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Gastroesophageal disorders

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. We developed a novel artificial simulator for endoscopic submucosal dissection (ESD) as a bridge between instructional videos and animal tissue training and aimed to evaluate the feasibility of using an artifi...

    Authors: Ming-Jen Chen, Horng-Yuan Wang, Chen-Wang Chang, Ching-Chung Lin, Chih-Jen Chen, Cheng-Hsin Chu, Tsang-En Wang and Shou-Chuan Shih

    Citation: BMC Gastroenterology 2016 16:112

    Content type: Research article

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  2. Gastric neuroendocrine neoplasms (G-NENs) are uncommon, and data on their management is limited. We here investigated the clinicopathological characteristics, surgical and survival outcomes in G-NENs among Chi...

    Authors: Chaoyong Shen, Huijiao Chen, Haining Chen, Yuan Yin, Luyin Han, Jiaju Chen, Sumin Tang, Xiaonan Yin, Zongguang Zhou, Bo Zhang and Zhixin Chen

    Citation: BMC Gastroenterology 2016 16:111

    Content type: Research article

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  3. Gastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk factor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical c...

    Authors: Xing-kang He, Dan Liu and Lei-min Sun

    Citation: BMC Gastroenterology 2016 16:109

    Content type: Research article

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  4. Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decad...

    Authors: Teresa Cutts, Sandra Holmes, Archana Kedar, Karen Beatty, Mohammad K. Mohammad and Thomas Abell

    Citation: BMC Gastroenterology 2016 16:107

    Content type: Research article

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  5. Defects in distal oesophageal peristalsis was thought to be an indication of incomplete bolus transit (BT). However, the role of transition zone (TZ) defects in the BT in gastroesophageal reflux disease (GORD)...

    Authors: Yu-wen Li, Chen-xi Xie, Kai-Ming Wu, Min-hu Chen and Ying-lian Xiao

    Citation: BMC Gastroenterology 2016 16:106

    Content type: Research article

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  6. In the medical literature are described only few clinical cases of esophageal food bolus impaction due to esophageal motility disorders. Moreover, the management of this condition is highly variable with no ev...

    Authors: Luigi Marano, Alessandro Cecchi, Federica Chiodo, Francesco Gullo, Pasquale Fiorillo, Luca Roncetti, Mattia Longaroni, Gianluca Proietti Silvestri, Silvano Lolli, Giorgio Nicolic and Alberto Patriti

    Citation: BMC Gastroenterology 2016 16:95

    Content type: Case report

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  7. Infection with Helicobacter pylori is associated with severe digestive diseases including chronic gastritis, peptic ulcer disease, and gastric cancer. Successful eradication of this common gastric pathogen in ind...

    Authors: Amin Talebi Bezmin Abadi and Johannes G. Kusters

    Citation: BMC Gastroenterology 2016 16:94

    Content type: Debate

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  8. Laparoscopic Nissen fundoplication (LNF) is the most common surgical procedure for the surgical management of gastro-esophageal reflux disease (GERD). Laparoscopic Toupet fundoplication (LTF) has been reported...

    Authors: Xing Du, Zhiwei Hu, Chao Yan, Chao Zhang, Zhonggao Wang and Jimin Wu

    Citation: BMC Gastroenterology 2016 16:88

    Content type: Research article

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  9. Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYS...

    Authors: M. Venerito, C. Helmke, D. Jechorek, T. Wex, R. Rosania, K. Antweiler, J. Weigt and P. Malfertheiner

    Citation: BMC Gastroenterology 2016 16:85

    Content type: Research article

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  10. Approximately half of the world’s population is infected with Helicobacter pylori (H.pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. A growing number of systematic reviews (...

    Authors: Yiqiao Xin, Jan Manson, Lindsay Govan, Robin Harbour, Jenny Bennison, Eleanor Watson and Olivia Wu

    Citation: BMC Gastroenterology 2016 16:80

    Content type: Research article

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  11. The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resista...

    Authors: Ju Yup Lee, Nayoung Kim, Kyung Sik Park, Hyun Jin Kim, Seon Mee Park, Gwang Ho Baik, Ki-Nam Shim, Jung Hwan Oh, Suck Chei Choi, Sung Eun Kim, Won Hee Kim, Seon-Young Park, Gwang Ha Kim, Bong Eun Lee, Yunju Jo and Su Jin Hong

    Citation: BMC Gastroenterology 2016 16:79

    Content type: Research article

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  12. Identifying a precise demarcation line (DL) is indispensable for pathological complete en bloc endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). We evaluated the useful condition of chromo...

