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Hepatobiliary and pancreatic disorders

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.


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  1. Several molecular prediction models based on the clinical parameters had been constructed to predict and diagnosis the risk of NAFLD, but the accuracy of these molecular prediction models remains need to be ve...

    Authors: Qing Zhang, Yueli Zhu, Wanjiang Yu, Zhipeng Xu, Zhenzhen Zhao, Shousheng Liu, Yongning Xin and Kuirong Lv

    Citation: BMC Gastroenterology 2021 21:88

    Content type: Research article

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  2. Disconnected pancreatic duct syndrome (DPDS) is a complication of acute necrotizing pancreatitis in the neck and body of the pancreas often manifesting as persistent pancreatic fluid collection (PFC) or extern...

    Authors: Eric Chong, Chathura Bathiya Ratnayake, Samantha Saikia, Manu Nayar, Kofi Oppong, Jeremy J. French, John A. Windsor and Sanjay Pandanaboyana

    Citation: BMC Gastroenterology 2021 21:87

    Content type: Research article

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  3. Hepatic cavernous hemangioma is the most common type of benign liver tumor. Although ruptures and hemorrhages of hepatic hemangioma are rare complications, they are associated with high mortality. Most practit...

    Authors: Yong-Guang Yang, Wei-Feng Chen, Wei-Heng Mai, Xiao-Fang Li, Hong-Lian Zhou, Li-Juan Liu and Ming-Yi Li

    Citation: BMC Gastroenterology 2021 21:84

    Content type: Case report

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  4. Liver cancer is one of the most common malignancies worldwide. HCC (hepatocellular carcinoma) is the predominant pathological type of liver cancer, accounting for approximately 75–85 % of all liver cancers. Li...

    Authors: Wenjie Wang, Chen Zhang, Qihong Yu, Xichuan Zheng, Chuanzheng Yin, Xueke Yan, Gang Liu and Zifang Song

    Citation: BMC Gastroenterology 2021 21:68

    Content type: Research article

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  5. Amyloid deposition in pancreas is rare. Lactoferrin amyloid deposition has not been reported in pancreas, till date. Presence of enhancing mural nodule in a cyst on imaging is a worrisome feature for malignanc...

    Authors: Katherine A. Baugh, Svetang Desai, George Van Buren 2nd, William E. Fisher, Carlos A. Farinas and Sadhna Dhingra

    Citation: BMC Gastroenterology 2021 21:66

    Content type: Case report

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  6. Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow ...

    Authors: Jiang Chen, Hongyu Li, Wenda Xu and Xiaozhong Guo

    Citation: BMC Gastroenterology 2021 21:58

    Content type: Research article

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  7. Pathological angiogenesis is involved in the development of hepatocellular carcinoma. In patients with chronic hepatitis C (CHC), the level of angiogenic factor angiopoietin (ANGP)-2 is reported to be increase...

    Authors: Yosuke Osawa, Sachiyo Yoshio, Yoshihiko Aoki, Masaaki Korenaga, Masatoshi Imamura, Takashi Oide, Miku Okawara, Hironari Kawai, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Taizo Mori, Taiji Yamazoe and Tatsuya Kanto

    Citation: BMC Gastroenterology 2021 21:55

    Content type: Research article

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  8. To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (b-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC).

    Authors: Pierleone Lucatelli, Gianluca De Rubeis, Bianca Rocco, Fabrizio Basilico, Alessandro Cannavale, Aurelio Abbatecola, Pier Giorgio Nardis, Mario Corona, Stefania Brozetti, Carlo Catalano and Mario Bezzi

    Citation: BMC Gastroenterology 2021 21:51

    Content type: Research article

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  9. This study evaluates preliminary results of image-guided percutaneous direct pancreatic duct intervention in the management of pancreatic fistula after surgery or pancreatitis when initially ineligible for sur...

