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Colorectal cancer

Section edited by Arndt Vogel

This section concerns all aspects of colorectal cancer including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Several DNA viruses are highly suspicious to have oncogenic effects in humans. This study investigates the presence of potentially oncogenic viruses such as SV40, JCV, BKV and EBV in patient-derived colorectal...

    Authors: Michael Gock, Marcel Kordt, Stephanie Matschos, Christina S. Mullins and Michael Linnebacher

    Citation: BMC Gastroenterology 2020 20:260

    Content type: Research article

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  3. Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerous proliferating cells, has been used as a diagnostic biomarker for colorectal cancer...

    Authors: Farideh Rigi, Aliakbar Jannatabad, Azra Izanloo, Reza Roshanravan, Hamid Reza Hashemian and Mohammad Amin Kerachian

    Citation: BMC Gastroenterology 2020 20:241

    Content type: Research article

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  4. A recent study by Digby et al. in BMC Gastroenterology evaluated the faecal haemoglobin, age and sex test (FAST) score in the assessment of patients with lower bowel symptoms attended in primary healthcare. Th...

    Authors: Joaquín Cubiella

    Citation: BMC Gastroenterology 2020 20:231

    Content type: Correspondence

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    The original article was published in BMC Gastroenterology 2019 19:213

  5. In the recent years two innovative approaches have become available for minimally invasive en bloc resections of large non-pedunculated rectal lesions (polyps and early cancers). One is Transanal Minimally Invasi...

    Authors: Nik Dekkers, Jurjen J. Boonstra, Leon M. G. Moons, Roel Hompes, Barbara A. Bastiaansen, Jurriaan B. Tuynman, Arjun D. Koch, Bas L. A. M. Weusten, Apollo Pronk, Peter A. Neijenhuis, Marinke Westerterp, Wilbert B. van den Hout, Alexandra M. J. Langers, Jolein van der Kraan, Alaa Alkhalaf, Jonathan Y. L. Lai…

    Citation: BMC Gastroenterology 2020 20:225

    Content type: Study protocol

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  6. To compare the outcomes of modified endoscopic mucosal resection (m-EMR) and endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (NETs) and evaluate the value of endoscopic morphology class...

    Authors: Xiang-Yao Wang, Ning-Li Chai, En-Qiang Linghu, Shao-Tian Qiu, Long-Song Li, Jia-Le Zou, Jing-Yuan Xiang and Xing-Xing Li

    Citation: BMC Gastroenterology 2020 20:200

    Content type: Research article

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  7. En-bloc resection of large, flat dysplastic mucosal lesions of the luminal GI tract can be challenging. In order to improve the efficacy of resection for lesions ≥2 cm and to optimize R0 resection rates of les...

    Authors: A. Sportes, Jung CFM, M. A. Gromski, P. Koehler, A. Seif Amir Hosseini, P. Kauffmann, V. Ellenrieder and E. Wedi

    Citation: BMC Gastroenterology 2020 20:195

    Content type: Technical advance

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  9. Alternative splicing (AS) is an important mechanism of regulating eukaryotic gene expression. Understanding the most common AS events in colorectal cancer (CRC) will help developing diagnostic, prognostic or t...

    Authors: Haifeng Lian, Aili Wang, Yuanyuan Shen, Qian Wang, Zhenru Zhou, Ranran Zhang, Kun Li, Chengxia Liu and Hongtao Jia

    Citation: BMC Gastroenterology 2020 20:171

    Content type: Research article

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  10. Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and co...

    Authors: Xian Hua Gao, Juan Li, Zi Ye Zhao, Xiao Dong Xu, Yi Qi Du, Hong Li Yan, Lian Jie Liu, Chen Guang Bai and Wei Zhang

    Citation: BMC Gastroenterology 2020 20:167

    Content type: Case report

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  12. Colorectal cancer (CRC) is the second most common malignant disease and the second most common cause of cancer death in Germany. Official CRC screening starts at age 50. As there is evidence that individuals w...

    Authors: Sabine Hoffmann, Alexander Crispin, Doris Lindoerfer, Gaby Sroczynski, Uwe Siebert, Ulrich Mansmann and FARKOR Consortium

    Citation: BMC Gastroenterology 2020 20:131

    Content type: Study Protocol

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  13. The fecal immunochemical test (FIT) is the second most commonly used colorectal cancer (CRC) screening modality in the United States; yet, follow-up of abnormal FIT results with diagnostic colonoscopy is under...

