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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Primary hyperoxaluria (PH) is an inherited disease lacking of hepatic oxalic acid metabolic enzymes which could lead to irreverisible renal damage. Currently, liver–kidney transplantation is a curative but hig...

    Authors: Jie Xiang, Zheng Chen, Fangshen Xu, Shengmin Mei, Zhiwei Li, Jie Zhou, Yinlei Dong, Yangjun Gu, Zhichao Huang and Zhenhua Hu

    Citation: BMC Gastroenterology 2020 20:208

    Content type: Research article

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  2. Transarterial chemoembolization (TACE), radiofrequency ablation (RFA), and iodine 125 seeds implantation are optional treatments for hepatocellular carcinoma (HCC). The aim of this study is to compare the effi...

    Authors: Lei Chen, Xuefeng Kan, Tao Sun, Yanqiao Ren, Yanyan Cao, Liangliang Yan, Bin Liang, Bin Xiong and Chuansheng Zheng

    Citation: BMC Gastroenterology 2020 20:205

    Content type: Research article

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  3. Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is an extremely uncommon pancreatic neoplasm that comprises less than 1% of all exocrine pancreatic tumors. To date, cases and data from who...

    Authors: Guangjian Yang, Jiangxia Yin, Kai Ou, Qiang Du, Wenhao Ren, Yujing Jin, Liming Peng and Lin Yang

    Citation: BMC Gastroenterology 2020 20:202

    Content type: Case report

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  4. Surgical site infection (SSI) is one of the most common complications after pancreaticoduodenectomy (PD). Thus, it is beneficial to preoperatively identify patients at high risk of developing SSI. The primary ...

    Authors: Wikran Suragul, Narongsak Rungsakulkij, Watoo Vassanasiri, Pongsatorn Tangtawee, Paramin Muangkaew, Somkit Mingphruedhi and Suraida Aeesoa

    Citation: BMC Gastroenterology 2020 20:201

    Content type: Research article

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  5. To investigate the effect of albumin infusion on cirrhotic patients admitted for acute gastrointestinal bleeding.

    Authors: Zhu Wang, Ya-Wen Xie, Qing Lu, Hai-Lin Yan, Xin-Bin Liu, Yi Long, Xian Zhang and Jin-Lin Yang

    Citation: BMC Gastroenterology 2020 20:198

    Content type: Research article

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  6. Selective deep biliary cannulation is the first and the most important step before further biliary therapy. Transpancreatic sphincterotomy (TPS), and needle knife fistulotomy (NKF) were commonly used in patien...

    Authors: Kai-Shun Liang, Chieh-Chang Chen, Wei-Chih Liao, Yu-Ting Kuo, Liang-Wei Tseng, Wen-Tsung He and Hsiu-Po Wang

    Citation: BMC Gastroenterology 2020 20:194

    Content type: Research article

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  7. Endoscopic biliary stenting by endoscopic retrograde cholangiopancreatography (ERCP) is the most common form of palliation for malignant hilar obstruction. However, ERCP in such cases is associated with a risk...

    Authors: Wen-hui Zhang, Peng-peng Ding, Lei Liu, Yan-ling Wang, Wen-hui Lai, Jing-jing Han, Jun Han and Han-wei Li

    Citation: BMC Gastroenterology 2020 20:189

    Content type: Research article

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  8. Acute-on-chronic liver failure (ACLF) is a clinic syndrome with substantial high short-term mortality. It is very important to stratify patients according to prognosis to decide management strategy. This study...

    Authors: Cuicui Xiao, Jiao Gong, Shuguang Zhu, Zhiwei Zhang, Sujuan Xi, Yutian Chong, Yusheng Jie and Qi Zhang

    Citation: BMC Gastroenterology 2020 20:188

    Content type: Research article

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  9. Nonalcoholic steatohepatitis (NASH) is a key turning point during the progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have shown that serum miRNA tests may be effective in the diagnosis...

    Authors: Shengliang Xin, Qiao Zhan, Xiaofan Chen, Jinghang Xu and Yanyan Yu

    Citation: BMC Gastroenterology 2020 20:186

    Content type: Research article

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  10. Biliary decompression can reduce symptoms and improve quality of life in patients with malignant biliary obstruction. Endoscopically placed stents have become the standard of care for biliary drainage with the...

