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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in < 1 person in 1,000,000 individuals. For accurate diagnosis, information regarding multiple graphic modalities in HEH is required. Howe...

    Authors: Jun Arai, Yuu Shimozuma, Yumi Otoyama, Ikuya Sugiura, Yoko Nakajima, Eiichi Hayashi, Atsushi Kajiwara, Risa Omori, Shojiro Uozumi, Miyuki Miyashita, Manabu Uchikoshi, Hiroyoshi Doi, Masashi Sakaki, Tianpeng Wang, Junichi Eguchi, Takayoshi Ito…

    Citation: BMC Gastroenterology 2019 19:187

    Content type: Case report

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  2. Choledocholithiasis is an endemic condition in the world. Although rare, foreign body migration with biliary complications needs to be considered in the differential diagnosis for patients presenting with typi...

    Authors: Min Yu, Bowen Huang, Ye Lin, Yuxue Nie, Zixuan Zhou, Shanshan Liu and Baohua Hou

    Citation: BMC Gastroenterology 2019 19:177

    Content type: Case report

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  3. Hepatolithiasis, featuring high incidence, severe symptoms, and common recurrence, poses a heavy disease burden. Endoscopic management provides an opportunity to cure hepatolithiasis, but fails to properly res...

    Authors: Jianying Lou, Qida Hu, Tao Ma, Wei Chen, Ji Wang and Prasoon Pankaj

    Citation: BMC Gastroenterology 2019 19:172

    Content type: Technical advance

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  4. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can induce a stronger regenerative ability than traditional 2-stage hepatectomy (TSH). ALPPS has become popular for achieving...

    Authors: Xukun Wu, Jiawei Rao, Xiaozhuan Zhou, Ronghai Deng and Yi Ma

    Citation: BMC Gastroenterology 2019 19:170

    Content type: Research article

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  5. Pruritus is a common symptom seen in patients with chronic liver disease. However, frequency and severity of pruritus in patients with chronic liver disease is unclear. We investigated frequency, severity and ...

    Authors: Hatsue Fujino, Mio Tanaka, Michio Imamura, Kei Morio, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Shoichi Takahashi, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C. Nelson Hayes and Kazuaki Chayama

    Citation: BMC Gastroenterology 2019 19:169

    Content type: Research article

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  6. The efficacy of some therapeutic methods (open surgical debridement (OSD), conservative treatment (CST) and minimally invasive drainage (MID)) for severe acute pancreatitis (SAP) and moderately severe acute pa...

    Authors: Kai Zhang, Xiaole Zhu, Chaoqun Hou, Chenyuan Shi, Yi Miao and Qiang Li

    Citation: BMC Gastroenterology 2019 19:168

    Content type: Research article

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  7. To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis.

    Authors: Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Keisuke Nakanishi, Yuki Tsuji, Naotaka Shimozato, Kei Moriya, Kenichiro Seki, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Ryuichi Noguchi, Masanori Matsumoto…

    Citation: BMC Gastroenterology 2019 19:167

    Content type: Research article

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  8. Extracorporeal liver support therapies (ELS) are technical options (for bridge-to-recovery as well as bridge-to-transplant) in patients with acute liver dysfunction (e.g. acute liver failure (ALF), acute-on ch...

    Authors: Thomas Wiesmann, Dominic Hoenl, Hinnerk Wulf and Marc Irqsusi

    Citation: BMC Gastroenterology 2019 19:160

    Content type: Research article

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  9. Primary sclerosing cholangitis is a chronic cholestatic liver disease. The pathomechanism is still not fully understood, but there is evidence that immune-mediated processes may contribute to disease progression.

    Authors: Theresa Hippchen, Peter Sauer, Benjamin Göppert, Peter Schirmacher, Daniel Nils Gotthardt, Karl-Heinz Weiss, Wolfgang Stremmel and Christian Rupp

    Citation: BMC Gastroenterology 2019 19:153

    Content type: Research article

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  10. Alcoholic liver disease (ALD) is the leading cause of liver transplantation (LT). The magnitude and risk factors of post-LT alcohol relapse are not well described. We conducted a meta-analysis to evaluate alco...

    Authors: Lancharat Chuncharunee, Noriyo Yamashiki, Ammarin Thakkinstian and Abhasnee Sobhonslidsuk

    Citation: BMC Gastroenterology 2019 19:150

    Content type: Research article

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  11. Caspase-1 is an evolutionarily conserved enzyme that proteolytically cleaves the precursors of the inflammatory cytokines interleukin 1β and interleukin 18. However, the role of caspase-1 in determining the se...

