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Gastroesophageal disorders

Section edited by Yeong Yeh Lee 

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 1 of 6

  1. Gastric schwannomas are rare benign tumors originating from the intramuscular plexus of the stomach and account for just 2.6% of gastric mesenchymal tumors. Gastric schwannoma (GS) with a surface ulcer is very...

    Authors: Caihua Tang, Qiyong Pan, Zeqing Xu, Xuan Zhou and Ying Wang

    Citation: BMC Gastroenterology 2020 20:36

    Content type: Case report

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  2. Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the go...

    Authors: Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2020 20:19

    Content type: Research article

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  3. Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer...

    Authors: Wenjing Zou, Xu Li, Cheng Li, Dan Liu, Yanyan Lv, Ying Yang, Nan Ye, Dan Guo and Shuixiang He

    Citation: BMC Gastroenterology 2020 20:17

    Content type: Research article

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  4. To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl4)-induced rat model.

    Authors: Shuangshuang Xie, Hanxiong Qi, Qing Li, Kun Zhang, Longjiang Zhang, Yue Cheng and Wen Shen

    Citation: BMC Gastroenterology 2020 20:14

    Content type: Research article

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  5. Gastrointestinal stromal tumors (GISTs) at the esophagogastric junction are rare and its treatment is complicated and challenging. Endoscopic resection has advantages with less complications compared to open a...

    Authors: Feng Xue, Wei Wang, Ning Shi, Xing-Bin Ma and Cheng-Xia Liu

    Citation: BMC Gastroenterology 2019 19:227

    Content type: Case report

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  6. Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD)....

    Authors: Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu and Fei Dai

    Citation: BMC Gastroenterology 2019 19:221

    Content type: Research article

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  7. Upper gastrointestinal endoscopic examination is a relatively safe procedure; however, all endoscopic procedures are invasive and are associated with a risk of iatrogenic perforation. To evaluate clinical outc...

    Authors: Dae Hwan Kang, Dae Gon Ryu, Cheol Woong Choi, Hyung Wook Kim, Su Bum Park, Su Jin Kim and Hyeong Seok Nam

    Citation: BMC Gastroenterology 2019 19:218

    Content type: Research article

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  8. To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC).

    Authors: Ze-Ning Huang, Jacopo Desiderio, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng and Chang-Ming Huang

    Citation: BMC Gastroenterology 2019 19:205

    Content type: Research article

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  9. Bleeding esophageal varices is a deadly complication of liver cirrhosis. Guidelines recommend an early diagnosis of esophageal varices before incident bleeding by screening all patients diagnosed with liver ci...

    Authors: Daniel W. Gunda, Semvua B. Kilonzo, Zakhia Mamballah, Paulina M. Manyiri, David C. Majinge, Hyasinta Jaka, Benson R. Kidenya and Humphrey D. Mazigo

    Citation: BMC Gastroenterology 2019 19:203

    Content type: Research article

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  10. Current magnet-controlled capsule endoscopy (MCE) for the stomach is not yet satisfactory with respect to navigation control, especially in the gastric fundus and cardia. A newly developed MCE system conducted...

    Authors: Chun-sheng Cheng, Ting-ji Sun and Hou-de Zhang

    Citation: BMC Gastroenterology 2019 19:184

    Content type: Research article

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  11. Pneumatic dilation (PD) is often billed as a “short term” treatment for achalasia but anecdotally can last years. This study sought to explore how long a single pneumatic dilation may induce symptom remission ...

    Authors: Abid T. Javed, Kevin Batte, Mohamed Khalaf, Mustafa Abdul-Hussein, Pooja S. Elias and Donald O. Castell

    Citation: BMC Gastroenterology 2019 19:181

    Content type: Research article

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  12. To compare the outcomes of submucosal tunneling endoscopic resection (STER) and submucosal excavation (ESE) for the treatment of submucosal tumors (SMTs) arising from the muscularis propria (MP) at the esophag...

    Authors: Hong-wei Xu, Qi Zhao, Shu-xia Yu, Ying Jiang, Jing-hua Hao and Bin Li

    Citation: BMC Gastroenterology 2019 19:174

    Content type: Research article

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  13. Intramural esophageal bronchogenic cyst is very rare. Surgical removal of the cysts is advised even the patients are asymptomatic, since the cyst can lead to complications, and there is a risk of malignant tra...

    Authors: Xun Yang, Ye Zong, Hai-Ying Zhao, Yong-Dong Wu and Ming Ji

    Citation: BMC Gastroenterology 2019 19:155

    Content type: Case report

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  14. This study aimed to understand the disease characteristics and treatment outcomes of Crohn’s disease (CD) in a real-world setting in China.

    Authors: Yue Li, Baili Chen, Xiang Gao, Naizhong Hu, Meifang Huang, Zhihua Ran, Zhanju Liu, Jie Zhong, Duowu Zou, Xiaoping Wu, Jianlin Ren, Jianqiu Sheng, Ping Zheng, Huahong Wang, Minhu Chen, Junrong Chen…

    Citation: BMC Gastroenterology 2019 19:145

    Content type: Research article

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  15. Individuals can be infected with multiple strains of Helicobacter pylori. However, the differences among co-infecting strains have not been well analyzed yet. This study aimed to investigate whether the virulence...

