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Colorectal cancer

This section concerns all aspects of colorectal cancer including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. As right colon polyps are challenging to detect, a retroflexed view of right colon (RV) may be useful. However, cecal retroflexion (CR) without a RV to the hepatic flexure (HF) is inadequate. We aimed to deter...

    Authors: Rajesh N. Keswani, Charles J. Kahi, Mark Benson, Andrew J. Gawron, Tonya R. Kaltenbach, Rena H. Yadlapati, Dyanna L. Gregory and Anna Duloy

    Citation: BMC Gastroenterology 2021 21:307

    Content type: Research article

    Published on:

  3. Endoscopic resection for large, laterally spreading tumors (LSTs) in the cecum is challenging. Here we report on the clinical outcomes of hybrid endoscopic submucosal dissection (ESD) in large cecal LSTs.

    Authors: Xiang-Yao Wang, Ning-Li Chai, Ya-Qi Zhai, Long-Song Li, Zan-Tao Wang, Jia-Le Zou, Yong-Sheng Shi and En-Qiang Linghu

    Citation: BMC Gastroenterology 2021 21:203

    Content type: Research article

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  4. Since December 2019, China has experienced a public health emergency from the coronavirus disease, which has become a pandemic and is impacting the care of cancer patients worldwide. This study evaluated the i...

    Authors: Yun Xu, Zong-Hao Huang, Charlie Zhi-Lin Zheng, Cong Li, Yu-Qin Zhang, Tian-An Guo, Fang-Qi Liu and Ye Xu

    Citation: BMC Gastroenterology 2021 21:185

    Content type: Research article

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  5. Prevention and early detection of colorectal cancer (CRC) is a global priority, with many countries conducting population-based CRC screening programs. Although colonoscopy is the most accurate diagnostic meth...

    Authors: Chang Woo Kim, Hyunjin Kim, Hyoung Rae Kim, Bong-Hyeon Kye, Hyung Jin Kim, Byung Soh Min, Tae Jeong Oh, Sungwhan An and Suk-Hwan Lee

    Citation: BMC Gastroenterology 2021 21:173

    Content type: Study protocol

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  6. Individuals with advanced colorectal adenomas (ACAs) are at high risk for colorectal cancer (CRC), and it is unclear which chemopreventive agent (CPA) is safe and cost-effective for secondary prevention. We ai...

    Authors: Sajesh K. Veettil, Siang Tong Kew, Kean Ghee Lim, Pochamana Phisalprapa, Suresh Kumar, Yeong Yeh Lee and Nathorn Chaiyakunapruk

    Citation: BMC Gastroenterology 2021 21:130

    Content type: Research article

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  7. A colorectal cancer screening programme (CCSP) was implemented from 2012 to 2017 in Tianjin, China. Residents with a positive faecal immunochemical test (FIT) or positive self-reported symptom questionnaire (S...

    Authors: Lizhong Zhao, Xiaorui Zhang, Yongjie Chen, Yuan Wang, Weihua Zhang and Wenli Lu

    Citation: BMC Gastroenterology 2021 21:117

    Content type: Research article

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  8. Colorectal cancer (CRC) is a major cancer burden, and prognosis is determined by many demographic and clinicopathologic factors. The present study aimed to construct a prognostic nomogram for colorectal cancer...

    Authors: Zheng Liu, Yao Xu, Guijun Xu, Vladimir P. Baklaushev, Vladimir P. Chekhonin, Karl Peltzer, Wenjuan Ma, Xin Wang, Guowen Wang and Chao Zhang

    Citation: BMC Gastroenterology 2021 21:103

    Content type: Research article

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  9. Testicular cancer (TC) survivors have an increased risk of various second primary malignancies. A recent cohort study detected an increased risk of colorectal cancer (CRC) in TC survivors treated with platinum...

