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Gastroesophageal disorders

Section edited by Yeong Yeh Lee 

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, corr...

    Authors: Sydnee Crankshaw, Julia Butt, Jennifer M. Gierisch, Nadine J. Barrett, Sabrena Mervin-Blake, Kevin Oeffinger, Steven Patierno, Valarie Worthy, Ronald Godbee and Meira Epplein

    Citation: BMC Gastroenterology 2020 20:261

    Content type: Research article

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  2. Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Therefore, identifying the predictive factors for surgical morbidity, disease recurrence, and long-term survival is necessa...

    Authors: Hitomi Takechi, Nobuaki Fujikuni, Kazuaki Tanabe, Minoru Hattori, Hironobu Amano, Toshio Noriyuki and Masahiro Nakahara

    Citation: BMC Gastroenterology 2020 20:256

    Content type: Research article

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  3. Controversies in terms of efficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the hand-sewn technique as a treatment for patients with esophageal cancer. The purpos...

    Authors: Seyed Ziaeddin Rasihashemi, Ali Ramouz, Samad Beheshtirouy and Hassan Amini

    Citation: BMC Gastroenterology 2020 20:250

    Content type: Research article

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  4. Esophageal fistula and stricture is rare but life-threatening complication for esophageal cancer. The management of esophageal fistula and stricture remains challenging. We aimed to determine the safety, feasi...

    Authors: Yonghua Bi, Mengfei Yi, Zepeng Yu, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:248

    Content type: Research article

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  5. NETest, a novel multi-gene liquid biopsy has utility in neuroendocrine tumor (NET) diagnosis and identification of residual disease. We independently assessed utility of the NETest to diagnose gastric neuroend...

    Authors: A. Malczewska, A. Procner, A. Walter, K. Kusnierz, W. Zajecki, H. Aslanian and B. Kos-Kudla

    Citation: BMC Gastroenterology 2020 20:235

    Content type: Research article

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  6. Melatonin has been shown with anticancer property and therapeutic potential for tumors. However, there lacks a systematic study on the molecular pathways of melatonin and its antitumor effects in gastrointesti...

    Authors: Lu Ao, Li Li, Huaqin Sun, Huxing Chen, Yawei Li, Haiyan Huang, Xianlong Wang, Zheng Guo and Ruixiang Zhou

    Citation: BMC Gastroenterology 2020 20:233

    Content type: Research article

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  7. Gastric cancer after Helicobacter pylori (HP) eradication is a crucial clinical challenge today as HP eradication therapy is widely performed. Detecting gastric cancer after HP eradication tends to be difficult w...

    Authors: Akiko Ohno, Jun Miyoshi, Atsushi Kato, Naohiko Miyamoto, Takahito Yatagai, Yu Hada, Mitsunori Kusuhara, Yoko Jimbo, Yosuke Ida, Kengo Tokunaga, Susumu Okamoto and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:232

    Content type: Research article

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  8. There is no current standard rescue treatment for dual drug-resistant strains of Helicobacter pylori (H. pylori). This aim of this study was to investigate the efficacy of rifabutin-based triple therapy for patie...

    Authors: Chia-Jung Kuo, Cheng-Yu Lin, Puo-Hsien Le, Pi-Yueh Chang, Chih-Ho Lai, Wey-Ran Lin, Ming-Ling Chang, Jun-Te Hsu, Hao-Tsai Cheng, Chi-Nan Tseng, Chun-Jung Lin, Ming-Yao Su, Sen-Yung Hsieh and Cheng-Tang Chiu

    Citation: BMC Gastroenterology 2020 20:218

    Content type: Research article

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  9. Gastroparesis is a recognized complication of diabetes but its pathogenic mechanism incompletely understood. Our aim was to determine whether HIF-1α and VEGF are secreted from gastric tissue is a fundamental f...

    Authors: Xueping Wu, Zhifang Yang, Zhihong Li, Ling Yang, Xinyan Wang, Congrong Wang and Jun Gu

    Citation: BMC Gastroenterology 2020 20:216

    Content type: Research article

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  10. Periampullary adenocarcinoma is a major clinical problem in high-risk patients including FAP population. A recent modification for visualizing the ampulla of Vater (AV) involves attaching a cap to the tip of t...