    Authors: Norifumi Numata, Shiro Oka, Shinji Tanaka, Yoshikazu Yoshifuku, Tomohiro Miwata, Yoji Sanomura, Koji Arihiro, Fumio Shimamoto and Kazuaki Chayama

    Citation: BMC Gastroenterology 2016 16:72

    Content type: Research article

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  13. Since the biological function of c-Jun N-terminal kinase (JNK) in gastric cancer remains unclear, we investigated the clinical significance of JNK activation and its association with FOXO1 activation.

    Authors: Youngsun Choi, Jinju Park, Yiseul Choi, Young San Ko, Da-Ae Yu, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Min A. Kim, Woo Ho Kim and Byung Lan Lee

    Citation: BMC Gastroenterology 2016 16:59

    Content type: Research article

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  14. Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induce...

    Authors: Thiago Gagliano-Jucá, Ronilson A. Moreno, Tiago Zaminelli, Mauro Napolitano, Antônio Frederico N. Magalhães, Aloísio Carvalhaes, Miriam S. Trevisan, John L. Wallace and Gilberto De Nucci

    Citation: BMC Gastroenterology 2016 16:58

    Content type: Research article

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  15. Pain and discomfort related to endoscopy sessions can be alleviated by sedation, which minimizes anxiety and allows safe examination. For outpatient endoscopy, reliable short-term sedation without secondary ef...

    Authors: Qiongzhen Li, Qinghe Zhou, Wangpin Xiao and Hongmei Zhou

    Citation: BMC Gastroenterology 2016 16:49

    Content type: Research article

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  16. Most patients with gastroesophageal reflux disease experience symptomatic relapse after stopping acid-suppressive medication. The aim of this study was to compare willingness to continue treatment with esomepr...

    Authors: Ekkehard Bayerdörffer, Marc-Andre Bigard, Werner Weiss, Fermín Mearin, Luis Rodrigo, Juan Enrique Dominguez Muñoz, Hennie Grundling, Tore Persson, Lars-Erik Svedberg, Nanna Keeling and Stefan Eklund

    Citation: BMC Gastroenterology 2016 16:48

    Content type: Research article

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  17. Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal t...

    Authors: Wei Wu, Feng Wang, Xin Gao, Tingting Niu, Xiaojuan Zhu, Xiaojun Yan and Haimin Chen

    Citation: BMC Gastroenterology 2016 16:41

    Content type: Research article

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  18. The prevalence of gastro-esophageal reflux disease (GERD) varies widely around the world. This study aimed to investigate the prevalence and risk factors of GERD in a general population of southern India.

    Authors: Hai-Yun Wang, Kondarapassery Balakumaran Leena, Amelie Plymoth, Maria-Pia Hergens, Li Yin, Kotacherry Trivikrama Shenoy and Weimin Ye

    Citation: BMC Gastroenterology 2016 16:36

    Content type: Research article

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  19. Hepatitis C virus (HCV) is a common chronic infection that is widely associated with symptoms of fatigue and abdominal pain. The aim of the present study was to determine the prevalence of functional dyspepsia...

    Authors: Hala I. Mohamed, Hamdy A. Mokarib, Zienab M. Saad and Wael M. Abd El Ghany

    Citation: BMC Gastroenterology 2016 16:32

    Content type: Research article

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  20. Esophageal variceal bleeding (EVB) is a serious and common complication of cirrhosis. Diabetes mellitus (DM) and chronic kidney disease (CKD) increase mortality in patients with cirrhosis. However, whether coe...

    Authors: Chia-Chi Lung, Zhi-Hong Jian, Jing-Yang Huang and Oswald Ndi Nfor

    Citation: BMC Gastroenterology 2016 16:29

    Content type: Research article

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  21. Approximately 0.2–1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM.

    Authors: Niranga Manjuri Devanarayana, Shaman Rajindrajith and Marc A. Benninga

    Citation: BMC Gastroenterology 2016 16:26

    Content type: Research article

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  22. Hepatocellular carcinoma (HCC) is one of most common and aggressive human malignancies in the world, especially, in eastern Asia, and its mortality is very high at any phase. We want to investigate mechanism o...

    Authors: Shunyan Weng, Liang Zhou, Qing Deng, Jiaxian Wang, Yan Yu, Jianwei Zhu and Yunsheng Yuan

    Citation: BMC Gastroenterology 2016 16:25

    Content type: Research article

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  23. L-thyroxine (L-T4) malabsorption is a potential concern in patients with autoimmune atrophic gastritis.

