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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Content type: Research article

    Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC...

    Authors: Huiyong Wu, Wei Zhao, Jianbo Zhang, Jianjun Han and Shuguang Liu

    Citation: BMC Gastroenterology 2018 18:174

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  2. Content type: Research article

    Patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC) are frequently found to be unresectable on exploration due to small distant metastasis. This study was to investigate predictors of ...

    Authors: Xinchun Liu, Yue Fu, Qiuyang Chen, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao and Jishu Wei

    Citation: BMC Gastroenterology 2018 18:168

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  3. Content type: Research article

    The incidence of liver-related events, cardiovascular events and type 2 diabetes mellitus in patients with histopathologically confirmed NAFLD remains unclear.

    Authors: Norio Akuta, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda and Hiromitsu Kumada

    Citation: BMC Gastroenterology 2018 18:165

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  4. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) often requires deep sedation. Dexmedetomidine, a highly selective α2-adrenoceptor agonist with sedative activity and minimal effects on respiration, has re...

    Authors: Osamu Inatomi, Takayuki Imai, Takehide Fujimoto, Kenichiro Takahashi, Yoshihiro Yokota, Noriaki Yamashita, Hiroshi Hasegawa, Atsushi Nishida, Shigeki Bamba, Mitsushige Sugimoto and Akira Andoh

    Citation: BMC Gastroenterology 2018 18:166

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  5. Content type: Case report

    Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancre...

    Authors: Yangbei Zhu, Shuling Wang, Shengbing Zhao, Lin Qi, Zhaoshen Li and Yu Bai

    Citation: BMC Gastroenterology 2018 18:163

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  6. Content type: Research article

    Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between...

    Authors: Jian Yang, Bin Yan, Lihong Yang, Huimin Li, Yajuan Fan, Feng Zhu, Jie Zheng and Xiancang Ma

    Citation: BMC Gastroenterology 2018 18:161

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  7. Content type: Research article

    Advanced pancreatic cancer is accompanied not only by bile duct obstruction, but also occasionally by duodenal obstruction. With new advances in chemotherapy and improvement in the management of stent dysfunct...

    Authors: Kazuyuki Matsumoto, Hironari Kato, Shigeru Horiguchi, Koichiro Tsutsumi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:157

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  8. Content type: Research article

    To overcome duodenobiliary reflux induced by biliary stents, antireflux valve (ARV) biliary stents have been developed and showed improvement in stent patency. However, negative study results have also been re...

    Authors: Chang-Il Kwon, Jong Pil Moon, Ho Yun, Seok Jeong, Dong Hee Koh, Woo Jung Lee, Kwang Hyun Ko and Dae Hwan Kang

    Citation: BMC Gastroenterology 2018 18:150

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  9. Content type: Research article

    This study is to investigate the association between the hepatic expression of Yin Yang 1 (YY1) and the progression of non-alcoholic fatty liver disease (NAFLD) in patients undergoing bariatric surgery.

    Authors: Xianwen Yuan, Jun Chen, Qi Cheng, Yinjuan Zhao, Pengzi Zhang, Xiaoyan Shao, Yan Bi, Xiaolei Shi, Yitao Ding, Xitai Sun and Bin Xue

    Citation: BMC Gastroenterology 2018 18:147

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  10. Content type: Research article

    Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to i...

    Authors: Wenfei Li, Hongjie Chen, Shuai Wu and Jie Peng

    Citation: BMC Gastroenterology 2018 18:144

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  11. Content type: Research article

    Pancreatic pseudocyst (PPC) is a common complication of acute and chronic pancreatitis. To our knowledge no study has systematically reported the risk factors for the formation, intervention and recurrence of ...

    Authors: Jie-hui Tan, Lei Zhou, Rong-chang Cao and Guo-wei Zhang

    Citation: BMC Gastroenterology 2018 18:143

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  12. Content type: Case report

    Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed drugs and can cause drug-induced liver injury. Although patients with drug-induced liver injury from NSAIDs often recover spontaneously,...

