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Colorectal cancer

Section edited by Arndt Vogel

This section concerns all aspects of colorectal cancer including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Content type: Research article

    Small nucleolar RNA host gene 6 (SNHG6) regulates diverse biological processes in cancers. Potential function of SNHG6 in human colon and rectal adenocarcinoma (CRC) was evaluated.

    Authors: Qianwen Shao, Jing Xu, Rong Deng, Wei Wei, Bing Zhou, Chao Yue, Miaoling Zhu and Haitao Zhu

    Citation: BMC Gastroenterology 2019 19:163

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  2. Content type: Research article

    The Fecal Occult Blood Test (FOBT) is one of the diagnostic modalities indicated for screening patients for Colorectal Cancer (CRC). Despite being approved only for screening for CRC, numerous studies in the p...

    Authors: Sarthak Soin, Olalekan Akanbi, Abdullah Ahmed, Yunha Kim, Sarbagya Pandit, Igor Wroblewski and Nasir Saleem

    Citation: BMC Gastroenterology 2019 19:161

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  3. Content type: Research article

    Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of MVD in stage II and III c...

    Authors: Sjoerd H. den Uil, Evert van den Broek, Veerle M. H. Coupé, Thomas T. Vellinga, Pien M. Delis-van Diemen, Herman Bril, Eric J. Th. Belt, Onno Kranenburg, Hein B. A. C. Stockmann, Jeroen A. M. Belien, Gerrit A. Meijer and Remond J. A. Fijneman

    Citation: BMC Gastroenterology 2019 19:146

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  4. Content type: Research article

    Reports showed adenoma miss rates (AMRs) of 22.5–27% in the right colon and 23.4–33.3% in the proximal colon. Missed lesions could contribute to postcolonoscopy cancers. Water exchange (WE) with near-complete ...

    Authors: Chi-Liang Cheng, Yen-Lin Kuo, Yu-Hsi Hsieh, Jui-Hsiang Tang and Felix W. Leung

    Citation: BMC Gastroenterology 2019 19:143

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  5. Content type: Case report

    The increasing life expectancy of individuals with Cystic Fibrosis (CF) is likely to be associated with new age-related challenges, colorectal cancer (CRC) most notably; recent consensus recommendations for CRC s...

    Authors: James M. Abraham, Kathleen Mahan, Tetyana Mettler, Jordan M. Dunitz and Alexander Khoruts

    Citation: BMC Gastroenterology 2019 19:137

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  6. Content type: Research article

    Our study aimed to determine the effect of probiotic consumption containing six viable microorganisms of 30 × 1010 cfu Lactobacillus and Bifidobacteria strains for six months on clinical outcomes and inflammatory...

    Authors: Liyana Zaharuddin, Norfilza Mohd Mokhtar, Khairul Najmi Muhammad Nawawi and Raja Affendi Raja Ali

    Citation: BMC Gastroenterology 2019 19:131

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  7. Content type: Research article

    Endoscopic mucosal resection (EMR) in piecemeal technique is the treatment standard for larger flat or sessile colorectal lesions. The method is burdened by a high recurrence rate mostly presenting as difficul...

    Authors: Annabell von Helden, Ralf Hildenbrand, Bernd Sido and Franz Ludwig Dumoulin

    Citation: BMC Gastroenterology 2019 19:121

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  8. Content type: Research article

    The effectiveness in surveillance colonoscopy largely depends on the quality of bowel preparation. We aimed to investigate the quality of bowel preparation segmentally and its effect on Adenoma Detection Rate ...

    Authors: Rui Guo, Yong-Jun Wang, Mo Liu, Jun Ge, Ling-Ye Zhang, Ling Ma, Wen-Yu Huang and Hui-Hong Zhai

    Citation: BMC Gastroenterology 2019 19:119

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  9. Content type: Research article

    Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population. Limited publications...

    Authors: A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson and S. C. Bell

    Citation: BMC Gastroenterology 2019 19:89

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  10. Content type: Research article

    Up to 30% of colorectal cancers develop through the serrated pathway. African Americans (AAs) suffer a disproportionate burden of colorectal cancer. The aim of this study was to evaluate clinicopathological fe...

    Authors: Mehdi Nouraie, Hassan Ashktorab, Nazli Atefi, Saman Azam, Taraneh Tarjoman, Edward Lee, Babak Shokrani, Ali Afsari, Akbar Soleimani, Adeyinka O. Laiyemo, Sanmeet Singh and Hassan Brim

    Citation: BMC Gastroenterology 2019 19:77

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  11. Content type: Research article

    Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to inves...

    Authors: Ming-zhi Xie, Ji-lin Li, Zheng-min Cai, Ke-zhi Li and Bang-li Hu

    Citation: BMC Gastroenterology 2019 19:46

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  12. Content type: Research article

    Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in...

