statin has been more and more widely used in chronic liver disease, however, existed studies have attained contradictory results. According to the present study, we aimed to test the efficacy and safety of sta...

    Authors: Yue Gu, Xueqin Yang, Hang Liang and Deli Li

    Citation: BMC Gastroenterology 2019 19:231

    Content type: Research article

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  3. Hepatocellular carcinoma (HCC) is a common human malignant cancer due to a high metastatic capacity and the recurrence rate is also high. This study is aim to investigate the role of musashi1 as a potential bi...

    Authors: Qiuhua Liu, Cuijie Zhou and Bo Zhang

    Citation: BMC Gastroenterology 2019 19:230

    Content type: Research article

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  4. A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SM...

    Authors: Yan Mardian, Yoshihiko Yano, Neneng Ratnasari, Lina Choridah, Widya Wasityastuti, Nurhuda Hendra Setyawan and Yoshitake Hayashi

    Citation: BMC Gastroenterology 2019 19:229

    Content type: Research article

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  5. Endoscopic nasobiliary drainage (ENBD) is widely used for biliary decompression in patients with biliary disease. However, it is difficult to reposition a nasobiliary catheter from the mouth to nostril. We dev...

    Authors: Seong Ji Choi, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim and Chi Hyuk Oh

    Citation: BMC Gastroenterology 2019 19:222

    Content type: Research article

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  6. Endoscopic ultrasound is useful for obtaining high-resolution images of pancreaticobiliary diseases, but is not readily available for physical checkups. In this study, we evaluated the safety and efficacy of s...

    Authors: Daisuke Uchida, Hironari Kato, Kazuyuki Matsumoto, Yuki Ishihara, Akihiro Matsumi, Yosuke Saragai, Saimon Takada, Shuntaro Yabe, Shinichiro Muro, Takeshi Tomoda, Shigeru Horiguchi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2019 19:220

    Content type: Research article

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  7. Portal vein thrombosis (PVT) is a common complication of cirrhosis. However, in patients with PVT and cirrhosis, there is no clear evidence supporting effective treatment modalities. In this study, we examined...

    Authors: Takehiro Hayashi, Hajime Takatori, Rika Horii, Kouki Nio, Takeshi Terashima, Noriho Iida, Masaaki Kitahara, Tetsuro Shimakami, Kuniaki Arai, Kazuya Kitamura, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda…

    Citation: BMC Gastroenterology 2019 19:217

    Content type: Research article

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  8. Endoscopic treatment of post-cholecystectomy biliary strictures (PCBS) with multiple plastic biliary stents placed sequentially is a minimally invasive alternative to surgery but requires multiple intervention...

    Authors: Andrea Tringali, D. Nageshwar Reddy, Thierry Ponchon, Horst Neuhaus, Ferrán González-Huix Lladó, Claudio Navarrete, Marco J. Bruno, Paul P. Kortan, Sundeep Lakhtakia, Joyce Peetermans, Matthew Rousseau, David Carr-Locke, Jacques Devière and Guido Costamagna

    Citation: BMC Gastroenterology 2019 19:214

    Content type: Research article

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  9. The clinical value of the controlling nutritional status (CONUT) score in hepatocellular carcinoma (HCC) has increased. The aim of this meta-analysis was to systematically review the association between the CO...

    Authors: Kosei Takagi, Piotr Domagala, Wojciech G. Polak, Stefan Buettner and Jan N. M. Ijzermans

    Citation: BMC Gastroenterology 2019 19:211

    Content type: Research article

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  10. To investigate the value of prolactin (PRL) in diagnosing non-alcoholic fatty liver disease (NAFLD).

    Authors: Pengzi Zhang, Wenghuan Feng, Xuehui Chu, Xitai Sun, Dalong Zhu and Yan Bi

    Citation: BMC Gastroenterology 2019 19:202

    Content type: Research article

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    The Correction to this article has been published in BMC Gastroenterology 2020 20:38

  11. Drug induced liver injury (DILI) is an important cause of acute liver injury and accounts for approximately 10% of all cases of acute hepatitis. Both prescription and natural health products (NHPs) have been i...

    Authors: Tyler Pitre, Jasmine Mah, Jaclyn Vertes, Rosario Rebello and Julie Zhu

    Citation: BMC Gastroenterology 2019 19:199

    Content type: Case report

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  12. Pancreatic cavernous hemangioma is an extremely rare benign tumor that is difficult to diagnose on an imaging examination, and its histopathological examination has rarely been reported.

    Authors: Tao Lianyuan, Wang Yafeng, Yu Haibo, Dong Yadong, Ma Jiahao, Lu Yuanxiang and Li Deyu

    Citation: BMC Gastroenterology 2019 19:197

    Content type: Case report

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  13. Although isolating Glissonean pedicles and hepatic veins are critical procedures during anatomical hepatectomy, there is no standardized approach. We propose the novel Laennec’s approach for laparoscopic anato...

