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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Content type: Research article

    The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed meth...

    Authors: Renáta Bor, Béla Vasas, Anna Fábián, Anita Bálint, Klaudia Farkas, Ágnes Milassin, László Czakó, Mariann Rutka, Tamás Molnár, Mónika Szűcs, László Tiszlavicz, László Kaizer, Sándor Hamar and Zoltán Szepes

    Citation: BMC Gastroenterology 2019 19:6

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  2. Content type: Research article

    The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not bee...

    Authors: Feiyang Wang, Zibo Meng, Shoukang Li, Yushun Zhang and Heshui Wu

    Citation: BMC Gastroenterology 2018 18:187

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  3. Content type: Research article

    To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers.

    Authors: Jian Hu, Nianyue Wang, Yongfeng Yang, Li Ma, Ruilin Han, Wei Zhang, Cunling Yan, Yijie Zheng and Xiaoqin Wang

    Citation: BMC Gastroenterology 2018 18:186

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  4. Content type: Research article

    Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best k...

    Authors: Lu Hao, Teng Wang, Lin He, Ya-Wei Bi, Di Zhang, Xiang-Peng Zeng, Lei Xin, Jun Pan, Dan Wang, Jun-Tao Ji, Ting-Ting Du, Jin-Huan Lin, Li-Sheng Wang, Wen-Bin Zou, Hui Chen, Ting Xie…

    Citation: BMC Gastroenterology 2018 18:182

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  5. Content type: Research article

    This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure ...

    Authors: Jing-Hua Li, Ning Zhu, Ying-Bin Min, Xiang-Zhou Shi, Yun-You Duan and Yi-Lin Yang

    Citation: BMC Gastroenterology 2018 18:181

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  6. Content type: Research article

    Intrahepatic cholangiocarcinoma (ICC) is a relatively rare subtype of cholangiocarcinoma. The study herein gathered experience of surgical treatment for ICC, and aimed to analyze the prognosis of patients who ...

    Authors: Kun-Ming Chan, Chun-Yi Tsai, Chun-Nan Yeh, Ta-Sen Yeh, Wei-Chen Lee, Yi-Yin Jan and Miin-Fu Chen

    Citation: BMC Gastroenterology 2018 18:180

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  7. Content type: Research article

    Acute decompensation (AD) has been shown to be associated with a high mortality rate for cirrhosis patients. This study aimed to develop a prognostic nomogram to evaluating the individual prognosis for AD of c...

    Authors: Fangyuan Gao, Xiaoshu Li, Gang Wan, Yuxin Li, Qun Zhang, Yao Liu, Huimin Liu, Hai Li and Xianbo Wang

    Citation: BMC Gastroenterology 2018 18:179

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  8. Content type: Research article

    The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.

    Authors: Francesco Giuseppe Foschi, Giorgio Bedogni, Marco Domenicali, Pierluigi Giacomoni, Anna Chiara Dall’Aglio, Francesca Dazzani, Arianna Lanzi, Fabio Conti, Sara Savini, Gaia Saini, Mauro Bernardi, Pietro Andreone, Amalia Gastaldelli, Andrea Casadei Gardini, Claudio Tiribelli, Stefano Bellentani…

    Citation: BMC Gastroenterology 2018 18:177

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  9. Content type: Research article

    Laparoscopic liver resection has been regarded as the standard treatment for liver tumors located at the left lateral liver sector. However, few studies have reported the results of laparoscopic left lateral s...

    Authors: Chao-Wei Lee, Hsin-I Tsai, Hao-Tsai Cheng, Wei-Ting Chen, Heng-Yuan Hsu, Chien-Chih Chiu, Yi-Ping Liu, Tsung-Han Wu, Ming-Chin Yu, Wei-Chen Lee and Miin-Fu Chen

    Citation: BMC Gastroenterology 2018 18:178

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  10. Content type: Research article

    Delayed gastric emptying (DGE) is one of the most frequent complications following pancreaticoduodenectomy. This meta-analysis aimed to evaluate the impact of Braun enteroenterostomy on DGE following pancreati...

    Authors: Yanming Zhou, Bin Hu, Kongyuan Wei and Xiaoying Si

    Citation: BMC Gastroenterology 2018 18:176

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  11. Content type: Research article

    Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC...