    Authors: Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli and Alessando Antonelli

    Citation: BMC Gastroenterology 2016 16:22

    Content type: Research article

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  24. The incidence of the para-aortic lymph node metastasis (PALM) in patients with advanced gastric cancer is 6 to 33 %. The prognosis is poor and the 5-year survival rate is only 12 to 23 % after gastrectomy with...

    Authors: Qi He, Long Ma, Yang Li and Guoli Li

    Citation: BMC Gastroenterology 2016 16:8

    Content type: Research article

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  25. The association of minimal change esophagitis (MCE) with GERD is controversial. i-Scan endoscopy (SE) provides high resolution and modulation of images that may improve minimal change lesion (MCL) detection. W...

    Authors: Nisa Netinatsunton, Jaksin Sottisuporn, Siriboon Attasaranya, Teepawit Witeerungrot, Naichaya Chamroonkul, Theeratus Jongboonyanuparp, Alan Geater and Bancha Ovartlarnporn

    Citation: BMC Gastroenterology 2016 16:4

    Content type: Research article

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  26. Eradication rates of standard triple therapy for Helicobacter pylori infections have decreased in recent years due to a worldwide increase in bacterial resistance. Sequential therapy has the advantage of a two-ph...

    Authors: Chung-Chuan Chan, Nai-Hsuan Chien, Chia-Long Lee, Yi-Chen Yang, Chih-Sheng Hung, Tien-Chien Tu and Chi-Hwa Wu

    Citation: BMC Gastroenterology 2015 15:170

    Content type: Research article

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  27. Gastric cancer is usually diagnosed in an advanced stage of disease and treatment options are sparse. Trastuzumab was recently approved for metastatic or locally advanced carcinomas arising in the stomach or i...

    Authors: Renato Santos Laboissiere, Marcelo Araújo Buzelin, Débora Balabram, Marina De Brot, Cristiana Buzelin Nunes, Rafael Malagoli Rocha, Mônica Maria Demas Álvares Cabral and Helenice Gobbi

    Citation: BMC Gastroenterology 2015 15:157

    Content type: Research article

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  28. Magnifying endoscopy with narrow-band imaging (ME-NBI) is more reliable than chromoendoscopy (CE) for delineating the horizontal extent of early gastric cancers prior to endoscopic submucosal dissection (ESD)....

    Authors: Kunihisa Uchita, Kenshi Yao, Noriya Uedo, Toshio Shimokawa, Takehiro Iwasaki, Koji Kojima, Ai Kawada, Mizu Nakayama, Michiyo Okazaki and Shinichi Iwamura

    Citation: BMC Gastroenterology 2015 15:155

    Content type: Research article

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  29. Helicobacter pylori infection is the most important risk factor for gastric cancer, for which eradication therapy is commonly performed. However, gastric cancer is sometimes discovered...

    Authors: Kosuke Sakitani, Yoshihiro Hirata, Nobumi Suzuki, Satoki Shichijo, Ayako Yanai, Takako Serizawa, Kei Sakamoto, Masao Akanuma, Shin Maeda, Yutaka Yamaji, Yasuhiko Iwamoto, Shoji Kawazu and Kazuhiko Koike

    Citation: BMC Gastroenterology 2015 15:143

    Content type: Research article

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  30. Reasons underlying the variability of physicians’ preferences for non-selective beta-blockers (BBs) and endoscopic variceal ligation (EVL) to prevent a first variceal bleed have not been empirically studied. O...

    Authors: Kathleen Yan, John FP Bridges, Salvador Augustin, Loren Laine, Guadalupe Garcia-Tsao and Liana Fraenkel

    Citation: BMC Gastroenterology 2015 15:55

    Content type: Research article

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  31. To compare the effects of laparoscopic-assisted gastrectomy (LAG) and open gastrectomy (OG) on serum interleukin-6 (IL-6) levels in gastric cancer (GC) patients from Asia.

    Authors: Zhen-Bo Shu, Hai-Ping Cao, Yong-Chao Li and Li-Bo Sun

    Citation: BMC Gastroenterology 2015 15:52

    Content type: Research article

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  32. Systemic sclerosis (SSc) is a generalized disorder of unknown etiology affecting the connective tissue of the body. It affects the skin and various internal organs. Gastrointestinal tract involvement is seen i...

    Authors: Tasleem Arif, Qazi Masood, Jaswinder Singh and Iffat Hassan

    Citation: BMC Gastroenterology 2015 15:24

    Content type: Research article

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  33. Empiric triple treatments for Helicobacter pylori (H. pylori) are increasingly unsuccessful. We evaluated factors associated with failure of these treatments in the central region of Portugal.