    Authors: Berbel L. M. Ykema, Tanya M. Bisseling, Manon C. W. Spaander, Leon M. G. Moons, Dorien van der Biessen-van Beek, Lisette Saveur, Martijn Kerst, Sasja F. Mulder, Ronald de Wit, Danielle Zweers, Gerrit A. Meijer, Jos H. Beijnen, Iris Lansdorp-Vogelaar, Flora E. van Leeuwen, Petur Snaebjornsson and Monique E. van Leerdam

    Citation: BMC Gastroenterology 2021 21:67

    Content type: Study protocol

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  10. Single nucleotide polymorphism (SNP)-based polygenic risk scoring is predictive of colorectal cancer (CRC) risk. However, few studies have investigated the association of genetic risk score (GRS) with detectio...

    Authors: Michael J. Northcutt, Zhuqing Shi, Michael Zijlstra, Ayush Shah, Siqun Zheng, Eugene F. Yen, Omar Khan, Mohammad Imran Beig, Polina Imas, Adam Vanderloo, Obaid Ansari, Jianfeng Xu and Jay L. Goldstein

    Citation: BMC Gastroenterology 2021 21:65

    Content type: Research article

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  11. Constitutional mismatch repair deficiency (CMMRD) is caused by biallelic pathogenic variants in one of the mismatch repair genes, and results in early onset colorectal cancer, leukemia, brain tumors and other ...

    Authors: Keinosuke Hizuka, Shin-ichiro Hagiwara, Takatoshi Maeyama, Hitoshi Honma, Masanobu Kawai, Kiwamu Akagi, Michiko Yasuhara, Naohiro Tomita and Yuri Etani

    Citation: BMC Gastroenterology 2021 21:60

    Content type: Case report

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  13. The Korean National Cancer Screening Program has been providing annual fecal immunochemical test for colorectal cancer (CRC) to adults aged 50 years and older since 2004. The Korean Colonoscopy Screening Pilot...

    Authors: Bomi Park, Jae Kwan Jun, Byung Chang Kim, Kui Son Choi and Mina Suh

    Citation: BMC Gastroenterology 2021 21:36

    Content type: Study protocol

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  14. Sedation is commonly used in gastrointestinal endoscopy; however, considerable variability in sedation practices has been reported. The objective of this review was to identify and synthesize existing recommen...

    Authors: Fahima Dossa, Olivia Megetto, Mafo Yakubu, David D. Q. Zhang and Nancy N. Baxter

    Citation: BMC Gastroenterology 2021 21:22

    Content type: Research article

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  15. Desmoglein2 (DSG2) is a transmembrane protein that helps regulate intercellular connections and contributes to desmosome assembly. Desmosome are associated with cell adhesion junctions, which play an important...

    Authors: Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao and Zhenqing Feng

    Citation: BMC Gastroenterology 2021 21:7

    Content type: Research article

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  16. Tuberous Sclerosis Complex (TSC) is a complex and heterogeneous genetic disease that has well-established clinical diagnostic criteria. These criteria do not include gastrointestinal tumors.

    Authors: Larissa Brussa Reis, Daniele Konzen, Cristina Brinckmann Oliveira Netto, Pedro Moacir Braghirolli Braghini, Gabriel Prolla and Patricia Ashton-Prolla

    Citation: BMC Gastroenterology 2020 20:394

    Content type: Case report

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  17. The risk of recurrent colonic adenoma associated with high-grade dysplasia (HGD) colon polyps at baseline colonoscopy remains unclear. We conducted a clinical cohort study with patients who underwent polypecto...

    Authors: Jia-Jang Chang, Cheng-Hung Chien, Shuo-Wei Chen, Li-Wei Chen, Ching-Jung Liu and Cho-Li Yen

    Citation: BMC Gastroenterology 2020 20:376

    Content type: Research article

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  18. The microsatellite instability (MSI) in colorectal cancer (CRC) has a more favorable clinical outcome and is characterized by highly upregulated expression of various immunological checkpoints than microsatell...

    Authors: Wen-juan Huang, Xin Wang, Meng-lin Zhang, Li Li and Rui-tao Wang

    Citation: BMC Gastroenterology 2020 20:373

    Content type: Research article

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  19. Despite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evalu...

