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Hepatobiliary and pancreatic disorders

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.


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  1. Infantile liver failure syndrome-2 (ILFS2) is caused by neuroblastoma amplified sequence (NBAS) mutation. The disease is characterized by recurrent episodes of acute liver failure (ALF) or by liver crisis trig...

    Authors: Weiran Li, Yu Zhu, Qin Guo and Chaomin Wan

    Citation: BMC Gastroenterology 2020 20:308

    Content type: Case report

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  2. Hepatitis B infection is a significant worldwide health issue, predispose to the development of liver cirrhosis and hepatocellular carcinoma. Entecavir is a potent oral antiviral agent of high genetic barrier ...

    Authors: Xiong Khee Cheong, Zhiqin Wong, Norazirah Md Nor and Bang Rom Lee

    Citation: BMC Gastroenterology 2020 20:305

    Content type: Case report

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  3. There are only 6 cases of intraductal papillary mucinous neoplasm (IPMN) complicated with intraductal hemorrhage have been reported in English literatures. All these 6 cases of IPMN occurred in the old people....

    Authors: Jianman Wu, Yin Lin and Jingwen Wu

    Citation: BMC Gastroenterology 2020 20:304

    Content type: Case report

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  4. We experienced a rare case of intraductal papillary mucinous neoplasm arising from Santorini’s duct (SD) forming a tumor protruding into the duodenum .

    Authors: Haruna Komatsubara, Hiroyuki Kato, Daisuke Noguchi, Kazuyuki Gyoten, Aoi Hayasaki, Yusuke Iizawa, Takehiro Fujii, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Hiroyuki Sakurai and Shugo Mizuno

    Citation: BMC Gastroenterology 2020 20:303

    Content type: Case report

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  5. We examined how extra-hepatic comorbidity burden impacts mortality in patients with cirrhosis referred for liver transplantation (LT).

    Authors: Scott Coppel, Karan Mathur, Burcin Ekser, Kavish R. Patidar, Eric Orman, Archita P. Desai, Eduardo Vilar-Gomez, Chandrashekhar Kubal, Naga Chalasani, Lauren Nephew and Marwan Ghabril

    Citation: BMC Gastroenterology 2020 20:302

    Content type: Research article

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  6. With the improvement of treatment and prognosis for patients with late malignant diseases, certain malignancies with distant metastasis (M1 category) have been further classified into M1a (single metastatic si...

    Authors: Fang Feng, Wei Cai, Gaoming Wang, Weigang Chen, Haochang Yang, Mingyu Sun and Li Zhou

    Citation: BMC Gastroenterology 2020 20:289

    Content type: Research article

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  7. The importance of donor-specific antibodies (DSA) after liver transplantation (LT) for graft and patient survival is an ongoing controversy. So far it has not been elucidated when and in how far DSA are harmfu...

    Authors: Katharina Willuweit, Alexandra Frey, Lisa Bieniek, Andreas Heinold, Matthias Büchter, Peter A. Horn, Heiner Wedemeyer and Kerstin Herzer

    Citation: BMC Gastroenterology 2020 20:288

    Content type: Research article

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  8. In the diagnosis of IgG4-related sclerosing cholangitis (IgG4-SC), differentiation from extrahepatic cholangiocarcinoma (ECC) is extremely important but is still a clinical challenge. This study aimed to eluci...

    Authors: Yasutaka Ishii, Masahiro Serikawa, Tomofumi Tsuboi, Ryota Kawamura, Ken Tsushima, Shinya Nakamura, Tetsuro Hirano, Ayami Fukiage, Juri Ikemoto, Yusuke Kiyoshita, Sho Saeki, Yosuke Tamura and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:287

    Content type: Research article

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  9. Pancreatic panniculitis is a rare skin manifestation in pancreatic disease patients that most frequently develops on the lower legs. We report the unique case of a 68-year-old man who suffered from pancreatic ...

    Authors: Yuki Yamashita, Satoru Joshita, Tetsuya Ito, Masafumi Maruyama, Shuichi Wada and Takeji Umemura

    Citation: BMC Gastroenterology 2020 20:286

    Content type: Case report

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  10. Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual s...