    Authors: Yue Hu, Jiong Shi, Shaohe Wang, Wenjie Zhang, Xitai Sun, Beicheng Sun and Decai Yu

    Citation: BMC Gastroenterology 2019 19:194

    Content type: Research article

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  14. Syphilis is a common disease that has been researched and focused on for many years, however, syphilitic hepatitis has not been well-recognized. We report this case of syphilitic hepatitis with intrahepatic chole...

    Authors: Jiaofeng Huang, Su Lin, Mingfang Wang, Bo Wan and Yueyong Zhu

    Citation: BMC Gastroenterology 2019 19:191

    Content type: Case report

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  15. Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in < 1 person in 1,000,000 individuals. For accurate diagnosis, information regarding multiple graphic modalities in HEH is required. Howe...

    Authors: Jun Arai, Yuu Shimozuma, Yumi Otoyama, Ikuya Sugiura, Yoko Nakajima, Eiichi Hayashi, Atsushi Kajiwara, Risa Omori, Shojiro Uozumi, Miyuki Miyashita, Manabu Uchikoshi, Hiroyoshi Doi, Masashi Sakaki, Tianpeng Wang, Junichi Eguchi, Takayoshi Ito…

    Citation: BMC Gastroenterology 2019 19:187

    Content type: Case report

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  16. Choledocholithiasis is an endemic condition in the world. Although rare, foreign body migration with biliary complications needs to be considered in the differential diagnosis for patients presenting with typi...

    Authors: Min Yu, Bowen Huang, Ye Lin, Yuxue Nie, Zixuan Zhou, Shanshan Liu and Baohua Hou

    Citation: BMC Gastroenterology 2019 19:177

    Content type: Case report

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  17. Hepatolithiasis, featuring high incidence, severe symptoms, and common recurrence, poses a heavy disease burden. Endoscopic management provides an opportunity to cure hepatolithiasis, but fails to properly res...

    Authors: Jianying Lou, Qida Hu, Tao Ma, Wei Chen, Ji Wang and Prasoon Pankaj

    Citation: BMC Gastroenterology 2019 19:172

    Content type: Technical advance

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  18. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can induce a stronger regenerative ability than traditional 2-stage hepatectomy (TSH). ALPPS has become popular for achieving...

    Authors: Xukun Wu, Jiawei Rao, Xiaozhuan Zhou, Ronghai Deng and Yi Ma

    Citation: BMC Gastroenterology 2019 19:170

    Content type: Research article

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  19. Pruritus is a common symptom seen in patients with chronic liver disease. However, frequency and severity of pruritus in patients with chronic liver disease is unclear. We investigated frequency, severity and ...

    Authors: Hatsue Fujino, Mio Tanaka, Michio Imamura, Kei Morio, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Shoichi Takahashi, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C. Nelson Hayes and Kazuaki Chayama

    Citation: BMC Gastroenterology 2019 19:169

    Content type: Research article

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  20. The efficacy of some therapeutic methods (open surgical debridement (OSD), conservative treatment (CST) and minimally invasive drainage (MID)) for severe acute pancreatitis (SAP) and moderately severe acute pa...

    Authors: Kai Zhang, Xiaole Zhu, Chaoqun Hou, Chenyuan Shi, Yi Miao and Qiang Li

    Citation: BMC Gastroenterology 2019 19:168

    Content type: Research article

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  21. To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis.

    Authors: Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Keisuke Nakanishi, Yuki Tsuji, Naotaka Shimozato, Kei Moriya, Kenichiro Seki, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Ryuichi Noguchi, Masanori Matsumoto…

    Citation: BMC Gastroenterology 2019 19:167

    Content type: Research article

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  22. Extracorporeal liver support therapies (ELS) are technical options (for bridge-to-recovery as well as bridge-to-transplant) in patients with acute liver dysfunction (e.g. acute liver failure (ALF), acute-on ch...

    Authors: Thomas Wiesmann, Dominic Hoenl, Hinnerk Wulf and Marc Irqsusi

    Citation: BMC Gastroenterology 2019 19:160

    Content type: Research article

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  23. Primary sclerosing cholangitis is a chronic cholestatic liver disease. The pathomechanism is still not fully understood, but there is evidence that immune-mediated processes may contribute to disease progression.

    Authors: Theresa Hippchen, Peter Sauer, Benjamin Göppert, Peter Schirmacher, Daniel Nils Gotthardt, Karl-Heinz Weiss, Wolfgang Stremmel and Christian Rupp

    Citation: BMC Gastroenterology 2019 19:153

    Content type: Research article

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  24. Alcoholic liver disease (ALD) is the leading cause of liver transplantation (LT). The magnitude and risk factors of post-LT alcohol relapse are not well described. We conducted a meta-analysis to evaluate alco...

