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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 1 of 11

  1. Endoscopic retrograde cholangiopancreatography (ERCP) is still performed using two-dimensional (2D) X-ray images. The success rate and risk of complications are considered operator-dependent. We explored perfo...

    Authors: Masao Toki, Hidekatsu Tateishi, Tsubasa Yoshida, Koichi Gondo, Shunsuke Watanabe and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:158

    Content type: Case report

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  2. Endoscopic retrograde biliary drainage (ERBD) is the most frequently performed procedure for treating benign or malignant biliary obstruction. Although duodenal perforations secondary to the biliary plastic st...

    Authors: Xiaopeng Wang, Junwen Qu and Kewei Li

    Citation: BMC Gastroenterology 2020 20:149

    Content type: Case report

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  3. The impact of hepatic steatosis (HS) on treatment response following nucleos(t)ide analogue (NA) treatment for chronic hepatitis B (CHB) patients has not been clearly elucidated. We aimed to investigate the di...

    Authors: Yi-Cheng Chen, Wen-Juei Jeng, Chao-Wei Hsu and Chun-Yen Lin

    Citation: BMC Gastroenterology 2020 20:146

    Content type: Research article

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  4. ERCP training models are very different in terms of anatomical differences, ethical issues, storage problems, realistic tactile sensation, durability and portability. There is no easy way to select an optimize...

    Authors: Chang-Il Kwon, Yeonsun Shin, Jaeok Hong, Minje Im, Guk Bae Kim, Dong Hee Koh, Tae Jun Song, Won Suk Park, Jong Jin Hyun and Seok Jeong

    Citation: BMC Gastroenterology 2020 20:145

    Content type: Research article

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  5. Type 2 diabetes mellitus (T2DM) increased the risk of developing pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplastic disease originating from the pancreas. Increasing evide...

    Authors: Ji-bin Yin, Na Li, Ming-ming Cui, Xin Wang and Rui-tao Wang

    Citation: BMC Gastroenterology 2020 20:143

    Content type: Research article

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  6. Histoplasma capsulatum is the most common endemic mycosis in the United States and frequently presents as an opportunistic infection in immunocompromised hosts. Though liver involvement is common in disseminated ...

    Authors: Steven Park, Janice Cheong, Kaitlin Kyi, Jose Aranez, Sohaib Abu-Farsakh, Christa Whitney-Miller, Bandar Al-Judaibi and Marie Laryea

    Citation: BMC Gastroenterology 2020 20:141

    Content type: Case report

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  7. Antiviral therapy for chronic hepatitis B (CHB) is effective and can substantially reduce the risk of progressive liver disease and hepatocellular carcinoma but is often administered for an indefinite duration...

    Authors: Nicole L. Allard, Jennifer H. MacLachlan, Anouk Dev, James Dwyer, Geeta Srivatsa, Timothy Spelman, Alexander J. Thompson and Benjamin C. Cowie

    Citation: BMC Gastroenterology 2020 20:140

    Content type: Research article

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  8. There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this an...

    Authors: Min Zhang, Su Lin, Ming-fang Wang, Jiao-feng Huang, Shi-ying Liu, Su-mei Wu, Hao-yang Zhang, Zi-mu Wu, Wen-Yue Liu, Dong-Chu Zhang, Chuan-ming Hao, Yue-yong Zhu, Ming-Hua Zheng and Xiao-zhong Wang

    Citation: BMC Gastroenterology 2020 20:139

    Content type: Research article

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  9. Pancreatic and peri-pancreatic neoplasms encompass a variety of histotypes characterized by a heterogeneous prognostic impact. miRNAs are considered efficient candidate biomarkers due to their high stability i...

    Authors: Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan and Aldo Scarpa

    Citation: BMC Gastroenterology 2020 20:137

    Content type: Research article

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  10. Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. W...

    Authors: Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Yee-Kit Tse, Becky Wing-Yan Yuen, Hester Wing-Sum Luk, Marco Ho-Bun Lam, Michael Kin-Kong Li, Ching Kong Loo, Owen Tak-Yin Tsang, Steven Woon-Choy Tsang, Henry Lik-Yuen Chan, Yun-Kwok Wing and Vincent Wai-Sun Wong

    Citation: BMC Gastroenterology 2020 20:128

    Content type: Research article

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  11. One of the most feared complications of endoscopic retrograde cholangiopancreatography (ERCP), with an incidence of 3.5 to 15%, is post ERCP pancreatitis (PEP). Given the role of statins in the reduction of sy...