    Authors: Leonardo Correa Silva, Rondinelle Martins Arruda, Paula Fortuci Resende Botelho, Leonardo Nogueira Taveira, Kelly Menezio Giardina, Marco Antonio de Oliveira, Julia Dias, Cleyton Zanardo Oliveira, Gilberto Fava and Denise Peixoto Guimarães

    Citation: BMC Gastroenterology 2020 20:214

    Content type: Research article

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  11. Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, th...

    Authors: Sunmin Kim, Dong Hyun Kim, Seon-Young Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi and Jong Sun Rew

    Citation: BMC Gastroenterology 2020 20:213

    Content type: Research article

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  12. Recurrence risk is a major concern after endoscopic resection (ER) of gastric neoplasms. This study was to compare metachronous risk in patients with and without synchronous neoplasms after complete ER.

    Authors: Ga-Yeong Shin, Hye Jin Cho, Jae Myung Park, Chul-Hyun Lim, Yu Kyung Cho and Myung-Gyu Choi

    Citation: BMC Gastroenterology 2020 20:206

    Content type: Research article

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  13. Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the le...

    Authors: Khalid Al-Regaiey, Suad Alshubrami, Ibrahim Al-Beeshi, Torki Alnasser, Abdulnasser Alwabel, Hassan Al-Beladi, Omar Al-Tujjar, Abdulrahman Alnasser, Assim A. Alfadda and Muhammad Iqbal

    Citation: BMC Gastroenterology 2020 20:199

    Content type: Research article

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  14. Placement of nasogastric (NG) tubes is a common procedure for patients especially in intensive care units (ICUs). Thus, it is important to determine the correct placement of the tube to prevent misplacement in...

    Authors: Elahe Heidarzadi, Rostam Jalali, Behzad Hemmatpoor and Nader Salari

    Citation: BMC Gastroenterology 2020 20:196

    Content type: Research article

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  15. Recently, a new international bleeding score was developed to predict 30-day hospital mortality in patients with upper gastrointestinal bleeding (UGIB). However, the efficacy of this newly developed scoring sy...

    Authors: Min Seong Kim, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Jae Kyu Sung, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee and Hyun Yong Jeong

    Citation: BMC Gastroenterology 2020 20:193

    Content type: Research article

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  16. The prevalence of Eosinophilic esophagitis (EoE) is increasing, a severe complication of EoE is spontaneous perforation of the oesophagus. It is of great importance to be aware of this risk and handle this sev...

    Authors: Helen Larsson and Stephen Attwood

    Citation: BMC Gastroenterology 2020 20:185

    Content type: Case report

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  17. Cyanoacrylate alone or in combination with other interventions, can be used to achieve variable rates of success in preventing rebleeding. Our study aims to assess the pooled risk of gastric and esophageal var...

    Authors: Zixuan Hu, Decai Zhang, Joel Swai, Tao Liu and Shaojun Liu

    Citation: BMC Gastroenterology 2020 20:181

    Content type: Research article

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  18. The prevalence of Barrett’s esophageal adenocarcinoma (BEA) is increasing in Japan. Accurate assessment of lymphovascular invasion (LVI) after endoscopic resection or surgery is essential in evaluating treatme...

    Authors: Isao Hosono, Ryoji Miyahara, Kazuhiro Furukawa, Kohei Funasaka, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Takio Yokoi, Tetsuya Tsukamoto, Yoshiki Hirooka and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2020 20:175

    Content type: Research article

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  19. Outcomes of gastroesophageal reflux disease (GERD) using Toupet fundoplication (TF) and Stretta radiofrequency (SRF) have not been compared and this study was conducted to compare therapeutic efficacy of the t...

    Authors: Lifeng Ma, Tao Li, Guochao Liu, Jianlong Wang, Zhaoqiang Yin and Jiansheng Kang

    Citation: BMC Gastroenterology 2020 20:162

    Content type: Research article

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  20. The reflux of noxious contents of the stomach may cause oesophageal and extra-oesophageal complications either by direct contact of aspirated gastric refluxate with the upper airway or by a vago-vagal reflex. ...

    Authors: Moses Ayodele Akinola, Titus Ayodeji Oyedele, Kolawole Oluseyi Akande, Olukayode Yinka Oluyemi, Omotayo Felicia Salami, Alaba Moses Adesina and Adedeji David Adebajo

    Citation: BMC Gastroenterology 2020 20:160

    Content type: Research article

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  21. Gastric cancer (GC) is a malignant tumour originating from the gastric mucosa epithelium that seriously threatens human health. DCLK1, miR-15b and lncRNA SNHG1 play potential roles in the occurrence of GC, but...