    Authors: Christopher Lawrence, Jose Nieto, Willis G. Parsons, André Roy, Nalini M. Guda, Stephen E. Steinberg, Muhammad K. Hasan, Juan Carlos Bucobo, Satish Nagula, Nicholas D. Dey and Jonathan M. Buscaglia

    Citation: BMC Gastroenterology 2020 20:184

    Content type: Research article

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  11. Infection of Echinococcus multilocularis causes in humans the alveolar echinococcosis. Although the infection has world-wide distribution it is rarely detected. Diagnosis of alveococcosis is difficult because of ...

    Authors: Ł. Pielok, M. Karczewski, W. Cierach, P. Zmora, E. Lenartowicz and J. Stefaniak

    Citation: BMC Gastroenterology 2020 20:176

    Content type: Case report

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  12. Currently, side-by-side (SBS) and stent-in-stent (SIS) are the two main techniques for stent deployment to treat hilar biliary obstructions. Previous studies comparing these two techniques are very limited, an...

    Authors: Wei-Zhong Zhou, Sheng Liu, Zheng-Qiang Yang, Yu-Tao Xian, Hong-dou Xu, Jun-zheng Wu and Hai-Bin Shi

    Citation: BMC Gastroenterology 2020 20:174

    Content type: Research article

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  13. Gallbladder carcinogenesis, frequently occurredin chronic cholecystitis patients, requires radical resection. We herein describe a hemorrhagic cholecystitis case that failed to be differentiated from gallbladd...

    Authors: Xin Zhang, Chunjun Zhang, Haifeng Huang, Junsen Wang, Yun Zhang and Qida Hu

    Citation: BMC Gastroenterology 2020 20:172

    Content type: Case report

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  14. Hereditary hemorrhagic telangiectasia (HHT) often involves the liver, and belongs to abnormal blood vessel disease. The etiology of Budd–Chiari syndrome (BCS) is not clear, but congenital vascular dysplasia is...

    Authors: Bai-Guo Xu, Jing Liang, Ke-Feng Jia and Tao Han

    Citation: BMC Gastroenterology 2020 20:169

    Content type: Case report

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  15. A single-centre cohort study was performed to identify the independent factors associated with the overall survival (OS) of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization ...

    Authors: María Pipa-Muñiz, Susana Sanmartino, Alicia Mesa, Carmen Álvarez-Navascués, Maria-Luisa González-Diéguez, Valle Cadahía, José-Eduardo Rodríguez, Florentino Vega, Manuel Rodríguez, Serafin-Marcos Costilla-García and María Varela

    Citation: BMC Gastroenterology 2020 20:166

    Content type: Research article

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  17. Patients with acute pancreatitis usually exhibit dyslipidemia and oxidative stress. However, the significance of high-density lipoprotein cholesterol (HDL-C) level, low-density lipoprotein cholesterol (LDL-C) ...

    Authors: Qin Wu, Xi Zhong, Min Fu, Hao Yang, Hong Bo, Xuelian Liao, Zhi Hu, Bo Wang, Zhongwei Zhang, Xiaodong Jin and Yan Kang

    Citation: BMC Gastroenterology 2020 20:164

    Content type: Research article

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  18. Emerging evidence demonstrates that surveillance of individuals at high-risk (HRIs) of developing pancreatic adenocarcinoma allows for identification and treatment of resectable tumors with improved survival. ...

    Authors: Ariel Bar-Mashiah, Anne Aronson, Monica Naparst, Christopher J. DiMaio and Aimee L. Lucas

    Citation: BMC Gastroenterology 2020 20:161

    Content type: Research article

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  19. Endoscopic retrograde cholangiopancreatography (ERCP) is still performed using two-dimensional (2D) X-ray images. The success rate and risk of complications are considered operator-dependent. We explored perfo...

    Authors: Masao Toki, Hidekatsu Tateishi, Tsubasa Yoshida, Koichi Gondo, Shunsuke Watanabe and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:158

    Content type: Case report

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  20. Endoscopic retrograde biliary drainage (ERBD) is the most frequently performed procedure for treating benign or malignant biliary obstruction. Although duodenal perforations secondary to the biliary plastic st...

    Authors: Xiaopeng Wang, Junwen Qu and Kewei Li

    Citation: BMC Gastroenterology 2020 20:149

    Content type: Case report

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  21. The impact of hepatic steatosis (HS) on treatment response following nucleos(t)ide analogue (NA) treatment for chronic hepatitis B (CHB) patients has not been clearly elucidated. We aimed to investigate the di...