    Authors: Yousaf Bashir Hadi, Syeda Fatima Naqvi, Abdelhai Abdelqader, Justin Kupec and John Nasr

    Citation: BMC Gastroenterology 2020 20:125

    Content type: Research article

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  12. For chronic hepatitis B (CHB) patients without willingness to extend the routine duration of interferon (IFN) therapy, it is important to identify patients who will benefit from treatment cessation. Hepatitis ...

    Authors: Shuai Wu, Wenfan Luo, Yin Wu, Hongjie Chen and Jie Peng

    Citation: BMC Gastroenterology 2020 20:121

    Content type: Research article

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  13. Cabozantinib was approved by the European Medicines Agency and the Federal Drug Administration as an option for sorafenib-resistant advanced hepatocellular carcinoma, increasing overall survival and progressio...

    Authors: Maximilian Sieg, Michael Hartmann, Utz Settmacher and Habibollah Arefian

    Citation: BMC Gastroenterology 2020 20:120

    Content type: Research article

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  14. Hepatitis B e antigen (HBeAg) seroclearance has been considered as the treatment endpoint in HBeAg-positive patients with chronic hepatitis B (CHB). Although HBeAg seroclearance has been accomplished, some asp...

    Authors: Hyun Woong Lee, Jung Il Lee, Saein Kim, Sora Kim, Hye Young Chang and Kwan Sik Lee

    Citation: BMC Gastroenterology 2020 20:113

    Content type: Research article

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  15. The purpose of this study is to investigate whether or not the complement system is systemically activated and to specify the clinical and prognostic implications of its components during hepatitis B virus rel...

    Authors: Qian Li, Qing Lu, Meng-Qi Zhu, Chong Huang, Kang-Kang Yu, Yu-Xian Huang, Xu Zhao, Xing-Guang Luo and Jian-Ming Zheng

    Citation: BMC Gastroenterology 2020 20:106

    Content type: Research article

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  16. Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit life-saving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). ...

    Authors: Paul M. Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Scott Harris, Usha Menon and William M. Rosenberg

    Citation: BMC Gastroenterology 2020 20:104

    Content type: Research article

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  17. Low 25-Hydroxy-vitamin-D; “25(OH)-D3” serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In th...

    Authors: Ahmad Salhab, Johnny Amer, Lu Yinying and Rifaat Safadi

    Citation: BMC Gastroenterology 2020 20:102

    Content type: Research article

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  18. Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofreq...

    Authors: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Yao-Chun Hsu, Chia-Chang Hsu, Tsung-Chin Wu, Jen-Hao Yeh, Pojen Hsiao, Pei-Min Hsieh, Hung-Yu Lin, Chih-Wen Shu and Chao-Ming Hung

    Citation: BMC Gastroenterology 2020 20:99

    Content type: Research article

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  19. Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...

    Authors: Xiaofei Li, Lina Sheng, Liwen Liu, Yongtao Hu, Yongxin Chen and Lianqing Lou

    Citation: BMC Gastroenterology 2020 20:98

    Content type: Research article

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  20. Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by damage to the nervous system and retinal degeneration. This cla...

    Authors: Mária Ondrejkovičová, Sylvia Dražilová, Monika Drakulová, Juan López Siles, Renáta Zemjarová Mezenská, Petra Jungová, Martin Fabián, Boris Rychlý and Miroslav Žigrai

    Citation: BMC Gastroenterology 2020 20:95

    Content type: Case report

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  21. There are conflicting data regarding the risk of hepatocellular carcinoma (HCC) after direct-acting antiviral agent (DAA) treatment. Risk of HCC in HCV genotype-3 infected persons after DAA therapy is not well...

    Authors: Ghias Un Nabi Tayyab, Shafqat Rasool, Bilal Nasir, Ghazala Rubi, Abdul-Badi Abou-Samra and Adeel A. Butt

    Citation: BMC Gastroenterology 2020 20:93

    Content type: Research article

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  22. Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractor...

