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Colorectal cancer

Section edited by Arndt Vogel

This section concerns all aspects of colorectal cancer including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Clear evidence on the benefit-harm balance and cost effectiveness of population-based screening for colorectal cancer (CRC) is missing. We aim to systematically evaluate the long-term effectiveness, harms and ...

    Authors: Beate Jahn, Gaby Sroczynski, Marvin Bundo, Nikolai Mühlberger, Sibylle Puntscher, Jovan Todorovic, Ursula Rochau, Willi Oberaigner, Hendrik Koffijberg, Timo Fischer, Irmgard Schiller-Fruehwirth, Dietmar Öfner, Friedrich Renner, Michael Jonas, Monika Hackl, Monika Ferlitsch…

    Citation: BMC Gastroenterology 2019 19:209

    Content type: Research article

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  2. Hyperlipidaemia may be a potential risk factor for the occurrence of intestinal polyps. This study aimed to evaluate correlation between lipidaemia and the formation of colorectal polyps.

    Authors: Chenxi Xie, Pingwu Wen, Jingling Su, Qin Li, Yandan Ren, Yueyu Liu, Renze Shen and Jianlin Ren

    Citation: BMC Gastroenterology 2019 19:195

    Content type: Research article

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  3. Endoscopic mucosal resection (EMR) to remove colon polyps is increasingly common in patients taking antithrombotic agents. The safety of EMR with submucosal saline injection has not been clearly demonstrated i...

    Authors: Daisuke Yamaguchi, Hisako Yoshida, Kei Ikeda, Yuki Takeuchi, Shota Yamashita, Amane Jubashi, Takahiro Yukimoto, Eri Takeshita, Wataru Yoshioka, Hiroko Fukuda, Naoyuki Tominaga, Nanae Tsuruoka, Tomohito Morisaki, Keisuke Ario, Seiji Tsunada and Kazuma Fujimoto

    Citation: BMC Gastroenterology 2019 19:192

    Content type: Research article

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  4. High cecal intubation rate (CIR) is associated with significant improved adenoma detection rate (ADR), however, self-reported CIR may be overestimated and inadequate documentation of cecal intubation is associ...

    Authors: Martin Buerger, Philipp Kasper, Gabriel Allo, Johannes Gillessen and Christoph Schramm

    Citation: BMC Gastroenterology 2019 19:190

    Content type: Research article

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  5. Colorectal cancer (CRC) screening rates are low in the general population and among health care providers. The aim of this study was to evaluate the CRC screening practices of general surgeons who provide spec...

    Authors: Suleyman Utku Celik, Hasan Gorkem Cay, Ersin Bayrakdar, Aysima Ince, Esra Nur Ince, Yasemin Celik, Yunus Emre Yucel, Mehmet Ali Koc, Siyar Ersoz and Cihangir Akyol

    Citation: BMC Gastroenterology 2019 19:183

    Content type: Research article

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  6. Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations.

    Authors: Jiang Liu, Li Tang, Jinhua Yi, Guimei Li, Youwang Lu, Yu Xu, Shuhua Zhao, Rui Mao, Xiaolu Li, Li Ren and Kunhua Wang

    Citation: BMC Gastroenterology 2019 19:173

    Content type: Research article

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  7. Small nucleolar RNA host gene 6 (SNHG6) regulates diverse biological processes in cancers. Potential function of SNHG6 in human colon and rectal adenocarcinoma (CRC) was evaluated.

    Authors: Qianwen Shao, Jing Xu, Rong Deng, Wei Wei, Bing Zhou, Chao Yue, Miaoling Zhu and Haitao Zhu

    Citation: BMC Gastroenterology 2019 19:163

    Content type: Research article

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  8. The Fecal Occult Blood Test (FOBT) is one of the diagnostic modalities indicated for screening patients for Colorectal Cancer (CRC). Despite being approved only for screening for CRC, numerous studies in the p...