    Authors: Lancharat Chuncharunee, Noriyo Yamashiki, Ammarin Thakkinstian and Abhasnee Sobhonslidsuk

    Citation: BMC Gastroenterology 2019 19:150

    Content type: Research article

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  25. Caspase-1 is an evolutionarily conserved enzyme that proteolytically cleaves the precursors of the inflammatory cytokines interleukin 1β and interleukin 18. However, the role of caspase-1 in determining the se...

    Authors: Xiangying Zhang, Peiling Dong, Lin Xu, Yuan Tian, Huayin Sun, Hongbo Shi, Zhongping Duan, Liyan Chen and Feng Ren

    Citation: BMC Gastroenterology 2019 19:148

    Content type: Research article

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  26. Prior hepatitis B virus infection (PBI) may increase the risk of developing hepatocellular carcinoma (HCC), but the impact of PBI on clinical outcomes following treatment for HCC remains unknown. The aim of th...

    Authors: Yutaka Midorikawa, Tadatoshi Takayama, Hisashi Nakayama, Tokio Higaki, Masamichi Moriguchi, Kyoji Moriya, Tatsuo Kanda, Shunichi Matsuoka and Mitsuhiko Moriyama

    Citation: BMC Gastroenterology 2019 19:147

    Content type: Research article

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  27. Paragangliomas, also known as chemodectomas, are rare tumors arise from chemoreceptor tissue, and most commonly locate at the bifurcation of the common carotid, the jugular foramen, aortic arch, and retroperit...

    Authors: Zhao-Ru Dong, Yan-Ni Xia, Yue-Yi Zhao, Rui Wu, Kai-Xuan Liu, Kai Shi, Lun-Jie Yan, Cheng-Yu Yao, Yu-Chuan Yan and Tao Li

    Citation: BMC Gastroenterology 2019 19:142

    Content type: Case report

    Published on:

    The Correction to this article has been published in BMC Gastroenterology 2019 19:152

  28. Abdominal compartment syndrome (ACS) is associated with mortality in patients with critical illness such as severe acute pancreatitis, but it remains unclear whether decompressive laparotomy for ACS can improv...

    Authors: Shinya Ikeda, Takuma Kagami, Shinya Tani, Takahiro Uotani, Mihoko Yamade, Yasushi Hamaya, Yoshifumi Morita, Takanori Sakaguchi, Satoshi Osawa and Ken Sugimoto

    Citation: BMC Gastroenterology 2019 19:141

    Content type: Case report

    Published on:

  29. Endoscopic transpapillary cannulation of the gallbladder is useful but challenging. This study aimed to investigate cystic duct anatomy patterns, which may guide cystic duct cannulation.

    Authors: Jun Cao, Xiwei Ding, Han Wu, Yonghua Shen, Ruhua Zheng, Chunyan Peng, Lei Wang and Xiaoping Zou

    Citation: BMC Gastroenterology 2019 19:139

    Content type: Research article

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  30. This study aims to evaluate the efficacy and safety of detecting and removing residual common bile duct stones (CBDS) using direct peroralcholangioscopy (DPOC) after performing endoscopic retrograde cholangiop...

    Authors: Jun-Jie Yang, Xiong-Chang Liu, Xiao-Qin Chen, Qi-Yong Zhang and Tian-Rang Liu

    Citation: BMC Gastroenterology 2019 19:135

    Content type: Research article

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  31. In cirrhosis upper-gastrointestinal-endoscopy (UGIE) identifies oesophageal varices (OV). UGIE is unavailable in most resource-limited settings. Therefore, we assessed prediction of presence of OV using hemato...

    Authors: K. Perera, S. K. Kodisinghe, D. S. Ediriweera, D. Moratuwagama, S. Williams, A. Pathmeswaran, M. A. Niriella and H. J. de Silva

    Citation: BMC Gastroenterology 2019 19:134

    Content type: Research article

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  32. Hepatocellular carcinoma (HCC) is a kind of malignancies to impact human health. It has been reported that aberrant toll-like receptor (TLR) signaling may contribute to the development and progression of HCC, ...

    Authors: Liyu Shi, Xiaoqiu Zheng, Yuzhuo Fan, Xiaolan Yang, Aimei Li and Jun Qian

    Citation: BMC Gastroenterology 2019 19:130

    Content type: Research article

    Published on:

  33. Imaging is an essential tool in the management of patients with Colorectal cancer (CRC) by helping evaluate number and sites of metastases, determine resectability, assess response to treatment, detect drug to...

