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Gastroesophageal disorders

Section edited by Yeong Yeh Lee 

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Content type: Case report

    Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

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  2. Content type: Research article

    An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

    Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel and René Thieme

    Citation: BMC Gastroenterology 2019 19:38

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  3. Content type: Case report

    Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of...

    Authors: King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng and Chao-Long Chen

    Citation: BMC Gastroenterology 2019 19:37

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  4. Content type: Research article

    The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). Thi...

    Authors: Yi-Hsuan Hsieh, Mei-Fong Wu, Pei-Yu Yang, Wei-Cheng Liao, Yao-Hsuan Hsieh, Yu-Jun Chang and I-Ching Lin

    Citation: BMC Gastroenterology 2019 19:33

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  5. Content type: Research article

    An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to ach...

    Authors: Steven Clayton, Elliot Cauble, Ambuj Kumar, Nirav Patil, Dennis Ledford, Narasaiah Kolliputi, Maria F. Lopes-Virella, Donald Castell and Joel Richter

    Citation: BMC Gastroenterology 2019 19:28

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  6. Content type: Research article

    In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, s...

    Authors: Sarah Turnipseed Edwards, Jose Cocjin, Stephanie Bolger Theut, Douglas Rivard, Ashley K. Sherman and Craig A. Friesen

    Citation: BMC Gastroenterology 2019 19:26

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  7. Content type: Research article

    Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no atte...

    Authors: Kyungeun Kim, Younghye Cho, Jin Hee Sohn, Dong-Hoon Kim, In Gu Do, Hyun Joo Lee, Sung-Im Do, Sangjeong Ahn, Hyoun Wook Lee and Seoung Wan Chae

    Citation: BMC Gastroenterology 2019 19:24

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  8. Content type: Research article

    The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may nece...

    Authors: Mohamed A. Elsebaey, Mohamed A. Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry and Sherief Abd-Elsalam

    Citation: BMC Gastroenterology 2019 19:23

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  9. Content type: Research article

    Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized ...

    Authors: Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner and Sabine Merkelbach-Bruse

    Citation: BMC Gastroenterology 2019 19:21

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  10. Content type: Research article

    This study assessed the feasibility and acceptability of two common types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s d...

    Authors: Garry A. Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed and Lindsay Bottoms

    Citation: BMC Gastroenterology 2019 19:19

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  11. Content type: Research article

    The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitio...

    Authors: Mohammed Akeel, Atef Shehata, Ahmed Elhafey, Erwa Elmakki, Thanaa Aboshouk, Hussein Ageely and Mohammed Mahfouz

    Citation: BMC Gastroenterology 2019 19:16

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  12. Content type: Research article

    Intramucosal, histologically mixed-type, low-grade (LG), well-differentiated gastric tubular adenocarcinomas (tub1s; LG-tub1s) have larger mean diameters and exhibit a higher frequency of the gastric mucin phe...

    Authors: Takashi Saitoh, Asako Takamura and Gen Watanabe

    Citation: BMC Gastroenterology 2018 18:189

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  13. Content type: Research article

    Gastric Cancer is highly prevalent and deadly worldwide. In Colombia, it is the most lethal form of cancer. Some single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes have been associated with an an...

    Authors: Denny Miley Cárdenas, Angie Carolina Sánchez, Daris Angélica Rosas, Esmeralda Rivero, Massiel Dayana Paparoni, Mildred Andreína Cruz, Yeicy Paola Suárez and Nestor Fabián Galvis

    Citation: BMC Gastroenterology 2018 18:184

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  14. Content type: Research article

    Cholangiocarcinoma (CCA) is a form of cancer that easily aggress to contiguous structures. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) are increased in majority species of cancers an...

    Authors: Manping Huang, Bin Huang, Guowen Li and Sainan Zeng

    Citation: BMC Gastroenterology 2018 18:169

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  15. Content type: Research article

    Endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) may facilitate tissue acquisition for a definitive diagnosis of gastrointestinal subepithelial tumors (SETs). This study aimed to determine the di...

    Authors: Do Hoon Kim, Gwang Ha Kim, Chang Min Cho, Chang Hwan Park, Soo-Young Na, Tae Hyeon Kim, Yu Kyung Cho, Ji Hyun Kim and Dong-Wan Seo

    Citation: BMC Gastroenterology 2018 18:151

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  16. Content type: Research article

    Successful H. pylori treatment requires the knowledge of local antimicrobial resistance. Data on the efficacy of H. pylori eradication regimens available in sub-Saharan Africa are scant, hence the optimal treatme...