    Authors: Wen Xie, Qi Wang, Yuanjiao Gao and Calvin Q. Pan

    Citation: BMC Gastroenterology 2018 18:142

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  13. Content type: Research article

    With the rising demands for pancreas transplantation, surgeons are trying to extend the donors pool and set up a more appropriate assessment system. We aim to evaluate the effect of donor hypertension on recip...

    Authors: Zhen-Hua Hu, Yang-Jun Gu, Wen-Qi Qiu, Jie Xiang, Zhi-Wei Li, Jie Zhou and Shu-Sen Zheng

    Citation: BMC Gastroenterology 2018 18:141

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  14. Content type: Research article

    Early onset pancreatic cancer (EOPC), i.e. pancreatic ductal adenocarcinoma (PDAC) occurring in patients below 50 years of age, is rare and there is limited information regarding risk factors, molecular basis ...

    Authors: Chara Ntala, Silvana Debernardi, Roger M. Feakins and Tatjana Crnogorac-Jurcevic

    Citation: BMC Gastroenterology 2018 18:139

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  15. Content type: Research article

    Transarterial chemoembolization (TACE) is the recommended treatment for hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) B-stage, whereas sorafenib is an orally administered smal...

    Authors: Lin Li, Wenzhuo Zhao, Mengmeng Wang, Jie Hu, Enxin Wang, Yan Zhao and Lei Liu

    Citation: BMC Gastroenterology 2018 18:138

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  16. Content type: Research article

    Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on si...

    Authors: Shuzhen Wang, Xin Zhang, Tao Han, Wen Xie, Yonggang Li, Hong Ma, Roman Liebe, Honglei Weng and Hui-Guo Ding

    Citation: BMC Gastroenterology 2018 18:137

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  17. Content type: Case report

    IgG4-related disease (IgG4-RD) is a newly recognized autoimmune systemic disorder characterized by elevated levels of serum IgG4 and abundant infiltration of IgG4-positive plasmacytes in the affected organs. T...

    Authors: Xuexue Deng, Ronghua Fang, Jianshu Zhang and Rongqiong Li

    Citation: BMC Gastroenterology 2018 18:136

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  18. Content type: Case report

    Iguratimod is a novel anti-rheumatic drug with the capability of anti-cytokines as report goes. It has been reported that iguratimod is effective and safe for rheumatoid arthritis and other rheumatisms. As sid...

    Authors: Xiao-li Li, Xiao-Chang Liu, Yu-Lin Song, Ru-Tao Hong and Hai Shi

    Citation: BMC Gastroenterology 2018 18:130

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  19. Content type: Research article

    Anorexia nervosa (AN) concerns approximately up to 1.8% of the pediatric female population. One of the complications that can occur in the course of this disease is acute liver failure. This study’s objective ...

    Authors: Katarzyna Górowska-Kowolik, Agata Chobot and Jarosław Kwiecień

    Citation: BMC Gastroenterology 2018 18:126

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  20. Content type: Research article

    A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potenti...

    Authors: Guo chao Niu, Lei Liu, Libo Zheng, Hong Zhang, David Q. Shih and Xiaolan Zhang

    Citation: BMC Gastroenterology 2018 18:127

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  21. Content type: Research article

    Currently, no standard of care or therapies have been established for patients with advanced HCC. We evaluated the efficacy and safety of conventional transarterial chemoembolization using gelatin sponges or m...

    Authors: Yi-Sheng Liu, Chia-Ying Lin, Ming-Tsung Chuang, Chia-Ying Lin, Yi-Shan Tsai, Chien-Kuo Wang and Ming-Ching Ou

    Citation: BMC Gastroenterology 2018 18:124

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  22. Content type: Research article

    The vertical transmission of HBV from mothers to their infants at birth or in early infancy has a significant role in the endemicity of HBV infection. Tenofovir is one of the most potent anti-HBV agents with a...