    Authors: Huiyong Wu, Wei Zhao, Jianbo Zhang, Jianjun Han and Shuguang Liu

    Citation: BMC Gastroenterology 2018 18:174

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  12. Content type: Research article

    Patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC) are frequently found to be unresectable on exploration due to small distant metastasis. This study was to investigate predictors of ...

    Authors: Xinchun Liu, Yue Fu, Qiuyang Chen, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao and Jishu Wei

    Citation: BMC Gastroenterology 2018 18:168

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  13. Content type: Research article

    The incidence of liver-related events, cardiovascular events and type 2 diabetes mellitus in patients with histopathologically confirmed NAFLD remains unclear.

    Authors: Norio Akuta, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda and Hiromitsu Kumada

    Citation: BMC Gastroenterology 2018 18:165

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  14. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) often requires deep sedation. Dexmedetomidine, a highly selective α2-adrenoceptor agonist with sedative activity and minimal effects on respiration, has re...

    Authors: Osamu Inatomi, Takayuki Imai, Takehide Fujimoto, Kenichiro Takahashi, Yoshihiro Yokota, Noriaki Yamashita, Hiroshi Hasegawa, Atsushi Nishida, Shigeki Bamba, Mitsushige Sugimoto and Akira Andoh

    Citation: BMC Gastroenterology 2018 18:166

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  15. Content type: Case report

    Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancre...

    Authors: Yangbei Zhu, Shuling Wang, Shengbing Zhao, Lin Qi, Zhaoshen Li and Yu Bai

    Citation: BMC Gastroenterology 2018 18:163

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  16. Content type: Research article

    Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between...

    Authors: Jian Yang, Bin Yan, Lihong Yang, Huimin Li, Yajuan Fan, Feng Zhu, Jie Zheng and Xiancang Ma

    Citation: BMC Gastroenterology 2018 18:161

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  17. Content type: Research article

    Advanced pancreatic cancer is accompanied not only by bile duct obstruction, but also occasionally by duodenal obstruction. With new advances in chemotherapy and improvement in the management of stent dysfunct...

    Authors: Kazuyuki Matsumoto, Hironari Kato, Shigeru Horiguchi, Koichiro Tsutsumi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:157

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  18. Content type: Research article

    To overcome duodenobiliary reflux induced by biliary stents, antireflux valve (ARV) biliary stents have been developed and showed improvement in stent patency. However, negative study results have also been re...

    Authors: Chang-Il Kwon, Jong Pil Moon, Ho Yun, Seok Jeong, Dong Hee Koh, Woo Jung Lee, Kwang Hyun Ko and Dae Hwan Kang

    Citation: BMC Gastroenterology 2018 18:150

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  19. Content type: Research article

    This study is to investigate the association between the hepatic expression of Yin Yang 1 (YY1) and the progression of non-alcoholic fatty liver disease (NAFLD) in patients undergoing bariatric surgery.

    Authors: Xianwen Yuan, Jun Chen, Qi Cheng, Yinjuan Zhao, Pengzi Zhang, Xiaoyan Shao, Yan Bi, Xiaolei Shi, Yitao Ding, Xitai Sun and Bin Xue

    Citation: BMC Gastroenterology 2018 18:147

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  20. Content type: Research article

    Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to i...

    Authors: Wenfei Li, Hongjie Chen, Shuai Wu and Jie Peng

    Citation: BMC Gastroenterology 2018 18:144

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  21. Content type: Research article

    Pancreatic pseudocyst (PPC) is a common complication of acute and chronic pancreatitis. To our knowledge no study has systematically reported the risk factors for the formation, intervention and recurrence of ...

    Authors: Jie-hui Tan, Lei Zhou, Rong-chang Cao and Guo-wei Zhang

    Citation: BMC Gastroenterology 2018 18:143

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  22. Content type: Case report

    Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed drugs and can cause drug-induced liver injury. Although patients with drug-induced liver injury from NSAIDs often recover spontaneously,...

    Authors: Wen Xie, Qi Wang, Yuanjiao Gao and Calvin Q. Pan

    Citation: BMC Gastroenterology 2018 18:142

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  23. Content type: Research article

    With the rising demands for pancreas transplantation, surgeons are trying to extend the donors pool and set up a more appropriate assessment system. We aim to evaluate the effect of donor hypertension on recip...

