Gastroesophageal disorders

Section edited by Yeong Yeh Lee and Jan Bornschein

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study

    Dental erosion (DE), one of oral hard tissue diseases, is one of the extraoesophageal symptoms defined as the Montreal Definition and Classification of gastroesophageal reflux disease (GERD). However, no study...

    Masaaki Watanabe, Eiji Nakatani, Hiroo Yoshikawa, Takahiro Kanno, Yoshiki Nariai, Aya Yoshino, Michael Vieth, Yoshikazu Kinoshita and Joji Sekine

    BMC Gastroenterology 2017 17:92

    Published on: 7 August 2017

  2. Case report

    Life-threatening bleeding from gastric dieulafoy’s lesion in a pregnant woman with hellp syndrome: a case report and literature review

    Dieulafoy’s lesion (DL) is one of the rare causes of upper gastrointestional bleeding. This disease is characterized by small sub-mucosal arteriole that eroded the stomach mucosa and cause severe upper GI blee...

    Chen Si, Zhu Xiuli, Xie Li, Jia Yong, Zhou Ying and Zhang Kaiguang

    BMC Gastroenterology 2017 17:89

    Published on: 31 July 2017

  3. Research article

    The prevalence of gastric heterotopia of the proximal esophagus is underestimated, but preneoplasia is rare - correlation with Barrett’s esophagus

    The previously reported prevalence of gastric heterotopia in the cervical esophagus, also termed inlet patch (IP), varies substantially, ranging from 0.18 to 14%. Regarding cases with adenocarcinoma within IP,...

    Ulrich Peitz, Michael Vieth, Matthias Evert, Jovana Arand, Albert Roessner and Peter Malfertheiner

    BMC Gastroenterology 2017 17:87

    Published on: 12 July 2017

  4. Research article

    Prokinetics for the treatment of functional dyspepsia: Bayesian network meta-analysis

    Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD.

    Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Tae Young Park, Suk Pyo Shin, Ki Tae Suk and Dong Joon Kim

    BMC Gastroenterology 2017 17:83

    Published on: 26 June 2017

  5. Research article

    Laparoscopic gastrectomy in obese gastric cancer patients: a comparative study with non-obese patients and evaluation of difference in laparoscopic methods

    Obesity is a growing epidemic around the world, and obese patients are generally regarded as high risk for surgery compared with normal weight patients. The purpose of this study was to evaluate the influence ...

    Ke Chen, Yu Pan, Shu-ting Zhai, Jia-qin Cai, Qi-long Chen, Ding-wei Chen, Yi-ping Zhu, Yu Zhang, Ya-ping Zhang, Hendi Maher and Xian-fa Wang

    BMC Gastroenterology 2017 17:78

    Published on: 19 June 2017

  6. Research article

    FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinoma

    FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition. It is a tumor suppressor gene that plays a role in the regulation of cell cycle exit and reentry via c-Myc, c-Jun and Notch deg...

    Mao-Ran Li, Chun-Chao Zhu, Tian-Long Ling, Ye-Qian Zhang, Jia Xu, En-Hao Zhao and Gang Zhao

    BMC Gastroenterology 2017 17:60

    Published on: 2 May 2017

  7. Research article

    Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study

    Efficacy of maintenance therapy in ulcerative colitis (UC) in the remission stage has been reported to depend on release profile or dosing regimen of oral 5-aminosalicylic acid (5-ASA) products used. Aim of th...

    Masakazu Nagahori, Shuji Kochi, Hiroyuki Hanai, Takayuki Yamamoto, Shiro Nakamura, Soji Omuro, Mamoru Watanabe and Toshifumi Hibi

    BMC Gastroenterology 2017 17:47

    Published on: 4 April 2017

  8. Research article

    Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

    Neoadjuvant chemotherapy has been increasingly practiced on gastric cancer (GC), and histological evaluation to predict outcome is urgent in clinical practice. There are five classic tumor regression grading (...

    Yuelu Zhu, Yongkun Sun, Shangying Hu, Yong Jiang, Jiangying Yue, Xuemin Xue, Lin Yang and Liyan Xue

    BMC Gastroenterology 2017 17:41

    Published on: 14 March 2017

  9. Case report

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas

    In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who ...

    Hiroyuki Matsubayashi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Yoshimi Kiyozumi, Yasue Horiuchi, Keiko Sasaki, Teiichi Sugiura, Katsuhiko Uesaka and Hiroyuki Ono

    BMC Gastroenterology 2017 17:37

    Published on: 7 March 2017

  10. Research article

    High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5

    Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellu...

    Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun and Zhongren Zhou

    BMC Gastroenterology 2017 17:33

    Published on: 17 February 2017

  11. Research article

    Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?

    Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxaci...

    Diogo Branquinho, Nuno Almeida, Carlos Gregório, José Eduardo Pina Cabral, Adriano Casela, Maria Manuel Donato and Luís Tomé

    BMC Gastroenterology 2017 17:31

    Published on: 15 February 2017

  12. Research article

    Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion

    Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in ...

    Ji Eun Kim, Jun Go, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong and Dae Youn Hwang

    BMC Gastroenterology 2017 17:21

    Published on: 26 January 2017

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