    Authors: Jean Damascene Kabakambira, Celestin Hategeka, Cameron Page, Cyprien Ntirenganya, Vincent Dusabejambo, Jules Ndoli, Francois Ngabonziza, DeVon Hale, Claude Bayingana and Tim Walker

    Citation: BMC Gastroenterology 2018 18:134

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  17. Content type: Research article

    Although many patients still have anxiety about upper gastrointestinal (GI) endoscopy, there have been few reports on the influence of distractions for a person who is going to undergo upper GI endoscopy soon....

    Authors: Masahiro Sogabe, Toshiya Okahisa, Yuka Adachi, Masanori Takehara, Shinichi Hamada, Jun Okazaki, Yasuteru Fujino, Akira Fukuya, Kaizo Kagemoto, Akihiro Hirao, Koichi Okamoto, Masahiko Nakasono and Tetsuji Takayama

    Citation: BMC Gastroenterology 2018 18:132

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  18. Content type: Research article

    Endoscopic submucosal dissection (ESD) of the postoperative stomach (ESD-P) for early gastric cancer (EGC) is considered a technically difficult procedure. However, it is difficult to compare the outcomes of E...

    Authors: Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2018 18:125

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  19. Content type: Research article

    Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders worldwide, with relevant impact on the quality of life and health care costs.The aim of our study is to assess the pr...

    Authors: Irene Martinucci, Michela Natilli, Valentina Lorenzoni, Luca Pappalardo, Anna Monreale, Giuseppe Turchetti, Dino Pedreschi, Santino Marchi, Roberto Barale and Nicola de Bortoli

    Citation: BMC Gastroenterology 2018 18:116

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  20. Content type: Research article

    Malignant growth and metastasis of gastrointestinal stromal tumors (GIST) occur in some patients even during the course of treatment, but their mechanisms remains poorly understand at the molecular level so far.

    Authors: Chaoyong Shen, Yuan Yin, Huijiao Chen, Ruixue Wang, Xiaonan Yin, Zhaolun Cai, Bo Zhang, Zhixin Chen and Zongguang Zhou

    Citation: BMC Gastroenterology 2018 18:105

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  21. Content type: Research article

    Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, acute and chronic complications of PEG have been reported. We aimed to determine risk factors associated with complications an...

    Authors: Gyu Young Pih, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2018 18:101

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  22. Content type: Research article

    The classifications and counts of white blood cells (WBCs) have been proved to be able to be used as prognostic markers in cancer cases. The present study investigated the potential values of the classificatio...

    Authors: Yin-Ling Wang, Xin-Xin Ge, Yi Wang, Meng-Dan Xu, Fei-Ran Gong, Min Tao, Wen-Jie Wang, Liu-Mei Shou, Kai Chen, Meng-Yao Wu and Wei Li

    Citation: BMC Gastroenterology 2018 18:99

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  23. Content type: Study protocol

    Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard tre...

    Authors: R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, Choung Hoang, Cara M. Kenney, Colleen D. Bond, Tricia F. Kunst, Anthony Letai and David S. Schrump

    Citation: BMC Gastroenterology 2018 18:94

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  24. Content type: Research article

    Submucosal hematoma has never been associated with caustic injuries. Long-term follow-up of patients who ingested ammonia is not well known and ammonia ingestion is rare.

    Authors: Moana Gelu-Simeon, Anh-Phuc Chuong, Faouzi Saliba, Guillaume Thiery, Marc Laurent, Claire Vilain, Marius Borel, Leonardo Amaral, Marceline Alexis, Georgette Saint-Georges and Eric Saillard

    Citation: BMC Gastroenterology 2018 18:92

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  25. Content type: Research article

    Gastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical ...

    Authors: Dongya Wang, Haige Zhu, Meng Guo, Xiaotong Fan, Shuangshuang Hu, Kemin Yan, Jia Sun, Jiaojiao Wang, Miaomiao Li, Haijuan Xiao and Zhiguo Liu

    Citation: BMC Gastroenterology 2018 18:81

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  26. Content type: Case report

    Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that affect the gastrointestinal tract. IFPs are generally considered benign, noninvasive lesions; however, we report a case of an invasive gastr...

    Authors: Hirofumi Harima, Tokuhiro Kimura, Kouichi Hamabe, Fusako Hisano, Yuko Matsuzaki, Kazutoshi Sanuki, Tadahiko Itoh, Kohsuke Tada and Isao Sakaida

    Citation: BMC Gastroenterology 2018 18:74

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  27. Content type: Research article

    A two-week course of therapy with an over-the-counter proton-pump inhibitor (PPI) is recommended for frequent heartburn. Limited research has been conducted on the sustained efficacy of short-term PPI therapy ...