    Authors: Li Wang, Meng-Xia Zhang, Mei-Fang Zhang and Zi-Wei Tu

    Citation: BMC Gastroenterology 2020 20:370

    Content type: Research article

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  20. Diarrhea is a common adverse event of fluoropyrimidine-based chemotherapy. However, limited data are available on the frequency and risk factors of complicated chemotherapy-induced diarrhea (CID) and small int...

    Authors: Miho Sakumura, Takayuki Ando, Ayumu Hosokawa, Takahiko Nakajima, Iori Motoo, Hiroshi Mihara, Akira Ueda, Shinya Kajiura, Sohachi Nanjo, Haruka Fujinami, Kohei Ogawa and Ichiro Yasuda

    Citation: BMC Gastroenterology 2020 20:355

    Content type: Research article

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  21. Eosinophilic gastrointestinal disorders (EGIDs) are a rare group of inflammatory disorders that can occur anywhere along the gastrointestinal tract, from the esophagus to the rectum. In particular, those with ...

    Authors: Ryo Ataka, Hirokazu Tanaka, Shintaro Yagi, Kei Yamane, Kenji Yoshino, Tomoyuki Miyauchi, Tomoaki Yoh, Keiichi Arafuka, Shinichi Fujita, Akihiko Hamada, Bunji Endo and Shinji Uemoto

    Citation: BMC Gastroenterology 2020 20:353

    Content type: Case report

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  23. Multiple polypoid colonic metastases are very rare which mainly originated from gastric carcinoma or melanoma. For rectal cancers, liver, lung and peritoneum are the most common metastatic sites. Here we prese...

    Authors: Yunlong Wu, Jiaolin Zhou, Tongtong Liu, Lai Xu and Yi Xiao

    Citation: BMC Gastroenterology 2020 20:337

    Content type: Case report

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  24. Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim o...

    Authors: Hajar Essangri, Mohammed Anass Majbar, Amine Benkabbou, Laila Amrani, Raouf Mohsine and Amine Souadka

    Citation: BMC Gastroenterology 2020 20:333

    Content type: Research article

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  25. We investigated the correlations between surgery-related factors and the incidence of anastomotic leakage after low anterior resection (LAR) for lower rectal cancer.

    Authors: Tetsushi Kinugasa, Sachiko Nagasu, Kenta Murotani, Tomoaki Mizobe, Takafumi Ochi, Taro Isobe, Fumihiko Fujita and Yoshito Akagi

    Citation: BMC Gastroenterology 2020 20:315

    Content type: Research article

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  26. Underwater endoscopic mucosal resection (UEMR) is a recently developed technique and can be performed during water-aided or ordinary colonoscopy for the treatment of colorectal polyps. The objective of this cl...

    Authors: Zhixin Zhang, Yonghong Xia, Hongyao Cui, Xin Yuan, Chunnian Wang, Jiarong Xie, Yarong Tong, Weihong Wang and Lei Xu

    Citation: BMC Gastroenterology 2020 20:311

    Content type: Research article

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  27. Poorly differentiated anal neuroendocrine carcinomas (ANECs) are rare lesions with poor prognosis, and the molecular etiology is only partially understood.

    Authors: Carl Christofer Juhlin, Henrik Falhammar, Magnus Kjellman, Jan Åhlén, Staffan Welin and Jan Calissendorff

    Citation: BMC Gastroenterology 2020 20:290

    Content type: Case report

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  28. The incidence of mucinous appendiceal adenocarcinomas (MAA) has increased over the past three decades. Advanced stage tumor diagnosis is likely attributable to non-specific findings. Here we describe advanced ...

    Authors: Katerina Roma, Mark Baldwin, Daniel Sedmak, Matthew Silva, William Stellar and Gina Many

    Citation: BMC Gastroenterology 2020 20:281

    Content type: Case report

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  29. African Americans (AA) are at high risk for Colorectal Cancer (CRC). Studies report a 30–60% increase in CRC risk with physical inactivity, obesity and metabolic syndrome. Activation of the WNT/β-catenin (CTNN...