    Authors: Akashi Fujita, Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Junya Sato, Yosuke Igarashi, Ryuichiro Araki, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe and Fumio Itoh

    Citation: BMC Gastroenterology 2020 20:285

    Content type: Research article

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  11. Inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral process of an undetermined cause that may involve a variety of organ systems, including the lungs, spleen, liver, lymph ...

    Authors: Antonio Calvo, Jesús Salas, Gloria Muñoz, Ana Díez and María Coral de la Vega

    Citation: BMC Gastroenterology 2020 20:282

    Content type: Case report

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  12. We aimed to compare the safety and effectiveness of the following procedures after pancreaticoduodenectomy: isolated pancreaticojejunostomy, isolated gastrojejunostomy, and conventional pancreaticojejunostomy.

    Authors: Yunxiao Lyu, Bin Wang, Yunxiao Cheng, Yueming Xu and Wei Bing Du

    Citation: BMC Gastroenterology 2020 20:279

    Content type: Research article

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  13. Almost all liver tumours can be removed laparoscopically, but some difficult tumour locations complicate laparoscopic surgery. Recurrent liver tumours often pose great difficulties to laparoscopic surgery due ...

    Authors: Baifeng Li, Tao Liu, Yijie Zhang and Jialin Zhang

    Citation: BMC Gastroenterology 2020 20:278

    Content type: Case report

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  14. Left-sided portal hypertension (LSPH) is an extremely rare clinical syndrome, and it is the only form of curable portal hypertension. It is primarily caused by pancreatic disease, and is associated with compli...

    Authors: Dajun Yu, Xiaolan Li, Jianping Gong, Jinzheng Li, Fei Xie and Jiejun Hu

    Citation: BMC Gastroenterology 2020 20:276

    Content type: Case report

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  15. Patients with liver cirrhosis typically exhibit abnormal coagulation parameters in conventional coagulation tests (CCTs). Rotational thromboelastometry (ROTEM) is a holistic blood coagulation assay. This metho...

    Authors: Jessica Seeßle, Jan Löhr, Marietta Kirchner, Josefin Michaelis and Uta Merle

    Citation: BMC Gastroenterology 2020 20:271

    Content type: Research article

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  16. Adenomatous gallbladder polyps, premalignant lesions of the gallbladder, have fatal outcomes, whereas cholesterol polyps have benign features. Herein, we proposed a novel, predictive scoring model of adenomato...

    Authors: Eun-young Kim and Tae-ho Hong

    Citation: BMC Gastroenterology 2020 20:268

    Content type: Research article

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  17. A pyogenic liver abscess (PLA) represents a pus-filled cavity within the liver parenchyma caused by the invasion and multiplication of bacteria. The most common offender isolated from the PLA in children is Staph...

    Authors: Petar Rasic, Srdjan Bosnic, Zorica V. Vasiljevic, Slavisa M. Djuricic, Vesna Topic, Maja Milickovic and Djordje Savic

    Citation: BMC Gastroenterology 2020 20:267

    Content type: Case report

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  18. MELD score and MELD score derivates are used to objectify and grade the risk of liver-related death in patients with liver cirrhosis. We recently proposed a new predictive model that combines serum creatinine ...

    Authors: Tomasz Dziodzio, Robert Öllinger, Wenzel Schöning, Antonia Rothkäppel, Radoslav Nikolov, Andrzej Juraszek, Paul V. Ritschl, Martin Stockmann, Johann Pratschke and Maximilian Jara

    Citation: BMC Gastroenterology 2020 20:265

    Content type: Research article

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  19. Postoperative pancreatic fistula (POPF) is a life-threatening postoperative complication. The aim of this study was to evaluate the efficacy of the fistula risk score (FRS) and preoperative body composition fa...

    Authors: Tomoyuki Abe, Hironobu Amano, Tsuyoshi Kobayashi, Keiji Hanada, Minoru Hattori, Masahiro Nakahara, Hideki Ohdan and Toshio Noriyuki

    Citation: BMC Gastroenterology 2020 20:264

    Content type: Research article

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  20. Chronic exposure to lead causes lead to accumulate mainly in the liver. In vivo studies have shown that lead toxicity is related to alterations in the inflammatory response. We aimed to evaluate the associatio...

