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Gastroesophageal disorders

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the und...

    Authors: Hubert Mönnikes, Thomas Schwan, Christo van Rensburg, Andrzej Straszak, Carmen Theek, Reinhold Lühmann, Peter Sander and Anne Tholen

    Citation: BMC Gastroenterology 2013 13:145

    Content type: Research article

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  2. Many individuals with gastroesophageal reflux disease (GERD) never visit their general practitioner. Therefore, prospective data about GERD and its natural history in the general population are scarce. The aim...

    Authors: Merel M Tielemans and Martijn GH van Oijen

    Citation: BMC Gastroenterology 2013 13:144

    Content type: Research article

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  3. MYC deregulation is a common event in gastric carcinogenesis, usually as a consequence of gene amplification, chromosomal translocations, or posttranslational mechanisms. FBXW7 is a p53-controlled tumor-suppresso...

    Authors: Danielle Queiroz Calcagno, Vanessa Morais Freitas, Mariana Ferreira Leal, Carolina Rosal Teixeira de Souza, Samia Demachki, Raquel Montenegro, Paulo Pimentel Assumpção, André Salim Khayat, Marília de Arruda Cardoso Smith, Andrea Kely Campos Ribeiro dos Santos and Rommel Rodriguez Burbano

    Citation: BMC Gastroenterology 2013 13:141

    Content type: Research article

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  4. The increasing trend of antibiotic resistance requires effective second-line Helicobacter pylori (H. pylori) treatment in high prevalence area of H. pylori. The aim of our study was to evaluate the reinfection ra...

    Authors: Min Soo Kim, Nayoung Kim, Sung Eun Kim, Hyun Jin Jo, Cheol Min Shin, Young Soo Park and Dong Ho Lee

    Citation: BMC Gastroenterology 2013 13:138

    Content type: Research article

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  5. There is a lack of consensus regarding the risk of postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD).

    Authors: Toshihisa Takeuchi, Kazuhiro Ota, Satoshi Harada, Shoko Edogawa, Yuichi Kojima, Satoshi Tokioka, Eiji Umegaki and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2013 13:136

    Content type: Research article

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  6. Information about gastro-oesophageal reflux disease (GERD) in patients with Diabetes mellitus type 2 (T2D) is scarce, although the incidence of both disorders is increasing.

    Authors: Regina Promberger, Johannes Lenglinger, Otto Riedl, Gernot Seebacher, Wolf Hans Eilenberg, Johannes Ott, Franz Martin Riegler, Michael Gadenstätter and Christoph Neumayer

    Citation: BMC Gastroenterology 2013 13:132

    Content type: Research article

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  7. Accurate prediction of Helicobacter pylori infection status on endoscopic images can contribute to early detection of gastric cancer, especially in Asia. We identified the diagnostic yield of endoscopy for H. pyl...

    Authors: Kazuhiro Watanabe, Naoyoshi Nagata, Takuro Shimbo, Ryo Nakashima, Etsuko Furuhata, Toshiyuki Sakurai, Naoki Akazawa, Chizu Yokoi, Masao Kobayakawa, Junichi Akiyama, Masashi Mizokami and Naomi Uemura

    Citation: BMC Gastroenterology 2013 13:128

    Content type: Research article

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  8. Helicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with gene expression profiles duri...

    Authors: Takeshi Toyoda, Tetsuya Tsukamoto, Masami Yamamoto, Hisayo Ban, Noriko Saito, Shinji Takasu, Liang Shi, Ayumi Saito, Seiji Ito, Yoshitaka Yamamura, Akiyoshi Nishikawa, Kumiko Ogawa, Takuji Tanaka and Masae Tatematsu

    Citation: BMC Gastroenterology 2013 13:122

    Content type: Research article

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  9. Hereditary diffuse gastric carcinoma is an autosomal dominant cancer syndrome associated with mutations of the E-cadherin gene (CDH1). E-cadherin is normally involved in cell-cell adhesion, so it not surprisin...