    Authors: Babak Shokrani, Hassan Brim, Tahmineh Hydari, Ali Afsari, Edward Lee, Mehdi Nouraie, Zaki Sherif and Hassan Ashktorab

    Citation: BMC Gastroenterology 2020 20:274

    Content type: Research article

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  31. Several DNA viruses are highly suspicious to have oncogenic effects in humans. This study investigates the presence of potentially oncogenic viruses such as SV40, JCV, BKV and EBV in patient-derived colorectal...

    Authors: Michael Gock, Marcel Kordt, Stephanie Matschos, Christina S. Mullins and Michael Linnebacher

    Citation: BMC Gastroenterology 2020 20:260

    Content type: Research article

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  33. Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerous proliferating cells, has been used as a diagnostic biomarker for colorectal cancer...

    Authors: Farideh Rigi, Aliakbar Jannatabad, Azra Izanloo, Reza Roshanravan, Hamid Reza Hashemian and Mohammad Amin Kerachian

    Citation: BMC Gastroenterology 2020 20:241

    Content type: Research article

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  34. A recent study by Digby et al. in BMC Gastroenterology evaluated the faecal haemoglobin, age and sex test (FAST) score in the assessment of patients with lower bowel symptoms attended in primary healthcare. Th...

    Authors: Joaquín Cubiella

    Citation: BMC Gastroenterology 2020 20:231

    Content type: Correspondence

    Published on:

    The original article was published in BMC Gastroenterology 2019 19:213

  35. In the recent years two innovative approaches have become available for minimally invasive en bloc resections of large non-pedunculated rectal lesions (polyps and early cancers). One is Transanal Minimally Invasi...

    Authors: Nik Dekkers, Jurjen J. Boonstra, Leon M. G. Moons, Roel Hompes, Barbara A. Bastiaansen, Jurriaan B. Tuynman, Arjun D. Koch, Bas L. A. M. Weusten, Apollo Pronk, Peter A. Neijenhuis, Marinke Westerterp, Wilbert B. van den Hout, Alexandra M. J. Langers, Jolein van der Kraan, Alaa Alkhalaf, Jonathan Y. L. Lai…

    Citation: BMC Gastroenterology 2020 20:225

    Content type: Study protocol

    Published on:

  36. To compare the outcomes of modified endoscopic mucosal resection (m-EMR) and endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (NETs) and evaluate the value of endoscopic morphology class...

    Authors: Xiang-Yao Wang, Ning-Li Chai, En-Qiang Linghu, Shao-Tian Qiu, Long-Song Li, Jia-Le Zou, Jing-Yuan Xiang and Xing-Xing Li

    Citation: BMC Gastroenterology 2020 20:200

    Content type: Research article

    Published on:

  37. En-bloc resection of large, flat dysplastic mucosal lesions of the luminal GI tract can be challenging. In order to improve the efficacy of resection for lesions ≥2 cm and to optimize R0 resection rates of les...

    Authors: A. Sportes, Jung CFM, M. A. Gromski, P. Koehler, A. Seif Amir Hosseini, P. Kauffmann, V. Ellenrieder and E. Wedi

    Citation: BMC Gastroenterology 2020 20:195

    Content type: Technical advance

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  39. Alternative splicing (AS) is an important mechanism of regulating eukaryotic gene expression. Understanding the most common AS events in colorectal cancer (CRC) will help developing diagnostic, prognostic or t...

    Authors: Haifeng Lian, Aili Wang, Yuanyuan Shen, Qian Wang, Zhenru Zhou, Ranran Zhang, Kun Li, Chengxia Liu and Hongtao Jia

    Citation: BMC Gastroenterology 2020 20:171

    Content type: Research article

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  40. Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and co...

    Authors: Xian Hua Gao, Juan Li, Zi Ye Zhao, Xiao Dong Xu, Yi Qi Du, Hong Li Yan, Lian Jie Liu, Chen Guang Bai and Wei Zhang

    Citation: BMC Gastroenterology 2020 20:167

    Content type: Case report

    Published on:

  42. Colorectal cancer (CRC) is the second most common malignant disease and the second most common cause of cancer death in Germany. Official CRC screening starts at age 50. As there is evidence that individuals w...

