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Gastroesophageal disorders

Section edited by Yeong Yeh Lee 

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Outcomes of gastroesophageal reflux disease (GERD) using Toupet fundoplication (TF) and Stretta radiofrequency (SRF) have not been compared and this study was conducted to compare therapeutic efficacy of the t...

    Authors: Lifeng Ma, Tao Li, Guochao Liu, Jianlong Wang, Zhaoqiang Yin and Jiansheng Kang

    Citation: BMC Gastroenterology 2020 20:162

    Content type: Research article

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  2. The reflux of noxious contents of the stomach may cause oesophageal and extra-oesophageal complications either by direct contact of aspirated gastric refluxate with the upper airway or by a vago-vagal reflex. ...

    Authors: Moses Ayodele Akinola, Titus Ayodeji Oyedele, Kolawole Oluseyi Akande, Olukayode Yinka Oluyemi, Omotayo Felicia Salami, Alaba Moses Adesina and Adedeji David Adebajo

    Citation: BMC Gastroenterology 2020 20:160

    Content type: Research article

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  3. Gastric cancer (GC) is a malignant tumour originating from the gastric mucosa epithelium that seriously threatens human health. DCLK1, miR-15b and lncRNA SNHG1 play potential roles in the occurrence of GC, but...

    Authors: Zhi-Qi Liu, Wei-Feng He, Yang-Jie Wu, Shun-Li Zhao, Ling Wang, Yan-Yi Ouyang and San-Yuan Tang

    Citation: BMC Gastroenterology 2020 20:156

    Content type: Research article

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  4. Many studies have found that large tumor suppressor kinase 1 (LATS1) and LATS2 play important roles in many diseases, but studies have been rare on the relationship between these genes and non-cardia gastric c...

    Authors: Li-cong Ma, Xu-yang Tian, Fang Gao, Wen-jie Dong, Tong Dang and Yan-bin Jia

    Citation: BMC Gastroenterology 2020 20:155

    Content type: Research article

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  5. Oesophageal stents have several well-known respiratory complications, including aspiration pneumonia, fistula and airway compression. However, bilateral vocal cord paralysis has rarely been described.

    Authors: Y. Chiche, G. Beltramo, T. Degand, A. Drouillard, C. Foignot, N. Baudouin, P. Bonniaud and M. Georges

    Citation: BMC Gastroenterology 2020 20:153

    Content type: Case report

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  6. Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteri...

    Authors: Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh and Habibollah Mahmoodzadeh

    Citation: BMC Gastroenterology 2020 20:152

    Content type: Research article

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  7. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely used techniques for the treatment of gastric epithelial dysplasia. Previous studies have compared the clinical outcome o...

    Authors: Min Kyung Back, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Jae Kyu Sung, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee and Hyun Yong Jeong

    Citation: BMC Gastroenterology 2020 20:148

    Content type: Research article

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  8. Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome...

    Authors: Craig Friesen, Meenal Singh, Vivekanand Singh and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2020 20:144

    Content type: Research article

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  9. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gas...

    Authors: Parham Habibzadeh, Mohammad Silawi, Hassan Dastsooz, Shima Bahramjahan, Shahrokh Ezzatzadegan Jahromi, Vahid Reza Ostovan, Majid Yavarian, Mohammad Mofatteh and Mohammad Ali Faghihi

    Citation: BMC Gastroenterology 2020 20:142

    Content type: Case report

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  10. Second-line (2 L) chemotherapies for advanced or metastatic gastric cancer have shown improved survival but there is no commonly accepted standard of care. This study examines real-world patient characteristic...

    Authors: David Gómez-Ulloa, Mayur Amonkar, Smita Kothari, Winson Y. Cheung, Ian Chau, John R. Zalcberg, Núria Lara Suriñach and Alfredo Falcone

    Citation: BMC Gastroenterology 2020 20:133

    Content type: Research article

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  11. Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting dev...