    Authors: Zhen-Hua Hu, Yang-Jun Gu, Wen-Qi Qiu, Jie Xiang, Zhi-Wei Li, Jie Zhou and Shu-Sen Zheng

    Citation: BMC Gastroenterology 2018 18:141

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  24. Content type: Research article

    Early onset pancreatic cancer (EOPC), i.e. pancreatic ductal adenocarcinoma (PDAC) occurring in patients below 50 years of age, is rare and there is limited information regarding risk factors, molecular basis ...

    Authors: Chara Ntala, Silvana Debernardi, Roger M. Feakins and Tatjana Crnogorac-Jurcevic

    Citation: BMC Gastroenterology 2018 18:139

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  25. Content type: Research article

    Transarterial chemoembolization (TACE) is the recommended treatment for hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) B-stage, whereas sorafenib is an orally administered smal...

    Authors: Lin Li, Wenzhuo Zhao, Mengmeng Wang, Jie Hu, Enxin Wang, Yan Zhao and Lei Liu

    Citation: BMC Gastroenterology 2018 18:138

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  26. Content type: Research article

    Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on si...

    Authors: Shuzhen Wang, Xin Zhang, Tao Han, Wen Xie, Yonggang Li, Hong Ma, Roman Liebe, Honglei Weng and Hui-Guo Ding

    Citation: BMC Gastroenterology 2018 18:137

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  27. Content type: Case report

    IgG4-related disease (IgG4-RD) is a newly recognized autoimmune systemic disorder characterized by elevated levels of serum IgG4 and abundant infiltration of IgG4-positive plasmacytes in the affected organs. T...

    Authors: Xuexue Deng, Ronghua Fang, Jianshu Zhang and Rongqiong Li

    Citation: BMC Gastroenterology 2018 18:136

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  28. Content type: Case report

    Iguratimod is a novel anti-rheumatic drug with the capability of anti-cytokines as report goes. It has been reported that iguratimod is effective and safe for rheumatoid arthritis and other rheumatisms. As sid...

    Authors: Xiao-li Li, Xiao-Chang Liu, Yu-Lin Song, Ru-Tao Hong and Hai Shi

    Citation: BMC Gastroenterology 2018 18:130

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  29. Content type: Research article

    Anorexia nervosa (AN) concerns approximately up to 1.8% of the pediatric female population. One of the complications that can occur in the course of this disease is acute liver failure. This study’s objective ...

    Authors: Katarzyna Górowska-Kowolik, Agata Chobot and Jarosław Kwiecień

    Citation: BMC Gastroenterology 2018 18:126

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  30. Content type: Research article

    A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potenti...

    Authors: Guo chao Niu, Lei Liu, Libo Zheng, Hong Zhang, David Q. Shih and Xiaolan Zhang

    Citation: BMC Gastroenterology 2018 18:127

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  31. Content type: Research article

    Currently, no standard of care or therapies have been established for patients with advanced HCC. We evaluated the efficacy and safety of conventional transarterial chemoembolization using gelatin sponges or m...

    Authors: Yi-Sheng Liu, Chia-Ying Lin, Ming-Tsung Chuang, Chia-Ying Lin, Yi-Shan Tsai, Chien-Kuo Wang and Ming-Ching Ou

    Citation: BMC Gastroenterology 2018 18:124

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  32. Content type: Research article

    The vertical transmission of HBV from mothers to their infants at birth or in early infancy has a significant role in the endemicity of HBV infection. Tenofovir is one of the most potent anti-HBV agents with a...

    Authors: Wenhui Li, Li Jia, Xin Zhao, Xiaoyuan Wu and Hongxia Tang

    Citation: BMC Gastroenterology 2018 18:121

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  33. Content type: Case report

    Acute pancreatitis is an acute inflammation of the pancreas that varies in severity from mild to life threatening usually requiring hospitalization. The true incidence of drug-induced pancreatitis (DIP) is ind...

    Authors: Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar and Vesna Tegeltija

    Citation: BMC Gastroenterology 2018 18:122

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  34. Content type: Research article

    The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening marke...