    Authors: Yi-Cheng Chen, Wen-Juei Jeng, Chao-Wei Hsu and Chun-Yen Lin

    Citation: BMC Gastroenterology 2020 20:146

    Content type: Research article

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  22. ERCP training models are very different in terms of anatomical differences, ethical issues, storage problems, realistic tactile sensation, durability and portability. There is no easy way to select an optimize...

    Authors: Chang-Il Kwon, Yeonsun Shin, Jaeok Hong, Minje Im, Guk Bae Kim, Dong Hee Koh, Tae Jun Song, Won Suk Park, Jong Jin Hyun and Seok Jeong

    Citation: BMC Gastroenterology 2020 20:145

    Content type: Research article

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  23. Type 2 diabetes mellitus (T2DM) increased the risk of developing pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplastic disease originating from the pancreas. Increasing evide...

    Authors: Ji-bin Yin, Na Li, Ming-ming Cui, Xin Wang and Rui-tao Wang

    Citation: BMC Gastroenterology 2020 20:143

    Content type: Research article

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  24. Histoplasma capsulatum is the most common endemic mycosis in the United States and frequently presents as an opportunistic infection in immunocompromised hosts. Though liver involvement is common in disseminated ...

    Authors: Steven Park, Janice Cheong, Kaitlin Kyi, Jose Aranez, Sohaib Abu-Farsakh, Christa Whitney-Miller, Bandar Al-Judaibi and Marie Laryea

    Citation: BMC Gastroenterology 2020 20:141

    Content type: Case report

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  25. Antiviral therapy for chronic hepatitis B (CHB) is effective and can substantially reduce the risk of progressive liver disease and hepatocellular carcinoma but is often administered for an indefinite duration...

    Authors: Nicole L. Allard, Jennifer H. MacLachlan, Anouk Dev, James Dwyer, Geeta Srivatsa, Timothy Spelman, Alexander J. Thompson and Benjamin C. Cowie

    Citation: BMC Gastroenterology 2020 20:140

    Content type: Research article

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  26. There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this an...

    Authors: Min Zhang, Su Lin, Ming-fang Wang, Jiao-feng Huang, Shi-ying Liu, Su-mei Wu, Hao-yang Zhang, Zi-mu Wu, Wen-Yue Liu, Dong-Chu Zhang, Chuan-ming Hao, Yue-yong Zhu, Ming-Hua Zheng and Xiao-zhong Wang

    Citation: BMC Gastroenterology 2020 20:139

    Content type: Research article

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  27. Pancreatic and peri-pancreatic neoplasms encompass a variety of histotypes characterized by a heterogeneous prognostic impact. miRNAs are considered efficient candidate biomarkers due to their high stability i...

    Authors: Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan and Aldo Scarpa

    Citation: BMC Gastroenterology 2020 20:137

    Content type: Research article

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  28. Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. W...

    Authors: Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Yee-Kit Tse, Becky Wing-Yan Yuen, Hester Wing-Sum Luk, Marco Ho-Bun Lam, Michael Kin-Kong Li, Ching Kong Loo, Owen Tak-Yin Tsang, Steven Woon-Choy Tsang, Henry Lik-Yuen Chan, Yun-Kwok Wing and Vincent Wai-Sun Wong

    Citation: BMC Gastroenterology 2020 20:128

    Content type: Research article

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  30. One of the most feared complications of endoscopic retrograde cholangiopancreatography (ERCP), with an incidence of 3.5 to 15%, is post ERCP pancreatitis (PEP). Given the role of statins in the reduction of sy...

    Authors: Yousaf Bashir Hadi, Syeda Fatima Naqvi, Abdelhai Abdelqader, Justin Kupec and John Nasr

    Citation: BMC Gastroenterology 2020 20:125

    Content type: Research article

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  31. For chronic hepatitis B (CHB) patients without willingness to extend the routine duration of interferon (IFN) therapy, it is important to identify patients who will benefit from treatment cessation. Hepatitis ...

    Authors: Shuai Wu, Wenfan Luo, Yin Wu, Hongjie Chen and Jie Peng

    Citation: BMC Gastroenterology 2020 20:121

    Content type: Research article

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  32. Cabozantinib was approved by the European Medicines Agency and the Federal Drug Administration as an option for sorafenib-resistant advanced hepatocellular carcinoma, increasing overall survival and progressio...