    Authors: Oscar Víctor Hernández Mondragón, Raúl Zamarripa Mottú, Omar Solórzano Pineda, Raúl Alberto Gutierrez Aguilar and Luís Fernando García Contreras

    Citation: BMC Gastroenterology 2020 20:132

    Content type: Technical advance

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  12. Hereditary diffuse gastric cancer is a rare condition that accounts for approximately 1–3% of all gastric cancer cases. Due to its rapid and invasive growth pattern, it is associated with a very poor prognosis...

    Authors: Elisabeth Niemeyer, Hamid Mofid, Carsten Zornig, Eike-Christian Burandt, Alexander Stein, Andreas Block and Alexander E. Volk

    Citation: BMC Gastroenterology 2020 20:129

    Content type: Case report

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  13. The association between Helicobacter pylori and reflux esophagitis (RE) remains controversial. This study aimed to prospectively evaluate the effect of H. pylori eradication on RE and gastroesophageal reflux (GER...

    Authors: Hee Kyong Na, Jeong Hoon Lee, Se Jeong Park, Hee Jung Park, Sun Ok Kim, Ji Yong Ahn, Do Hoon Kim, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2020 20:123

    Content type: Research article

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  14. In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival...

    Authors: Keshen Wang, Xiangyan Jiang, Yanxian Ren, Zhijian Ma, Xiaocheng Cheng, Fan Li, Jingying Xiao, Zeyuan Yu and Zuoyi Jiao

    Citation: BMC Gastroenterology 2020 20:100

    Content type: Research article

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  15. Previous reports of foreign-body ingestion focused primarily on accidental ingestion and very few studies focused on intentional ingestion of foreign body (FB) in China. Our study aimed to compare the prevalen...

    Authors: Ye Zong, Haiying Zhao, Can Sun, Ming Ji, Yongdong Wu, Shutian Zhang and Yongjun Wang

    Citation: BMC Gastroenterology 2020 20:90

    Content type: Research article

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  16. Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes are frequently placed in patients to provide enteral nutrition. We report a case of a complete rupture of a PEG tube intra-abdominally with associated pe...

    Authors: Maan Al Halabi, Wakim Wakim, Hicham Moukaddam and Ahmad Husari

    Citation: BMC Gastroenterology 2020 20:82

    Content type: Case report

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  17. Esophageal intramural pseudodiverticulosis is an uncommon, idiopathic disorder characterized by multiple small outpouchings protruding from the esophageal lumen. Esophageal intramural pseudodiverticulosis is a...

    Authors: Osman Ali, Hazel Asumu, Tanisha Kaur, Angelina Mathew and Raymond Kim

    Citation: BMC Gastroenterology 2020 20:72

    Content type: Case report

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  18. Endoscopic full-thickness resection (EFTR) is difficult to perform in a retroflexed fashion in the gastric fundus. The present study aims at exploring whether direct EFTR can be a simple, effective and safe pr...

    Authors: Jinlong Hu, Nan Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang and Siyu Sun

    Citation: BMC Gastroenterology 2020 20:70

    Content type: Technical advance

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  19. Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports descr...

    Authors: Marian Dejaeger, Maud Lormans, Eddy Dejaeger and Katleen Fagard

    Citation: BMC Gastroenterology 2020 20:63

    Content type: Case report

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  20. Lymph node (LN) metastasis is negligible in early gastric cancer (EGC) within expanded criteria for endoscopic submucosal dissection (ESD). However, regional lymph nodes in abdominal CT scans are sometimes enl...

    Authors: Dong Seok Lee, Jong Kyu Park, Sang Jin Lee and Gab Jin Cheon

    Citation: BMC Gastroenterology 2020 20:51

    Content type: Research article

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  21. Gastric schwannomas are rare benign tumors originating from the intramuscular plexus of the stomach and account for just 2.6% of gastric mesenchymal tumors. Gastric schwannoma (GS) with a surface ulcer is very...

