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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 1 of 9

  1. Content type: Research article

    Antiviral treatment for chronic hepatitis B (CHB) is largely unavailable in sub-Saharan Africa; hence, little is known about the prognosis after initiating treatment in African CHB patients. In this study we a...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Girmay Medhin, Bitsatab Mekasha, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Gastroenterology 2019 19:74

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  2. Content type: Research article

    Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early predic...

    Authors: Jianhua Wan, Xiaoyu Yang, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2019 19:67

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  3. Content type: Research article

    Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

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  4. Content type: Research article

    Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with...

    Authors: Jian Sun, Huiguo Ding, Guofeng Chen, Guiqiang Wang, Lai Wei, Jiming Zhang, Qing Xie, Mobin Wan, Hong Tang, Shijun Chen, Zhiliang Gao, Yuming Wang, Dazhi Zhang, Wenxiang Huang, Jifang Sheng, Qin Ning…

    Citation: BMC Gastroenterology 2019 19:65

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  5. Content type: Research article

    Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

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  6. Content type: Research article

    Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiati...

    Authors: Xing Hu, Xiaojie Huang, Hui Chen, Tong Zhang, Jianhua Hou, Aixin Song, Lei Ding, Weiyuan Liu, Hao Wu and Fankun Meng

    Citation: BMC Gastroenterology 2019 19:60

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  7. Content type: Research article

    The latest 8th edition of the AJCC staging system emphasizes the importance of tumor size however, the clinical significance of the combination of tumor location with tumor size remains unknown.

    Authors: Zibo Meng, Mingsi Cao, Yushun Zhang, Zhiqiang Liu, Shihong Wu and Heshui Wu

    Citation: BMC Gastroenterology 2019 19:59

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  8. Content type: Case report

    Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in t...

    Authors: Rugile Mickuniene, Ieva Stundiene, Tomas Jucaitis, Dileta Valanciene and Jonas Valantinas

    Citation: BMC Gastroenterology 2019 19:57

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  9. Content type: Research article

    The prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among elderly have not been well described. Our aim was to assess the prevalence, risk factors and mortality of NAFLD in individuals old...

    Authors: Pegah Golabi, James Paik, Rashmi Reddy, Elisabetta Bugianesi, Gregory Trimble and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:56

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  10. Content type: Research article

    Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success ra...

    Authors: Yan Chen, Yueping Jiang, Wei Qian, Qihong Yu, Yuanhang Dong, Huiyun Zhu, Feng Liu, Yiqi Du, Dong Wang and Zhaoshen Li

    Citation: BMC Gastroenterology 2019 19:54

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  11. Content type: Research article

    As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic h...

    Authors: Yayun Liu, Meng Jiang, Jianya Xue, Hongli Yan and Xuesong Liang

    Citation: BMC Gastroenterology 2019 19:53

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:72

  12. Content type: Research article

    Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis. Despite good diagnostic performance, clinical application of CAP is limited due to the influences of covariates...

    Authors: Ke Pu, Yuping Wang, Suyang Bai, Hui Wei, Yongning Zhou, Jiangao Fan and Liang Qiao

    Citation: BMC Gastroenterology 2019 19:51

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  13. Content type: Research article

    Bilomas are defined collections of bile fluids mainly caused by iatrogenic injuries of the bile duct system. Owing to the infrequency of this disease, studies addressing bilomas are rare.

    Authors: S. Würstle, A. Göß, C. D. Spinner, W. Huber, H. Algül, C. Schlag, R. M. Schmid, A. Weber, A. Obermeier and J. Schneider

    Citation: BMC Gastroenterology 2019 19:50

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  14. Content type: Research article

    Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn’s disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in i...

    Authors: Fotios S. Fousekis, Konstantinos H. Katsanos, Vasileios I. Theopistos, Gerasimos Baltayiannis, Maria Kosmidou, Georgios Glantzounis, Leonidas Christou, Epameinondas V. Tsianos and Dimitrios K. Christodoulou

    Citation: BMC Gastroenterology 2019 19:48

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  15. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead to liver cirrhosis or liver cancer. Small intestinal bacterial overgrowt...