    Authors: Zhi-Qi Liu, Wei-Feng He, Yang-Jie Wu, Shun-Li Zhao, Ling Wang, Yan-Yi Ouyang and San-Yuan Tang

    Citation: BMC Gastroenterology 2020 20:156

    Content type: Research article

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  22. Many studies have found that large tumor suppressor kinase 1 (LATS1) and LATS2 play important roles in many diseases, but studies have been rare on the relationship between these genes and non-cardia gastric c...

    Authors: Li-cong Ma, Xu-yang Tian, Fang Gao, Wen-jie Dong, Tong Dang and Yan-bin Jia

    Citation: BMC Gastroenterology 2020 20:155

    Content type: Research article

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  23. Oesophageal stents have several well-known respiratory complications, including aspiration pneumonia, fistula and airway compression. However, bilateral vocal cord paralysis has rarely been described.

    Authors: Y. Chiche, G. Beltramo, T. Degand, A. Drouillard, C. Foignot, N. Baudouin, P. Bonniaud and M. Georges

    Citation: BMC Gastroenterology 2020 20:153

    Content type: Case report

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  24. Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteri...

    Authors: Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh and Habibollah Mahmoodzadeh

    Citation: BMC Gastroenterology 2020 20:152

    Content type: Research article

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  25. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely used techniques for the treatment of gastric epithelial dysplasia. Previous studies have compared the clinical outcome o...

    Authors: Min Kyung Back, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Jae Kyu Sung, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee and Hyun Yong Jeong

    Citation: BMC Gastroenterology 2020 20:148

    Content type: Research article

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  26. Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome...

    Authors: Craig Friesen, Meenal Singh, Vivekanand Singh and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2020 20:144

    Content type: Research article

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  27. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gas...

    Authors: Parham Habibzadeh, Mohammad Silawi, Hassan Dastsooz, Shima Bahramjahan, Shahrokh Ezzatzadegan Jahromi, Vahid Reza Ostovan, Majid Yavarian, Mohammad Mofatteh and Mohammad Ali Faghihi

    Citation: BMC Gastroenterology 2020 20:142

    Content type: Case report

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  28. Second-line (2 L) chemotherapies for advanced or metastatic gastric cancer have shown improved survival but there is no commonly accepted standard of care. This study examines real-world patient characteristic...

    Authors: David Gómez-Ulloa, Mayur Amonkar, Smita Kothari, Winson Y. Cheung, Ian Chau, John R. Zalcberg, Núria Lara Suriñach and Alfredo Falcone

    Citation: BMC Gastroenterology 2020 20:133

    Content type: Research article

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  29. Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting dev...

    Authors: Oscar Víctor Hernández Mondragón, Raúl Zamarripa Mottú, Omar Solórzano Pineda, Raúl Alberto Gutierrez Aguilar and Luís Fernando García Contreras

    Citation: BMC Gastroenterology 2020 20:132

    Content type: Technical advance

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  30. Hereditary diffuse gastric cancer is a rare condition that accounts for approximately 1–3% of all gastric cancer cases. Due to its rapid and invasive growth pattern, it is associated with a very poor prognosis...

    Authors: Elisabeth Niemeyer, Hamid Mofid, Carsten Zornig, Eike-Christian Burandt, Alexander Stein, Andreas Block and Alexander E. Volk

    Citation: BMC Gastroenterology 2020 20:129

    Content type: Case report

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  31. The association between Helicobacter pylori and reflux esophagitis (RE) remains controversial. This study aimed to prospectively evaluate the effect of H. pylori eradication on RE and gastroesophageal reflux (GER...

    Authors: Hee Kyong Na, Jeong Hoon Lee, Se Jeong Park, Hee Jung Park, Sun Ok Kim, Ji Yong Ahn, Do Hoon Kim, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2020 20:123

    Content type: Research article

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  32. In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival...