    Authors: Sarthak Soin, Olalekan Akanbi, Abdullah Ahmed, Yunha Kim, Sarbagya Pandit, Igor Wroblewski and Nasir Saleem

    Citation: BMC Gastroenterology 2019 19:161

    Content type: Research article

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  9. Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of MVD in stage II and III c...

    Authors: Sjoerd H. den Uil, Evert van den Broek, Veerle M. H. Coupé, Thomas T. Vellinga, Pien M. Delis-van Diemen, Herman Bril, Eric J. Th. Belt, Onno Kranenburg, Hein B. A. C. Stockmann, Jeroen A. M. Belien, Gerrit A. Meijer and Remond J. A. Fijneman

    Citation: BMC Gastroenterology 2019 19:146

    Content type: Research article

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  10. Reports showed adenoma miss rates (AMRs) of 22.5–27% in the right colon and 23.4–33.3% in the proximal colon. Missed lesions could contribute to postcolonoscopy cancers. Water exchange (WE) with near-complete ...

    Authors: Chi-Liang Cheng, Yen-Lin Kuo, Yu-Hsi Hsieh, Jui-Hsiang Tang and Felix W. Leung

    Citation: BMC Gastroenterology 2019 19:143

    Content type: Research article

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  11. The increasing life expectancy of individuals with Cystic Fibrosis (CF) is likely to be associated with new age-related challenges, colorectal cancer (CRC) most notably; recent consensus recommendations for CRC s...

    Authors: James M. Abraham, Kathleen Mahan, Tetyana Mettler, Jordan M. Dunitz and Alexander Khoruts

    Citation: BMC Gastroenterology 2019 19:137

    Content type: Case report

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  12. Our study aimed to determine the effect of probiotic consumption containing six viable microorganisms of 30 × 1010 cfu Lactobacillus and Bifidobacteria strains for six months on clinical outcomes and inflammatory...

    Authors: Liyana Zaharuddin, Norfilza Mohd Mokhtar, Khairul Najmi Muhammad Nawawi and Raja Affendi Raja Ali

    Citation: BMC Gastroenterology 2019 19:131

    Content type: Research article

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  13. Endoscopic mucosal resection (EMR) in piecemeal technique is the treatment standard for larger flat or sessile colorectal lesions. The method is burdened by a high recurrence rate mostly presenting as difficul...

    Authors: Annabell von Helden, Ralf Hildenbrand, Bernd Sido and Franz Ludwig Dumoulin

    Citation: BMC Gastroenterology 2019 19:121

    Content type: Research article

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  14. The effectiveness in surveillance colonoscopy largely depends on the quality of bowel preparation. We aimed to investigate the quality of bowel preparation segmentally and its effect on Adenoma Detection Rate ...

    Authors: Rui Guo, Yong-Jun Wang, Mo Liu, Jun Ge, Ling-Ye Zhang, Ling Ma, Wen-Yu Huang and Hui-Hong Zhai

    Citation: BMC Gastroenterology 2019 19:119

    Content type: Research article

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  15. Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population. Limited publications...

    Authors: A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson and S. C. Bell

    Citation: BMC Gastroenterology 2019 19:89

    Content type: Research article

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  16. Up to 30% of colorectal cancers develop through the serrated pathway. African Americans (AAs) suffer a disproportionate burden of colorectal cancer. The aim of this study was to evaluate clinicopathological fe...

    Authors: Mehdi Nouraie, Hassan Ashktorab, Nazli Atefi, Saman Azam, Taraneh Tarjoman, Edward Lee, Babak Shokrani, Ali Afsari, Akbar Soleimani, Adeyinka O. Laiyemo, Sanmeet Singh and Hassan Brim

    Citation: BMC Gastroenterology 2019 19:77

    Content type: Research article

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  17. Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to inves...

    Authors: Ming-zhi Xie, Ji-lin Li, Zheng-min Cai, Ke-zhi Li and Bang-li Hu

    Citation: BMC Gastroenterology 2019 19:46

    Content type: Research article

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  18. Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in...