    Authors: Ji Won Seo, Jae Yong Park, Tae-Seop Shin and Jae Gyu Kim

    Citation: BMC Gastroenterology 2019 19:140

    Content type: Research article

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  16. Risk stratification for patients with nonvariceal upper gastrointestinal (NVUGI) bleeding is crucial for successful prognosis and treatment. Recently, the AIMS65 score has been used to predict mortality risk a...

    Authors: Min Seong Kim, Jeongmin Choi and Won Chang Shin

    Citation: BMC Gastroenterology 2019 19:136

    Content type: Research article

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  17. Eradicating Helicobacter pylori infection is clinically challenging, notably in cases with penicillin allergy. Cephalosporin could be used in lieu of amoxicillin to eradicate Helicobacter pylori. The current work...

    Authors: Zhiqiang Song, Wei Fu and Liya Zhou

    Citation: BMC Gastroenterology 2019 19:132

    Content type: Research article

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  18. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution o...

    Authors: Dong Chen, Zhonggao Wang, Zhiwei Hu, Yan Liang, Fei Xiao and Jimin Wu

    Citation: BMC Gastroenterology 2019 19:108

    Content type: Research article

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  19. Our aim was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy and its association to characteristics and postoperative change in body ...

    Authors: Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Sunao Uemura, Masaya Munekage, Keiichiro Yokota, Michiya Kobayashi and Kazuhiro Hanazaki

    Citation: BMC Gastroenterology 2019 19:104

    Content type: Research article

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  20. Aryl-hydrocarbon receptor (AhR) is a multiple ligand-activated transcription factor that has important roles in xenobiotic, physiological, or pathological functions. Transgenic mice systemically expressing con...

    Authors: Ai Dantsuka, Osamu Ichii, Annika Hanberg, Yaser Hosny Ali Elewa, Saori Otsuka-Kanazawa, Teppei Nakamura and Yasuhiro Kon

    Citation: BMC Gastroenterology 2019 19:102

    Content type: Research article

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  21. The outcomes of patients with refractory benign esophageal strictures (RBES) are unclear, and the clinical efficacy of dilation versus stent placement is lacking. Our objective was to explore the role of endos...

    Authors: Qing Lu, Hailin Yan, Yilan Wang, Tiantian Lei, Linlin Zhu, Hongsheng Ma and Jinlin Yang

    Citation: BMC Gastroenterology 2019 19:95

    Content type: Research article

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  22. Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

    Content type: Case report

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  23. An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

    Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel and René Thieme

    Citation: BMC Gastroenterology 2019 19:38

    Content type: Research article

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  24. Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of...

    Authors: King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng and Chao-Long Chen

    Citation: BMC Gastroenterology 2019 19:37

    Content type: Case report

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  25. The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). Thi...

    Authors: Yi-Hsuan Hsieh, Mei-Fong Wu, Pei-Yu Yang, Wei-Cheng Liao, Yao-Hsuan Hsieh, Yu-Jun Chang and I-Ching Lin

    Citation: BMC Gastroenterology 2019 19:33

    Content type: Research article

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  26. An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to ach...

    Authors: Steven Clayton, Elliot Cauble, Ambuj Kumar, Nirav Patil, Dennis Ledford, Narasaiah Kolliputi, Maria F. Lopes-Virella, Donald Castell and Joel Richter

    Citation: BMC Gastroenterology 2019 19:28

    Content type: Research article

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  27. In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, s...

    Authors: Sarah Turnipseed Edwards, Jose Cocjin, Stephanie Bolger Theut, Douglas Rivard, Ashley K. Sherman and Craig A. Friesen

    Citation: BMC Gastroenterology 2019 19:26

    Content type: Research article

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  28. Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no atte...

    Authors: Kyungeun Kim, Younghye Cho, Jin Hee Sohn, Dong-Hoon Kim, In Gu Do, Hyun Joo Lee, Sung-Im Do, Sangjeong Ahn, Hyoun Wook Lee and Seoung Wan Chae

    Citation: BMC Gastroenterology 2019 19:24

    Content type: Research article

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  29. The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may nece...

    Authors: Mohamed A. Elsebaey, Mohamed A. Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry and Sherief Abd-Elsalam

    Citation: BMC Gastroenterology 2019 19:23

    Content type: Research article

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  30. Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized ...

    Authors: Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner and Sabine Merkelbach-Bruse

    Citation: BMC Gastroenterology 2019 19:21

    Content type: Research article

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  31. This study assessed the feasibility and acceptability of two common types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s d...

    Authors: Garry A. Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed and Lindsay Bottoms

    Citation: BMC Gastroenterology 2019 19:19

    Content type: Research article

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  32. The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitio...