    Authors: Mitsuhito Koizumi, Teru Kumagi, Taira Kuroda, Yoshiki Imamura, Kozue Kanemitsu, Kohei Ogawa, Yasutsugu Takada and Yoichi Hiasa

    Citation: BMC Gastroenterology 2020 20:92

    Content type: Research article

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  23. Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was...

    Authors: Theodoros Androutsakos, Maria Schina, Abraham Pouliakis, Athanasios Kontos, Nikolaos Sipsas and Gregorios Hatzis

    Citation: BMC Gastroenterology 2020 20:91

    Content type: Research article

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  24. Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The current recommendations for gastroesophageal varices include pharmacological treatme...

    Authors: Yujen Tseng, Lili Ma, Minzhi Lv, Tiancheng Luo, Chengfeng Liu, Yichao Wei, Chu Liu, Ji Zhou, Zhiping Yan, Pengju Xu, Guohua Hu, Hong Ding, Yuan Ji, Shiyao Chen and Jian Wang

    Citation: BMC Gastroenterology 2020 20:83

    Content type: Research article

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  25. Vascular invasion is an important criterion for resectability and deciding the therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC), but imaging diagnosis is currently difficult. Endoscopic ultraso...

    Authors: Kenta Yamada, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroyuki Tanaka, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2020 20:81

    Content type: Research article

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  26. This study aimed to develop prognostic models for predicting 28- and 90-day mortality rates of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) through artificial neural network (AN...

    Authors: Yixin Hou, Qianqian Zhang, Fangyuan Gao, Dewen Mao, Jun Li, Zuojiong Gong, Xinla Luo, Guoliang Chen, Yong Li, Zhiyun Yang, Kewei Sun and Xianbo Wang

    Citation: BMC Gastroenterology 2020 20:75

    Content type: Research article

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  27. Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease nowadays. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD around t...

    Authors: Shu-ting Wang, Jing Zheng, He-wei Peng, Xiao-lin Cai, Xin-ting Pan, Hui-quan Li, Qi-zhu Hong and Xian-E Peng

    Citation: BMC Gastroenterology 2020 20:66

    Content type: Research article

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  28. Ineffective antibiotic therapy increases mortality of acute cholangitis. The choice of antibiotics should reflect local resistance patterns and avoid the overuse of broad-spectrum agents. In this study, we ana...

    Authors: Tassilo Kruis, Sarah Güse-Jaschuck, Britta Siegmund, Thomas Adam and Hans-Jörg Epple

    Citation: BMC Gastroenterology 2020 20:65

    Content type: Research article

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  29. Endoscopic retrograde cholangio-pancreatography (ERCP) is commonly performed in the management of pancreatic and biliary disease. Duodenoscopes are specialized endoscopes used to perform ERCP, and inherent to ...

    Authors: Nauzer Forbes, B. Joseph Elmunzer, Thibault Allain, Millie Chau, Hannah F. Koury, Sydney Bass, Paul J. Belletrutti, Martin J. Cole, Emmanuel Gonzalez-Moreno, Ahmed Kayal, Puja Kumar, Rachid Mohamed, Christian Turbide, Andre G. Buret and Steven J. Heitman

    Citation: BMC Gastroenterology 2020 20:64

    Content type: Study protocol

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  30. Crigler Najjar type 1 is a rare autosomal recessive condition caused by the absence of UDPGT enzyme due to mutations in the UGT1A1 gene. This enzyme is responsible for elimination of unconjugated bilirubin fro...

    Authors: Sailaja Valmiki, Kiran Kumar Mandapati, Leela Krishna Vamsee Miriyala, Chayarani Chandrashekhar Kelgeri, Mohamed Rela, Naresh P. Shanmugam and Durga Rao Vegulada

    Citation: BMC Gastroenterology 2020 20:62

    Content type: Case report

    Published on:

  31. Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hypon...

    Authors: Shunsuke Shiba, Po-sung Chu, Nobuhiro Nakamoto, Karin Yamataka, Nobuhito Taniki, Keisuke Ojiro, Akihiro Yamaguchi, Rei Morikawa, Aya Yoshida, Akihiko Ikura, Hirotoshi Ebinuma, Hidetsugu Saito and Takanori Kanai

    Citation: BMC Gastroenterology 2020 20:53

    Content type: Research article

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  32. We investigated real-world effectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, 4, or 6.