    Authors: Xiangying Zhang, Peiling Dong, Lin Xu, Yuan Tian, Huayin Sun, Hongbo Shi, Zhongping Duan, Liyan Chen and Feng Ren

    Citation: BMC Gastroenterology 2019 19:148

    Content type: Research article

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  12. Prior hepatitis B virus infection (PBI) may increase the risk of developing hepatocellular carcinoma (HCC), but the impact of PBI on clinical outcomes following treatment for HCC remains unknown. The aim of th...

    Authors: Yutaka Midorikawa, Tadatoshi Takayama, Hisashi Nakayama, Tokio Higaki, Masamichi Moriguchi, Kyoji Moriya, Tatsuo Kanda, Shunichi Matsuoka and Mitsuhiko Moriyama

    Citation: BMC Gastroenterology 2019 19:147

    Content type: Research article

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  13. Paragangliomas, also known as chemodectomas, are rare tumors arise from chemoreceptor tissue, and most commonly locate at the bifurcation of the common carotid, the jugular foramen, aortic arch, and retroperit...

    Authors: Zhao-Ru Dong, Yan-Ni Xia, Yue-Yi Zhao, Rui Wu, Kai-Xuan Liu, Kai Shi, Lun-Jie Yan, Cheng-Yu Yao, Yu-Chuan Yan and Tao Li

    Citation: BMC Gastroenterology 2019 19:142

    Content type: Case report

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:152

  14. Abdominal compartment syndrome (ACS) is associated with mortality in patients with critical illness such as severe acute pancreatitis, but it remains unclear whether decompressive laparotomy for ACS can improv...

    Authors: Shinya Ikeda, Takuma Kagami, Shinya Tani, Takahiro Uotani, Mihoko Yamade, Yasushi Hamaya, Yoshifumi Morita, Takanori Sakaguchi, Satoshi Osawa and Ken Sugimoto

    Citation: BMC Gastroenterology 2019 19:141

    Content type: Case report

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  15. Endoscopic transpapillary cannulation of the gallbladder is useful but challenging. This study aimed to investigate cystic duct anatomy patterns, which may guide cystic duct cannulation.

    Authors: Jun Cao, Xiwei Ding, Han Wu, Yonghua Shen, Ruhua Zheng, Chunyan Peng, Lei Wang and Xiaoping Zou

    Citation: BMC Gastroenterology 2019 19:139

    Content type: Research article

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  16. This study aims to evaluate the efficacy and safety of detecting and removing residual common bile duct stones (CBDS) using direct peroralcholangioscopy (DPOC) after performing endoscopic retrograde cholangiop...

    Authors: Jun-Jie Yang, Xiong-Chang Liu, Xiao-Qin Chen, Qi-Yong Zhang and Tian-Rang Liu

    Citation: BMC Gastroenterology 2019 19:135

    Content type: Research article

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  17. In cirrhosis upper-gastrointestinal-endoscopy (UGIE) identifies oesophageal varices (OV). UGIE is unavailable in most resource-limited settings. Therefore, we assessed prediction of presence of OV using hemato...

    Authors: K. Perera, S. K. Kodisinghe, D. S. Ediriweera, D. Moratuwagama, S. Williams, A. Pathmeswaran, M. A. Niriella and H. J. de Silva

    Citation: BMC Gastroenterology 2019 19:134

    Content type: Research article

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  18. Hepatocellular carcinoma (HCC) is a kind of malignancies to impact human health. It has been reported that aberrant toll-like receptor (TLR) signaling may contribute to the development and progression of HCC, ...

    Authors: Liyu Shi, Xiaoqiu Zheng, Yuzhuo Fan, Xiaolan Yang, Aimei Li and Jun Qian

    Citation: BMC Gastroenterology 2019 19:130

    Content type: Research article

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  19. Imaging is an essential tool in the management of patients with Colorectal cancer (CRC) by helping evaluate number and sites of metastases, determine resectability, assess response to treatment, detect drug to...

    Authors: Vincenza Granata, Roberta Fusco, Elisabetta de Lutio di Castelguidone, Antonio Avallone, Raffaele Palaia, Paolo Delrio, Fabiana Tatangelo, Gerardo Botti, Roberto Grassi, Francesco Izzo and Antonella Petrillo

    Citation: BMC Gastroenterology 2019 19:129

    Content type: Research article

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  20. To provide criteria for the differential diagnosis of serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) by analyzing the imaging features of these two neoplasms by endoscopic ultrasound (EUS).

    Authors: Lisen Zhong, Ningli Chai, Enqiang Linghu, Huikai Li, Jing Yang and Ping Tang

    Citation: BMC Gastroenterology 2019 19:127

    Content type: Research article

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  21. This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis fact...

