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Gastroesophageal disorders

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The clinical endoscopic phenotypes of gastroesophageal reflux disease (GERD) are classified as Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive gastroesophageal reflux disease (NERD). NERD is...

    Authors: Mónica R. Zavala-Solares, Gabriela Fonseca-Camarillo, Miguel Valdovinos, Julio Granados, Guido Grajales-Figueroa, Luis Zamora-Nava, Nancy Aguilar-Olivos, Luis R. Valdovinos-García and Jesús K. Yamamoto-Furusho

    Citation: BMC Gastroenterology 2021 21:201

    Content type: Research article

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  2. Clostridioides difficile (C. difficile) is a major nosocomial pathogen that infects the human gut and can cause diarrheal disease. A dominant risk factor is antibiotic treatment that disrupts the normal gut micro...

    Authors: Dana Binyamin, Orna Nitzan, Maya Azrad, Zohar Hamo, Omry Koren and Avi Peretz

    Citation: BMC Gastroenterology 2021 21:166

    Content type: Research article

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  3. Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. Despite improvements in diagnostic endoscopy and imaging studies, dif...

    Authors: Xuemei Liu, Xinglong Wu, Biguang Tuo and Huichao Wu

    Citation: BMC Gastroenterology 2021 21:151

    Content type: Case report

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  4. The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitate covering the gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whe...

    Authors: Xueqin Chen, Ning Dai, Yanyong Deng, Xin Sun, Mingqing Zhang, Jie Pan, Zhiming Huang, Guoliang Ye, Jianmin Si, Lan Wang and Shujie Chen

    Citation: BMC Gastroenterology 2021 21:124

    Content type: Research article

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  5. Endoscopic submucosal dissection (ESD) has been accepted as a standard treatment for early gastric cardiac cancer (EGCC). Here, we investigate the clinical outcomes of the EGCC patients who underwent ESD in di...

    Authors: Ting Fan, Qi Sun, Shouli Cao, Xiangshan Fan, Qin Huang, Shu Zhang, Ying Lv, Xiaoqi Zhang, Tingsheng Ling, Lei Wang, Xiaoping Zou and Guifang Xu

    Citation: BMC Gastroenterology 2021 21:119

    Content type: Research article

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  6. Endoscopic resection has been used for high-grade intraepithelial neoplasia (HGIN) and superficial esophageal squamous cell carcinoma (ESCC) with limited risk of lymph node metastasis. However, some of these l...

    Authors: Lang Yang, Hua Jin, Xiao-li Xie, Yang-tian Cao, Zhen-hua Liu, Na Li, Peng Jin, Yu-qi He and Jian-qiu Sheng

    Citation: BMC Gastroenterology 2021 21:114

    Content type: Research article

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  7. Risk stratification before endoscopy is crucial for proper management of patients suspected as having upper gastrointestinal bleeding (UGIB). There is no consensus regarding the role of nasogastric lavage for ...

    Authors: Eun Jeong Gong, Li-chang Hsing, Hyun Il Seo, Myeongsook Seo, Baek Gyu Jun, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon and Min-Ju Kim

    Citation: BMC Gastroenterology 2021 21:113

    Content type: Research article

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  8. Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer). However, published studies on their onset of action are scarce. Therefo...

    Authors: Maxim Voropaiev and Deborah Nock

    Citation: BMC Gastroenterology 2021 21:112

    Content type: Research article

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  9. Vaping, or e-cigarettes, heat nicotine and other chemicals to create a vapor that is inhaled. The practice has gained rapid popularity with 41 million people globally reporting regular or occasional use. Altho...

    Authors: Trisha Satya Pasricha and Bharati Kochar

    Citation: BMC Gastroenterology 2021 21:106

    Content type: Case report

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  10. Health care professionals in endoscopic labs have an elevated risk for COVID-19 infection, therefore, we aimed to determine the effect of current pandemic on the workflow and infection prevention and control s...

    Authors: Renáta Bor, Kata Judit Szántó, Anna Fábián, Klaudia Farkas, Mónika Szűcs, Mariann Rutka, Tibor Tóth, Anita Bálint, Ágnes Milassin, Zsolt Dubravcsik, Zoltán Szepes and Tamás Molnár

    Citation: BMC Gastroenterology 2021 21:98

    Content type: Research article

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  11. Epstein–Barr virus (EBV)-positive gastric carcinoma (GC) is defined by the proliferation of GC cells with EBV infection. The co-existence of EBV-positive and -negative components in a single GC is rare. We rep...