    Authors: Leslie E Hamilton, Kirsten Jones, Neal Church and Shaun Medlicott

    Citation: BMC Gastroenterology 2013 13:114

    Content type: Case report

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  10. The aim of this study was to evaluate the time trend of seropositivity of Helicobacter pylori (H. pylori) over the period of 13 years in an asymptomatic Korean population, and investigate associated risk factors.

    Authors: Seon Hee Lim, Jin-Won Kwon, Nayoung Kim, Gwang Ha Kim, Jung Mook Kang, Min Jung Park, Jeong Yoon Yim, Heung Up Kim, Gwang Ho Baik, Geom Seog Seo, Jeong Eun Shin, Young-Eun Joo, Joo Sung Kim and Hyun Chae Jung

    Citation: BMC Gastroenterology 2013 13:104

    Content type: Research article

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  11. Esophageal stricture (ES) and gastric outlet obstruction (GOO) can occurred in patients injured by the ingestion of corrosive agents. These complications may occur concurrently but has not been reported in the...

    Authors: Yi-Chun Chiu, Chih-Ming Liang, William Tam, Keng-Liang Wu, Long-Sheng Lu, Ming-Luen Hu, Wei-Chen Tai, King-Wah Chiu and Seng-Kee Chuah

    Citation: BMC Gastroenterology 2013 13:99

    Content type: Research article

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  12. Identifying and monitoring high-risk patients can aid the prevention of esophageal cancer (EC). The interaction of environmental risk factor exposure and genetic susceptibility may contribute to the etiology o...

    Authors: Polat Dura, Jody Salomon, Rene HM Te Morsche, Hennie MJ Roelofs, Jon O Kristinsson, Theo Wobbes, Ben JM Witteman, Adriaan CITL Tan, Joost PH Drenth and Wilbert HM Peters

    Citation: BMC Gastroenterology 2013 13:97

    Content type: Research article

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  13. Ligation-assisted endoscopic enucleation (EE-L) was developed for the pathological diagnosis and resection of small gastrointestinal tumors originating from the muscularis propria. The technique combines endos...

    Authors: Jintao Guo, Zhijun Liu, Siyu Sun, Sheng Wang, Nan Ge, Xiang Liu, Guoxin Wang and Xianghong Yang

    Citation: BMC Gastroenterology 2013 13:88

    Content type: Research article

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  14. The detection of serum tumor marker becomes a common method for screening tumors. However, this method has not been widely used for routine gastric cancer screening. In this study we aimed to determine whether...

    Authors: Chao-Zhu He, Kun-He Zhang, Qing Li, Xiao-Hua Liu, Yan Hong and Nong-Hua Lv

    Citation: BMC Gastroenterology 2013 13:87

    Content type: Research article

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  15. Proton-pump inhibitors such as omeprazole are a standard treatment to prevent non-steroidal anti-inflammatory drug-induced upper gastrointestinal mucosal injuries. However, it is unclear which drugs may protec...

    Authors: Takanori Kuramoto, Eiji Umegaki, Sadaharu Nouda, Ken Narabayashi, Yuichi Kojima, Yukiko Yoda, Kumi Ishida, Ken Kawakami, Yosuke Abe, Toshihisa Takeuchi, Takuya Inoue, Mitsuyuki Murano, Satoshi Tokioka and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2013 13:85

    Content type: Research article

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  16. The study aimed to survey for FD in a primary care setting in a population known to have an extremely low prevalence of Helicobacter pylori (H. pylori) infection, with the hypothesis that in such a population, dy...

    Authors: Yeong Yeh Lee, Noriza Wahab, Nazri Mustaffa, Norwati Daud, Noorhayati Mohd Noor, Juwita Shaaban and Andrew Seng Boon Chua

    Citation: BMC Gastroenterology 2013 13:84

    Content type: Research article

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  17. Prior studies suggest that obstructive sleep apnea may be associated with gastroesophageal reflux disease, a strong risk factor for Barrett’s esophagus. The goals of this pilot case–control study were to deter...

