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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 1 of 9

  1. Content type: Research article

    To provide criteria for the differential diagnosis of serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) by analyzing the imaging features of these two neoplasms by endoscopic ultrasound (EUS).

    Authors: Lisen Zhong, Ningli Chai, Enqiang Linghu, Huikai Li, Jing Yang and Ping Tang

    Citation: BMC Gastroenterology 2019 19:127

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  2. Content type: Research article

    This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis fact...

    Authors: Li-Wei Chen, Cheng-Hung Chien, Sheng-Fong Kuo, Chia-Ying Yu, Chih-Lang Lin and Rong-Nan Chien

    Citation: BMC Gastroenterology 2019 19:126

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  3. Content type: Research article

    General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis...

    Authors: Feryal Savari, Seyyed Ali Mard, Mohammad Badavi, Anahita Rezaie and Mohammad Kazem Gharib-Naseri

    Citation: BMC Gastroenterology 2019 19:125

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  4. Content type: Case report

    Cystic fibrosis (CF) is a genetic disorder of the epithelial CFTR apical chloride channel resulting in multi-organ manifestations, including pancreatic exocrine secretion. In the pancreas, CFTR abnormality res...

    Authors: J. Dixon Johns and Steven M. Rowe

    Citation: BMC Gastroenterology 2019 19:123

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  5. Content type: Research article

    The identification of patients with advanced liver fibrosis secondary to non-alcoholic fatty liver disease (NAFLD) remains challenging. Using non-invasive liver fibrosis tests (NILT) in primary care may permit...

    Authors: Ankur Srivastava, Simcha Jong, Anna Gola, Ruth Gailer, Sarah Morgan, Karen Sennett, Sudeep Tanwar, Elena Pizzo, James O’Beirne, Emmanuel Tsochatzis, Julie Parkes and William Rosenberg

    Citation: BMC Gastroenterology 2019 19:122

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  7. Content type: Research article

    Multiple organ failure (MOF) is a serious complication of moderately severe (MASP) and severe acute pancreatitis (SAP). This study aimed to develop and assess three machine-learning models to predict MOF.

    Authors: Qiu Qiu, Yong-jian Nian, Yan Guo, Liang Tang, Nan Lu, Liang-zhi Wen, Bin Wang, Dong-feng Chen and Kai-jun Liu

    Citation: BMC Gastroenterology 2019 19:118

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  9. Content type: Case report

    Acute anaemia in decompensated liver cirrhosis is commonly caused due to gastrointestinal bleeding; however, sometimes, detecting the site of blood loss is challenging.

    Authors: Marco Biolato, Claudia Tarli, Giuseppe Marrone, Brunella Barbaro, Antonio Liguori, Antonio Gasbarrini and Antonio Grieco

    Citation: BMC Gastroenterology 2019 19:112

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  10. Content type: Research article

    Beta-herpesviruses are common opportunistic pathogens that cause morbidity after liver transplantation (LT).

    Authors: Conrad Rauber, Katja Bartelheimer, Taotao Zhou, Christian Rupp, Paul Schnitzler, Peter Schemmer, Peter Sauer, Karl Heinz Weiss and Daniel Nils Gotthardt

    Citation: BMC Gastroenterology 2019 19:110

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  11. Content type: Case report

    Biliary mucinous cystic neoplasms are rare cystic lesions of the liver which carry pre-malignant potential. Given the scarcity of reports in the literature, they pose a considerable challenge to clinical manag...

    Authors: Côme Tholomier, Yifan Wang, Olga Aleynikova, Tsafrir Vanounou and Jean-Sebastien Pelletier

    Citation: BMC Gastroenterology 2019 19:103

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  12. Content type: Research article

    The preventive effects of antiviral therapy to reduce rebleeding rate in patients with hepatitis B-related cirrhosis undergoing endoscopic treatment have not yet been reported.