    Authors: Xi Li, Ricardo Paz-Fumagalli, Weiping Wang, Beau B. Toskich, John A. Stauffer, Gregory T. Frey, J. Mark McKinney and Justin H. Nguyen

    Citation: BMC Gastroenterology 2021 21:44

    Content type: Research article

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  10. A series of evidence revealed that body mass index was an important confounding factor in the research of uric acid and ischemic heart disease/hypertension. The objective of this study was to investigate wheth...

    Authors: Mimi Zhou, Nan Yang, Xin Xing, Danyan Chang, Juan Li, Jiang Deng, Yi Chen, Chunhua Hu, Rou Zhang, Xiaolan Lu, Yingren Zhao and Yingli He

    Citation: BMC Gastroenterology 2021 21:43

    Content type: Research article

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  11. Nutrition is a modifiable risk factor that plays an important role in the prevention or delaying of the onset of non-alcoholic fatty liver disease (NAFLD). Previous studies have focused on NAFLD and individual...

    Authors: Ammar Salehi-sahlabadi, Samaneh Sadat, Sara Beigrezaei, Makan Pourmasomi, Awat Feizi, Reza Ghiasvand, Amir Hadi, Cain C. T. Clark and Maryam Miraghajani

    Citation: BMC Gastroenterology 2021 21:41

    Content type: Research article

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  12. Thrombocytopenia can rapidly improve in chronic hepatitis C (CHC) patients receiving direct-acting antiviral agents (DAA). The role of baseline (BL) thrombopoietin (TPO) in this phenomenon is unclear.

    Authors: Yen-Chun Chen, Ping-Hung Ko, Chi-Che Lee, Chih-Wei Tseng and Kuo-Chih Tseng

    Citation: BMC Gastroenterology 2021 21:30

    Content type: Research article

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  13. To evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) on hepatic sinusoidal obstruction syndrome (HSOS) associated with consumption of Gynura segetum (GS).

    Authors: Lijie Zhang, Qing Li, Joyman Makamure, Dan Zhao, Ziyi Liu, Chuansheng Zheng and Bin Liang

    Citation: BMC Gastroenterology 2021 21:26

    Content type: Research article

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  14. An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was alwa...

    Authors: Takeshi Urade, Juan Manuel Verde, Alain García Vázquez, Konstanze Gunzert, Patrick Pessaux, Jacques Marescaux and Mariano Eduardo Giménez

    Citation: BMC Gastroenterology 2021 21:24

    Content type: Research article

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  15. The histological diagnosis of autoimmune pancreatitis (AIP) by an endoscopic ultrasound (EUS)-guided approach is still challenging.

    Authors: Koichiro Tsutsumi, Toru Ueki, Yasuhiro Noma, Kunihiro Omonishi, Kyotaro Ohno, Soichiro Kawahara, Takashi Oda, Hironari Kato and Hiroyuki Okada

    Citation: BMC Gastroenterology 2021 21:21

    Content type: Research article

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  16. Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an infrequent type of primary liver cancer that comprises hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). This study investigat...

    Authors: Chih-Wen Lin, Tsung-Chin Wu, Hung-Yu Lin, Chao-Ming Hung, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Ya-Ling Huang, Yu-Chan Li, Ya-Chin Wang, Chih-Wen Shu and Yaw-Sen Chen

    Citation: BMC Gastroenterology 2021 21:20

    Content type: Research article

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  17. Combining upper and lower gastrointestinal tract (GI) approaches allows expansion of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) indications for pelvic lesions. The upper GI approach has been...

    Authors: Naoki Mita, Takuji Iwashita, Akihiko Senju, Hironao Ichikawa, Yuhei Iwasa, Shinya Uemura, Ichiro Yasuda and Masahito Shimizu

    Citation: BMC Gastroenterology 2021 21:18

    Content type: Research article

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  18. The gold standard for the diagnosis of liver fibrosis and nonalcoholic fatty liver disease (NAFLD) is liver biopsy. Various noninvasive modalities, e.g., ultrasonography, elastography and clinical predictive s...