    Authors: Ken Miyabe, Motonobu Saito, Kei Koyama, Michinobu Umakoshi, Yukinobu Ito, Makoto Yoshida, Yukitsugu Kudo-Asabe, Katsuharu Saito, Hiroshi Nanjo, Daichi Maeda, Keisuke Matsusaka, Akiteru Goto and Koji Kono

    Citation: BMC Gastroenterology 2021 21:97

    Content type: Case report

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  12. This randomized, open-label trial aimed to compare the efficacy of 10-day bismuth-containing quadruple therapy (BQT) with 7-day proton-pump inhibitor-clarithromycin containing standard triple therapy (STT) as ...

    Authors: Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Jin Young Park and Il Ju Choi

    Citation: BMC Gastroenterology 2021 21:95

    Content type: Research article

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  13. Esophageal cancer is one of the most aggressive malignancies, and is associated with multiple genetic mutations. At present, the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation has been obs...

    Authors: Aihemaijiang Kuerbanjiang, Maimaitiyiming Maimaituerxun, Yanjun Zhang, Yiliang Li, Gang Cui, Aibaidula Abuduhabaier, Abuduwaili Aierken, Buya Miranbieke, Meilikezati Anzaer and Yusufu Maimaiti

    Citation: BMC Gastroenterology 2021 21:86

    Content type: Research article

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  14. Positron emission tomography (PET) has the potential for visualization and quantification of gastric emptying (GE). The traditional Chinese medicine (TCM) has been recognized promising for constipation. This s...

    Authors: Xueyan Chen, Yu Liu, Donghui Pan, Maoyu Cao, Xinyu Wang, Lizhen Wang, Yuping Xu, Yan Wang, Junjie Yan, Juan Liu and Min Yang

    Citation: BMC Gastroenterology 2021 21:69

    Content type: Research article

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  15. Methods have been developed for preventing delayed bleeding (DB) after gastric endoscopic submucosal dissection (GESD). However, none of the methods can completely prevent DB. We hypothesized that DB could be ...

    Authors: Satoshi Abiko, Soichiro Oda, Akimitsu Meno, Akane Shido, Sonoe Yoshida, Ayumu Yoshikawa, Kazuaki Harada, Naoki Kawagishi, Itsuki Sano, Hisashi Oda and Takuto Miyagishima

    Citation: BMC Gastroenterology 2021 21:63

    Content type: Research article

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  16. Gastric ectopic pancreas (GEPs) is a rare developmental anomaly which is difficult to differentiate it from submucosal tumor such as gastric stromal tumor (GST) by imaging methods. Since the treatments of the ...

    Authors: Chang Liu, Fang Yang, Wenming Zhang, Weiqun Ao, Yongyu An, Cui Zhang, Bailing Dai, Cailing Pu and Jian Wang

    Citation: BMC Gastroenterology 2021 21:52

    Content type: Research article

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  17. Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disease characterized by chronic abdominal discomfort and pain. The mechanisms of abdominal pain, as a relevant symptom, in IBS are...

    Authors: Zhongyuan Lin, Yimin Wang, Shiqing Lin, Decheng Liu, Guohui Mo, Hui Zhang and Yunling Dou

    Citation: BMC Gastroenterology 2021 21:48

    Content type: Research article

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  18. Leiomyoma is the most common benign oesophageal tumour. Half of all leiomyoma patients have oesophagus-associated complaints, such as dysphagia and epigastric pain, and the other 50% are asymptomatic with a di...

    Authors: László Andrási, Zoltán Szepes, László Tiszlavicz, György Lázár and Attila Paszt

    Citation: BMC Gastroenterology 2021 21:47

    Content type: Case report

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  19. Aorto-esophageal fistula (AEF) caused by foreign bodies ingestion is a rare but devastating disorder. Thoracic endovascular aortic repair (TEVAR) has become a widely accepted intervention for treating aorto-es...