    Authors: Linda C Cummings, Ninad Shah, Santo Maimone, Wajeeh Salah, Vijay Khiani and Amitabh Chak

    Citation: BMC Gastroenterology 2013 13:82

    Content type: Research article

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  18. Stricture formation is one of the major complications after endoscopic removal of large superficial squamous cell neoplasms of the esophagus, and local steroid injections have been adopted to prevent it. Howev...

    Authors: Kouichi Nonaka, Mitsuo Miyazawa, Shinichi Ban, Masayasu Aikawa, Naoe Akimoto, Isamu Koyama and Hiroto Kita

    Citation: BMC Gastroenterology 2013 13:72

    Content type: Research article

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  19. The treatment for the eradication of Helicobacter pylori (H. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. In developing countries, increased resistance to antibiotics...

    Authors: Tomás Navarro-Rodriguez, Fernando Marcuz Silva, Ricardo Correa Barbuti, Rejane Mattar, Joaquim Prado Moraes-Filho, Maricê Nogueira de Oliveira, Cristina S Bogsan, Décio Chinzon and Jaime Natan Eisig

    Citation: BMC Gastroenterology 2013 13:56

    Content type: Research article

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  20. Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adver...

    Authors: Kentaro Sugano, Yoshikazu Kinoshita, Hiroto Miwa and Tsutomu Takeuchi

    Citation: BMC Gastroenterology 2013 13:54

    Content type: Research article

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  21. Surface electrogastrography (EGG) is a non-invasive method for clinical assessment of gastric myoelectrical activity. Different forms of general anaesthesia might have various effects on porcine EGG. The aim o...

    Authors: Ilja Tachecí, Jaroslav Květina, Martin Kuneš, Michal Pavlík, Marcela Kopáčová, Vladimír Černý, Stanislav Rejchrt, Jithinraj Edakkanambeth Varayil and Jan Bureš

    Citation: BMC Gastroenterology 2013 13:48

    Content type: Research article

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  22. Gastrointestinal reflux disease (GERD) is a common disorder that negatively impacts health-related quality of life (HRQL) and work productivity. Many patients have only a partial response to proton pump inhibi...

    Authors: Stanislas Bruley des Varannes, Helena Granstedt Löfman, Maria Karlsson, Peter Wahlqvist, Magnus Ruth, Mary Lou Furstnau, Nicolas Despiégel and Nils-Olov Stålhammar

    Citation: BMC Gastroenterology 2013 13:39

    Content type: Research article

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  23. The transcription factor nuclear factor-κB (NF-κB) has been implicated in gastric cancer metastasis, but the underlying molecular mechanisms remain unclear. We investigated the role of the interaction between ...

    Authors: Jiyeon Yoon, Sung Jin Cho, Young San Ko, Jinju Park, Dong Hoon Shin, In Chan Hwang, Sang Yeun Han, Seon Young Nam, Min A Kim, Mee Soo Chang, Hye Seung Lee, Woo Ho Kim and Byung Lan Lee

    Citation: BMC Gastroenterology 2013 13:29

    Content type: Research article

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  24. Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma wa...

    Authors: Hitomi Minami, Naoyuki Yamaguchi, Kayoko Matsushima, Yuko Akazawa, Ken Ohnita, Fuminao Takeshima, Toshiyuki Nakayama, Tomayoshi Hayashi, Haruhiro Inoue, Kazuhiko Nakao and Hajime Isomoto

    Citation: BMC Gastroenterology 2013 13:22

    Content type: Research article

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  25. Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response ...

    Authors: Arne Kandulski, Ulrich Peitz, Klaus Mönkemüller, Helmut Neumann, Jochen Weigt and Peter Malfertheiner

    Citation: BMC Gastroenterology 2013 13:12

    Content type: Research article

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  26. Ulceration of the oesophageal squamous mucosa (ulcerative oesophagitis) is a pathological manifestation of gastro-oesophageal reflux disease, and is a major risk factor for the development of Barrett’s oesopha...