    Authors: Keshen Wang, Xiangyan Jiang, Yanxian Ren, Zhijian Ma, Xiaocheng Cheng, Fan Li, Jingying Xiao, Zeyuan Yu and Zuoyi Jiao

    Citation: BMC Gastroenterology 2020 20:100

    Content type: Research article

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  33. Previous reports of foreign-body ingestion focused primarily on accidental ingestion and very few studies focused on intentional ingestion of foreign body (FB) in China. Our study aimed to compare the prevalen...

    Authors: Ye Zong, Haiying Zhao, Can Sun, Ming Ji, Yongdong Wu, Shutian Zhang and Yongjun Wang

    Citation: BMC Gastroenterology 2020 20:90

    Content type: Research article

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  34. Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes are frequently placed in patients to provide enteral nutrition. We report a case of a complete rupture of a PEG tube intra-abdominally with associated pe...

    Authors: Maan Al Halabi, Wakim Wakim, Hicham Moukaddam and Ahmad Husari

    Citation: BMC Gastroenterology 2020 20:82

    Content type: Case report

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  35. Esophageal intramural pseudodiverticulosis is an uncommon, idiopathic disorder characterized by multiple small outpouchings protruding from the esophageal lumen. Esophageal intramural pseudodiverticulosis is a...

    Authors: Osman Ali, Hazel Asumu, Tanisha Kaur, Angelina Mathew and Raymond Kim

    Citation: BMC Gastroenterology 2020 20:72

    Content type: Case report

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  36. Endoscopic full-thickness resection (EFTR) is difficult to perform in a retroflexed fashion in the gastric fundus. The present study aims at exploring whether direct EFTR can be a simple, effective and safe pr...

    Authors: Jinlong Hu, Nan Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang and Siyu Sun

    Citation: BMC Gastroenterology 2020 20:70

    Content type: Technical advance

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  37. Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports descr...

    Authors: Marian Dejaeger, Maud Lormans, Eddy Dejaeger and Katleen Fagard

    Citation: BMC Gastroenterology 2020 20:63

    Content type: Case report

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  38. Lymph node (LN) metastasis is negligible in early gastric cancer (EGC) within expanded criteria for endoscopic submucosal dissection (ESD). However, regional lymph nodes in abdominal CT scans are sometimes enl...

    Authors: Dong Seok Lee, Jong Kyu Park, Sang Jin Lee and Gab Jin Cheon

    Citation: BMC Gastroenterology 2020 20:51

    Content type: Research article

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  39. Gastric schwannomas are rare benign tumors originating from the intramuscular plexus of the stomach and account for just 2.6% of gastric mesenchymal tumors. Gastric schwannoma (GS) with a surface ulcer is very...

    Authors: Caihua Tang, Qiyong Pan, Zeqing Xu, Xuan Zhou and Ying Wang

    Citation: BMC Gastroenterology 2020 20:36

    Content type: Case report

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  40. Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the go...

    Authors: Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2020 20:19

    Content type: Research article

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  41. Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer...

    Authors: Wenjing Zou, Xu Li, Cheng Li, Dan Liu, Yanyan Lv, Ying Yang, Nan Ye, Dan Guo and Shuixiang He

    Citation: BMC Gastroenterology 2020 20:17

    Content type: Research article

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  42. To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl4)-induced rat model.

    Authors: Shuangshuang Xie, Hanxiong Qi, Qing Li, Kun Zhang, Longjiang Zhang, Yue Cheng and Wen Shen

    Citation: BMC Gastroenterology 2020 20:14

    Content type: Research article

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  43. Gastrointestinal stromal tumors (GISTs) at the esophagogastric junction are rare and its treatment is complicated and challenging. Endoscopic resection has advantages with less complications compared to open a...

    Authors: Feng Xue, Wei Wang, Ning Shi, Xing-Bin Ma and Cheng-Xia Liu

    Citation: BMC Gastroenterology 2019 19:227

    Content type: Case report

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  44. Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD)....

    Authors: Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu and Fei Dai

    Citation: BMC Gastroenterology 2019 19:221

    Content type: Research article

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  45. Upper gastrointestinal endoscopic examination is a relatively safe procedure; however, all endoscopic procedures are invasive and are associated with a risk of iatrogenic perforation. To evaluate clinical outc...

    Authors: Dae Hwan Kang, Dae Gon Ryu, Cheol Woong Choi, Hyung Wook Kim, Su Bum Park, Su Jin Kim and Hyeong Seok Nam

    Citation: BMC Gastroenterology 2019 19:218

    Content type: Research article

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