    Authors: Yu-Yan Zhang, Shan Li, Xiang-Lei Yuan and Bing Hu

    Citation: BMC Gastroenterology 2021 21:46

    Content type: Case report

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  20. Upper gastrointestinal (GI) bleeding is the most important presentation of an aorto-duodenal fistula (ADF). Early diagnosis is difficult, and the disease is associated with high mortality. The present study ai...

    Authors: Chikamasa Ichita, Akiko Sasaki, Chihiro Sumida, Karen Kimura, Takashi Nishino, Junichi Tasaki, Sakue Masuda, Kazuya Koizumi, Jun Kawachi and Makoto Kako

    Citation: BMC Gastroenterology 2021 21:45

    Content type: Research article

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  21. Gastrointestinal tumor bleeding remains a clinical challenge because it is difficult to treat with conventional endoscopic hemostatic options. Recently, an endoscopic hemostatic powder (UI-EWD) was developed a...

    Authors: Jongbeom Shin, Boram Cha, Jin-Seok Park, Weonjin Ko, Kye Sook Kwon, Jin-Woo Lee, Hyung Kil Kim and Yong Woon Shin

    Citation: BMC Gastroenterology 2021 21:40

    Content type: Research article

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  22. Adenocarcinoma in Esophagogastric Junction (AEG) is a severe gastrointestinal malignancy with a unique clinicopathological feature. Hence, we aimed to develop a competing risk nomogram for predicting survival ...

    Authors: Tongbo Wang, Yan Wu, Hong Zhou, Chaorui Wu, Xiaojie Zhang, Yingtai Chen and Dongbing Zhao

    Citation: BMC Gastroenterology 2021 21:38

    Content type: Research article

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  23. Percutaneous Endoscopic Gastrostomy (PEG) can involve some complications, despite the good safety of its track record. The Buried Bumper Syndrome (BBS) is a rare, late and dangerous complication that consists ...

    Authors: A. G. Gravina, A. Tessitore, V. M. Ormando, F. Nagar, M. Romeo, M. R. Amato, M. Dallio, C. Loguercio, A. Federico, M. Romano and F. Ferraro

    Citation: BMC Gastroenterology 2021 21:31

    Content type: Case report

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  24. Gastritis cystica polyposa (GCP) is a recently recognized entity histologically characterized by hyperplasia and cystic dilatation of the gastric glands spreading through the submucosal layer. Its symptoms inc...

    Authors: Masaaki Yoshikawa, Hiroki Kinoshita, Naoki Nishimura, Rieko Takai, Takuya Matsuda, Satoshi Nakatani, Erika Shioyama, Kosuke Takeda and Hitoshi Yoshiji

    Citation: BMC Gastroenterology 2021 21:27

    Content type: Case report

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  25. Impairment of activities of daily living (ADL) due to hemorrhagic gastroduodenal ulcers (HGU) has rarely been evaluated. We analyzed the risk factors of poor prognosis, including mortality and impairment of AD...

    Authors: Junya Arai, Jun Kato, Nobuo Toda, Ken Kurokawa, Chikako Shibata, Shigeyuki Kurosaki, Kazuyoshi Funato, Mayuko Kondo, Kaoru Takagi, Kentaro Kojima, Takamasa Ohki, Michiharu Seki and Kazumi Tagawa

    Citation: BMC Gastroenterology 2021 21:16

    Content type: Research article

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  26. The number of positive lymph nodes, which was defined as “N stage”, is mostly used to predict the survival of D2-resected gastric cancer patients, not the location. A “central lymph node” (CnLN) was defined by...

    Authors: Huiwen Lu, Bochao Zhao, Rui Huang, Yimeng Sun, Zirui Zhu, Huimian Xu and Baojun Huang

    Citation: BMC Gastroenterology 2021 21:15

    Content type: Research article

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  27. Angiographic embolization is now considered the first-line therapy for acute gastrointestinal (GI) bleeding refractory to endoscopic therapy. The success of angiographic embolization depends on the detection o...

    Authors: Chungjo Choi, Hyun Lim, Min-Jeong Kim, Bo Young Lee, Sung-Yeun Kim, Jae Seung Soh, Ho Suk Kang, Sung Hoon Moon and Jong Hyeok Kim

    Citation: BMC Gastroenterology 2020 20:426

    Content type: Research article

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  28. Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that has been known since the early 1990s. Swallowed topical corticosteroids (STC) belong to the therapeutic cornerstones. We describe a delayed...