    Authors: Maximilian Sieg, Michael Hartmann, Utz Settmacher and Habibollah Arefian

    Citation: BMC Gastroenterology 2020 20:120

    Content type: Research article

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  35. Hepatitis B e antigen (HBeAg) seroclearance has been considered as the treatment endpoint in HBeAg-positive patients with chronic hepatitis B (CHB). Although HBeAg seroclearance has been accomplished, some asp...

    Authors: Hyun Woong Lee, Jung Il Lee, Saein Kim, Sora Kim, Hye Young Chang and Kwan Sik Lee

    Citation: BMC Gastroenterology 2020 20:113

    Content type: Research article

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  37. The purpose of this study is to investigate whether or not the complement system is systemically activated and to specify the clinical and prognostic implications of its components during hepatitis B virus rel...

    Authors: Qian Li, Qing Lu, Meng-Qi Zhu, Chong Huang, Kang-Kang Yu, Yu-Xian Huang, Xu Zhao, Xing-Guang Luo and Jian-Ming Zheng

    Citation: BMC Gastroenterology 2020 20:106

    Content type: Research article

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  38. Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit life-saving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). ...

    Authors: Paul M. Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Scott Harris, Usha Menon and William M. Rosenberg

    Citation: BMC Gastroenterology 2020 20:104

    Content type: Research article

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  39. Low 25-Hydroxy-vitamin-D; “25(OH)-D3” serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In th...

    Authors: Ahmad Salhab, Johnny Amer, Lu Yinying and Rifaat Safadi

    Citation: BMC Gastroenterology 2020 20:102

    Content type: Research article

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  41. Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofreq...

    Authors: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Yao-Chun Hsu, Chia-Chang Hsu, Tsung-Chin Wu, Jen-Hao Yeh, Pojen Hsiao, Pei-Min Hsieh, Hung-Yu Lin, Chih-Wen Shu and Chao-Ming Hung

    Citation: BMC Gastroenterology 2020 20:99

    Content type: Research article

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  42. Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...

    Authors: Xiaofei Li, Lina Sheng, Liwen Liu, Yongtao Hu, Yongxin Chen and Lianqing Lou

    Citation: BMC Gastroenterology 2020 20:98

    Content type: Research article

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  43. Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by damage to the nervous system and retinal degeneration. This cla...

    Authors: Mária Ondrejkovičová, Sylvia Dražilová, Monika Drakulová, Juan López Siles, Renáta Zemjarová Mezenská, Petra Jungová, Martin Fabián, Boris Rychlý and Miroslav Žigrai

    Citation: BMC Gastroenterology 2020 20:95

    Content type: Case report

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  45. There are conflicting data regarding the risk of hepatocellular carcinoma (HCC) after direct-acting antiviral agent (DAA) treatment. Risk of HCC in HCV genotype-3 infected persons after DAA therapy is not well...

    Authors: Ghias Un Nabi Tayyab, Shafqat Rasool, Bilal Nasir, Ghazala Rubi, Abdul-Badi Abou-Samra and Adeel A. Butt

    Citation: BMC Gastroenterology 2020 20:93

    Content type: Research article

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  46. Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractor...

    Authors: Mitsuhito Koizumi, Teru Kumagi, Taira Kuroda, Yoshiki Imamura, Kozue Kanemitsu, Kohei Ogawa, Yasutsugu Takada and Yoichi Hiasa

    Citation: BMC Gastroenterology 2020 20:92

    Content type: Research article

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  47. Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was...

    Authors: Theodoros Androutsakos, Maria Schina, Abraham Pouliakis, Athanasios Kontos, Nikolaos Sipsas and Gregorios Hatzis

    Citation: BMC Gastroenterology 2020 20:91

    Content type: Research article

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  49. Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The current recommendations for gastroesophageal varices include pharmacological treatme...

    Authors: Yujen Tseng, Lili Ma, Minzhi Lv, Tiancheng Luo, Chengfeng Liu, Yichao Wei, Chu Liu, Ji Zhou, Zhiping Yan, Pengju Xu, Guohua Hu, Hong Ding, Yuan Ji, Shiyao Chen and Jian Wang

    Citation: BMC Gastroenterology 2020 20:83

    Content type: Research article

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