    Authors: Jinsong Su, Jiajie Lai, Ruikun Yang, Bo Xu, Ying Zhu, Mingdong Zhao, Chen Yang and Guanzhao Liang

    Citation: BMC Gastroenterology 2019 19:17

    Content type: Research article

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  19. Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomat...

    Authors: ChangxiChen, Yushan Mao, Juan Du, Yimin Xu, Zhongwei Zhu and Hongbao Cao

    Citation: BMC Gastroenterology 2019 19:14

    Content type: Research article

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  20. Associations between colorectal cancer and microbiota have been identified. Archived fecal samples might be valuable sample sources for investigating causality in carcinogenesis and biomarkers discovery due to...

    Authors: Trine B. Rounge, Roger Meisal, Jan Inge Nordby, Ole Herman Ambur, Thomas de Lange and Geir Hoff

    Citation: BMC Gastroenterology 2018 18:171

    Content type: Research article

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  21. Symptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) upda...

    Authors: Jesús-Miguel Herrero, Pablo Vega, María Salve, Luis Bujanda and Joaquín Cubiella

    Citation: BMC Gastroenterology 2018 18:155

    Content type: Research article

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  22. Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypect...

    Authors: W. J. Tan, N. ZP. Ng, Y. D. Chen, Y. H. M. Chee, F. J. Foo, C. L. Tang and M. H. Chew

    Citation: BMC Gastroenterology 2018 18:133

    Content type: Research article

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  23. Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aim...

    Authors: Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida and Hiroshi Yoshida

    Citation: BMC Gastroenterology 2018 18:117

    Content type: Research article

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  24. The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for...

    Authors: Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

    Citation: BMC Gastroenterology 2018 18:77

    Content type: Research article

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  25. Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goa...

    Authors: Paul James, Mehdi Hegagi, Mae Hegagi, Lilia Antonova, Alaa Rostom, Catherine Dube, Sanjay Murthy, Rakesh Goel and Avijit Chatterjee

    Citation: BMC Gastroenterology 2018 18:73

    Content type: Research article

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  26. Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Authors: Darina Kohoutova, Jaroslav Pejchal and Jan Bures

    Citation: BMC Gastroenterology 2018 18:65

    Content type: Research article

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  27. Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

    Authors: Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Gastroenterology 2018 18:31

    Content type: Research article

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  28. In recent years, there has been growing concern about the overuse of colonoscopy (CC). Our objective was to evaluate the incidence rate and cumulative probability of having a potentially inadequate CC (PI-CC, ...

    Authors: Santiago Esteban, Ricardo Ricci, Sergio Terrasa and Karin Kopitowski

    Citation: BMC Gastroenterology 2017 17:162

    Content type: Research article

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  29. Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymo...

    Authors: Jonathan Barontini, Marco Antinucci, Sergio Tofanelli, Maurizio Cammalleri, Massimo Dal Monte, Federica Gemignani, Pavel Vodicka, Roberto Marangoni, Ludmila Vodickova, Juozas Kupcinskas, Veronika Vymetalkova, Asta Forsti, Federico Canzian, Angelika Stein, Victor Moreno, Nicola Mastrodonato…

    Citation: BMC Gastroenterology 2017 17:104

    Content type: Research article

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  30. The risk of colorectal cancer (CRC) varies around the world and between females and males. We aimed to compare the risk of CRC among immigrants to Ontario, Canada, to its general population.

    Authors: Lawrence Paszat, Rinku Sutradhar, Ying Liu, Nancy N. Baxter, Jill Tinmouth and Linda Rabeneck

    Citation: BMC Gastroenterology 2017 17:85

    Content type: Research article

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  31. Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this ...