    Authors: Caroline Michèle Andrist, Lukas Jörg, Thomas Greuter, Anna Gschwend, Alex Straumann and Arthur Helbling

    Citation: BMC Gastroenterology 2020 20:419

    Content type: Case report

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  29. Helicobacter pylori, a 2 × 1 μm spiral-shaped bacterium, is the most common risk factor for gastric cancer worldwide. Clinically, patients presenting with symptoms of gastritis, routinely undergo gastric biopsies...

    Authors: Sebastian Klein, Jacob Gildenblat, Michaele Angelika Ihle, Sabine Merkelbach-Bruse, Ka-Won Noh, Martin Peifer, Alexander Quaas and Reinhard Büttner

    Citation: BMC Gastroenterology 2020 20:417

    Content type: Research article

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  30. The association of upper gastrointestinal endoscopic findings with sex, age, and Helicobacter pylori infection in asymptomatic healthy people is unclear. The aim of this study was to retrospectively determine the...

    Authors: Haosu Huang, Yanting Rong, Meng Wang, Zimeng Guo, Yanghua Yu, Zhenpu Long, Xiaoxiao Chen, Hanyue Wang, Junjie Ding, Lu Yan and Jie Peng

    Citation: BMC Gastroenterology 2020 20:412

    Content type: Research article

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  31. Helicobacter pylori (H. pylori) infection is a major cause of chronic gastritis, peptic ulcer diseases and cancer. Genistein (4′,5,7-trihydroxyisoflavone), a tyrosine-specific-protein kinase inhibitor, has been ...

    Authors: Prasong Siriviriyakul, Duangporn Werawatganon, Nisarat Phetnoo, Kanjana Somanawat, Tanittha Chatsuwan, Naruemon Klaikeaw and Maneerat Chayanupatkul

    Citation: BMC Gastroenterology 2020 20:410

    Content type: Research article

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  32. Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss posto...

    Authors: Yasufumi Koterazawa, Taro Oshikiri, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki and Yoshihiro Kakeji

    Citation: BMC Gastroenterology 2020 20:407

    Content type: Research article

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  33. The resistance rate of Helicobacter pylori to clarithromycin (CAM) is high among infected children in Japan. Therefore, a new method for detecting CAM-resistant H. pylori using a minimally invasive technique is s...

    Authors: Toshihiko Kakiuchi, Kazutoshi Hashiguchi, Ichiro Imamura, Aiko Nakayama, Ayako Takamori, Masumi Okuda and Muneaki Matsuo

    Citation: BMC Gastroenterology 2020 20:397

    Content type: Technical advance

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  34. There are often specific endoscopic findings caused by deposition of lanthanum (La) in the gastric mucosa of patients taking lanthanum carbonate (LaC), a novel phosphate binder for patients on hemodialysis. We...

    Authors: Shinya Nishida, Kazuhiro Ota, Kimiaki Hattori, Taro Iwatsubo, Shimpei Kawaguchi, Yuichi Kojima, Toshihisa Takeuchi, Tamaki Maeda, Masahiro Sakaguchi and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2020 20:396

    Content type: Research article

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  35. The current virtual chromoendoscopy equipment cannot completely detect superficial squamous cell carcinoma (SCC) in the esophagus, despite its development in the recent years. Thus, in this study, we aimed to ...

    Authors: Taro Iwatsubo, Ryu Ishihara, Yasushi Yamasaki, Yusuke Tonai, Kenta Hamada, Minoru Kato, Sho Suzuki, Mitsuhiro Kono, Hiromu Fukuda, Yusaku Shimamoto, Kentaro Nakagawa, Masayasu Ohmori, Masamichi Arao, Kenshi Matsuno, Hiroyoshi Iwagami, Shuntaro Inoue…

    Citation: BMC Gastroenterology 2020 20:389

    Content type: Research article

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  36. Amplification of HER2 gene (ERBB2) and overexpression of HER2 protein on cancer cells are found in 10–26% of gastric cancer (GC) and esophagogastric junction cancer (EGJC). Gene copy number variation (CNV) could ...