    Authors: Caihua Tang, Qiyong Pan, Zeqing Xu, Xuan Zhou and Ying Wang

    Citation: BMC Gastroenterology 2020 20:36

    Content type: Case report

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  22. Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the go...

    Authors: Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2020 20:19

    Content type: Research article

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  23. Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer...

    Authors: Wenjing Zou, Xu Li, Cheng Li, Dan Liu, Yanyan Lv, Ying Yang, Nan Ye, Dan Guo and Shuixiang He

    Citation: BMC Gastroenterology 2020 20:17

    Content type: Research article

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  24. To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl4)-induced rat model.

    Authors: Shuangshuang Xie, Hanxiong Qi, Qing Li, Kun Zhang, Longjiang Zhang, Yue Cheng and Wen Shen

    Citation: BMC Gastroenterology 2020 20:14

    Content type: Research article

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  25. Gastrointestinal stromal tumors (GISTs) at the esophagogastric junction are rare and its treatment is complicated and challenging. Endoscopic resection has advantages with less complications compared to open a...

    Authors: Feng Xue, Wei Wang, Ning Shi, Xing-Bin Ma and Cheng-Xia Liu

    Citation: BMC Gastroenterology 2019 19:227

    Content type: Case report

    Published on:

  26. Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD)....

    Authors: Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu and Fei Dai

    Citation: BMC Gastroenterology 2019 19:221

    Content type: Research article

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  27. Upper gastrointestinal endoscopic examination is a relatively safe procedure; however, all endoscopic procedures are invasive and are associated with a risk of iatrogenic perforation. To evaluate clinical outc...

    Authors: Dae Hwan Kang, Dae Gon Ryu, Cheol Woong Choi, Hyung Wook Kim, Su Bum Park, Su Jin Kim and Hyeong Seok Nam

    Citation: BMC Gastroenterology 2019 19:218

    Content type: Research article

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  28. To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC).

    Authors: Ze-Ning Huang, Jacopo Desiderio, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng and Chang-Ming Huang

    Citation: BMC Gastroenterology 2019 19:205

    Content type: Research article

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  29. Bleeding esophageal varices is a deadly complication of liver cirrhosis. Guidelines recommend an early diagnosis of esophageal varices before incident bleeding by screening all patients diagnosed with liver ci...

    Authors: Daniel W. Gunda, Semvua B. Kilonzo, Zakhia Mamballah, Paulina M. Manyiri, David C. Majinge, Hyasinta Jaka, Benson R. Kidenya and Humphrey D. Mazigo

    Citation: BMC Gastroenterology 2019 19:203

    Content type: Research article

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  30. Current magnet-controlled capsule endoscopy (MCE) for the stomach is not yet satisfactory with respect to navigation control, especially in the gastric fundus and cardia. A newly developed MCE system conducted...

    Authors: Chun-sheng Cheng, Ting-ji Sun and Hou-de Zhang

    Citation: BMC Gastroenterology 2019 19:184

    Content type: Research article

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  31. Pneumatic dilation (PD) is often billed as a “short term” treatment for achalasia but anecdotally can last years. This study sought to explore how long a single pneumatic dilation may induce symptom remission ...

    Authors: Abid T. Javed, Kevin Batte, Mohamed Khalaf, Mustafa Abdul-Hussein, Pooja S. Elias and Donald O. Castell

    Citation: BMC Gastroenterology 2019 19:181

    Content type: Research article

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  32. To compare the outcomes of submucosal tunneling endoscopic resection (STER) and submucosal excavation (ESE) for the treatment of submucosal tumors (SMTs) arising from the muscularis propria (MP) at the esophag...

    Authors: Hong-wei Xu, Qi Zhao, Shu-xia Yu, Ying Jiang, Jing-hua Hao and Bin Li

    Citation: BMC Gastroenterology 2019 19:174

    Content type: Research article

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  33. Intramural esophageal bronchogenic cyst is very rare. Surgical removal of the cysts is advised even the patients are asymptomatic, since the cyst can lead to complications, and there is a risk of malignant tra...