    Authors: Li-Wei Chen, Cheng-Hung Chien, Sheng-Fong Kuo, Chia-Ying Yu, Chih-Lang Lin and Rong-Nan Chien

    Citation: BMC Gastroenterology 2019 19:126

    Content type: Research article

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  22. General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis...

    Authors: Feryal Savari, Seyyed Ali Mard, Mohammad Badavi, Anahita Rezaie and Mohammad Kazem Gharib-Naseri

    Citation: BMC Gastroenterology 2019 19:125

    Content type: Research article

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  23. Cystic fibrosis (CF) is a genetic disorder of the epithelial CFTR apical chloride channel resulting in multi-organ manifestations, including pancreatic exocrine secretion. In the pancreas, CFTR abnormality res...

    Authors: J. Dixon Johns and Steven M. Rowe

    Citation: BMC Gastroenterology 2019 19:123

    Content type: Case report

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  24. The identification of patients with advanced liver fibrosis secondary to non-alcoholic fatty liver disease (NAFLD) remains challenging. Using non-invasive liver fibrosis tests (NILT) in primary care may permit...

    Authors: Ankur Srivastava, Simcha Jong, Anna Gola, Ruth Gailer, Sarah Morgan, Karen Sennett, Sudeep Tanwar, Elena Pizzo, James O’Beirne, Emmanuel Tsochatzis, Julie Parkes and William Rosenberg

    Citation: BMC Gastroenterology 2019 19:122

    Content type: Research article

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  26. Multiple organ failure (MOF) is a serious complication of moderately severe (MASP) and severe acute pancreatitis (SAP). This study aimed to develop and assess three machine-learning models to predict MOF.

    Authors: Qiu Qiu, Yong-jian Nian, Yan Guo, Liang Tang, Nan Lu, Liang-zhi Wen, Bin Wang, Dong-feng Chen and Kai-jun Liu

    Citation: BMC Gastroenterology 2019 19:118

    Content type: Research article

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  28. Acute anaemia in decompensated liver cirrhosis is commonly caused due to gastrointestinal bleeding; however, sometimes, detecting the site of blood loss is challenging.

    Authors: Marco Biolato, Claudia Tarli, Giuseppe Marrone, Brunella Barbaro, Antonio Liguori, Antonio Gasbarrini and Antonio Grieco

    Citation: BMC Gastroenterology 2019 19:112

    Content type: Case report

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  29. Beta-herpesviruses are common opportunistic pathogens that cause morbidity after liver transplantation (LT).

    Authors: Conrad Rauber, Katja Bartelheimer, Taotao Zhou, Christian Rupp, Paul Schnitzler, Peter Schemmer, Peter Sauer, Karl Heinz Weiss and Daniel Nils Gotthardt

    Citation: BMC Gastroenterology 2019 19:110

    Content type: Research article

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  30. Biliary mucinous cystic neoplasms are rare cystic lesions of the liver which carry pre-malignant potential. Given the scarcity of reports in the literature, they pose a considerable challenge to clinical manag...

    Authors: Côme Tholomier, Yifan Wang, Olga Aleynikova, Tsafrir Vanounou and Jean-Sebastien Pelletier

    Citation: BMC Gastroenterology 2019 19:103

    Content type: Case report

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  31. The preventive effects of antiviral therapy to reduce rebleeding rate in patients with hepatitis B-related cirrhosis undergoing endoscopic treatment have not yet been reported.

    Authors: Lingling He, Xiaohui Ye, Jiali Ma, Ping Li, Yu Jiang, Julong Hu, Junru Yang, Yuling Zhou, Xiuxia Liang, Yijun Lin and Hongshan Wei

    Citation: BMC Gastroenterology 2019 19:101

    Content type: Research article

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  32. Radical surgery for Bismuth type III/IV hilar cholangiocellular carcinoma, which was usually considered unresectable, seems to improve prognosis by increasing the surgical curability rate. However, the dilemma...

    Authors: Qi-jiong Li, Zhong-guo Zhou, Xiao-jun Lin, Xiang-ming Lao, Bo-kang Cui and Sheng-ping Li

    Citation: BMC Gastroenterology 2019 19:99

    Content type: Research article

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  33. Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with va...

    Authors: Jianhua Hu, Xiaoli Zhang, Guodong Yu, Huan Cai, Jueqing Gu, Menglin Hu, Dairong Xiang, Jiangshan Lian, Liang Yu, Hongyu Jia, Yimin Zhang and Yida Yang

    Citation: BMC Gastroenterology 2019 19:94

    Content type: Research article

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  34. The removal of large bile duct stones (> 15 mm) by conventional endoscopic sphincterotomy (EST) and endoscopic papillary balloon dilation (EPBD) can be challenging, requiring mechanical lithotripsy (ML) in add...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Cheng-Kun Wu, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Keng-Liang Wu, Seng-Kee Chuah and Chung-Huang Kuo

    Citation: BMC Gastroenterology 2019 19:93

    Content type: Research article

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  35. Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...