    Authors: Wenhui Li, Li Jia, Xin Zhao, Xiaoyuan Wu and Hongxia Tang

    Citation: BMC Gastroenterology 2018 18:121

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  23. Content type: Case report

    Acute pancreatitis is an acute inflammation of the pancreas that varies in severity from mild to life threatening usually requiring hospitalization. The true incidence of drug-induced pancreatitis (DIP) is ind...

    Authors: Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar and Vesna Tegeltija

    Citation: BMC Gastroenterology 2018 18:122

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  24. Content type: Research article

    The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening marke...

    Authors: Birgit Tsaknakis, Rawan Masri, Ahmad Amanzada, Golo Petzold, Volker Ellenrieder, Albrecht Neesse and Steffen Kunsch

    Citation: BMC Gastroenterology 2018 18:123

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  25. Content type: Research article

    Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The p...

    Authors: Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang and Zhijun Duan

    Citation: BMC Gastroenterology 2018 18:112

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  26. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populati...

    Authors: Bashu Dev Pardhe, Shreena Shakya, Anjeela Bhetwal, Jennifer Mathias, Puspa Raj Khanal, Roshan Pandit, Jyotsna Shakya, Hari Om Joshi and Sujan Babu Marahatta

    Citation: BMC Gastroenterology 2018 18:109

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  27. Content type: Research article

    Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distrib...

    Authors: Marta Gravito-Soares, Elisa Gravito-Soares, Dário Gomes, Nuno Almeida and Luís Tomé

    Citation: BMC Gastroenterology 2018 18:108

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  28. Content type: Research article

    Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic variations in Indian patients with PFIC are lacking.

    Authors: Anjali Sharma, Ujjal Poddar, Shikha Agnihotry, Shubha R. Phadke, Surender K. Yachha and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2018 18:107

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  29. Content type: Research article

    Recently, although studies have investigated the role of NSAIDs in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), selection of the ideal drug, the time and route of i...

    Authors: Yunxiao Lyu, Yunxiao Cheng, Bin Wang, Yueming Xu and Weibing Du

    Citation: BMC Gastroenterology 2018 18:106

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  30. Content type: Research article

    Laparoscopic pancreaticoduodenectomy (LPD) remains to be established as a safe and effective alternative to open pancreaticoduodenectomy (OPD) for pancreatic-head and periampullary malignancy. The purpose of t...

    Authors: Ke Chen, Xiao-long Liu, Yu Pan, Hendi Maher and Xian-fa Wang

    Citation: BMC Gastroenterology 2018 18:102

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  31. Content type: Case report

    Chronic Hepatitis C Virus (HCV) infection has been commonly linked to the development of autoimmunity, in part through activation of B cells. B cells are also postulated to play a pathogenic role in the autoim...

    Authors: Henry H. Nguyen, Abdullah Khathlan, Marvin J. Fritzler and Mark G. Swain

    Citation: BMC Gastroenterology 2018 18:97

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  32. Content type: Case report

    Transient infantile hypertriglyceridemia (HTGTI) is an autosomal recessive disorder caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene.

    Authors: Jia-Qi Li, Xin-Bao Xie, Jia-Yan Feng, Lian Chen, Kuerbanjiang Abuduxikuer, Yi Lu, Yu-Chuan Li and Jian-She Wang

    Citation: BMC Gastroenterology 2018 18:96

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  33. Content type: Case report

    Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications,...

    Authors: Cheng Zhang, Yue-Feng Ma and Yu-Long Yang

    Citation: BMC Gastroenterology 2018 18:90

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  34. Content type: Research article

    Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between h...

    Authors: Xiaoyao Li, Lu Ke, Jie Dong, Bo Ye, Lei Meng, Wenjian Mao, Qi Yang, Weiqin Li and Jieshou Li

    Citation: BMC Gastroenterology 2018 18:89

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  35. Content type: Study protocol

    Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases....