    Authors: Vivy T. Cusumano, Edgar Corona, Diana Partida, Liu Yang, Christine Yu and Folasade P. May

    Citation: BMC Gastroenterology 2020 20:115

    Content type: Research article

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  14. It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not comp...

    Authors: Fausto Riu Pons, Montserrat Andreu, Dolores Naranjo, Marco Antonio Álvarez-González, Agustín Seoane, Josep Maria Dedeu, Luis Barranco and Xavier Bessa

    Citation: BMC Gastroenterology 2020 20:111

    Content type: Research article

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  15. There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should no...

    Authors: Shaojun Chen, Li Hua, Chengjun Feng, Qia Mo, Mengzhuan Wei, Yongqi Shen, Zhan Lin, Guisheng Li, Junyi Xu, Chengxian Guo and Haixin Huang

    Citation: BMC Gastroenterology 2020 20:96

    Content type: Research article

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  16. The database used for the NHS Bowel Cancer Screening Programme (BCSP) derives participant information from primary care records. Combining predictors with FOBTs has shown to improve referral decisions and accu...

    Authors: Jennifer Anne Cooper, Ronan Ryan, Nick Parsons, Chris Stinton, Tom Marshall and Sian Taylor-Phillips

    Citation: BMC Gastroenterology 2020 20:78

    Content type: Research article

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  17. Gastrointestinal system (GIS) malignancy with pregnancy is a very rare condition and is not common outside Japan. The incidence is between 0.025–0.1% for each pregnancy. GIS malignancies are diagnosed late in ...

    Authors: Mustafa Yildiz, Yesim Akgun, Hale Ozer and Veli Mihmanli

    Citation: BMC Gastroenterology 2020 20:33

    Content type: Case report

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  18. The association between natural killer (NK) cells and survival in colorectal cancer (CRC) patients remains controversial. This study aimed to clarify the prognostic value of peripheral blood NK cells in CRC pa...

    Authors: Yan-ping Tang, Ming-zhi Xie, Ke-zhi Li, Ji-lin Li, Zheng-min Cai and Bang-li Hu

    Citation: BMC Gastroenterology 2020 20:31

    Content type: Research article

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  19. The Asia-Pacific Colorectal Screening (APCS) score is effective to screen high-risk groups of advanced colorectal neoplasia (ACN) patients but needs revising and can be combined with the fecal immunochemical t...

    Authors: Xu-xia He, Si-yi Yuan, Wen-bin Li, Hong Yang, Wen Ji, Zhi-qiang Wang, Jian-yu Hao, Chuan Chen, Wei-qing Chen, Ying-xin Gao, Ling-bo Li, Kai-liang Cheng, Jia-ming Qian, Li Wang and Jing-nan Li

    Citation: BMC Gastroenterology 2019 19:226

    Content type: Research article

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  20. Many patients present in primary care with lower bowel symptoms, but significant bowel disease (SBD), comprising colorectal cancer (CRC), advanced adenoma (AA), or inflammatory bowel disease (IBD), is uncommon...

    Authors: Jayne Digby, Judith A. Strachan, Craig Mowat, Robert J. C. Steele and Callum G. Fraser

    Citation: BMC Gastroenterology 2019 19:213

    Content type: Research article

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    The Correspondence to this article has been published in BMC Gastroenterology 2020 20:231

  21. Clear evidence on the benefit-harm balance and cost effectiveness of population-based screening for colorectal cancer (CRC) is missing. We aim to systematically evaluate the long-term effectiveness, harms and ...

    Authors: Beate Jahn, Gaby Sroczynski, Marvin Bundo, Nikolai Mühlberger, Sibylle Puntscher, Jovan Todorovic, Ursula Rochau, Willi Oberaigner, Hendrik Koffijberg, Timo Fischer, Irmgard Schiller-Fruehwirth, Dietmar Öfner, Friedrich Renner, Michael Jonas, Monika Hackl, Monika Ferlitsch…

    Citation: BMC Gastroenterology 2019 19:209

    Content type: Research article

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  22. Hyperlipidaemia may be a potential risk factor for the occurrence of intestinal polyps. This study aimed to evaluate correlation between lipidaemia and the formation of colorectal polyps.

    Authors: Chenxi Xie, Pingwu Wen, Jingling Su, Qin Li, Yandan Ren, Yueyu Liu, Renze Shen and Jianlin Ren

    Citation: BMC Gastroenterology 2019 19:195

    Content type: Research article

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  23. Endoscopic mucosal resection (EMR) to remove colon polyps is increasingly common in patients taking antithrombotic agents. The safety of EMR with submucosal saline injection has not been clearly demonstrated i...