    Authors: Lingling He, Xiaohui Ye, Jiali Ma, Ping Li, Yu Jiang, Julong Hu, Junru Yang, Yuling Zhou, Xiuxia Liang, Yijun Lin and Hongshan Wei

    Citation: BMC Gastroenterology 2019 19:101

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  13. Content type: Research article

    Radical surgery for Bismuth type III/IV hilar cholangiocellular carcinoma, which was usually considered unresectable, seems to improve prognosis by increasing the surgical curability rate. However, the dilemma...

    Authors: Qi-jiong Li, Zhong-guo Zhou, Xiao-jun Lin, Xiang-ming Lao, Bo-kang Cui and Sheng-ping Li

    Citation: BMC Gastroenterology 2019 19:99

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  14. Content type: Research article

    Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with va...

    Authors: Jianhua Hu, Xiaoli Zhang, Guodong Yu, Huan Cai, Jueqing Gu, Menglin Hu, Dairong Xiang, Jiangshan Lian, Liang Yu, Hongyu Jia, Yimin Zhang and Yida Yang

    Citation: BMC Gastroenterology 2019 19:94

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  15. Content type: Research article

    The removal of large bile duct stones (> 15 mm) by conventional endoscopic sphincterotomy (EST) and endoscopic papillary balloon dilation (EPBD) can be challenging, requiring mechanical lithotripsy (ML) in add...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Cheng-Kun Wu, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Keng-Liang Wu, Seng-Kee Chuah and Chung-Huang Kuo

    Citation: BMC Gastroenterology 2019 19:93

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  16. Content type: Case report

    Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...

    Authors: Tao Lu, Bin Song, Hong Pu, Xinglan Li, Qiqi Chen and Chong Yang

    Citation: BMC Gastroenterology 2019 19:92

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  17. Content type: Research article

    The fibrosis-4 index (FIB-4) has been reported to be associated with all-cause mortality in several chronic diseases. In this study, we investigated whether at diagnosis could be associated with all-cause mort...

    Authors: Hee Jin Park, Jun Yong Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Gastroenterology 2019 19:90

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  18. Content type: Research article

    Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes af...

    Authors: Xiaoling Chi, Huanming Xiao, Meijie Shi, Gaoshu Cai, Yubao Xie, Junmin Jiang, Guangjun Tian, Shuduo Wu, Chaozhen Zhang, Pengtao Zhao and Jiezhen Chen

    Citation: BMC Gastroenterology 2019 19:88

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  19. Content type: Research article

    The relationship between visceral adiposity and acute pancreatitis (AP) has not been completely elucidated. This study evaluated the significance of visceral adipose tissue (VAT) and the ratio of VAT to skelet...

    Authors: Jiarong Xie, Lu Xu, Yuning Pan, Peifei Li, Yi Liu, Yue Pan and Lei Xu

    Citation: BMC Gastroenterology 2019 19:87

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  20. Content type: Research article

    Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of...

    Authors: Yinping Li, Xiaomei Wang, Ge Yu, Haibo Sun, Juan Lv, Xiumei Chi, Ruihong Wu, Xiuzhu Gao and Junqi Niu

    Citation: BMC Gastroenterology 2019 19:86

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  21. Content type: Case report

    Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms...

    Authors: Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya and Shuji Terai

    Citation: BMC Gastroenterology 2019 19:85

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  22. Content type: Research article

    Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present ...

    Authors: Ye-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao Xun

    Citation: BMC Gastroenterology 2019 19:84

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  23. Content type: Case report

    Chronic hepatitis E represents an emerging challenge in organ transplantation, as there are currently no established treatment options for patients who fail to clear hepatitis E virus (HEV) following reduction...