    Authors: David A. Peura, Anne Le Moigne, Heather Wassel and Charles Pollack

    Citation: BMC Gastroenterology 2018 18:69

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  28. Content type: Case report

    Corrosive esophageal strictures are common. The severity of the strictures depends on type, quantity, duration of contact and concentration of the caustic substance ingested. Endoscopic balloon dilation and en...

    Authors: C. Gambardella, A. Allaria, G. Siciliano, C. Mauriello, R. Patrone, N. Avenia, A. Polistena, A. Sanguinetti, S. Napolitano and G. Conzo

    Citation: BMC Gastroenterology 2018 18:68

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  29. Content type: Research article

    We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett’s Esophagus among patients undergoing radiofrequency ablation treatment.

    Authors: Tyler Luckett, Chaitanya Allamneni, Kevin Cowley, John Eick, Allison Gullick and Shajan Peter

    Citation: BMC Gastroenterology 2018 18:67

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  30. Content type: Research article

    Helicobacter pylori (H. pylori) infection can induce individual inflammatory and immune reactions which associated with extra-digestive disorders. Our aim is to investigate the association between H. pylori infec...

    Authors: Bo-Lin Pan, Chih-Fang Huang, Seng-Kee Chuah, Jui-Chin Chiang and Song-Seng Loke

    Citation: BMC Gastroenterology 2018 18:54

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  31. Content type: Case report

    Epidermolysis bullosa (EB) constitutes a heterogenous group of rare multisystem genetically transmitted disorders comprising several blistering muco-cutaneous diseases with a monogenic basis and either autosom...

    Authors: Agata Michalak, Halina Cichoż-Lach, Beata Prozorow-Król, Leszek Buk and Monika Dzida

    Citation: BMC Gastroenterology 2018 18:47

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  32. Content type: Research article

    Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days after ESD, when t...

    Authors: Koichi Izumikawa, Masaya Iwamuro, Tomoki Inaba, Shigenao Ishikawa, Kenji Kuwaki, Ichiro Sakakihara, Kumiko Yamamoto, Sakuma Takahashi, Shigetomi Tanaka, Masaki Wato and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:46

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  33. Content type: Research article

    For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compa...

    Authors: Liuting Yang, Xiaoyue Jiang, Han Yan, Yingying Li, Hongchao Zhen, Bingmei Chang, Seyed Kariminia and Qin Li

    Citation: BMC Gastroenterology 2018 18:43

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  34. Content type: Research article

    Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancer. A new multi-functional ESD device was developed to achieve complete ESD with a single device. A metal plate attached to ...

    Authors: Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2018 18:35

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  35. Content type: Research article

    The gastric microbiota has recently been implicated in the causation of organic/structural gastroduodenal diseases (gastric and duodenal ulcers, gastric cancer) in patients with Helicobacter pylori (H. pylori) in...

    Authors: Verima Pereira, Philip Abraham, Sivaramaiah Nallapeta and Anjali Shetty

    Citation: BMC Gastroenterology 2018 18:20

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  36. Content type: Case report

    We present the first description of en bloc endoscopic submucosal dissection (ESD) for total circumferential Barrett’s adenocarcinoma, predominantly of the long-segment Barrett’s esophagus (LSBE), with a 2-year f...

    Authors: Miki Kaneko, Akira Mitoro, Motoyuki Yoshida, Masayoshi Sawai, Yasushi Okura, Masanori Furukawa, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Hideto Kawaratani, Mitsuteru Kitade, Kousuke Kaji, Hiroaki Takaya, Yasuhiko Sawada, Kenichiro Seki, Shinya Sato…

    Citation: BMC Gastroenterology 2018 18:16

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  37. Content type: Research article

    Slingshot homolog-1 (SSH1) plays an important role in pathological processes, including in the occurrence and development of tumours. The purpose of this study was to determine whether SSH1 is a key biomarker ...

    Authors: Yusufu Maimaiti, Maimaitiaili Maimaitiming, Yiliang Li, Saifuding Aibibula, Azatijiang Ainiwaer, Aikebaier Aili, Zhenzhu Sun and Kelimu Abudureyimu

    Citation: BMC Gastroenterology 2018 18:12

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  38. Content type: Research article

    Gastroesophageal reflux disease (GERD) is a factor that has a significant negative impact on the quality of life (QoL). Vertebral fractures and/or spinal malalignment may influence the frequency of GERD. Howev...