    Authors: Daisuke Yamaguchi, Hisako Yoshida, Kei Ikeda, Yuki Takeuchi, Shota Yamashita, Amane Jubashi, Takahiro Yukimoto, Eri Takeshita, Wataru Yoshioka, Hiroko Fukuda, Naoyuki Tominaga, Nanae Tsuruoka, Tomohito Morisaki, Keisuke Ario, Seiji Tsunada and Kazuma Fujimoto

    Citation: BMC Gastroenterology 2019 19:192

    Content type: Research article

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  24. High cecal intubation rate (CIR) is associated with significant improved adenoma detection rate (ADR), however, self-reported CIR may be overestimated and inadequate documentation of cecal intubation is associ...

    Authors: Martin Buerger, Philipp Kasper, Gabriel Allo, Johannes Gillessen and Christoph Schramm

    Citation: BMC Gastroenterology 2019 19:190

    Content type: Research article

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  25. Colorectal cancer (CRC) screening rates are low in the general population and among health care providers. The aim of this study was to evaluate the CRC screening practices of general surgeons who provide spec...

    Authors: Suleyman Utku Celik, Hasan Gorkem Cay, Ersin Bayrakdar, Aysima Ince, Esra Nur Ince, Yasemin Celik, Yunus Emre Yucel, Mehmet Ali Koc, Siyar Ersoz and Cihangir Akyol

    Citation: BMC Gastroenterology 2019 19:183

    Content type: Research article

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  26. Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations.

    Authors: Jiang Liu, Li Tang, Jinhua Yi, Guimei Li, Youwang Lu, Yu Xu, Shuhua Zhao, Rui Mao, Xiaolu Li, Li Ren and Kunhua Wang

    Citation: BMC Gastroenterology 2019 19:173

    Content type: Research article

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  28. Small nucleolar RNA host gene 6 (SNHG6) regulates diverse biological processes in cancers. Potential function of SNHG6 in human colon and rectal adenocarcinoma (CRC) was evaluated.

    Authors: Qianwen Shao, Jing Xu, Rong Deng, Wei Wei, Bing Zhou, Chao Yue, Miaoling Zhu and Haitao Zhu

    Citation: BMC Gastroenterology 2019 19:163

    Content type: Research article

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  29. The Fecal Occult Blood Test (FOBT) is one of the diagnostic modalities indicated for screening patients for Colorectal Cancer (CRC). Despite being approved only for screening for CRC, numerous studies in the p...

    Authors: Sarthak Soin, Olalekan Akanbi, Abdullah Ahmed, Yunha Kim, Sarbagya Pandit, Igor Wroblewski and Nasir Saleem

    Citation: BMC Gastroenterology 2019 19:161

    Content type: Research article

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  30. Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of MVD in stage II and III c...

    Authors: Sjoerd H. den Uil, Evert van den Broek, Veerle M. H. Coupé, Thomas T. Vellinga, Pien M. Delis-van Diemen, Herman Bril, Eric J. Th. Belt, Onno Kranenburg, Hein B. A. C. Stockmann, Jeroen A. M. Belien, Gerrit A. Meijer and Remond J. A. Fijneman

    Citation: BMC Gastroenterology 2019 19:146

    Content type: Research article

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  31. Reports showed adenoma miss rates (AMRs) of 22.5–27% in the right colon and 23.4–33.3% in the proximal colon. Missed lesions could contribute to postcolonoscopy cancers. Water exchange (WE) with near-complete ...

    Authors: Chi-Liang Cheng, Yen-Lin Kuo, Yu-Hsi Hsieh, Jui-Hsiang Tang and Felix W. Leung

    Citation: BMC Gastroenterology 2019 19:143

    Content type: Research article

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  32. The increasing life expectancy of individuals with Cystic Fibrosis (CF) is likely to be associated with new age-related challenges, colorectal cancer (CRC) most notably; recent consensus recommendations for CRC s...

    Authors: James M. Abraham, Kathleen Mahan, Tetyana Mettler, Jordan M. Dunitz and Alexander Khoruts

    Citation: BMC Gastroenterology 2019 19:137

    Content type: Case report

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  33. Our study aimed to determine the effect of probiotic consumption containing six viable microorganisms of 30 × 1010 cfu Lactobacillus and Bifidobacteria strains for six months on clinical outcomes and inflammatory...

    Authors: Liyana Zaharuddin, Norfilza Mohd Mokhtar, Khairul Najmi Muhammad Nawawi and Raja Affendi Raja Ali

    Citation: BMC Gastroenterology 2019 19:131

    Content type: Research article

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  34. Endoscopic mucosal resection (EMR) in piecemeal technique is the treatment standard for larger flat or sessile colorectal lesions. The method is burdened by a high recurrence rate mostly presenting as difficul...