    Authors: Phunchai Charatcharoenwitthaya, Virasak Wongpaitoon, Piyawat Komolmit, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Teerha Piratvisuth, Theeranun Sanpajit, Chinnavat Sutthivana, Chalermrat Bunchorntavakul, Abhasnee Sobhonslidsuk, Soonthorn Chonprasertsuk, Chotipong Siripipattanamongkol, Supatsri Sethasine and Tawesak Tanwandee

    Citation: BMC Gastroenterology 2020 20:47

    Content type: Research article

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  33. Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibro...

    Authors: Atsuko Takai, Kentaro Kikuchi, Mayuko Ichimura, Koichi Tsuneyama, Yuki Moritoki, Kotaro Matsumoto, Hiromichi Tsunashima, Takeshi Onda, Noriyuki Kuniyoshi, Tomoyuki Nariyama, Sho Ohyatsu, Juri Kubota, Kozue Nagumo, Shinpei Sato, Masumi Hara and Hiroshi Miyakawa

    Citation: BMC Gastroenterology 2020 20:46

    Content type: Research article

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  34. The level and profiles of blood free carnitine and acylcarnitines, obtained by acylcarnitine analysis using tandem mass spectrometry, reflect various metabolic conditions. We aimed to examine the level of free...

    Authors: Hisamitsu Miyaaki, Hironori Kobayashi, Satoshi Miuma, Masanori Fukusima, Ryu Sasaki, Masafumi Haraguchi and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2020 20:41

    Content type: Research article

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  35. One major etiology of hepatic sinusoidal obstruction syndrome (HSOS) in China is the intake of pyrrolizidine alkaloids (PAs). Since PAs-induced HSOS is a rare disease that has not been clearly characterized un...

    Authors: Fang Liu, Xinxin Rong, Hui Guo, Dong Xu, Chang Liu, Lingling Meng, Xiaoqian Yang, Tingting Guo, Xuefeng Kan and Yuhu Song

    Citation: BMC Gastroenterology 2020 20:30

    Content type: Research article

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  36. Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognost...

    Authors: Jan-Hendrik Bockmann, Marcel Grube, Vanessa Hamed, Johann von Felden, Johanna Landahl, Malte Wehmeyer, Katja Giersch, Michaela T. Hall, John M. Murray, Maura Dandri, Stefan Lüth, Ansgar W. Lohse, Marc Lütgehetmann and Julian Schulze Zur Wiesch

    Citation: BMC Gastroenterology 2020 20:24

    Content type: Research article

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  37. Biliary tract cancers (BTC) have a poor prognosis even after curative resection because of frequent local and distant recurrences. Therefore, the importance of adjuvant therapy in BTC has been advocated to imp...

    Authors: Hyera Kim, Mi Hwa Heo and Jin Young Kim

    Citation: BMC Gastroenterology 2020 20:20

    Content type: Research article

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  38. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has high accuracy and a low complication rate; therefore, it has been widely used as a useful tool for diagnosis of and to determine treatment stra...

    Authors: Nami Sato, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Rintaro Mikata, Naoya Kato and Masayuki Ohtsuka

    Citation: BMC Gastroenterology 2020 20:13

    Content type: Case report

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  39. ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the s...

    Authors: Xuefeng Ma, Shousheng Liu, Jie Zhang, Mengzhen Dong, Yifen Wang, Mengke Wang and Yongning Xin

    Citation: BMC Gastroenterology 2020 20:10

    Content type: Research article

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  40. The anti-immunological rejection therapy for small-for-size syndrome (SFSS) after live donor liver transplantation (LDLT) play a central role in keeping graft survival. The hepatocyte number and grafts functio...

    Authors: Yanhu Feng, Zhijian Han, Zedong Feng, Bofang Wang, Huijuan Cheng, Luxi Yang, Yangbing Li, Baohong Gu, Xuemei Li, Yahao Li, Yumin Li, Chen Wang and Hao Chen

    Citation: BMC Gastroenterology 2020 20:7

    Content type: Research article

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  41. Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence o...

    Authors: Yen-Hsiang Liao, Ren-Jun Hsu, Tzu-Hwei Wang, Chen-Ta Wu, Sheng-Yao Huang, Chung-Y. Hsu, Yuan-Chih Su, Wen-Lin Hsu and Dai-Wei Liu

    Citation: BMC Gastroenterology 2020 20:6

    Content type: Research article

    Published on:

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