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Hepatobiliary and pancreatic disorders

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.


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  1. Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that specifically occurs in pregnancy. Elevated levels of liver transaminases aspartate aminotransferase, alanine aminotransferase and serum bili...

    Authors: Rong Li, Xuehai Chen, Zhongzhen Liu, Yan Chen, Chuan Liu, Lingfei Ye, Liang Xiao, Zhenjun Yang, Jian He, Wen-Jing Wang and Hongbo Qi

    Citation: BMC Gastroenterology 2020 20:395

    Content type: Research article

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  2. To investigate the value of serum hydroxybutyrate dehydrogenase (HBDH) level, an isozyme of lactate dehydrogenase, in evaluating the severity of acute pancreatitis (AP).

    Authors: Weiming Xiao, Weili Liu, Ling Yin, Yong Li, Guotao Lu, Xinnong Liu, Weijuan Gong, Yanbing Ding, Mei Wang and Zhigang Yan

    Citation: BMC Gastroenterology 2020 20:393

    Content type: Research article

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  3. An epidermoid cyst in an intrapancreatic accessory spleen (ECIPAS) in the pancreas head is an extremely rare condition. The natural course of this condition is not well known, and it is difficult to diagnose b...

    Authors: Hyo Jung Ko, Jae Ryong Shim, Tae Beom Lee, Byung Hyun Choi, Jung-Hee Lee, Je Ho Ryu and Kwangho Yang

    Citation: BMC Gastroenterology 2020 20:392

    Content type: Case report

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  4. To determine the safety and efficacy of different doses of tolvaptan for treating Chinese cirrhotic patients with or without hyponatraemia who still had ascites after routine therapy with diuretics.

    Authors: Jieting Tang, Yongfeng Wang, Tao Han, Qing Mao, Jun Cheng, Huiguo Ding, Jia Shang, Qin Zhang, Junqi Niu, Feng Ji, Chengwei Chen, Jidong Jia, Xiangjun Jiang, Nonghua Lv, Yueqiu Gao, Zhenghua Wang…

    Citation: BMC Gastroenterology 2020 20:391

    Content type: Research article

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  5. Ultrasound (US) imaging is known to underestimate tumor size in clinical. This study is aimed to compare the size measurements of hepatocellular carcinoma (HCC) in three US imaging modalities, i.e. two-dimensi...

    Authors: Fei Chen, Fei Wang, Si Sun, Mei Zhu and Zheng Liu

    Citation: BMC Gastroenterology 2020 20:390

    Content type: Research article

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  6. In the correspondence from Abdurrahman et al., they raised three main concerns and critiques of our recently published article entitled “Syphilitic hepatitis: a case report and review of the literature”. First...

    Authors: Jiaofeng Huang, Bo Wan, Mingfang Wang, Yueyong Zhu and Su Lin

    Citation: BMC Gastroenterology 2020 20:385

    Content type: Correspondence

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    The original article was published in BMC Gastroenterology 2020 20:379

  7. Lipid profiles are declined in patients with viral liver cirrhosis and correlated with severity of liver disease. Hepatitis B virus (HBV) is the leading cause of liver cirrhosis in China. Our primary aim was t...

    Authors: Ran Cheng, Ning Tan, Qian Kang, Hao Luo, Hongyu Chen, Jiali Pan, Yifan Han, Yuqing Yang and Xiaoyuan Xu

    Citation: BMC Gastroenterology 2020 20:381

    Content type: Research article

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  8. Syphilis is a sexuality transmitted disease caused by Treponema pallidum. Liver involvement is very rarely seen and occurs in the second phase of the disease. Syphilitic hepatitis generally is mild clinical condi...

    Authors: Abdurrahman Kaya and Sibel Yıldız Kaya

    Citation: BMC Gastroenterology 2020 20:379

    Content type: Correspondence

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    The original article was published in BMC Gastroenterology 2019 19:191

    The Correspondence to this article has been published in BMC Gastroenterology 2020 20:385

  9. Hepatic artery dissection after liver transplantation is an uncommon morbidity. The onset mechanism and management for this disorder remain unclear. The present report describes the cases of two patients with ...