    Authors: Arthur J. A. T. Braat, Dik J. Kwekkeboom, Boen L. R. Kam, Jaap J. M. Teunissen, Wouter W. de Herder, Koen M. A. Dreijerink, Rob van Rooij, Gerard C. Krijger, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: BMC Gastroenterology 2018 18:84

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  36. Content type: Research article

    Portopulmonary hypertension (PPH) was once regarded as a contraindicaton to liver transplantation (LT). However, growing evidence has indicated that PPH patients undergoing LT may show similar outcomes compare...

    Authors: Bingsong Huang, Yi Shi, Jun Liu, Paul M. Schroder, Suxiong Deng, Maogen Chen, Jun Li, Yi Ma and Ronghai Deng

    Citation: BMC Gastroenterology 2018 18:79

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  37. Content type: Research article

    One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide ...

    Authors: Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz and Per Stål

    Citation: BMC Gastroenterology 2018 18:78

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  38. Content type: Study protocol

    Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessm...

    Authors: Imeke Goldschmidt, André Karch, Rafael Mikolajczyk, Frauke Mutschler, Norman Junge, Eva Doreen Pfister, Tamara Möhring, Lorenzo d’Antiga, Patrick McKiernan, Deirdre Kelly, Dominique Debray, Valérie McLin, Joanna Pawlowska, Loreto Hierro, Kerstin Daemen, Jana Keil…

    Citation: BMC Gastroenterology 2018 18:63

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  39. Content type: Research article

    Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after o...

    Authors: Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike…

    Citation: BMC Gastroenterology 2018 18:62

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  40. Content type: Research article

    Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the pr...

    Authors: Xiuqing Pang, Xinhua Li, Zhishuo Mo, Jing Huang, Hong Deng, Ziying Lei, Xingrong Zheng, Zhiying Feng, Dongying Xie and Zhiliang Gao

    Citation: BMC Gastroenterology 2018 18:61

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  41. Content type: Research article

    Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitr...

    Authors: Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin and Mark R. Thursz

    Citation: BMC Gastroenterology 2018 18:60

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  42. Content type: Research article

    In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immu...

    Authors: Beate E. Preuß, Christoph P. Berg, Christoph Werner, Sandra Plankenhorn, Nisar P. Malek and Reinhild Klein

    Citation: BMC Gastroenterology 2018 18:58

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  43. Content type: Case report

    An intra-abdominal abscess can sometimes become serious and difficult to treat. The current standard treatment strategy for intra-abdominal abscess is percutaneous imaging-guided drainage. However, in cases of...

    Authors: Shinichi Morita, Kenya Kamimura, Takeshi Suda, Chiyumi Oda, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi and Shuji Terai

    Citation: BMC Gastroenterology 2018 18:55

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  44. Content type: Case report

    Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, ...

    Authors: Martino Gerosa, Marco Chiarelli, Angelo Guttadauro, Matilde De Simone, Fulvio Tagliabue, Melchiorre Costa, Sabina Terragni and Ugo Cioffi

    Citation: BMC Gastroenterology 2018 18:52

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  45. Content type: Research article

    Pancreatic duct obstructions are common in patients with pancreaticoduodenectomy. However, it is often neglected in follow up. This study was to review the outcomes of pancreatic duct obstruction and explore t...

    Authors: Lingfu Zhang, Dianrong Xiu, Chunhui Yuan, Bin Jiang and Zhaolai Ma

    Citation: BMC Gastroenterology 2018 18:53

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  46. Content type: Research article

    Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histologic...

    Authors: Rui Yu, Qiangwei Shi, Lei Liu and Lidong Chen

    Citation: BMC Gastroenterology 2018 18:51

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  47. Content type: Research article

    There are few reports about resection of portal vein (PV)/superior mesenteric vein (SMV) and reconstruction by using allogeneic vein. This case-control study was designed to explore the feasibility and safety ...

    Authors: Xing-mao Zhang, Jie Zhang, Hua Fan, Qiang He and Ren Lang

    Citation: BMC Gastroenterology 2018 18:49

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