    Authors: Xun Yang, Ye Zong, Hai-Ying Zhao, Yong-Dong Wu and Ming Ji

    Citation: BMC Gastroenterology 2019 19:155

    Content type: Case report

    Published on:

  34. This study aimed to understand the disease characteristics and treatment outcomes of Crohn’s disease (CD) in a real-world setting in China.

    Authors: Yue Li, Baili Chen, Xiang Gao, Naizhong Hu, Meifang Huang, Zhihua Ran, Zhanju Liu, Jie Zhong, Duowu Zou, Xiaoping Wu, Jianlin Ren, Jianqiu Sheng, Ping Zheng, Huahong Wang, Minhu Chen, Junrong Chen…

    Citation: BMC Gastroenterology 2019 19:145

    Content type: Research article

    Published on:

  35. Individuals can be infected with multiple strains of Helicobacter pylori. However, the differences among co-infecting strains have not been well analyzed yet. This study aimed to investigate whether the virulence...

    Authors: Ji Won Seo, Jae Yong Park, Tae-Seop Shin and Jae Gyu Kim

    Citation: BMC Gastroenterology 2019 19:140

    Content type: Research article

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  36. Risk stratification for patients with nonvariceal upper gastrointestinal (NVUGI) bleeding is crucial for successful prognosis and treatment. Recently, the AIMS65 score has been used to predict mortality risk a...

    Authors: Min Seong Kim, Jeongmin Choi and Won Chang Shin

    Citation: BMC Gastroenterology 2019 19:136

    Content type: Research article

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  37. Eradicating Helicobacter pylori infection is clinically challenging, notably in cases with penicillin allergy. Cephalosporin could be used in lieu of amoxicillin to eradicate Helicobacter pylori. The current work...

    Authors: Zhiqiang Song, Wei Fu and Liya Zhou

    Citation: BMC Gastroenterology 2019 19:132

    Content type: Research article

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  38. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution o...

    Authors: Dong Chen, Zhonggao Wang, Zhiwei Hu, Yan Liang, Fei Xiao and Jimin Wu

    Citation: BMC Gastroenterology 2019 19:108

    Content type: Research article

    Published on:

  39. Our aim was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy and its association to characteristics and postoperative change in body ...

    Authors: Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Sunao Uemura, Masaya Munekage, Keiichiro Yokota, Michiya Kobayashi and Kazuhiro Hanazaki

    Citation: BMC Gastroenterology 2019 19:104

    Content type: Research article

    Published on:

  40. Aryl-hydrocarbon receptor (AhR) is a multiple ligand-activated transcription factor that has important roles in xenobiotic, physiological, or pathological functions. Transgenic mice systemically expressing con...

    Authors: Ai Dantsuka, Osamu Ichii, Annika Hanberg, Yaser Hosny Ali Elewa, Saori Otsuka-Kanazawa, Teppei Nakamura and Yasuhiro Kon

    Citation: BMC Gastroenterology 2019 19:102

    Content type: Research article

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  41. The outcomes of patients with refractory benign esophageal strictures (RBES) are unclear, and the clinical efficacy of dilation versus stent placement is lacking. Our objective was to explore the role of endos...

    Authors: Qing Lu, Hailin Yan, Yilan Wang, Tiantian Lei, Linlin Zhu, Hongsheng Ma and Jinlin Yang

    Citation: BMC Gastroenterology 2019 19:95

    Content type: Research article

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  42. Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

    Content type: Case report

    Published on:

  43. An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

    Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel and René Thieme

    Citation: BMC Gastroenterology 2019 19:38

    Content type: Research article

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  44. Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of...

    Authors: King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng and Chao-Long Chen

    Citation: BMC Gastroenterology 2019 19:37

    Content type: Case report

    Published on:

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