    Authors: Keita Shimata, Yasuhiko Sugawara, Tomoaki Irie, Yuzuru Sambommatsu, Masashi Kadohisa, Sho Ibuki, Seiichi Kawabata, Kaori Isono, Masaki Honda, Hidekazu Yamamoto and Taizo Hibi

    Citation: BMC Gastroenterology 2020 20:378

    Content type: Case report

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  10. Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this stud...

    Authors: Giulia Malaguarnera, Vito Emanuele Catania, Saverio Latteri, Antonio Maria Borzì, Gaetano Bertino, Roberto Madeddu, Filippo Drago and Michele Malaguarnera

    Citation: BMC Gastroenterology 2020 20:375

    Content type: Research article

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  11. Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely...

    Authors: Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Hiroko Setoyama, Yutaka Sasaki and Yasuhito Tanaka

    Citation: BMC Gastroenterology 2020 20:371

    Content type: Research article

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  12. Using fluorescence in situ hybridisation (FISH) to detect any gain of chromosomes 3, 7, or 17 and loss of the 9p21 locus has been proven to be sensitive in the diagnosis of pancreatobiliary tumors. However, bo...

    Authors: Xiaohong Pu, Hongwei Zheng, Xin Yang, Qing Ye, Zhiwen Fan, Jun Yang, Xiangshan Fan, Xiaoping Zhou, Yudong Qiu, Qin Huang, Hongyan Wu and Jun Chen

    Citation: BMC Gastroenterology 2020 20:367

    Content type: Research article

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  13. The development of gallbladder disease (GBD) is related to bile acid (BA) metabolism, and the rate of BA circulation increases the risk of biliary cancer. However, it is unclear whether patterns of circulating...

    Authors: Linshi Wu, Yinping Wang, Sibo Zhu, Xunxia Bao, Zhiliang Fu, Timing Zhen, Zhiqing Yuan, Qiwei Li, Zheng Deng, Jianhua Sun and Tao Chen

    Citation: BMC Gastroenterology 2020 20:363

    Content type: Research article

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  14. A care pathway for nonalcoholic fatty liver disease (NAFLD) in Kaiser Permanente San Diego, California was instituted in August 2017 to improve efficiency of disease staging and promote lifestyle modification.

    Authors: Heather Patton, Raoul Burchette, Stephanie Tovar, Jose Pio, Jiaxiao Shi and Lisa M. Nyberg

    Citation: BMC Gastroenterology 2020 20:362

    Content type: Research article

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  15. Gastric varices are encountered less frequently than esophageal varices. Nonetheless, gastric variceal bleeding is more severe and associated with worse outcomes. Conventionally, gastric varices have been desc...

    Authors: Cyriac Abby Philips, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan and Philip Augustine

    Citation: BMC Gastroenterology 2020 20:361

    Content type: Review

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  16. Kawasaki disease (KD) or mucocutaneous lymph node syndrome is a vasculitis that mostly occurs in young children. Adult-onset KD (AKD) is rare and often misdiagnosed. Here we report a rare case of KD with chole...

    Authors: Massimo Gallerani, Marco Pala, Fabio Fabbian and Alfredo De Giorgi

    Citation: BMC Gastroenterology 2020 20:357

    Content type: Case report

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  17. Kawasaki Disease (KD) is the most common paediatric vasculitis affecting small to medium arteries. Although the average age of diagnosis is 3.4 years with a well-defined clinical presentation, older patients w...

    Authors: Krishan Pratap, Logan S. Gardner, David Gillis, Martin Newman, Dana Wainwright and Roger Prentice

    Citation: BMC Gastroenterology 2020 20:352

    Content type: Case report

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  18. Hepatolithiasis often leads to atrophy–hypertrophy complex due to bile duct obstruction, inflammation or infection in the affected liver segments and compensatory response in the normal segments. In severe bil...

    Authors: Wei Wang, ZiJie Zhang and Jian Wang

    Citation: BMC Gastroenterology 2020 20:350

    Content type: Case report

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  19. Previous studies have demonstrated the benefits of thymosin alpha-1 (Tα1) in anti-virus, immunological enhancement and anti-inflammation. However, it is controversial about the efficacy and safety of entecavir...