    Authors: Tetsuro Ohba, Shigeto Ebata, Kensuke Koyama and Hirotaka Haro

    Citation: BMC Gastroenterology 2018 18:8

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  39. Content type: Research article

    Upper gastrointestinal bleeding (UGIB) is a common gastrointestinal emergency, which is potentially fatal. Proper management of UGIB requires risk-stratification of patients which can guide the type and aggres...

    Authors: Sibtain M. Moledina and Ewaldo Komba

    Citation: BMC Gastroenterology 2017 17:165

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  40. Content type: Research article

    Increasing attention is focused on the relationship of inflammation biomarkers with malignant tumors. The purpose of the present study was to detect whether the preoperative the red distribution width (RDW) an...

    Authors: Shiqing Cheng, Fuyan Han, Yong Wang, Yanqiu Xu, Teng Qu, Ying Ju and Zhiming Lu

    Citation: BMC Gastroenterology 2017 17:163

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  41. Content type: Research article

    Risk scoring systems are used to evaluate patients with upper gastrointestinal bleeding (UGIB). We compared Glasgow-Blatchford score (GBS), modified GBS (mGBS), and Pre-endoscopy Rockall score (Pre-E RS) for i...

    Authors: Il-Gyu Ko, Sung-Eun Kim, Bok Soon Chang, Min Seob Kwak, Jin Young Yoon, Jae Myung Cha, Hyun Phil Shin, Joung Il Lee, Sang Hyun Kim, Jin Hee Han and Jung Won Jeon

    Citation: BMC Gastroenterology 2017 17:159

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  42. Content type: Case report

    Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left unt...

    Authors: Flaminia Purchiaroni, Takeshi Nakajima, Taku Sakamoto, Seiichiro Abe and Yutaka Saito

    Citation: BMC Gastroenterology 2017 17:152

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  43. Content type: Case report

    Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare malignant disease. Advanced EBSCC (AEBSCC) has a poorer prognosis than the more common esophageal squamous cell carcinoma, but no treatment policy ...

    Authors: Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Homma Taku, Moritaka Ohhara, Toshirou Takimoto and Yoshiaki Tanaka

    Citation: BMC Gastroenterology 2017 17:151

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  44. Content type: Research article

    Blue laser imaging (BLI) and linked color imaging (LCI) are the color enhancement features of the LASEREO endoscopic system, which provide a narrow band light observation function and expansion and reduction o...

    Authors: Yoshikazu Yoshifuku, Yoji Sanomura, Shiro Oka, Mio Kurihara, Takeshi Mizumoto, Tomohiro Miwata, Yuji Urabe, Toru Hiyama, Shinji Tanaka and Kazuaki Chayama

    Citation: BMC Gastroenterology 2017 17:150

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  45. Content type: Research article

    Gastric cancer is a frequent malignant tumor worldwide and its early detection is crucial for curing the disease and enhancing patients’ survival rate. This study aimed to assess whether the multi-disciplinary...

    Authors: Lianjun Di, Huichao Wu, Rong Zhu, Youfeng Li, Xinglong Wu, Rui Xie, Hongping Li, Haibo Wang, Hua Zhang, Hong Xiao, Hui Chen, Hong Zhen, Kui Zhao, Xuefeng Yang, Ming Xie and Bigung Tuo

    Citation: BMC Gastroenterology 2017 17:147

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  46. Content type: Research article

    Although Helicobacter-induced gastric inflammation is the major predisposing factor for gastric carcinogenesis, the precise mechanism by which chronic gastritis causes gastric cancer remains unclear. Intestinal a...

    Authors: Wataru Shibata, Soichiro Sue, Sachiko Tsumura, Yasuaki Ishii, Takeshi Sato, Eri Kameta, Makoto Sugimori, Hiroaki Yamada, Hiroaki Kaneko, Tomohiko Sasaki, Tomohiro Ishii, Toshihide Tamura, Masaaki Kondo and Shin Maeda

    Citation: BMC Gastroenterology 2017 17:145

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    The Correction to this article has been published in BMC Gastroenterology 2018 18:4

  47. Content type: Research article

    The prognosis of a gastrointestinal stromal tumor (GIST) is influenced by its anatomic site; however, few studies on the prognosis of gastric GISTs have been reported. The aims of this study were to evaluate l...

    Authors: Chul Hong Park, Gwang Ha Kim, Bong Eun Lee, Geun Am Song, Do Youn Park, Kyung Un Choi, Dae Hwan Kim and Tae Yong Jeon

    Citation: BMC Gastroenterology 2017 17:141

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