    Authors: Yoga Fitriakusumah, C. Rinaldi A. Lesmana, Winda Permata Bastian, Chyntia O. M. Jasirwan, Irsan Hasan, Marcellus Simadibrata, Juferdy Kurniawan, Andri Sanityoso Sulaiman and Rino A. Gani

    Citation: BMC Gastroenterology 2019 19:43

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  16. Content type: Research article

    The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

    Authors: Linda Heitz, Wolfgang Kratzer, Tilmann Gräter and Julian Schmidberger

    Citation: BMC Gastroenterology 2019 19:42

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  17. Content type: Research article

    Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent mod...

    Authors: Gao Sun, Charles V. Jackson, Karen Zimmerman, Li-Kun Zhang, Courtney M. Finnearty, George E. Sandusky, Guodong Zhang, Richard G. Peterson and Yi-Xin (Jim) Wang

    Citation: BMC Gastroenterology 2019 19:41

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  18. Content type: Study protocol

    The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...

    Authors: Rianne van Rijn, Aad P. van den Berg, Joris I. Erdmann, Nigel Heaton, Bart van Hoek, Jeroen de Jonge, Henri G. D. Leuvenink, Shekar V. K. Mahesh, Sarah Mertens, Diethard Monbaliu, Paolo Muiesan, M. Thamara P. R. Perera, Wojciech G. Polak, Xavier Rogiers, Roberto I. Troisi, Yvonne de Vries…

    Citation: BMC Gastroenterology 2019 19:40

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  19. Content type: Research article

    Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP w...

    Authors: Marcus Reuterwall, Jeanne Lubbe, Lars Enochsson, Lars Lundell, Magnus Konradsson, Frederik Swahn, Marco Del Chiaro, Matthias Löhr and Urban Arnelo

    Citation: BMC Gastroenterology 2019 19:35

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  20. Content type: Research article

    The recurrence of esophageal varices remains high in patients with hepatic portal hypertension after the endoscopic esophageal variceal eradication therapies, including endoscopic variceal band ligation (EVL),...

    Authors: Junfu Zheng, Yuening Zhang, Peng Li, Shibin Zhang, Yue Li, Lei Li and Huiguo Ding

    Citation: BMC Gastroenterology 2019 19:32

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  21. Content type: Research article

    Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-...

    Authors: Xiang-Peng Zeng, Ting-Ting Liu, Lu Hao, Lei Xin, Teng Wang, Lin He, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Hong-Lei Guo, Hui Chen…

    Citation: BMC Gastroenterology 2019 19:31

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  22. Content type: Research article

    Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnos...

    Authors: Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D. Goodman and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:27

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  23. Content type: Research article

    Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from margi...

    Authors: Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata and Taizo Hibi

    Citation: BMC Gastroenterology 2019 19:25

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  24. Content type: Research article

    Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, ge...

    Authors: Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez and Ahmed Abdel Sallam

    Citation: BMC Gastroenterology 2019 19:22

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  25. Content type: Research article

    Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is...

    Authors: Tingting Qi, Congyan Zhu, Guanting Lu, Jun Hao, Qinjun He, Yongpeng Chen, Fuyuan Zhou, Jinjun Chen and Jinlin Hou

    Citation: BMC Gastroenterology 2019 19:20

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  26. Content type: Research article

    Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

    Authors: Kessarin Thanapirom, Sombat Treeprasertsuk, Ngamphol Soonthornworasiri, Kittiyod Poovorawan, Roongruedee Chaiteerakij, Piyawat Komolmit, Kamthorn Phaosawasdi and Massimo Pinzani

    Citation: BMC Gastroenterology 2019 19:18

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  27. Content type: Research article

    The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed meth...

    Authors: Renáta Bor, Béla Vasas, Anna Fábián, Anita Bálint, Klaudia Farkas, Ágnes Milassin, László Czakó, Mariann Rutka, Tamás Molnár, Mónika Szűcs, László Tiszlavicz, László Kaizer, Sándor Hamar and Zoltán Szepes

    Citation: BMC Gastroenterology 2019 19:6

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  28. Content type: Research article

    The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not bee...