    Authors: Montserrat Fraga, Jérôme Gouttenoire, Roland Sahli, Haithem Chtioui, Cristina Marcu, Manuel Pascual, Darius Moradpour and Julien Vionnet

    Citation: BMC Gastroenterology 2019 19:76

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  24. Content type: Research article

    Antiviral treatment for chronic hepatitis B (CHB) is largely unavailable in sub-Saharan Africa; hence, little is known about the prognosis after initiating treatment in African CHB patients. In this study we a...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Girmay Medhin, Bitsatab Mekasha, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Gastroenterology 2019 19:74

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  25. Content type: Research article

    Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early predic...

    Authors: Jianhua Wan, Xiaoyu Yang, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2019 19:67

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  26. Content type: Research article

    Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

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  27. Content type: Research article

    Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with...

    Authors: Jian Sun, Huiguo Ding, Guofeng Chen, Guiqiang Wang, Lai Wei, Jiming Zhang, Qing Xie, Mobin Wan, Hong Tang, Shijun Chen, Zhiliang Gao, Yuming Wang, Dazhi Zhang, Wenxiang Huang, Jifang Sheng, Qin Ning…

    Citation: BMC Gastroenterology 2019 19:65

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  28. Content type: Research article

    Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

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  29. Content type: Research article

    Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiati...

    Authors: Xing Hu, Xiaojie Huang, Hui Chen, Tong Zhang, Jianhua Hou, Aixin Song, Lei Ding, Weiyuan Liu, Hao Wu and Fankun Meng

    Citation: BMC Gastroenterology 2019 19:60

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  30. Content type: Research article

    The latest 8th edition of the AJCC staging system emphasizes the importance of tumor size however, the clinical significance of the combination of tumor location with tumor size remains unknown.

    Authors: Zibo Meng, Mingsi Cao, Yushun Zhang, Zhiqiang Liu, Shihong Wu and Heshui Wu

    Citation: BMC Gastroenterology 2019 19:59

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  31. Content type: Case report

    Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in t...

    Authors: Rugile Mickuniene, Ieva Stundiene, Tomas Jucaitis, Dileta Valanciene and Jonas Valantinas

    Citation: BMC Gastroenterology 2019 19:57

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  32. Content type: Research article

    The prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among elderly have not been well described. Our aim was to assess the prevalence, risk factors and mortality of NAFLD in individuals old...

    Authors: Pegah Golabi, James Paik, Rashmi Reddy, Elisabetta Bugianesi, Gregory Trimble and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:56

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  33. Content type: Research article

    Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success ra...

    Authors: Yan Chen, Yueping Jiang, Wei Qian, Qihong Yu, Yuanhang Dong, Huiyun Zhu, Feng Liu, Yiqi Du, Dong Wang and Zhaoshen Li

    Citation: BMC Gastroenterology 2019 19:54

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  34. Content type: Research article

    As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic h...

    Authors: Yayun Liu, Meng Jiang, Jianya Xue, Hongli Yan and Xuesong Liang

    Citation: BMC Gastroenterology 2019 19:53

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:72

  35. Content type: Research article

    Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis. Despite good diagnostic performance, clinical application of CAP is limited due to the influences of covariates...

    Authors: Ke Pu, Yuping Wang, Suyang Bai, Hui Wei, Yongning Zhou, Jiangao Fan and Liang Qiao

    Citation: BMC Gastroenterology 2019 19:51

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  36. Content type: Research article

    Bilomas are defined collections of bile fluids mainly caused by iatrogenic injuries of the bile duct system. Owing to the infrequency of this disease, studies addressing bilomas are rare.

    Authors: S. Würstle, A. Göß, C. D. Spinner, W. Huber, H. Algül, C. Schlag, R. M. Schmid, A. Weber, A. Obermeier and J. Schneider

    Citation: BMC Gastroenterology 2019 19:50

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  37. Content type: Research article

    Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn’s disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in i...