    Authors: Tao Lu, Bin Song, Hong Pu, Xinglan Li, Qiqi Chen and Chong Yang

    Citation: BMC Gastroenterology 2019 19:92

    Content type: Case report

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  36. The fibrosis-4 index (FIB-4) has been reported to be associated with all-cause mortality in several chronic diseases. In this study, we investigated whether at diagnosis could be associated with all-cause mort...

    Authors: Hee Jin Park, Jun Yong Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Gastroenterology 2019 19:90

    Content type: Research article

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  37. Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes af...

    Authors: Xiaoling Chi, Huanming Xiao, Meijie Shi, Gaoshu Cai, Yubao Xie, Junmin Jiang, Guangjun Tian, Shuduo Wu, Chaozhen Zhang, Pengtao Zhao and Jiezhen Chen

    Citation: BMC Gastroenterology 2019 19:88

    Content type: Research article

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  38. The relationship between visceral adiposity and acute pancreatitis (AP) has not been completely elucidated. This study evaluated the significance of visceral adipose tissue (VAT) and the ratio of VAT to skelet...

    Authors: Jiarong Xie, Lu Xu, Yuning Pan, Peifei Li, Yi Liu, Yue Pan and Lei Xu

    Citation: BMC Gastroenterology 2019 19:87

    Content type: Research article

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  39. Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of...

    Authors: Yinping Li, Xiaomei Wang, Ge Yu, Haibo Sun, Juan Lv, Xiumei Chi, Ruihong Wu, Xiuzhu Gao and Junqi Niu

    Citation: BMC Gastroenterology 2019 19:86

    Content type: Research article

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  40. Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms...

    Authors: Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya and Shuji Terai

    Citation: BMC Gastroenterology 2019 19:85

    Content type: Case report

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  41. Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present ...

    Authors: Ye-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao Xun

    Citation: BMC Gastroenterology 2019 19:84

    Content type: Research article

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  42. Chronic hepatitis E represents an emerging challenge in organ transplantation, as there are currently no established treatment options for patients who fail to clear hepatitis E virus (HEV) following reduction...

    Authors: Montserrat Fraga, Jérôme Gouttenoire, Roland Sahli, Haithem Chtioui, Cristina Marcu, Manuel Pascual, Darius Moradpour and Julien Vionnet

    Citation: BMC Gastroenterology 2019 19:76

    Content type: Case report

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  43. Antiviral treatment for chronic hepatitis B (CHB) is largely unavailable in sub-Saharan Africa; hence, little is known about the prognosis after initiating treatment in African CHB patients. In this study we a...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Girmay Medhin, Bitsatab Mekasha, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Gastroenterology 2019 19:74

    Content type: Research article

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  44. Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early predic...

    Authors: Jianhua Wan, Xiaoyu Yang, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2019 19:67

    Content type: Research article

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  45. Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

    Content type: Research article

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  46. Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with...

    Authors: Jian Sun, Huiguo Ding, Guofeng Chen, Guiqiang Wang, Lai Wei, Jiming Zhang, Qing Xie, Mobin Wan, Hong Tang, Shijun Chen, Zhiliang Gao, Yuming Wang, Dazhi Zhang, Wenxiang Huang, Jifang Sheng, Qin Ning…

    Citation: BMC Gastroenterology 2019 19:65

    Content type: Research article

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  47. Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

    Content type: Research article

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  48. Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiati...

    Authors: Xing Hu, Xiaojie Huang, Hui Chen, Tong Zhang, Jianhua Hou, Aixin Song, Lei Ding, Weiyuan Liu, Hao Wu and Fankun Meng

    Citation: BMC Gastroenterology 2019 19:60

    Content type: Research article

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  49. The latest 8th edition of the AJCC staging system emphasizes the importance of tumor size however, the clinical significance of the combination of tumor location with tumor size remains unknown.

    Authors: Zibo Meng, Mingsi Cao, Yushun Zhang, Zhiqiang Liu, Shihong Wu and Heshui Wu

    Citation: BMC Gastroenterology 2019 19:59

    Content type: Research article

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  50. Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in t...

    Authors: Rugile Mickuniene, Ieva Stundiene, Tomas Jucaitis, Dileta Valanciene and Jonas Valantinas

    Citation: BMC Gastroenterology 2019 19:57

    Content type: Case report

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