    Authors: Feiyang Wang, Zibo Meng, Shoukang Li, Yushun Zhang and Heshui Wu

    Citation: BMC Gastroenterology 2018 18:187

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  29. Content type: Research article

    To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers.

    Authors: Jian Hu, Nianyue Wang, Yongfeng Yang, Li Ma, Ruilin Han, Wei Zhang, Cunling Yan, Yijie Zheng and Xiaoqin Wang

    Citation: BMC Gastroenterology 2018 18:186

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  30. Content type: Research article

    Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best k...

    Authors: Lu Hao, Teng Wang, Lin He, Ya-Wei Bi, Di Zhang, Xiang-Peng Zeng, Lei Xin, Jun Pan, Dan Wang, Jun-Tao Ji, Ting-Ting Du, Jin-Huan Lin, Li-Sheng Wang, Wen-Bin Zou, Hui Chen, Ting Xie…

    Citation: BMC Gastroenterology 2018 18:182

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  31. Content type: Research article

    This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure ...

    Authors: Jing-Hua Li, Ning Zhu, Ying-Bin Min, Xiang-Zhou Shi, Yun-You Duan and Yi-Lin Yang

    Citation: BMC Gastroenterology 2018 18:181

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  32. Content type: Research article

    Intrahepatic cholangiocarcinoma (ICC) is a relatively rare subtype of cholangiocarcinoma. The study herein gathered experience of surgical treatment for ICC, and aimed to analyze the prognosis of patients who ...

    Authors: Kun-Ming Chan, Chun-Yi Tsai, Chun-Nan Yeh, Ta-Sen Yeh, Wei-Chen Lee, Yi-Yin Jan and Miin-Fu Chen

    Citation: BMC Gastroenterology 2018 18:180

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  33. Content type: Research article

    Acute decompensation (AD) has been shown to be associated with a high mortality rate for cirrhosis patients. This study aimed to develop a prognostic nomogram to evaluating the individual prognosis for AD of c...

    Authors: Fangyuan Gao, Xiaoshu Li, Gang Wan, Yuxin Li, Qun Zhang, Yao Liu, Huimin Liu, Hai Li and Xianbo Wang

    Citation: BMC Gastroenterology 2018 18:179

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  34. Content type: Research article

    Laparoscopic liver resection has been regarded as the standard treatment for liver tumors located at the left lateral liver sector. However, few studies have reported the results of laparoscopic left lateral s...

    Authors: Chao-Wei Lee, Hsin-I Tsai, Hao-Tsai Cheng, Wei-Ting Chen, Heng-Yuan Hsu, Chien-Chih Chiu, Yi-Ping Liu, Tsung-Han Wu, Ming-Chin Yu, Wei-Chen Lee and Miin-Fu Chen

    Citation: BMC Gastroenterology 2018 18:178

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  35. Content type: Research article

    The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.

    Authors: Francesco Giuseppe Foschi, Giorgio Bedogni, Marco Domenicali, Pierluigi Giacomoni, Anna Chiara Dall’Aglio, Francesca Dazzani, Arianna Lanzi, Fabio Conti, Sara Savini, Gaia Saini, Mauro Bernardi, Pietro Andreone, Amalia Gastaldelli, Andrea Casadei Gardini, Claudio Tiribelli, Stefano Bellentani…

    Citation: BMC Gastroenterology 2018 18:177

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  36. Content type: Research article

    Delayed gastric emptying (DGE) is one of the most frequent complications following pancreaticoduodenectomy. This meta-analysis aimed to evaluate the impact of Braun enteroenterostomy on DGE following pancreati...

    Authors: Yanming Zhou, Bin Hu, Kongyuan Wei and Xiaoying Si

    Citation: BMC Gastroenterology 2018 18:176

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  37. Content type: Research article

    Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC...