    Authors: Birgit Tsaknakis, Rawan Masri, Ahmad Amanzada, Golo Petzold, Volker Ellenrieder, Albrecht Neesse and Steffen Kunsch

    Citation: BMC Gastroenterology 2018 18:123

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  35. Content type: Research article

    Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The p...

    Authors: Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang and Zhijun Duan

    Citation: BMC Gastroenterology 2018 18:112

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  36. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populati...

    Authors: Bashu Dev Pardhe, Shreena Shakya, Anjeela Bhetwal, Jennifer Mathias, Puspa Raj Khanal, Roshan Pandit, Jyotsna Shakya, Hari Om Joshi and Sujan Babu Marahatta

    Citation: BMC Gastroenterology 2018 18:109

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  37. Content type: Research article

    Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distrib...

    Authors: Marta Gravito-Soares, Elisa Gravito-Soares, Dário Gomes, Nuno Almeida and Luís Tomé

    Citation: BMC Gastroenterology 2018 18:108

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  38. Content type: Research article

    Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic variations in Indian patients with PFIC are lacking.

    Authors: Anjali Sharma, Ujjal Poddar, Shikha Agnihotry, Shubha R. Phadke, Surender K. Yachha and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2018 18:107

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  39. Content type: Research article

    Recently, although studies have investigated the role of NSAIDs in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), selection of the ideal drug, the time and route of i...

    Authors: Yunxiao Lyu, Yunxiao Cheng, Bin Wang, Yueming Xu and Weibing Du

    Citation: BMC Gastroenterology 2018 18:106

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  40. Content type: Research article

    Laparoscopic pancreaticoduodenectomy (LPD) remains to be established as a safe and effective alternative to open pancreaticoduodenectomy (OPD) for pancreatic-head and periampullary malignancy. The purpose of t...

    Authors: Ke Chen, Xiao-long Liu, Yu Pan, Hendi Maher and Xian-fa Wang

    Citation: BMC Gastroenterology 2018 18:102

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  41. Content type: Case report

    Chronic Hepatitis C Virus (HCV) infection has been commonly linked to the development of autoimmunity, in part through activation of B cells. B cells are also postulated to play a pathogenic role in the autoim...

    Authors: Henry H. Nguyen, Abdullah Khathlan, Marvin J. Fritzler and Mark G. Swain

    Citation: BMC Gastroenterology 2018 18:97

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  42. Content type: Case report

    Transient infantile hypertriglyceridemia (HTGTI) is an autosomal recessive disorder caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene.

    Authors: Jia-Qi Li, Xin-Bao Xie, Jia-Yan Feng, Lian Chen, Kuerbanjiang Abuduxikuer, Yi Lu, Yu-Chuan Li and Jian-She Wang

    Citation: BMC Gastroenterology 2018 18:96

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  43. Content type: Case report

    Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications,...

    Authors: Cheng Zhang, Yue-Feng Ma and Yu-Long Yang

    Citation: BMC Gastroenterology 2018 18:90

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  44. Content type: Research article

    Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between h...

    Authors: Xiaoyao Li, Lu Ke, Jie Dong, Bo Ye, Lei Meng, Wenjian Mao, Qi Yang, Weiqin Li and Jieshou Li

    Citation: BMC Gastroenterology 2018 18:89

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  45. Content type: Study protocol

    Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases....

    Authors: Arthur J. A. T. Braat, Dik J. Kwekkeboom, Boen L. R. Kam, Jaap J. M. Teunissen, Wouter W. de Herder, Koen M. A. Dreijerink, Rob van Rooij, Gerard C. Krijger, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: BMC Gastroenterology 2018 18:84

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  46. Content type: Research article

    Portopulmonary hypertension (PPH) was once regarded as a contraindicaton to liver transplantation (LT). However, growing evidence has indicated that PPH patients undergoing LT may show similar outcomes compare...

    Authors: Bingsong Huang, Yi Shi, Jun Liu, Paul M. Schroder, Suxiong Deng, Maogen Chen, Jun Li, Yi Ma and Ronghai Deng

    Citation: BMC Gastroenterology 2018 18:79

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  47. Content type: Research article

    One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide ...

    Authors: Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz and Per Stål

    Citation: BMC Gastroenterology 2018 18:78

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