    Authors: Vincenza Granata, Roberta Fusco, Elisabetta de Lutio di Castelguidone, Antonio Avallone, Raffaele Palaia, Paolo Delrio, Fabiana Tatangelo, Gerardo Botti, Roberto Grassi, Francesco Izzo and Antonella Petrillo

    Citation: BMC Gastroenterology 2019 19:129

    Content type: Research article

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  34. To provide criteria for the differential diagnosis of serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) by analyzing the imaging features of these two neoplasms by endoscopic ultrasound (EUS).

    Authors: Lisen Zhong, Ningli Chai, Enqiang Linghu, Huikai Li, Jing Yang and Ping Tang

    Citation: BMC Gastroenterology 2019 19:127

    Content type: Research article

    Published on:

  35. This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis fact...

    Authors: Li-Wei Chen, Cheng-Hung Chien, Sheng-Fong Kuo, Chia-Ying Yu, Chih-Lang Lin and Rong-Nan Chien

    Citation: BMC Gastroenterology 2019 19:126

    Content type: Research article

    Published on:

  36. General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis...

    Authors: Feryal Savari, Seyyed Ali Mard, Mohammad Badavi, Anahita Rezaie and Mohammad Kazem Gharib-Naseri

    Citation: BMC Gastroenterology 2019 19:125

    Content type: Research article

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  37. Cystic fibrosis (CF) is a genetic disorder of the epithelial CFTR apical chloride channel resulting in multi-organ manifestations, including pancreatic exocrine secretion. In the pancreas, CFTR abnormality res...

    Authors: J. Dixon Johns and Steven M. Rowe

    Citation: BMC Gastroenterology 2019 19:123

    Content type: Case report

    Published on:

  38. The identification of patients with advanced liver fibrosis secondary to non-alcoholic fatty liver disease (NAFLD) remains challenging. Using non-invasive liver fibrosis tests (NILT) in primary care may permit...

    Authors: Ankur Srivastava, Simcha Jong, Anna Gola, Ruth Gailer, Sarah Morgan, Karen Sennett, Sudeep Tanwar, Elena Pizzo, James O’Beirne, Emmanuel Tsochatzis, Julie Parkes and William Rosenberg

    Citation: BMC Gastroenterology 2019 19:122

    Content type: Research article

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  39. Multiple organ failure (MOF) is a serious complication of moderately severe (MASP) and severe acute pancreatitis (SAP). This study aimed to develop and assess three machine-learning models to predict MOF.

    Authors: Qiu Qiu, Yong-jian Nian, Yan Guo, Liang Tang, Nan Lu, Liang-zhi Wen, Bin Wang, Dong-feng Chen and Kai-jun Liu

    Citation: BMC Gastroenterology 2019 19:118

    Content type: Research article

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  40. Acute anaemia in decompensated liver cirrhosis is commonly caused due to gastrointestinal bleeding; however, sometimes, detecting the site of blood loss is challenging.

    Authors: Marco Biolato, Claudia Tarli, Giuseppe Marrone, Brunella Barbaro, Antonio Liguori, Antonio Gasbarrini and Antonio Grieco

    Citation: BMC Gastroenterology 2019 19:112

    Content type: Case report

    Published on:

  41. Beta-herpesviruses are common opportunistic pathogens that cause morbidity after liver transplantation (LT).

    Authors: Conrad Rauber, Katja Bartelheimer, Taotao Zhou, Christian Rupp, Paul Schnitzler, Peter Schemmer, Peter Sauer, Karl Heinz Weiss and Daniel Nils Gotthardt

    Citation: BMC Gastroenterology 2019 19:110

    Content type: Research article

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  42. Biliary mucinous cystic neoplasms are rare cystic lesions of the liver which carry pre-malignant potential. Given the scarcity of reports in the literature, they pose a considerable challenge to clinical manag...

    Authors: Côme Tholomier, Yifan Wang, Olga Aleynikova, Tsafrir Vanounou and Jean-Sebastien Pelletier

    Citation: BMC Gastroenterology 2019 19:103

    Content type: Case report

    Published on:

  43. The preventive effects of antiviral therapy to reduce rebleeding rate in patients with hepatitis B-related cirrhosis undergoing endoscopic treatment have not yet been reported.

    Authors: Lingling He, Xiaohui Ye, Jiali Ma, Ping Li, Yu Jiang, Julong Hu, Junru Yang, Yuling Zhou, Xiuxia Liang, Yijun Lin and Hongshan Wei

    Citation: BMC Gastroenterology 2019 19:101

    Content type: Research article

    Published on:

  44. Radical surgery for Bismuth type III/IV hilar cholangiocellular carcinoma, which was usually considered unresectable, seems to improve prognosis by increasing the surgical curability rate. However, the dilemma...

    Authors: Qi-jiong Li, Zhong-guo Zhou, Xiao-jun Lin, Xiang-ming Lao, Bo-kang Cui and Sheng-ping Li

    Citation: BMC Gastroenterology 2019 19:99

    Content type: Research article

    Published on:

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