    Authors: Dan Peng, Hai-Yan Xing, Chen Li, Xian-Feng Wang, Min Hou, Bin Li and Jian-Hong Chen

    Citation: BMC Gastroenterology 2020 20:348

    Content type: Research article

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  20. Vitamin D (VD) is important in hepatic fibrogenesis in animal models and human studies. VD deficiency is associated with liver fibrosis progression. Metabolic dysfunction of the liver, as an intermediate organ...

    Authors: Supachaya Sriphoosanaphan, Kessarin Thanapirom, Sirinporn Suksawatamnuay, Panarat Thaimai, Sukanya Sittisomwong, Kanokwan Sonsiri, Nunthiya Srisoonthorn, Nicha Teeratorn, Nattaporn Tanpowpong, Bundit Chaopathomkul, Sombat Treeprasertsuk, Yong Poovorawan and Piyawat Komolmit

    Citation: BMC Gastroenterology 2020 20:346

    Content type: Research article

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  21. Several genetic variants are known to be associated with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the longitudinal associations between genetic variants and NAFLD.

    Authors: Goh Eun Chung, Eunsoon Shin, Min-Sun Kwak, Jong In Yang, Jong-Eun Lee, Eun Kyung Choe and Jeong Yoon Yim

    Citation: BMC Gastroenterology 2020 20:344

    Content type: Research article

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  22. Multiple murine models of nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) have been established by using obesogenic diets and/or chemical induction. MS-NASH mouse (formally FATZO) is a spontaneou...

    Authors: Guodong Zhang, Xiaoli Wang, Tzu-Yang Chung, Weiwei Ye, Lauren Hodge, Likun Zhang, Keefe Chng, Yong-Fu Xiao and Yixin Jim Wang

    Citation: BMC Gastroenterology 2020 20:339

    Content type: Research article

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  23. Genetic anaemias lead us to reflect on the classic ‘trolley dilemma’, when there are two choices but neither one is satisfactory. Either we do not treat anaemia and the patient suffers from chronic tiredness a...

    Authors: Guilherme Rossi Assis-Mendonça, Marlone Cunha-Silva, Mariana Franson Fernandes, Luiza Dias Torres, Monica Pinheiro de Almeida Verissimo, Marcelo Trevisan Neves Okano, Daniel Ferraz Mazo, Cristina Alba Lalli, Tiago Sevá-Pereira, Rafael Fantelli Stelini and Larissa Bastos Eloy da Costa

    Citation: BMC Gastroenterology 2020 20:332

    Content type: Case report

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  24. We report our experience of treating anastomotic strictures using a novel type of fully covered metal stent (FCSEMS). This stent, known as the Kaffes Stent, is short-length with an antimigration waist and is e...

    Authors: Ben Warner, Phillip Harrison, Muhammad Farman, John Devlin, David Reffitt, Yasser El-Sherif, Shirin E. Khorsandi, Andreas Prachalias, Miriam Cortes Cerisuelo, Krish Menon, Wayel Jassem, Parthi Srinivasan, Hector Vilca-Melendez, Michael Heneghan, Nigel Heaton and Deepak Joshi

    Citation: BMC Gastroenterology 2020 20:329

    Content type: Research article

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  25. This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery.

    Authors: Tomoaki Bekki, Tomoyuki Abe, Hironobu Amano, Minoru Hattori, Tsuyoshi Kobayashi, Masahiro Nakahara, Hideki Ohdan and Toshio Noriyuki

    Citation: BMC Gastroenterology 2020 20:328

    Content type: Research article

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  26. Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D. Although in...

    Authors: Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype and Christophe M. Deroose

    Citation: BMC Gastroenterology 2020 20:324

    Content type: Case report

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  27. Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (I...

    Authors: Zhenyang Shen, Jingbo Xiao, Junjun Wang, Lungen Lu, Xinjian Wan and Xiaobo Cai

    Citation: BMC Gastroenterology 2020 20:322

    Content type: Research article

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  28. Infection is common in acute-on-chronic liver failure (ACLF), which may worsen the clinical condition and prognosis. However, the characteristics of infection and its influence on prognosis in hepatitis B viru...