    Authors: Huiyong Wu, Wei Zhao, Jianbo Zhang, Jianjun Han and Shuguang Liu

    Citation: BMC Gastroenterology 2018 18:174

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  38. Content type: Research article

    Patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC) are frequently found to be unresectable on exploration due to small distant metastasis. This study was to investigate predictors of ...

    Authors: Xinchun Liu, Yue Fu, Qiuyang Chen, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao and Jishu Wei

    Citation: BMC Gastroenterology 2018 18:168

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  39. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) often requires deep sedation. Dexmedetomidine, a highly selective α2-adrenoceptor agonist with sedative activity and minimal effects on respiration, has re...

    Authors: Osamu Inatomi, Takayuki Imai, Takehide Fujimoto, Kenichiro Takahashi, Yoshihiro Yokota, Noriaki Yamashita, Hiroshi Hasegawa, Atsushi Nishida, Shigeki Bamba, Mitsushige Sugimoto and Akira Andoh

    Citation: BMC Gastroenterology 2018 18:166

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  40. Content type: Research article

    The incidence of liver-related events, cardiovascular events and type 2 diabetes mellitus in patients with histopathologically confirmed NAFLD remains unclear.

    Authors: Norio Akuta, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda and Hiromitsu Kumada

    Citation: BMC Gastroenterology 2018 18:165

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  41. Content type: Case report

    Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancre...

    Authors: Yangbei Zhu, Shuling Wang, Shengbing Zhao, Lin Qi, Zhaoshen Li and Yu Bai

    Citation: BMC Gastroenterology 2018 18:163

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  42. Content type: Research article

    Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between...

    Authors: Jian Yang, Bin Yan, Lihong Yang, Huimin Li, Yajuan Fan, Feng Zhu, Jie Zheng and Xiancang Ma

    Citation: BMC Gastroenterology 2018 18:161

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  43. Content type: Research article

    Advanced pancreatic cancer is accompanied not only by bile duct obstruction, but also occasionally by duodenal obstruction. With new advances in chemotherapy and improvement in the management of stent dysfunct...

    Authors: Kazuyuki Matsumoto, Hironari Kato, Shigeru Horiguchi, Koichiro Tsutsumi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:157

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  44. Content type: Research article

    To overcome duodenobiliary reflux induced by biliary stents, antireflux valve (ARV) biliary stents have been developed and showed improvement in stent patency. However, negative study results have also been re...

    Authors: Chang-Il Kwon, Jong Pil Moon, Ho Yun, Seok Jeong, Dong Hee Koh, Woo Jung Lee, Kwang Hyun Ko and Dae Hwan Kang

    Citation: BMC Gastroenterology 2018 18:150

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  45. Content type: Research article

    This study is to investigate the association between the hepatic expression of Yin Yang 1 (YY1) and the progression of non-alcoholic fatty liver disease (NAFLD) in patients undergoing bariatric surgery.

    Authors: Xianwen Yuan, Jun Chen, Qi Cheng, Yinjuan Zhao, Pengzi Zhang, Xiaoyan Shao, Yan Bi, Xiaolei Shi, Yitao Ding, Xitai Sun and Bin Xue

    Citation: BMC Gastroenterology 2018 18:147

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  46. Content type: Research article

    Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to i...

    Authors: Wenfei Li, Hongjie Chen, Shuai Wu and Jie Peng

    Citation: BMC Gastroenterology 2018 18:144

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  47. Content type: Research article

    Pancreatic pseudocyst (PPC) is a common complication of acute and chronic pancreatitis. To our knowledge no study has systematically reported the risk factors for the formation, intervention and recurrence of ...

    Authors: Jie-hui Tan, Lei Zhou, Rong-chang Cao and Guo-wei Zhang

    Citation: BMC Gastroenterology 2018 18:143

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  48. Content type: Case report

    Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed drugs and can cause drug-induced liver injury. Although patients with drug-induced liver injury from NSAIDs often recover spontaneously,...

    Authors: Wen Xie, Qi Wang, Yuanjiao Gao and Calvin Q. Pan

    Citation: BMC Gastroenterology 2018 18:142

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