    Authors: Mohammed Akeel, Atef Shehata, Ahmed Elhafey, Erwa Elmakki, Thanaa Aboshouk, Hussein Ageely and Mohammed Mahfouz

    Citation: BMC Gastroenterology 2019 19:16

    Content type: Research article

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  33. Intramucosal, histologically mixed-type, low-grade (LG), well-differentiated gastric tubular adenocarcinomas (tub1s; LG-tub1s) have larger mean diameters and exhibit a higher frequency of the gastric mucin phe...

    Authors: Takashi Saitoh, Asako Takamura and Gen Watanabe

    Citation: BMC Gastroenterology 2018 18:189

    Content type: Research article

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  34. Gastric Cancer is highly prevalent and deadly worldwide. In Colombia, it is the most lethal form of cancer. Some single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes have been associated with an an...

    Authors: Denny Miley Cárdenas, Angie Carolina Sánchez, Daris Angélica Rosas, Esmeralda Rivero, Massiel Dayana Paparoni, Mildred Andreína Cruz, Yeicy Paola Suárez and Nestor Fabián Galvis

    Citation: BMC Gastroenterology 2018 18:184

    Content type: Research article

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  35. Cholangiocarcinoma (CCA) is a form of cancer that easily aggress to contiguous structures. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) are increased in majority species of cancers an...

    Authors: Manping Huang, Bin Huang, Guowen Li and Sainan Zeng

    Citation: BMC Gastroenterology 2018 18:169

    Content type: Research article

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  36. Endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) may facilitate tissue acquisition for a definitive diagnosis of gastrointestinal subepithelial tumors (SETs). This study aimed to determine the di...

    Authors: Do Hoon Kim, Gwang Ha Kim, Chang Min Cho, Chang Hwan Park, Soo-Young Na, Tae Hyeon Kim, Yu Kyung Cho, Ji Hyun Kim and Dong-Wan Seo

    Citation: BMC Gastroenterology 2018 18:151

    Content type: Research article

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  37. Successful H. pylori treatment requires the knowledge of local antimicrobial resistance. Data on the efficacy of H. pylori eradication regimens available in sub-Saharan Africa are scant, hence the optimal treatme...

    Authors: Jean Damascene Kabakambira, Celestin Hategeka, Cameron Page, Cyprien Ntirenganya, Vincent Dusabejambo, Jules Ndoli, Francois Ngabonziza, DeVon Hale, Claude Bayingana and Tim Walker

    Citation: BMC Gastroenterology 2018 18:134

    Content type: Research article

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  38. Although many patients still have anxiety about upper gastrointestinal (GI) endoscopy, there have been few reports on the influence of distractions for a person who is going to undergo upper GI endoscopy soon....

    Authors: Masahiro Sogabe, Toshiya Okahisa, Yuka Adachi, Masanori Takehara, Shinichi Hamada, Jun Okazaki, Yasuteru Fujino, Akira Fukuya, Kaizo Kagemoto, Akihiro Hirao, Koichi Okamoto, Masahiko Nakasono and Tetsuji Takayama

    Citation: BMC Gastroenterology 2018 18:132

    Content type: Research article

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  39. Endoscopic submucosal dissection (ESD) of the postoperative stomach (ESD-P) for early gastric cancer (EGC) is considered a technically difficult procedure. However, it is difficult to compare the outcomes of E...

    Authors: Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2018 18:125

    Content type: Research article

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  40. Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders worldwide, with relevant impact on the quality of life and health care costs.The aim of our study is to assess the pr...

    Authors: Irene Martinucci, Michela Natilli, Valentina Lorenzoni, Luca Pappalardo, Anna Monreale, Giuseppe Turchetti, Dino Pedreschi, Santino Marchi, Roberto Barale and Nicola de Bortoli

    Citation: BMC Gastroenterology 2018 18:116

    Content type: Research article

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  41. Malignant growth and metastasis of gastrointestinal stromal tumors (GIST) occur in some patients even during the course of treatment, but their mechanisms remains poorly understand at the molecular level so far.

    Authors: Chaoyong Shen, Yuan Yin, Huijiao Chen, Ruixue Wang, Xiaonan Yin, Zhaolun Cai, Bo Zhang, Zhixin Chen and Zongguang Zhou

    Citation: BMC Gastroenterology 2018 18:105

    Content type: Research article

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  42. Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, acute and chronic complications of PEG have been reported. We aimed to determine risk factors associated with complications an...

    Authors: Gyu Young Pih, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2018 18:101

    Content type: Research article

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  43. The classifications and counts of white blood cells (WBCs) have been proved to be able to be used as prognostic markers in cancer cases. The present study investigated the potential values of the classificatio...

    Authors: Yin-Ling Wang, Xin-Xin Ge, Yi Wang, Meng-Dan Xu, Fei-Ran Gong, Min Tao, Wen-Jie Wang, Liu-Mei Shou, Kai Chen, Meng-Yao Wu and Wei Li

    Citation: BMC Gastroenterology 2018 18:99

    Content type: Research article

    Published on:

  44. Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard tre...

    Authors: R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, Choung Hoang, Cara M. Kenney, Colleen D. Bond, Tricia F. Kunst, Anthony Letai and David S. Schrump

    Citation: BMC Gastroenterology 2018 18:94

    Content type: Study protocol

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