    Authors: Tongluk Teerasarntipan, Roongruedee Chaiteerakij, Piyapan Prueksapanich and Duangporn Werawatganon

    Citation: BMC Gastroenterology 2020 20:263

    Content type: Research article

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  21. Non-alcoholic fatty liver disease (NAFLD) is a frequent condition in obese patients and regularly progresses to non-alcoholic steatohepatitis (NASH) and subsequent cirrhosis. Histologic evaluation is the gold ...

    Authors: Sophia Marie-Therese Schmitz, Andreas Kroh, Tom Florian Ulmer, Julia Andruszkow, Tom Luedde, Jonathan Frederik Brozat, Ulf Peter Neumann and Patrick Hamid Alizai

    Citation: BMC Gastroenterology 2020 20:254

    Content type: Research article

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  22. Health care costs are growing faster than the rest of the global economy, according to the World Health Organization (WHO). Countries’ health expenditures include paying for general medicine, diagnostic proced...

    Authors: Larissa Akeme Nakano, Eduardo Luiz Rachid Cançado, Cleuber Esteves Chaves, Maria Cristina Vaz Madeira, Jéssica Toshie Katayose, Mariana Akemi Nabeshima, Victor Fossaluza, Gabriela Guimarães Uhrigshardt, Zheng Liting, Vanusa Barbosa Pinto, Flair José Carrilho and Suzane Kioko Ono

    Citation: BMC Gastroenterology 2020 20:253

    Content type: Research article

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  23. Beta-thalassemia represents a heterogeneous group of haemoglobin inherited disorders, among the most common genetic diseases in the world, frequent in the Mediterranean basin. As beta-thalassemia patients’ sur...

    Authors: Alessandra Mangia, Davide Bellini, Umberto Cillo, Andrea Laghi, Giuseppe Pelle, Vanna Maria Valori and Eugenio Caturelli

    Citation: BMC Gastroenterology 2020 20:251

    Content type: Review

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  24. Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have conclud...

    Authors: Cheng Peng, Zhuonan Li, Zishan Xie, Zhanpeng Wang, Yanshuo Ye, Bo Li and Wei Li

    Citation: BMC Gastroenterology 2020 20:249

    Content type: Research article

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  25. Cystinosis is a multisystemic disease resulting from cystine accumulation primarily in kidney and many other tissues. We intended to study the evolution of less commonly seen extrarenal complications of cystin...

    Authors: Rezan Topaloglu, Ayşe Gültekingil Keser, Bora Gülhan, Fatih Ozaltin, Hülya Demir, Türkmen Çiftci, Numan Demir, Çağrı Mesut Temucin, Aysel Yuce and Okhan Akhan

    Citation: BMC Gastroenterology 2020 20:242

    Content type: Research article

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  26. The aim of the study was to compare the onset of oral feeding in the first 24 h after hospital admission with usual oral refeeding and determine whether the timing of the onset of oral feeding influences the r...

    Authors: Edgard Efrén Lozada-Hernández, Omar Barrón-González, Santa Vázquez-Romero, Martin Cano-Rosas and Evelia Apolinar-Jimenez

    Citation: BMC Gastroenterology 2020 20:228

    Content type: Research article

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  27. Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with ...

    Authors: Xiaochun Xie, Jie Dong, Guotao Lu, Kun Gao, Xiaoyao Li, Wenjian Mao, Faxi Chen, Zhihui Tong, Baiqiang Li and Weiqin Li

    Citation: BMC Gastroenterology 2020 20:222

    Content type: Research article

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  28. Therapy targeting programmed death-1 or programmed death-1 ligand-1 (PD-1/PD-L1) has been developed for various solid malignant tumors, such as melanoma and non-small-cell lung cancer (NSCLC), but this approac...