    Authors: Fotios S. Fousekis, Konstantinos H. Katsanos, Vasileios I. Theopistos, Gerasimos Baltayiannis, Maria Kosmidou, Georgios Glantzounis, Leonidas Christou, Epameinondas V. Tsianos and Dimitrios K. Christodoulou

    Citation: BMC Gastroenterology 2019 19:48

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  38. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead to liver cirrhosis or liver cancer. Small intestinal bacterial overgrowt...

    Authors: Yoga Fitriakusumah, C. Rinaldi A. Lesmana, Winda Permata Bastian, Chyntia O. M. Jasirwan, Irsan Hasan, Marcellus Simadibrata, Juferdy Kurniawan, Andri Sanityoso Sulaiman and Rino A. Gani

    Citation: BMC Gastroenterology 2019 19:43

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  39. Content type: Research article

    The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

    Authors: Linda Heitz, Wolfgang Kratzer, Tilmann Gräter and Julian Schmidberger

    Citation: BMC Gastroenterology 2019 19:42

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  40. Content type: Research article

    Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent mod...

    Authors: Gao Sun, Charles V. Jackson, Karen Zimmerman, Li-Kun Zhang, Courtney M. Finnearty, George E. Sandusky, Guodong Zhang, Richard G. Peterson and Yi-Xin (Jim) Wang

    Citation: BMC Gastroenterology 2019 19:41

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  41. Content type: Study protocol

    The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...

    Authors: Rianne van Rijn, Aad P. van den Berg, Joris I. Erdmann, Nigel Heaton, Bart van Hoek, Jeroen de Jonge, Henri G. D. Leuvenink, Shekar V. K. Mahesh, Sarah Mertens, Diethard Monbaliu, Paolo Muiesan, M. Thamara P. R. Perera, Wojciech G. Polak, Xavier Rogiers, Roberto I. Troisi, Yvonne de Vries…

    Citation: BMC Gastroenterology 2019 19:40

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  43. Content type: Research article

    Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP w...

    Authors: Marcus Reuterwall, Jeanne Lubbe, Lars Enochsson, Lars Lundell, Magnus Konradsson, Frederik Swahn, Marco Del Chiaro, Matthias Löhr and Urban Arnelo

    Citation: BMC Gastroenterology 2019 19:35

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  44. Content type: Research article

    The recurrence of esophageal varices remains high in patients with hepatic portal hypertension after the endoscopic esophageal variceal eradication therapies, including endoscopic variceal band ligation (EVL),...

    Authors: Junfu Zheng, Yuening Zhang, Peng Li, Shibin Zhang, Yue Li, Lei Li and Huiguo Ding

    Citation: BMC Gastroenterology 2019 19:32

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  45. Content type: Research article

    Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-...

    Authors: Xiang-Peng Zeng, Ting-Ting Liu, Lu Hao, Lei Xin, Teng Wang, Lin He, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Hong-Lei Guo, Hui Chen…

    Citation: BMC Gastroenterology 2019 19:31

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  46. Content type: Research article

    Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnos...

    Authors: Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D. Goodman and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:27

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  47. Content type: Research article

    Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from margi...

    Authors: Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata and Taizo Hibi

    Citation: BMC Gastroenterology 2019 19:25

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  48. Content type: Research article

    Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, ge...

    Authors: Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez and Ahmed Abdel Sallam

    Citation: BMC Gastroenterology 2019 19:22

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  49. Content type: Research article

    Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is...

    Authors: Tingting Qi, Congyan Zhu, Guanting Lu, Jun Hao, Qinjun He, Yongpeng Chen, Fuyuan Zhou, Jinjun Chen and Jinlin Hou

    Citation: BMC Gastroenterology 2019 19:20

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  50. Content type: Research article

    Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

    Authors: Kessarin Thanapirom, Sombat Treeprasertsuk, Ngamphol Soonthornworasiri, Kittiyod Poovorawan, Roongruedee Chaiteerakij, Piyawat Komolmit, Kamthorn Phaosawasdi and Massimo Pinzani

    Citation: BMC Gastroenterology 2019 19:18

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