    Authors: Pakanat Decharatanachart, Roongruedee Chaiteerakij, Thodsawit Tiyarattanachai and Sombat Treeprasertsuk

    Citation: BMC Gastroenterology 2021 21:10

    Content type: Research article

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  19. Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in ...

    Authors: Yoshito Oka, Shigetsugu Takano, Yusuke Kouchi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Isamu Hosokawa, Takashi Mishima, Takanori Konishi, Takashi Kishimoto and Masayuki Ohtsuka

    Citation: BMC Gastroenterology 2021 21:9

    Content type: Case report

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  20. Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is a standard method for pathological diagnosis of pancreatic solid lesions. The EchoTip ProCore 20G® (PC20), a 20-gauge biopsy needle wit...

    Authors: Shunsuke Watanabe, Jun Miyoshi, Masao Toki, Komei Kambayashi, Shuichi Kitada, Takeshi Nosaka, Tomoyuki Goto, Hirotaka Ota, Kazushige Ochiai, Koichi Gondo, Nobuhito Ikeuchi, Shujiro Tsuji, Kenji Nakamura, Junji Shibahara and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2021 21:8

    Content type: Research article

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  21. At present, most assessments of liver fibrosis staging mainly focus on non-invasive diagnostic methods. This study aims to construct a noninvasive model to predict liver histology for antiviral therapy in chro...

    Authors: Shanshan Chen, Haijun Huang and Wei Huang

    Citation: BMC Gastroenterology 2021 21:4

    Content type: Research article

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  22. What kind of patients with hypertriglyceridemic acute pancreatitis (HLAP) might benefit from plasmapheresis (PP) remains unknown. The objective of this study is to determine the predict function of total chole...

    Authors: Zhu Chen, Xiaolong Huang, Na Han, Yanxia Guo, Jing Chen, Yaogui Ning and Minwei Zhang

    Citation: BMC Gastroenterology 2021 21:3

    Content type: Research article

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  23. Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis. The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arterie...

    Authors: Xiaoyu Sun, Shunxiong Tang, Binbin Hou, Zhijun Duan, Zhen Liu, Yang Li, Shoucheng He, Qiuming Wang and Qingyong Chang

    Citation: BMC Gastroenterology 2021 21:2

    Content type: Research article

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  24. The role of platelets on the prognosis of patients with liver transplantation remains unclear. Thus, we aimed to evaluate the influence of preoperative platelet count on postoperative morbidity after liver tra...

    Authors: Qingshan Li, Yue Wang, Tao Ma, Fenggang Ren, Fan Mu, Rongqian Wu, Yi Lv and Bo Wang

    Citation: BMC Gastroenterology 2021 21:1

    Content type: Research article

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  25. End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Africa, where hepatitis B virus (HBV) is an important risk factor. We aimed to describe clinical characteristics o...

    Authors: Yvonne Ayerki Nartey, Yaw Asante Awuku, Adwoa Agyei-Nkansah, Amoako Duah, Sally Afua Bampoh, Joshua Ayawin, Shadrack Osei Asibey, Niklas K. Björkström, Weimin Ye, Mary Yeboah Afihene, Lewis Rowland Roberts and Amelie Plymoth

    Citation: BMC Gastroenterology 2020 20:428

    Content type: Research article

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  26. Chronic liver disease (CLD) is often complicated by severe thrombocytopenia (platelet count < 50,000/µL). Platelet transfusion has been a gold standard for increasing the platelet count to prevent hemorrhagic ...

    Authors: Hiroaki Nomoto, Naoki Morimoto, Kouichi Miura, Shunji Watanabe, Yoshinari Takaoka, Hiroshi Maeda, Takahiro Sasaki, Yohei Koyashiki, Hidekazu Kurata, Norikatsu Numao, Norio Isoda and Hironori Yamamoto

    Citation: BMC Gastroenterology 2020 20:427

    Content type: Research article

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  27. Treating hernias is one of the oldest challenges in surgery. The gallbladder as content in the case of abdominal hernias has only been reported in a few cases in the current literature. Cholecyst has only been...