    Authors: Jinsong Su, Jiajie Lai, Ruikun Yang, Bo Xu, Ying Zhu, Mingdong Zhao, Chen Yang and Guanzhao Liang

    Citation: BMC Gastroenterology 2019 19:17

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  13. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomat...

    Authors: ChangxiChen, Yushan Mao, Juan Du, Yimin Xu, Zhongwei Zhu and Hongbao Cao

    Citation: BMC Gastroenterology 2019 19:14

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  14. Content type: Research article

    Associations between colorectal cancer and microbiota have been identified. Archived fecal samples might be valuable sample sources for investigating causality in carcinogenesis and biomarkers discovery due to...

    Authors: Trine B. Rounge, Roger Meisal, Jan Inge Nordby, Ole Herman Ambur, Thomas de Lange and Geir Hoff

    Citation: BMC Gastroenterology 2018 18:171

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  15. Content type: Research article

    Symptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) upda...

    Authors: Jesús-Miguel Herrero, Pablo Vega, María Salve, Luis Bujanda and Joaquín Cubiella

    Citation: BMC Gastroenterology 2018 18:155

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  16. Content type: Research article

    Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypect...

    Authors: W. J. Tan, N. ZP. Ng, Y. D. Chen, Y. H. M. Chee, F. J. Foo, C. L. Tang and M. H. Chew

    Citation: BMC Gastroenterology 2018 18:133

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  17. Content type: Research article

    Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aim...

    Authors: Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida and Hiroshi Yoshida

    Citation: BMC Gastroenterology 2018 18:117

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  18. Content type: Research article

    The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for...

    Authors: Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

    Citation: BMC Gastroenterology 2018 18:77

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  19. Content type: Research article

    Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goa...

    Authors: Paul James, Mehdi Hegagi, Mae Hegagi, Lilia Antonova, Alaa Rostom, Catherine Dube, Sanjay Murthy, Rakesh Goel and Avijit Chatterjee

    Citation: BMC Gastroenterology 2018 18:73

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  20. Content type: Research article

    Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Authors: Darina Kohoutova, Jaroslav Pejchal and Jan Bures

    Citation: BMC Gastroenterology 2018 18:65

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  21. Content type: Research article

    Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

    Authors: Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Gastroenterology 2018 18:31

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  22. Content type: Research article

    In recent years, there has been growing concern about the overuse of colonoscopy (CC). Our objective was to evaluate the incidence rate and cumulative probability of having a potentially inadequate CC (PI-CC, ...

    Authors: Santiago Esteban, Ricardo Ricci, Sergio Terrasa and Karin Kopitowski

    Citation: BMC Gastroenterology 2017 17:162

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  23. Content type: Research article

    Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymo...

    Authors: Jonathan Barontini, Marco Antinucci, Sergio Tofanelli, Maurizio Cammalleri, Massimo Dal Monte, Federica Gemignani, Pavel Vodicka, Roberto Marangoni, Ludmila Vodickova, Juozas Kupcinskas, Veronika Vymetalkova, Asta Forsti, Federico Canzian, Angelika Stein, Victor Moreno, Nicola Mastrodonato…

    Citation: BMC Gastroenterology 2017 17:104

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  24. Content type: Research article

    The risk of colorectal cancer (CRC) varies around the world and between females and males. We aimed to compare the risk of CRC among immigrants to Ontario, Canada, to its general population.

    Authors: Lawrence Paszat, Rinku Sutradhar, Ying Liu, Nancy N. Baxter, Jill Tinmouth and Linda Rabeneck

    Citation: BMC Gastroenterology 2017 17:85

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  25. Content type: Research article

    Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this ...

    Authors: Stephanie Wong, Ilmars Lidums, Christophe Rosty, Andrew Ruszkiewicz, Susan Parry, Aung Ko Win, Yoko Tomita, Sina Vatandoust, Amanda Townsend, Dainik Patel, Jennifer E. Hardingham, David Roder, Eric Smith, Paul Drew, Julie Marker, Wendy Uylaki…

    Citation: BMC Gastroenterology 2017 17:56

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  26. Content type: Research article

    Limited data are available for advanced colorectal neoplasm in asymptomatic individuals aged 40–49 years. We aimed to identify risk factors and develop a simple prediction model for advanced colorectal neoplas...

    Authors: Yoo Mi Park, Hee Sun Kim, Jae Jun Park, Su Jung Baik, Young Hoon Youn, Jie-Hyun Kim and Hyojin Park

    Citation: BMC Gastroenterology 2017 17:7

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  27. Content type: Research article

    A multicentre cohort study was held in Morocco, designed to evaluate the quality of life of cancer patients. The aim of this paper is to report the assessment of the quality of life of early colorectal cancer ...

    Authors: Hind Mrabti, Mounia Amziren, Ibrahim ElGhissassi, Youssef Bensouda, Narjiss Berrada, