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Colorectal cancer

Section edited by Arndt Vogel

This section concerns all aspects of colorectal cancer including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Content type: Research article

    Although type V pit pattern analysis is effective in determining the invasion depth of early colorectal cancers, the clinical results may vary because findings are operator-dependent. This study aimed to asses...

    Authors: Taku Sakamoto, Takahisa Matsuda, Takeshi Nakajima, Yutaka Saito and Takahiro Fujii

    Citation: BMC Gastroenterology 2014 14:100

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  2. Content type: Research article

    Cytosolic nonspecific dipetidase (CN2) belongs to the family of M20 metallopeptidases. It was stated in previous articles that higher expression levels of CN2 were observed in renal cell carcinoma and breast c...

    Authors: Conglong Xue, Zhenwei Zhang, Honglan Yu, Miao Yu, Kaitao Yuan, Ting Yang, Mingyong Miao and Hanping Shi

    Citation: BMC Gastroenterology 2014 14:96

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  3. Content type: Case report

    Colon cancer can arise from the mucosa in a colonic diverticulum. Although colon diverticulum is a common disease, few cases have been previously reported on colon cancer associated with a diverticulum. We rep...

    Authors: Yasumichi Yagi, Yasuhiro Shoji, Shozo Sasaki, Akemi Yoshikawa, Yuji Tsukioka, Wataru Fukushima, Hisashi Hirosawa, Ryohei Izumi and Katsuhiko Saito

    Citation: BMC Gastroenterology 2014 14:90

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  4. Content type: Research article

    Serrated lesions of the colorectum as categorized by pathology include hyperplastic polyps, sessile serrated adenomas without dysplasia, and traditional serrated adenomas with dysplasia. The aim of this study ...

    Authors: Hyun Young Kim, Seon Mie Kim, Ji-Hyun Seo, Eun-Ha Park, Nayoung Kim and Dong Ho Lee

    Citation: BMC Gastroenterology 2014 14:82

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  5. Content type: Research article

    Acute colonic obstruction is the most common complication of colorectal cancer (CRC) in elderly patients. Medical treatment has been associated with higher perioperative morbidity and mortality rates. There is...

    Authors: Ming-gao Guo, Yi Feng, Jia-zhe Liu, Qi Zheng, Jian-zhong Di, Yu Wang, You-ben Fan and Xin-Yu Huang

    Citation: BMC Gastroenterology 2014 14:76

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  6. Content type: Research article

    KRAS mutations are frequently found in colorectal cancer (CRC) indicating the importance of its genotyping in the study of the molecular mechanisms behind this disease. Although major advances have occurred over...

    Authors: Carlos Gil Ferreira, Veronica Aran, Ilana Zalcberg-Renault, Ana Paula Victorino, Jonas H Salem, Martin H Bonamino, Fernando M Vieira and Mariano Zalis

    Citation: BMC Gastroenterology 2014 14:73

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  7. Content type: Research article

    In patients with incomplete colonoscopy, cecal intubation is sometimes unsuccessful due to a redundant or tortuous colon. Repeat colonoscopy may be successful with the use of alternate endoscopes or careful at...

    Authors: Andrew J Gawron, Annapoorani Veerappan and Rajesh N Keswani

    Citation: BMC Gastroenterology 2014 14:56

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  8. Content type: Research article

    Patients aged 65 years and older represent the majority of patients with metastatic colorectal cancer (mCRC). However, this patient population is often underrepresented in clinical trials and probably undertre...

    Authors: Lubomir Slavicek, Tomas Pavlik, Jiri Tomasek, Zbynek Bortlicek, Tomas Buchler, Bohuslav Melichar, Rostislav Vyzula, Jana Prausova, Jindrich Finek, Ondrej Majek and Ladislav Dusek

    Citation: BMC Gastroenterology 2014 14:53

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  9. Content type: Research article

    Colorectal cancer (CRC) may be reduced by healthy lifestyle behaviours. We determined the extent of self-reported lifestyle changes in people at increased risk of CRC, and the association of these reports with...

    Authors: Gregory P Tarr, Andrew Crowley, Rhys John, Jonathan B Kok, Ho-Nam L Lee, Hasif Mustafa, Kia M Sii, Rebecca Smith, Sung-Eun Q Son, Lauren J Weaver, Claire Cameron, John D Dockerty, Michael Schultz and Iain A Murray

    Citation: BMC Gastroenterology 2014 14:22

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  10. Content type: Research article

    Cyclooxygenase-2 (COX-2, PTGS2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation and angiogenesis. COX...

    Authors: Hennie MJ Roelofs, Rene HM te Morsche, Bjorn WH van Heumen, Fokko M Nagengast and Wilbert HM Peters

    Citation: BMC Gastroenterology 2014 14:9005

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  11. Content type: Case report

    Histological regression of solid tumors in adults receiving no treatment is rare. Specifically, spontaneous partial and complete regression of colorectal cancers account for less than 2% of such cases and thos...

    Authors: Fumihiko Nakamura, Taku Sakamoto, Takeshi Nakajima, Yutaka Saito, Hirokazu Taniguchi and Takahisa Matsuda

    Citation: BMC Gastroenterology 2013 13:146

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  12. Content type: Case report

    Laterally spreading tumors (LSTs) are generally defined as superficial lesions ≥10 mm in diameter that typically extend laterally rather than vertically along the colonic wall. LSTs are usually categorized int...

    Authors: Hideaki Miyamoto, Yasuhiro Oono, Kuang-l Fu, Hiroaki Ikematsu, Satoshi Fujii, Takashi Kojima, Tomonori Yano, Atsushi Ochiai, Yutaka Sasaki and Kazuhiro Kaneko

    Citation: BMC Gastroenterology 2013 13:129

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  13. Content type: Research article

    Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 e...

    Authors: Wen-Ting Liao, Jun-Ling Liu, Zheng-Gen Wang, Yan-Mei Cui, Ling Shi, Ting-Ting Li, Xiao-Hui Zhao, Xiu-Ting Chen, Yan-Qing Ding and Li-Bing Song

    Citation: BMC Gastroenterology 2013 13:126

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  14. Content type: Research article

    Information on the impact of cecal insertion time on colorectal neoplasm detection is limited. Our objective was to determine the association between cecal insertion time and colorectal neoplasm detection rate...

    Authors: Moon Hee Yang, Juhee Cho, Sanjay Rampal, Eun Kyung Choi, Yoon-Ho Choi, Jun Haeng Lee, Young-Ho Kim, Dong Kyung Chang, Poong-Lyul Rhee, Jae J Kim, Eliseo Guallar, Jong Chul Rhee and Hee Jung Son

    Citation: BMC Gastroenterology 2013 13:124

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  15. Content type: Research article

    African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol...

    Authors: Hassan Ashktorab, Hassan Hassanzadeh Namin, Teletia Taylor, Carla Williams, Hassan Brim, Thomas Mellman, Babak Shokrani, Cheryl L Holt, Adeyinka O Laiyemo and Mehdi Nouraie

    Citation: BMC Gastroenterology 2013 13:101

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  16. Content type: Research article

    Pain is common during colonic insufflation required for CT colonography. We therefore evaluate whether a single intravenous alfentanil bolus has a clinically relevant analgesic effect compared with placebo in ...

    Authors: Thierry N Boellaard, Marije P van der Paardt, Markus W Hollmann, Susanne Eberl, Jan Peringa, Lex J Schouten, Giedre Kavaliauskiene, Jurgen H Runge, Jeroen AW Tielbeek and Jaap Stoker

    Citation: BMC Gastroenterology 2013 13:94

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  17. Content type: Research article

    Enhanced EGF receptor (EGFR) signaling is a hallmark of many human cancers, though the role of enhanced EGFR signaling within the surrounding tumor stroma has not been well studied. The myofibroblast is an imp...

    Authors: James Yoo, Citlali Ekaterina Rodriguez Perez, Wenxian Nie, James Sinnett-Smith and Enrique Rozengurt

    Citation: BMC Gastroenterology 2013 13:90

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  18. Content type: Research article

    There is uncertainty on the benefit of adjuvant chemotherapy in patients with stage II colorectal cancers. The aim of this study is to investigate the combined role of clinical, pathological and molecular para...

    Authors: Marisa Donada, Serena Bonin, Renzo Barbazza, Daniel Pettirosso and Giorgio Stanta

    Citation: BMC Gastroenterology 2013 13:36

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  19. Content type: Research article

    The variable-stiffness colonoscope (VSC) appears to have advantages over the standard adult colonoscope (SAC), although data are conflicting. To provide a comprehensive up-to-date review, we conducted a meta-a...

    Authors: Qin Xie, Bin Chen, Liu Liu and Huatian Gan

    Citation: BMC Gastroenterology 2012 12:151

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  20. Content type: Research article

    People vary in how they respond to symptoms. The purpose of this study was to assess whether serious disease is more likely to be present in patients who report that they take any symptoms less seriously than ...

    Authors: Barbara-Ann Adelstein, Petra Macaskill, Robin M Turner and Les Irwig

    Citation: BMC Gastroenterology 2012 12:130

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  21. Content type: Research article

    Little data exists on the factors associated with health care seeking behaviour for primary symptoms of colorectal cancer (CRC). This study aimed to identify individual, provider and psychosocial factors assoc...

    Authors: Ryan J Courtney, Christine L Paul, Robert W Sanson-Fisher, Finlay A Macrae, John Attia and Mark McEvoy

    Citation: BMC Gastroenterology 2012 12:100

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  22. Content type: Case report

    Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate ...

    Authors: Yoichi Hamai, Jun Hihara, Manabu Emi, Yoshiro Aoki, Kei Kushitani, Kazuaki Tanabe and Morihito Okada

    Citation: BMC Gastroenterology 2012 12:98

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  23. Content type: Research article

    Luteolin is a 3',4',5,7-tetrahydroxyflavone found in various fruits and vegetables. We have shown previously that luteolin reduces HT-29 cell growth by inducing apoptosis and cell cycle arrest. The objective o...

    Authors: Do Young Lim, Han Jin Cho, Jongdai Kim, Chu Won Nho, Ki Won Lee and Jung Han Yoon Park

    Citation: BMC Gastroenterology 2012 12:9

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