    Authors: Annabell von Helden, Ralf Hildenbrand, Bernd Sido and Franz Ludwig Dumoulin

    Citation: BMC Gastroenterology 2019 19:121

    Content type: Research article

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  35. The effectiveness in surveillance colonoscopy largely depends on the quality of bowel preparation. We aimed to investigate the quality of bowel preparation segmentally and its effect on Adenoma Detection Rate ...

    Authors: Rui Guo, Yong-Jun Wang, Mo Liu, Jun Ge, Ling-Ye Zhang, Ling Ma, Wen-Yu Huang and Hui-Hong Zhai

    Citation: BMC Gastroenterology 2019 19:119

    Content type: Research article

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  36. Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population. Limited publications...

    Authors: A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson and S. C. Bell

    Citation: BMC Gastroenterology 2019 19:89

    Content type: Research article

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  37. Up to 30% of colorectal cancers develop through the serrated pathway. African Americans (AAs) suffer a disproportionate burden of colorectal cancer. The aim of this study was to evaluate clinicopathological fe...

    Authors: Mehdi Nouraie, Hassan Ashktorab, Nazli Atefi, Saman Azam, Taraneh Tarjoman, Edward Lee, Babak Shokrani, Ali Afsari, Akbar Soleimani, Adeyinka O. Laiyemo, Sanmeet Singh and Hassan Brim

    Citation: BMC Gastroenterology 2019 19:77

    Content type: Research article

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  38. Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to inves...

    Authors: Ming-zhi Xie, Ji-lin Li, Zheng-min Cai, Ke-zhi Li and Bang-li Hu

    Citation: BMC Gastroenterology 2019 19:46

    Content type: Research article

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  39. Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in...

    Authors: Jinsong Su, Jiajie Lai, Ruikun Yang, Bo Xu, Ying Zhu, Mingdong Zhao, Chen Yang and Guanzhao Liang

    Citation: BMC Gastroenterology 2019 19:17

    Content type: Research article

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  40. Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomat...

    Authors: ChangxiChen, Yushan Mao, Juan Du, Yimin Xu, Zhongwei Zhu and Hongbao Cao

    Citation: BMC Gastroenterology 2019 19:14

    Content type: Research article

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  41. Associations between colorectal cancer and microbiota have been identified. Archived fecal samples might be valuable sample sources for investigating causality in carcinogenesis and biomarkers discovery due to...

    Authors: Trine B. Rounge, Roger Meisal, Jan Inge Nordby, Ole Herman Ambur, Thomas de Lange and Geir Hoff

    Citation: BMC Gastroenterology 2018 18:171

    Content type: Research article

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  42. Symptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) upda...

    Authors: Jesús-Miguel Herrero, Pablo Vega, María Salve, Luis Bujanda and Joaquín Cubiella

    Citation: BMC Gastroenterology 2018 18:155

    Content type: Research article

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  43. Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypect...

    Authors: W. J. Tan, N. ZP. Ng, Y. D. Chen, Y. H. M. Chee, F. J. Foo, C. L. Tang and M. H. Chew

    Citation: BMC Gastroenterology 2018 18:133

    Content type: Research article

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  44. Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aim...

    Authors: Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida and Hiroshi Yoshida

    Citation: BMC Gastroenterology 2018 18:117

    Content type: Research article

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  46. The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for...

    Authors: Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

    Citation: BMC Gastroenterology 2018 18:77

    Content type: Research article

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  47. Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goa...

    Authors: Paul James, Mehdi Hegagi, Mae Hegagi, Lilia Antonova, Alaa Rostom, Catherine Dube, Sanjay Murthy, Rakesh Goel and Avijit Chatterjee

    Citation: BMC Gastroenterology 2018 18:73

    Content type: Research article

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  48. Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Authors: Darina Kohoutova, Jaroslav Pejchal and Jan Bures

    Citation: BMC Gastroenterology 2018 18:65

    Content type: Research article

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  49. Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

    Authors: Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Gastroenterology 2018 18:31

    Content type: Research article

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  50. In recent years, there has been growing concern about the overuse of colonoscopy (CC). Our objective was to evaluate the incidence rate and cumulative probability of having a potentially inadequate CC (PI-CC, ...

    Authors: Santiago Esteban, Ricardo Ricci, Sergio Terrasa and Karin Kopitowski

    Citation: BMC Gastroenterology 2017 17:162

    Content type: Research article

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