    Authors: Miku Obayashi, Yasushi Shibasaki, Toru Koakutsu, Yoshiro Hayashi, Tsuyoshi Shoji, Kazuhisa Hirayama, Masanori Yamazaki, Yasuhiro Takayanagi, Hiroshi Shibata, Masato Nakamura and Hirotoshi Maruo

    Citation: BMC Gastroenterology 2020 20:220

    Content type: Case report

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  29. Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound imag...

    Authors: Hideki Fujii, Haruna Doi, Tetsuhisa Ko, Taito Fukuma, Toru Kadono, Kohei Asaeda, Reo Kobayashi, Takahiro Nakano, Toshifumi Doi, Yoshikazu Nakatsugawa, Shinya Yamada, Takeshi Nishimura, Naoya Tomatsuri, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura…

    Citation: BMC Gastroenterology 2020 20:217

    Content type: Research article

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  30. Hepatocellular carcinoma (HCC), the most common type of liver cancer, is one of the leading causes of cancer-related death worldwide with an inferior prognosis. In Indonesia, the average life expectancy is les...

    Authors: Chyntia Olivia Maurine Jasirwan, Alessa Fahira, Lianda Siregar and Imelda Loho

    Citation: BMC Gastroenterology 2020 20:215

    Content type: Research article

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  31. To evaluate an innovative open necrosectomy strategy with continuous positive drainage and prophylactic diverting loop ileostomy for the management of late infected pancreatic necrosis (LIPN).

    Authors: Dong-Guang Niu, Wei-Qin Li, Qian Huang, Fan Yang, Wei-Liang Tian, Chen Li, Lian-An Ding, Hong-Chun Fang and Yun-Zhao Zhao

    Citation: BMC Gastroenterology 2020 20:212

    Content type: Research article

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  32. Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. ...

    Authors: Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang…

    Citation: BMC Gastroenterology 2020 20:210

    Content type: Research article

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  33. Primary hyperoxaluria (PH) is an inherited disease lacking of hepatic oxalic acid metabolic enzymes which could lead to irreverisible renal damage. Currently, liver–kidney transplantation is a curative but hig...

    Authors: Jie Xiang, Zheng Chen, Fangshen Xu, Shengmin Mei, Zhiwei Li, Jie Zhou, Yinlei Dong, Yangjun Gu, Zhichao Huang and Zhenhua Hu

    Citation: BMC Gastroenterology 2020 20:208

    Content type: Research article

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  34. Transarterial chemoembolization (TACE), radiofrequency ablation (RFA), and iodine 125 seeds implantation are optional treatments for hepatocellular carcinoma (HCC). The aim of this study is to compare the effi...

    Authors: Lei Chen, Xuefeng Kan, Tao Sun, Yanqiao Ren, Yanyan Cao, Liangliang Yan, Bin Liang, Bin Xiong and Chuansheng Zheng

    Citation: BMC Gastroenterology 2020 20:205

    Content type: Research article

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  35. Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is an extremely uncommon pancreatic neoplasm that comprises less than 1% of all exocrine pancreatic tumors. To date, cases and data from who...

    Authors: Guangjian Yang, Jiangxia Yin, Kai Ou, Qiang Du, Wenhao Ren, Yujing Jin, Liming Peng and Lin Yang

    Citation: BMC Gastroenterology 2020 20:202

    Content type: Case report

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  36. Surgical site infection (SSI) is one of the most common complications after pancreaticoduodenectomy (PD). Thus, it is beneficial to preoperatively identify patients at high risk of developing SSI. The primary ...

    Authors: Wikran Suragul, Narongsak Rungsakulkij, Watoo Vassanasiri, Pongsatorn Tangtawee, Paramin Muangkaew, Somkit Mingphruedhi and Suraida Aeesoa

    Citation: BMC Gastroenterology 2020 20:201

    Content type: Research article

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  37. To investigate the effect of albumin infusion on cirrhotic patients admitted for acute gastrointestinal bleeding.

    Authors: Zhu Wang, Ya-Wen Xie, Qing Lu, Hai-Lin Yan, Xin-Bin Liu, Yi Long, Xian Zhang and Jin-Lin Yang

    Citation: BMC Gastroenterology 2020 20:198

    Content type: Research article

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  38. Selective deep biliary cannulation is the first and the most important step before further biliary therapy. Transpancreatic sphincterotomy (TPS), and needle knife fistulotomy (NKF) were commonly used in patien...