    Authors: Anna Grenda, Kamila Wojas-Krawczyk, Tomasz Skoczylas, Paweł Krawczyk, Jadwiga Sierocińska-Sawa, Grzegorz Wallner and Janusz Milanowski

    Citation: BMC Gastroenterology 2020 20:382

    Content type: Research article

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  37. To develop the Patient Health Questionnaire-8 (PHQ-8) as a more reliable approach than the Somatic Symptom Scale-8 (SSS-8), evaluating somatization which might be a critical factor influencing the quality of l...

    Authors: Chaoqun Yuan, Guizhen Yong, Xi Wang, Ting Xie, Chunyan Wang, Yuan Yuan and Guobin He

    Citation: BMC Gastroenterology 2020 20:359

    Content type: Research article

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  38. With more prevalent gastroesophageal reflux disease comes increased cases of Barrett's esophagus and esophageal adenocarcinoma. Image-enhanced endoscopy using linked-color imaging (LCI) differentiates between ...

    Authors: Tsutomu Takeda, Daisuke Asaoka, Daiki Abe, Maiko Suzuki, Yuta Nakagawa, Hitoshi Sasaki, Yoshihiro Inami, Muneo Ikemura, Hisanori Utsunomiya, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Yoichi Akazawa, Kohei Matsumoto…

    Citation: BMC Gastroenterology 2020 20:356

    Content type: Research article

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  39. Placement of feeding jejunostomy (PFJ) during esophagectomy is an effective method to maintain adequate nutrition, but is associated with serious complications such as bowel obstruction and jejunal torsion. Th...

    Authors: Teppei Kamada, Hironori Ohdaira, Hideyuki Takeuchi, Junji Takahashi, Rui Marukuchi, Eisaku Ito, Norihiko Suzuki, Satoshi Narihiro, Sojun Hoshimoto, Masashi Yoshida, Mitsuyoshi Urashima and Yutaka Suzuki

    Citation: BMC Gastroenterology 2020 20:354

    Content type: Research article

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  40. Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remai...

    Authors: Yaohui Wang, Xiuqing Li, Lili Gao, Chenxi Wang, Yifen Zhang and Qin Huang

    Citation: BMC Gastroenterology 2020 20:351

    Content type: Research article

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  41. The significance of human epidermal growth factor receptor 2 (Her2) and nucleus-associated antigen Ki-67 expression remains controversial in gastric adenocarcinoma (GaC). The aim of this study was to investiga...

    Authors: Zhijian Wei, Lei Huang, Xinyue Zhang and Aman Xu

    Citation: BMC Gastroenterology 2020 20:343

    Content type: Research article

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  42. Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is a rare low-grade clonal lymphoid proliferation, included as a provisional entity in the current World Health Organization classific...

    Authors: Magda Zanelli, Maurizio Zizzo, Francesca Sanguedolce, Giovanni Martino, Alessandra Soriano, Stefano Ricci, Carolina Castro Ruiz, Valerio Annessi and Stefano Ascani

    Citation: BMC Gastroenterology 2020 20:336

    Content type: Case report

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  43. Anastomotic leakage is common and life-threatening complication after esophagectomy. The management of esophageal anastomotic leakage remains challenging. We aimed to determine the safety, feasibility and effi...

    Authors: Yonghua Bi, Zhengyang Wu, Mengfei Yi, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:330

    Content type: Research article

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  44. Postoperative pancreatic fistula (POPF) is a serious complication after gastric cancer surgery. The current study aimed to investigate the significance of the anatomic location of the pancreas as a predictor f...

    Authors: Jun Kinoshita, Takahisa Yamaguchi, Hiroto Saito, Hideki Moriyama, Mari Shimada, Shiro Terai, Koichi Okamoto, Shinichi Nakanuma, Isamu Makino, Keishi Nakamura, Hidehiro Tajima, Itasu Ninomiya and Sachio Fushida

    Citation: BMC Gastroenterology 2020 20:325

    Content type: Research article

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    60 days to first decision for all manuscripts
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    2.489 - 2-year Impact Factor
    2.796 - 5-year Impact Factor
    1.018 - SNIP (Source-Normalized Impact per Paper)
    0.957 - SJR (SCImago Journal Rank)

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