    Authors: Sabine Hoffmann, Alexander Crispin, Doris Lindoerfer, Gaby Sroczynski, Uwe Siebert, Ulrich Mansmann and FARKOR Consortium

    Citation: BMC Gastroenterology 2020 20:131

    Content type: Study Protocol

    Published on:

  43. The fecal immunochemical test (FIT) is the second most commonly used colorectal cancer (CRC) screening modality in the United States; yet, follow-up of abnormal FIT results with diagnostic colonoscopy is under...

    Authors: Vivy T. Cusumano, Edgar Corona, Diana Partida, Liu Yang, Christine Yu and Folasade P. May

    Citation: BMC Gastroenterology 2020 20:115

    Content type: Research article

    Published on:

  44. It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not comp...

    Authors: Fausto Riu Pons, Montserrat Andreu, Dolores Naranjo, Marco Antonio Álvarez-González, Agustín Seoane, Josep Maria Dedeu, Luis Barranco and Xavier Bessa

    Citation: BMC Gastroenterology 2020 20:111

    Content type: Research article

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  45. There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should no...

    Authors: Shaojun Chen, Li Hua, Chengjun Feng, Qia Mo, Mengzhuan Wei, Yongqi Shen, Zhan Lin, Guisheng Li, Junyi Xu, Chengxian Guo and Haixin Huang

    Citation: BMC Gastroenterology 2020 20:96

    Content type: Research article

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  46. The database used for the NHS Bowel Cancer Screening Programme (BCSP) derives participant information from primary care records. Combining predictors with FOBTs has shown to improve referral decisions and accu...

    Authors: Jennifer Anne Cooper, Ronan Ryan, Nick Parsons, Chris Stinton, Tom Marshall and Sian Taylor-Phillips

    Citation: BMC Gastroenterology 2020 20:78

    Content type: Research article

    Published on:

  47. Gastrointestinal system (GIS) malignancy with pregnancy is a very rare condition and is not common outside Japan. The incidence is between 0.025–0.1% for each pregnancy. GIS malignancies are diagnosed late in ...

    Authors: Mustafa Yildiz, Yesim Akgun, Hale Ozer and Veli Mihmanli

    Citation: BMC Gastroenterology 2020 20:33

    Content type: Case report

    Published on:

  48. The association between natural killer (NK) cells and survival in colorectal cancer (CRC) patients remains controversial. This study aimed to clarify the prognostic value of peripheral blood NK cells in CRC pa...

    Authors: Yan-ping Tang, Ming-zhi Xie, Ke-zhi Li, Ji-lin Li, Zheng-min Cai and Bang-li Hu

    Citation: BMC Gastroenterology 2020 20:31

    Content type: Research article

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  49. The Asia-Pacific Colorectal Screening (APCS) score is effective to screen high-risk groups of advanced colorectal neoplasia (ACN) patients but needs revising and can be combined with the fecal immunochemical t...

    Authors: Xu-xia He, Si-yi Yuan, Wen-bin Li, Hong Yang, Wen Ji, Zhi-qiang Wang, Jian-yu Hao, Chuan Chen, Wei-qing Chen, Ying-xin Gao, Ling-bo Li, Kai-liang Cheng, Jia-ming Qian, Li Wang and Jing-nan Li

    Citation: BMC Gastroenterology 2019 19:226

    Content type: Research article

    Published on:

  50. Many patients present in primary care with lower bowel symptoms, but significant bowel disease (SBD), comprising colorectal cancer (CRC), advanced adenoma (AA), or inflammatory bowel disease (IBD), is uncommon...

    Authors: Jayne Digby, Judith A. Strachan, Craig Mowat, Robert J. C. Steele and Callum G. Fraser

    Citation: BMC Gastroenterology 2019 19:213

    Content type: Research article

    Published on:

    The Correspondence to this article has been published in BMC Gastroenterology 2020 20:231

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