    Authors: Stephanie Wong, Ilmars Lidums, Christophe Rosty, Andrew Ruszkiewicz, Susan Parry, Aung Ko Win, Yoko Tomita, Sina Vatandoust, Amanda Townsend, Dainik Patel, Jennifer E. Hardingham, David Roder, Eric Smith, Paul Drew, Julie Marker, Wendy Uylaki…

    Citation: BMC Gastroenterology 2017 17:56

    Content type: Research article

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  32. Limited data are available for advanced colorectal neoplasm in asymptomatic individuals aged 40–49 years. We aimed to identify risk factors and develop a simple prediction model for advanced colorectal neoplas...

    Authors: Yoo Mi Park, Hee Sun Kim, Jae Jun Park, Su Jung Baik, Young Hoon Youn, Jie-Hyun Kim and Hyojin Park

    Citation: BMC Gastroenterology 2017 17:7

    Content type: Research article

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  33. A multicentre cohort study was held in Morocco, designed to evaluate the quality of life of cancer patients. The aim of this paper is to report the assessment of the quality of life of early colorectal cancer ...

    Authors: Hind Mrabti, Mounia Amziren, Ibrahim ElGhissassi, Youssef Bensouda, Narjiss Berrada, Halima Abahssain, Saber Boutayeb, Samira El Fakir, Chakib Nejjari, Abdellatif Benider, Nawfel Mellas, Omar El Mesbahi, Maria Bennani, Rachid Bekkali, Ahmed Zidouh and Hassan Errihani

    Citation: BMC Gastroenterology 2016 16:131

    Content type: Research article

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  34. The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adul...

    Authors: Eugenia Shmidt, Vandana Nehra, Val Lowe and Amy S. Oxentenko

    Citation: BMC Gastroenterology 2016 16:125

    Content type: Research article

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  35. To assess public preferences for colorectal cancer (CRC) surveillance tests for intermediate-risk adenomas, using a hypothetical scenario.

    Authors: Bernardette Bonello, Alex Ghanouni, Harriet L. Bowyer, Eilidh MacRae, Wendy Atkin, Stephen P. Halloran, Jane Wardle and Christian von Wagner

    Citation: BMC Gastroenterology 2016 16:113

    Content type: Research article

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  36. Increasing morbidity and mortality from colorectal cancer is evident in recent years in the developing Asian nations. Particularly in Thailand and most neighbouring low-income countries, screening colonoscopy ...

    Authors: Bunchorn Siripongpreeda, Chulabhorn Mahidol, Navara Dusitanond, Tassanee Sriprayoon, Bunlung Muyphuag, Thaniya Sricharunrat, Narongchai Teerayatanakul, Watanya Chaiwong, Wipra Worasawate, Prassanee Sattayarungsee, Juthamas Sangthongdee, Jirapa Prarom, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak and Chirayu U. Auewarakul

    Citation: BMC Gastroenterology 2016 16:101

    Content type: Research article

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  37. Molecular studies suggest inhibition of colorectal mucosal polyamines (PAs) may be a promising approach to prevent colorectal cancer (CRC). Inhibition of ornithine decarboxylase (ODC) using low-dose eflornithi...

    Authors: Carol A. Burke, Evelien Dekker, N. Jewel Samadder, Elena Stoffel and Alfred Cohen

    Citation: BMC Gastroenterology 2016 16:87

    Content type: Study protocol

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  38. High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in bowel preparation quality through patient education. However, the effect of patient ...

    Authors: Jin-Seok Park, Min Su Kim, HyungKil Kim, Shin Il Kim, Chun Ho Shin, Hyun Jung Lee, Won Seop Lee and Soyoung Moon

    Citation: BMC Gastroenterology 2016 16:64

    Content type: Research article

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  39. Colorectal cancer (CRC) is the fourth leading cause of cancer-related death in Europe and the United States. Detecting the disease at an early stage improves outcomes. Risk prediction models which combine mult...