    Authors: Xing-Ran Zhai, Jing-Jing Tong, Hong-Min Wang, Xiang Xu, Xiu-Ying Mu, Jing Chen, Zi-Feng Liu, Yu Wang, Hai-Bin Su and Jin-Hua Hu

    Citation: BMC Gastroenterology 2020 20:320

    Content type: Research article

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  29. Pancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LB...

    Authors: Kazuya Miyamoto, Kazuyuki Matsumoto, Hironari Kato, Ryuichi Yoshida, Yuzo Umeda, Hirohumi Inoue, Takehiro Tanaka, Akihiro Matsumi, Yosuke Saragai, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Takeshi Tomoda, Shigeru Horiguchi, Takahito Yagi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2020 20:319

    Content type: Research article

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  30. Caroli syndrome (CS) is a rare congenital disorder without pathognomonic clinical symptoms or laboratory findings; therefore, the diagnosis is often delayed. The objective of this study was to investigate the ...

    Authors: Wen Shi, Xiao-ming Huang, Yun-lu Feng, Feng-dan Wang, Xiao-xing Gao and Yang Jiao

    Citation: BMC Gastroenterology 2020 20:317

    Content type: Research article

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  31. Evaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several l...

    Authors: Naoyuki Ueda, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, C. Nelson Hayes, Michiya Yokozaki and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:314

    Content type: Research article

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  32. We investigated whether duodenal major papilla morphology could be a risk factor for failure of selective biliary cannulation (SBC) and post endoscopic retrograde cholangiography and pancreatography (ERCP) com...

    Authors: Po-Han Chen, Chun-Fang Tung, Yen-Chung Peng, Hong-Zen Yeh, Chi-Sen Chang and Chia-Chang Chen

    Citation: BMC Gastroenterology 2020 20:310

    Content type: Research article

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  33. Infantile liver failure syndrome-2 (ILFS2) is caused by neuroblastoma amplified sequence (NBAS) mutation. The disease is characterized by recurrent episodes of acute liver failure (ALF) or by liver crisis trig...

    Authors: Weiran Li, Yu Zhu, Qin Guo and Chaomin Wan

    Citation: BMC Gastroenterology 2020 20:308

    Content type: Case report

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  34. Hepatitis B infection is a significant worldwide health issue, predispose to the development of liver cirrhosis and hepatocellular carcinoma. Entecavir is a potent oral antiviral agent of high genetic barrier ...

    Authors: Xiong Khee Cheong, Zhiqin Wong, Norazirah Md Nor and Bang Rom Lee

    Citation: BMC Gastroenterology 2020 20:305

    Content type: Case report

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  35. There are only 6 cases of intraductal papillary mucinous neoplasm (IPMN) complicated with intraductal hemorrhage have been reported in English literatures. All these 6 cases of IPMN occurred in the old people....

    Authors: Jianman Wu, Yin Lin and Jingwen Wu

    Citation: BMC Gastroenterology 2020 20:304

    Content type: Case report

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  36. We experienced a rare case of intraductal papillary mucinous neoplasm arising from Santorini’s duct (SD) forming a tumor protruding into the duodenum .

    Authors: Haruna Komatsubara, Hiroyuki Kato, Daisuke Noguchi, Kazuyuki Gyoten, Aoi Hayasaki, Yusuke Iizawa, Takehiro Fujii, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Hiroyuki Sakurai and Shugo Mizuno

    Citation: BMC Gastroenterology 2020 20:303

    Content type: Case report

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  37. We examined how extra-hepatic comorbidity burden impacts mortality in patients with cirrhosis referred for liver transplantation (LT).

    Authors: Scott Coppel, Karan Mathur, Burcin Ekser, Kavish R. Patidar, Eric Orman, Archita P. Desai, Eduardo Vilar-Gomez, Chandrashekhar Kubal, Naga Chalasani, Lauren Nephew and Marwan Ghabril

    Citation: BMC Gastroenterology 2020 20:302

    Content type: Research article

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  38. With the improvement of treatment and prognosis for patients with late malignant diseases, certain malignancies with distant metastasis (M1 category) have been further classified into M1a (single metastatic si...