    Authors: Cameron M Smith, Michael Z Michael, David I Watson, Grace Tan, David St J Astill, Richard Hummel and Damian J Hussey

    Citation: BMC Gastroenterology 2013 13:4

    Content type: Research article

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  27. Aberrant methylation patterns in CpG island are known to be influential in gene silencing. Histamine plays important physiological roles in the upper gastrointestinal tract and acts via the H2 receptor. We rep...

    Authors: Tomoe Nomura, Tomomitsu Tahara, Hisakazu Shiroeda, Takahiro Minato, Yasuhiro Matsue, Ranji Hayashi, Kazuhiro Matsunaga, Toshimi Otsuka, Masakatsu Nakamura, Nobuyuki Toshikuni, Tomoyuki Shibata and Tomiyasu Arisawa

    Citation: BMC Gastroenterology 2013 13:1

    Content type: Research article

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  28. The best sites for biopsy-based tests to evaluate H. pylori infection in gastritis with atrophy are not well known. This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree o...

    Authors: Hung-Chieh Lan, Tseng-Shing Chen, Anna Fen-Yau Li, Full-Young Chang and Han-Chieh Lin

    Citation: BMC Gastroenterology 2012 12:182

    Content type: Research article

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  29. Recent advances in the management of Barrett’s Esophagus (BE) have placed greater emphasis on accurate diagnosis of BE as well as better prediction of risk for progression to esophageal adenocarcinoma (EAC). H...

    Authors: Eric Ellsworth, Sara A Jackson, Shyam J Thakkar, Dennis M Smith Jr and Sydney Finkelstein

    Citation: BMC Gastroenterology 2012 12:181

    Content type: Research article

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  30. Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of abd...

    Authors: John D Seeger, Sherry Quinn, David L Earnest, Anthony Lembo, Braden Kuo, Elena Rivero and Alexander M Walker

    Citation: BMC Gastroenterology 2012 12:171

    Content type: Research article

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  31. Gastric intestinal metaplasia (IM) usually appears in flat mucosa and shows few morphologic changes, making diagnosis using conventional endoscopy unreliable. Magnifying narrow-band imaging (NBI) endoscopy ena...

    Authors: Jin Kwang An, Geun Am Song, Gwang Ha Kim, Do Youn Park, Na Ri Shin, Bong Eun Lee, Hyun Young Woo, Dong Yup Ryu, Dong Uk Kim and Jeong Heo

    Citation: BMC Gastroenterology 2012 12:169

    Content type: Research article

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  32. Rumination syndrome (RS) is a functional gastrointestinal disorder (FGD) increasingly recognized in children and adolescents. The epidemiology of this condition in school aged children is poorly understood. Th...

    Authors: Shaman Rajindrajith, Niranga Manjuri Devanarayana and Bonaventure Jayasiri Crispus Perera

    Citation: BMC Gastroenterology 2012 12:163

    Content type: Research article

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  33. Data about prevalence of gastroesophageal reflux diseases (GERD) from Asian populations are still scarce. To provide additional data on prevalence of GERD and investigate its potential risk factors, we perform...

    Authors: Tiantian Chen, Ming Lu, Xiaofeng Wang, Yajun Yang, Juan Zhang, Li Jin and Weimin Ye

    Citation: BMC Gastroenterology 2012 12:161

    Content type: Research article

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  34. High expression of Bmi-1, a key regulatory component of the polycomb repressive complex-1, has been associated with many solid and hematologic malignancies including esophageal squamous cell carcinoma. However...

    Authors: Bonnie Choy, Santhoshi Bandla, Yinglin Xia, Dongfeng Tan, Arjun Pennathur, James D Luketich, Tony E Godfrey, Jeffrey H Peters, Jun Sun and Zhongren Zhou

    Citation: BMC Gastroenterology 2012 12:146

    Content type: Research article

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  35. Gastric cancer is one of the most significant diseases, and esophago-gastro-duodenoscopy (EGD) is one of screening methods for gastric cancer. This study was conducted to identify the optimal screening interva...