    Authors: Tom G. S. Williams, Joaquín Cubiella, Simon J. Griffin, Fiona M. Walter and Juliet A. Usher-Smith

    Citation: BMC Gastroenterology 2016 16:63

    Content type: Research article

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  40. Endoscopic mucosal resection (EMR) is currently the most used technique for resection of large distal colorectal polyps. However, in large lesions EMR can often only be performed in a piecemeal fashion resulti...

    Authors: Y. Backes, L. M. G. Moons, J. D. van Bergeijk, L. Berk, F. ter Borg, P. C. J. ter Borg, S. G. Elias, J. M. J. Geesing, J. N. Groen, M. Hadithi, J. C. H. Hardwick, M. Kerkhof, M. J. J. Mangen, J. W. A. Straathof, R. Schröder, M. P. Schwartz…

    Citation: BMC Gastroenterology 2016 16:56

    Content type: Study protocol

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  41. Incidence of anal carcinoma (AC) is increasing and timely diagnosis is critical for efficient therapy. However, there is a paucity of recent studies addressing clinical symptoms and physical findings of anal c...

    Authors: Matthias Sauter, Georg Keilholz, Helmut Kranzbühler, Norbert Lombriser, Meher Prakash, Stephan R. Vavricka and Benjamin Misselwitz

    Citation: BMC Gastroenterology 2016 16:46

    Content type: Research article

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  42. A clinical risk index employing age, sex, family history of colorectal cancer (CRC), smoking history and body mass index (BMI) may be useful for prioritizing screening with colonoscopy. The aim of this study w...

    Authors: Arlinda Ruco, David Stock, Robert J. Hilsden, S. Elizabeth McGregor, Lawrence F. Paszat, Refik Saskin and Linda Rabeneck

    Citation: BMC Gastroenterology 2015 15:162

    Content type: Research article

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  43. The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treat...

    Authors: Beatrix Bencsikova, Zbynek Bortlicek, Jana Halamkova, Lenka Ostrizkova, Igor Kiss, Bohuslav Melichar, Tomas Pavlik, Ladislav Dusek, Dalibor Valik, Rostislav Vyzula and Lenka Zdrazilova-Dubska

    Citation: BMC Gastroenterology 2015 15:37

    Content type: Research article

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  44. Colonoscopy offers limited protection against right-sided colon cancer, a significant proportion of which arise from the serrated pathway of carcinogenesis. The aim of this study was to compare cap-assisted co...

    Authors: Fadi Rzouq, Neil Gupta, Sachin Wani, Prateek Sharma, Ajay Bansal and Amit Rastogi

    Citation: BMC Gastroenterology 2015 15:11

    Content type: Research article

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  45. MicroRNA-21 (miR-21) is an oncogenic microRNA that regulates the expression of multiple cancer-related target genes. miR-21 has been associated with progression of some types of cancer. Metastasis-associated p...

    Authors: Won Kyung Kang, Jin Kwon Lee, Seong Taek Oh, Sung Hak Lee and Chan Kwon Jung

    Citation: BMC Gastroenterology 2015 15:2

    Content type: Research article

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  46. Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in a...

    Authors: Li-Chun Chang, Han-Mo Chiu, Chia-Tung Shun, Jin-Tung Liang, Jaw-Town Lin, Chien-Chuan Chen, Yi-Chia Lee and Ming-Shiang Wu

    Citation: BMC Gastroenterology 2014 14:221

    Content type: Research article

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  47. Faecal immunochemical tests (FITs) are commonly used in colorectal cancer (CRC) screening. Diagnostic accuracy of FIT differs between males and females. This so far unexplained difference could result in a dis...

    Authors: Sietze T van Turenhout, Frank A Oort, René WM van der Hulst, Arjen P Visscher, Jochim S Terhaar sive Droste, Pieter Scholten, Anneke A Bouman, Gerrit A Meijer, Chris JJ Mulder, Leo GM van Rossum and Veerle MH Coupé

    Citation: BMC Gastroenterology 2014 14:217

    Content type: Research article

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