    Authors: János Tajti Jr., József Pieler, Szabolcs Ábrahám, Zsolt Simonka, Attila Paszt and György Lázár

    Citation: BMC Gastroenterology 2020 20:425

    Content type: Case report

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  28. Infection with Entamoeba histolytica and associated complications are relatively rare in developed countries. The overall low prevalence in the Western world as well as the possibly prolonged latency period betwe...

    Authors: Rainer W. J. Kaiser, Julian Allgeier, Alexander B. Philipp, Julia Mayerle, Camilla Rothe, Claudia Wallrauch and Mark op den Winkel

    Citation: BMC Gastroenterology 2020 20:424

    Content type: Case report

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  29. Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in m...

    Authors: Minoru Oshima, Keiichi Okano, Hironobu Suto, Yasuhisa Ando, Hideki Kamada, Tsutomu Masaki, Shigeo Takahashi, Toru Shibata and Yasuyuki Suzuki

    Citation: BMC Gastroenterology 2020 20:423

    Content type: Research article

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  30. Immunoglobulin G4 (IgG4) associated autoimmune hepatitis (AIH) has been recognized as a type of autoimmune disease that responds to corticosteroid. The diagnosis is based on elevation of the serum IgG4 level, ...

    Authors: Arunchai Chang, Cheep Charoenlap, Keerati Akarapatima, Attapon Rattanasupar and Varayu Prachayakul

    Citation: BMC Gastroenterology 2020 20:420

    Content type: Case report

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  31. This study explored the prognostic significance of Glypican (GPC) family genes in patients with pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy using data from The Cancer Genome Atlas (TC...

    Authors: Jun-Qi Liu, Xi-Wen Liao, Xiang-Kun Wang, Cheng-Kun Yang, Xin Zhou, Zheng-Qian Liu, Quan-Fa Han, Tian-Hao Fu, Guang-Zhi Zhu, Chuang-Ye Han, Hao Su, Jian-Lu Huang, Guo-Tian Ruan, Ling Yan, Xin-Ping Ye and Tao Peng

    Citation: BMC Gastroenterology 2020 20:415

    Content type: Research article

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  32. In current guidelines, endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended in pancreatic cystic lesions (PCLs) with worrisome features (size ≥ 3 cm, mural nodule, or Wirsung dilation).

    Authors: Sandra Faias, Marília Cravo, João Pereira da Silva, Paula Chaves and A. Dias Pereira

    Citation: BMC Gastroenterology 2020 20:413

    Content type: Research article

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  33. Stromal fibroblasts associated with pancreatic ductal adenocarcinoma (PDAC) play an important role in tumor progression through interactions with cancer cells. Our proposed combination strategies of in vitro a...

    Authors: Yasunori Nishida, Akiko Kawano Nagatsuma, Motohiro Kojima, Naoto Gotohda and Atsushi Ochiai

    Citation: BMC Gastroenterology 2020 20:411

    Content type: Research article

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  34. Infection is one of the important causes of death in patients with severe acute pancreatitis (SAP), but the bacterial spectrum and antibiotic resistance are constantly changing. Making good use of antibiotics ...

    Authors: Ning Fan, Yong Hu, Hong Shen, Shengjie Liu, Guang Zhao, Lanju Sun, Chunyan Li, Xin Zhao, Yanning Li, Jianhua Wang and Yunfeng Cui

    Citation: BMC Gastroenterology 2020 20:405

    Content type: Research article

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  35. Intracholecystic papillary neoplasms (ICPNs) of the gallbladder are rare, preinvasive lesions characterized by an intracholecystic papillary growth that may be associated with invasive adenocarcinoma. The natu...

    Authors: Chi Hyuk Oh and Seok Ho Dong

    Citation: BMC Gastroenterology 2020 20:404

    Content type: Case report

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  36. Pancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency (EPI). This allows the study of digestive processes and pancreatic enzyme replacement therapies. However, detailed descrip...