    Authors: Daiki Kobayashi, Osamu Takahashi, Hiroko Arioka and Tsuguya Fukui

    Citation: BMC Gastroenterology 2012 12:144

    Content type: Research article

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  36. Proton pump is an integral membrane protein that is ubiquitous ATP binding cassette (ABC) involved in many transport processes in all living organisms, among which a specialized form of pump, so called p-type pro...

    Authors: Ho-Jae Lee, Young-Min Han, Eun-Hee Kim, Yoon-Jae Kim and Ki-Baik Hahm

    Citation: BMC Gastroenterology 2012 12:143

    Content type: Research article

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  37. Asthmatics are known to have esophageal hypomotility. Vagal hypofunction and prolonged intra-esophageal acidification cause esophageal hypomotility. The contribution of gastroesophageal reflux (GER) and vagal ...

    Authors: D Lakmali Amarasiri, Arunasalam Pathmeswaran, Anuradha S Dassanayake, Arjuna P de Silva, Channa D Ranasinha and H Janaka de Silva

    Citation: BMC Gastroenterology 2012 12:140

    Content type: Research article

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  38. Despite genetic polymorphism in response to platinum/5-Fu chemotherapy in gastric cancer (GC) has been studied, data reported so far are conflicting and critical consideration is needed before translation to t...

    Authors: Zhen Wang, Jun-qiang Chen, Jin-lu Liu, Xin-gan Qin and Yuan Huang

    Citation: BMC Gastroenterology 2012 12:137

    Content type: Research article

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  39. Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitati...

    Authors: James P Franciosi, Kevin A Hommel, Allison B Greenberg, Charles W DeBrosse, Alexandria J Greenler, J Pablo Abonia, Marc E Rothenberg and James W Varni

    Citation: BMC Gastroenterology 2012 12:135

    Content type: Research article

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  40. In this post-hoc analysis of a randomized, double blind, placebo controlled trial, we measured the sensitivity and specificity of Helicobacter pylori IgG-antibody titer changes, hematoxylin and eosin (H&E) stains...

    Authors: Harald E Vonkeman, HTJI deLeest, MAFJ van deLaar, J vanBaarlen, KSS Steen, WF Lems, JWJ Bijlsma, EJ Kuipers, HHML Houben, M Janssen and BAC Dijkmans

    Citation: BMC Gastroenterology 2012 12:133

    Content type: Research article

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  41. Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30–80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of ...

    Authors: Sara Fill Malfertheiner, Maximilian V Malfertheiner, Siegfried Kropf, Serban-Dan Costa and Peter Malfertheiner

    Citation: BMC Gastroenterology 2012 12:131

    Content type: Research article

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  42. Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts. The aim of the study was to investigate the expression pattern of selecte...

    Authors: Klaus Mönkemüller, Thomas Wex, Doerthe Kuester, Lucia C Fry, Arne Kandulski, Siegfried Kropf, Albert Roessner and Peter Malfertheiner

    Citation: BMC Gastroenterology 2012 12:128

    Content type: Research article

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  43. Gastric subepithelial tumors are usually asymptomatic and observed incidentally during endoscopic examination. Although most of these tumors are considered benign, some have a potential for malignant transform...

    Authors: Yin-Yi Chu, Jau-Min Lien, Ming-Hung Tsai, Cheng-Tang Chiu, Tse-Ching Chen, Kuo-Ching Yang and Soh-Ching Ng

    Citation: BMC Gastroenterology 2012 12:124

    Content type: Research article

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  44. The “Rusch” intubation stylet is used to make endotracheal tube intubation easy. We designed this study to evaluate the usage of this equipment in the guidance of nasogastric tube (NGT) insertion.

    Authors: Yung-Fong Tsai, Chiao-Fen Luo, Amina Illias, Chih-Chung Lin and Huang-Ping Yu

    Citation: BMC Gastroenterology 2012 12:99

    Content type: Research article

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  45. The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the in...

    Authors: Hiroshi Iida, Masahiko Inamori, Tetsuro Fujii, Yusuke Sekino, Hiroki Endo, Kunihiro Hosono, Takashi Nonaka, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito…

    Citation: BMC Gastroenterology 2012 12:25

    Content type: Research article

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