    Authors: Fang Feng, Wei Cai, Gaoming Wang, Weigang Chen, Haochang Yang, Mingyu Sun and Li Zhou

    Citation: BMC Gastroenterology 2020 20:289

    Content type: Research article

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  39. The importance of donor-specific antibodies (DSA) after liver transplantation (LT) for graft and patient survival is an ongoing controversy. So far it has not been elucidated when and in how far DSA are harmfu...

    Authors: Katharina Willuweit, Alexandra Frey, Lisa Bieniek, Andreas Heinold, Matthias Büchter, Peter A. Horn, Heiner Wedemeyer and Kerstin Herzer

    Citation: BMC Gastroenterology 2020 20:288

    Content type: Research article

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  40. In the diagnosis of IgG4-related sclerosing cholangitis (IgG4-SC), differentiation from extrahepatic cholangiocarcinoma (ECC) is extremely important but is still a clinical challenge. This study aimed to eluci...

    Authors: Yasutaka Ishii, Masahiro Serikawa, Tomofumi Tsuboi, Ryota Kawamura, Ken Tsushima, Shinya Nakamura, Tetsuro Hirano, Ayami Fukiage, Juri Ikemoto, Yusuke Kiyoshita, Sho Saeki, Yosuke Tamura and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:287

    Content type: Research article

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  41. Pancreatic panniculitis is a rare skin manifestation in pancreatic disease patients that most frequently develops on the lower legs. We report the unique case of a 68-year-old man who suffered from pancreatic ...

    Authors: Yuki Yamashita, Satoru Joshita, Tetsuya Ito, Masafumi Maruyama, Shuichi Wada and Takeji Umemura

    Citation: BMC Gastroenterology 2020 20:286

    Content type: Case report

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  42. Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual s...

    Authors: Akashi Fujita, Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Junya Sato, Yosuke Igarashi, Ryuichiro Araki, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe and Fumio Itoh

    Citation: BMC Gastroenterology 2020 20:285

    Content type: Research article

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  43. Inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral process of an undetermined cause that may involve a variety of organ systems, including the lungs, spleen, liver, lymph ...

    Authors: Antonio Calvo, Jesús Salas, Gloria Muñoz, Ana Díez and María Coral de la Vega

    Citation: BMC Gastroenterology 2020 20:282

    Content type: Case report

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  44. We aimed to compare the safety and effectiveness of the following procedures after pancreaticoduodenectomy: isolated pancreaticojejunostomy, isolated gastrojejunostomy, and conventional pancreaticojejunostomy.

    Authors: Yunxiao Lyu, Bin Wang, Yunxiao Cheng, Yueming Xu and Wei Bing Du

    Citation: BMC Gastroenterology 2020 20:279

    Content type: Research article

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  45. Almost all liver tumours can be removed laparoscopically, but some difficult tumour locations complicate laparoscopic surgery. Recurrent liver tumours often pose great difficulties to laparoscopic surgery due ...

    Authors: Baifeng Li, Tao Liu, Yijie Zhang and Jialin Zhang

    Citation: BMC Gastroenterology 2020 20:278

    Content type: Case report

    Published on:

  46. Left-sided portal hypertension (LSPH) is an extremely rare clinical syndrome, and it is the only form of curable portal hypertension. It is primarily caused by pancreatic disease, and is associated with compli...

    Authors: Dajun Yu, Xiaolan Li, Jianping Gong, Jinzheng Li, Fei Xie and Jiejun Hu

    Citation: BMC Gastroenterology 2020 20:276

    Content type: Case report

    Published on:

  47. Patients with liver cirrhosis typically exhibit abnormal coagulation parameters in conventional coagulation tests (CCTs). Rotational thromboelastometry (ROTEM) is a holistic blood coagulation assay. This metho...

    Authors: Jessica Seeßle, Jan Löhr, Marietta Kirchner, Josefin Michaelis and Uta Merle

    Citation: BMC Gastroenterology 2020 20:271

    Content type: Research article

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