    Authors: Andreas Minh Luu, Alexander Brock, Sabrina Ritz, Sandra Junghänel, Ingo Aldag, Stella Edskes, Marcus Hartmann, Michael Hessler, Michael Praktiknjo, Philip Arnemann, Christian Ertmer, Waldemar Uhl, Juergen Schnekenburger and Torsten Herzog

    Citation: BMC Gastroenterology 2020 20:403

    Content type: Research article

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  37. The clinical benefits of treatment with radiofrequency ablation (RFA) and repeat hepatic resection (RHR) for recurrent hepatocellular carcinoma (RHCC) remain controversial. This meta-analysis aims to evaluate ...

    Authors: Daopeng Yang, Bowen Zhuang, Yan Wang, Xiaoyan Xie and Xiaohua Xie

    Citation: BMC Gastroenterology 2020 20:402

    Content type: Research article

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  38. The World Health Organization's updated classification of digestive system neuroendocrine tumors in 2010 first proposed the classification of mixed adenoneuroendocrine carcinoma (MANEC). The incidence of bilia...

    Authors: Sulai Liu, Zhendong Zhong, Meng Xiao, Yinghui Song, Youye Zhu, Bo Hu, Zengpeng Sun, Weimin Yi and Chuang Peng

    Citation: BMC Gastroenterology 2020 20:399

    Content type: Case report

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  39. Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that specifically occurs in pregnancy. Elevated levels of liver transaminases aspartate aminotransferase, alanine aminotransferase and serum bili...

    Authors: Rong Li, Xuehai Chen, Zhongzhen Liu, Yan Chen, Chuan Liu, Lingfei Ye, Liang Xiao, Zhenjun Yang, Jian He, Wen-Jing Wang and Hongbo Qi

    Citation: BMC Gastroenterology 2020 20:395

    Content type: Research article

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  40. To investigate the value of serum hydroxybutyrate dehydrogenase (HBDH) level, an isozyme of lactate dehydrogenase, in evaluating the severity of acute pancreatitis (AP).

    Authors: Weiming Xiao, Weili Liu, Ling Yin, Yong Li, Guotao Lu, Xinnong Liu, Weijuan Gong, Yanbing Ding, Mei Wang and Zhigang Yan

    Citation: BMC Gastroenterology 2020 20:393

    Content type: Research article

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  41. An epidermoid cyst in an intrapancreatic accessory spleen (ECIPAS) in the pancreas head is an extremely rare condition. The natural course of this condition is not well known, and it is difficult to diagnose b...

    Authors: Hyo Jung Ko, Jae Ryong Shim, Tae Beom Lee, Byung Hyun Choi, Jung-Hee Lee, Je Ho Ryu and Kwangho Yang

    Citation: BMC Gastroenterology 2020 20:392

    Content type: Case report

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  42. To determine the safety and efficacy of different doses of tolvaptan for treating Chinese cirrhotic patients with or without hyponatraemia who still had ascites after routine therapy with diuretics.

    Authors: Jieting Tang, Yongfeng Wang, Tao Han, Qing Mao, Jun Cheng, Huiguo Ding, Jia Shang, Qin Zhang, Junqi Niu, Feng Ji, Chengwei Chen, Jidong Jia, Xiangjun Jiang, Nonghua Lv, Yueqiu Gao, Zhenghua Wang…

    Citation: BMC Gastroenterology 2020 20:391

    Content type: Research article

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  43. Ultrasound (US) imaging is known to underestimate tumor size in clinical. This study is aimed to compare the size measurements of hepatocellular carcinoma (HCC) in three US imaging modalities, i.e. two-dimensi...

    Authors: Fei Chen, Fei Wang, Si Sun, Mei Zhu and Zheng Liu

    Citation: BMC Gastroenterology 2020 20:390

    Content type: Research article

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