    Authors: Kai-Shun Liang, Chieh-Chang Chen, Wei-Chih Liao, Yu-Ting Kuo, Liang-Wei Tseng, Wen-Tsung He and Hsiu-Po Wang

    Citation: BMC Gastroenterology 2020 20:194

    Content type: Research article

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  39. Endoscopic biliary stenting by endoscopic retrograde cholangiopancreatography (ERCP) is the most common form of palliation for malignant hilar obstruction. However, ERCP in such cases is associated with a risk...

    Authors: Wen-hui Zhang, Peng-peng Ding, Lei Liu, Yan-ling Wang, Wen-hui Lai, Jing-jing Han, Jun Han and Han-wei Li

    Citation: BMC Gastroenterology 2020 20:189

    Content type: Research article

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  40. Acute-on-chronic liver failure (ACLF) is a clinic syndrome with substantial high short-term mortality. It is very important to stratify patients according to prognosis to decide management strategy. This study...

    Authors: Cuicui Xiao, Jiao Gong, Shuguang Zhu, Zhiwei Zhang, Sujuan Xi, Yutian Chong, Yusheng Jie and Qi Zhang

    Citation: BMC Gastroenterology 2020 20:188

    Content type: Research article

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  41. Nonalcoholic steatohepatitis (NASH) is a key turning point during the progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have shown that serum miRNA tests may be effective in the diagnosis...

    Authors: Shengliang Xin, Qiao Zhan, Xiaofan Chen, Jinghang Xu and Yanyan Yu

    Citation: BMC Gastroenterology 2020 20:186

    Content type: Research article

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  42. Biliary decompression can reduce symptoms and improve quality of life in patients with malignant biliary obstruction. Endoscopically placed stents have become the standard of care for biliary drainage with the...

    Authors: Christopher Lawrence, Jose Nieto, Willis G. Parsons, André Roy, Nalini M. Guda, Stephen E. Steinberg, Muhammad K. Hasan, Juan Carlos Bucobo, Satish Nagula, Nicholas D. Dey and Jonathan M. Buscaglia

    Citation: BMC Gastroenterology 2020 20:184

    Content type: Research article

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  43. Infection of Echinococcus multilocularis causes in humans the alveolar echinococcosis. Although the infection has world-wide distribution it is rarely detected. Diagnosis of alveococcosis is difficult because of ...

    Authors: Ł. Pielok, M. Karczewski, W. Cierach, P. Zmora, E. Lenartowicz and J. Stefaniak

    Citation: BMC Gastroenterology 2020 20:176

    Content type: Case report

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  44. Currently, side-by-side (SBS) and stent-in-stent (SIS) are the two main techniques for stent deployment to treat hilar biliary obstructions. Previous studies comparing these two techniques are very limited, an...

    Authors: Wei-Zhong Zhou, Sheng Liu, Zheng-Qiang Yang, Yu-Tao Xian, Hong-dou Xu, Jun-zheng Wu and Hai-Bin Shi

    Citation: BMC Gastroenterology 2020 20:174

    Content type: Research article

    Published on:

  45. Gallbladder carcinogenesis, frequently occurredin chronic cholecystitis patients, requires radical resection. We herein describe a hemorrhagic cholecystitis case that failed to be differentiated from gallbladd...

    Authors: Xin Zhang, Chunjun Zhang, Haifeng Huang, Junsen Wang, Yun Zhang and Qida Hu

    Citation: BMC Gastroenterology 2020 20:172

    Content type: Case report

    Published on:

  46. Hereditary hemorrhagic telangiectasia (HHT) often involves the liver, and belongs to abnormal blood vessel disease. The etiology of Budd–Chiari syndrome (BCS) is not clear, but congenital vascular dysplasia is...

    Authors: Bai-Guo Xu, Jing Liang, Ke-Feng Jia and Tao Han

    Citation: BMC Gastroenterology 2020 20:169

    Content type: Case report

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