    Authors: Nuno Almeida, Maria Manuel Donato, José Manuel Romãozinho, Cristina Luxo, Olga Cardoso, Maria Augusta Cipriano, Carol Marinho, Alexandra Fernandes, Carlos Calhau and Carlos Sofia

    Citation: BMC Gastroenterology 2015 15:23

    Content type: Research article

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  34. We have demonstrated previously that NFKB1 single nucleotide polymorphism (SNP) rs4648068 GG homozygote was associated with the increased risk of gastric cancer in Chinese Han population. In this study, we con...

    Authors: Ying Chen, Renquan Lu, Hui Zheng, Ran Xiao, Jingjing Feng, Hongling Wang, Xiang Gao and Lin Guo

    Citation: BMC Gastroenterology 2015 15:21

    Content type: Research article

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  35. Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. To date, there have been few studies on the clinical characteristics of GEDs according to the morpholo...

    Authors: Dong Hoon Baek, Gwang Ha Kim, Do Youn Park, Bong Eun Lee, Hye Kyung Jeon, Won Lim and Geun Am Song

    Citation: BMC Gastroenterology 2015 15:17

    Content type: Research article

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  36. Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic ge...

    Authors: Phillip Stahl, Carsten Seeschaaf, Patrick Lebok, Asad Kutup, Maximillian Bockhorn, Jakob R Izbicki, Carsten Bokemeyer, Ronald Simon, Guido Sauter and Andreas H Marx

    Citation: BMC Gastroenterology 2015 15:7

    Content type: Research article

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  37. In this study, we evaluated the technical feasibility of mucosal approximation of large ulcers via an endoscopic suturing system after endoscopic submucosal dissection (ESD), assessed the durability of these s...

    Authors: Masakuni Kobayashi, Kazuki Sumiyama, Yamato Ban, Akira Dobashi, Tomohiko Richard Ohya, Daisuke Aizawa, Shinichi Hirooka, Kiyokazu Nakajima and Hisao Tajiri

    Citation: BMC Gastroenterology 2015 15:5

    Content type: Research article

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  38. Esophageal stenosis following endoscopic submucosal dissection (ESD) is a serious adverse event that makes subsequent management more difficult.

    Authors: Hiroaki Takahashi, Yoshiaki Arimura, Satoshi Okahara, Junichi Kodaira, Kaku Hokari, Hiroyuki Tsukagoshi, Yasuhisa Shinomura and Masao Hosokawa

    Citation: BMC Gastroenterology 2015 15:1

    Content type: Research article

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  39. Wireless pH-monitoring is an accurate method for diagnosing adults with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the use of the Bravo capsule on children investigated for G...

    Authors: Michaela Boström, Ola Thorsson, Ervin Toth and Daniel Agardh

    Citation: BMC Gastroenterology 2014 14:9001

    Content type: Research article

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  40. Helicobacter pylori chronic infection is associated with chronic gastritis, peptic ulcer, and gastric cancer. Cytotoxin-associated gene A (cagA)-positive H. pylori strains increase the risk of gastric pathology....

    Authors: Fredy Omar Beltrán-Anaya, Tomás Manuel Poblete, Adolfo Román-Román, Salomón Reyes, José de Sampedro, Oscar Peralta-Zaragoza, Miguel Ángel Rodríguez, Oscar del Moral-Hernández, Berenice Illades-Aguiar and Gloria Fernández-Tilapa

    Citation: BMC Gastroenterology 2014 14:223

    Content type: Research article

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  41. Upper gastrointestinal bleeding (UGIB) remains a common medical problem worldwide that has significant associated morbidity, mortality, and health care resource use. This study outlines the aetiology, clinical...

    Authors: Olusegun I Alatise, Adeniyi S Aderibigbe, Adewale O Adisa, Olusegun Adekanle, Augustine E Agbakwuru and Anthony O Arigbabu

    Citation: BMC Gastroenterology 2014 14:210

    Content type: Research article

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  42. The γ-aminobutyric acid type B-receptor agonist lesogaberan (AZD3355) has been developed for use in patients with gastroesophageal reflux disease (GERD) symptoms despite proton pump inhibitor (PPI) therapy (pa...

    Authors: Philip B Miner Jr, Debra G Silberg, Magnus Ruth, Frank Miller and John Pandolfino

    Citation: BMC Gastroenterology 2014 14:188

    Content type: Research article

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  43. Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalenc...

    Authors: Thangam Venkatesan, Essam A Zaki, Nilay Kumar, Jyotirmoy Sengupta, Muhammad Ali, Baber Malik, Aniko Szabo, Miranda AL van Tilburg and Richard G Boles

    Citation: BMC Gastroenterology 2014 14:181

    Content type: Research article

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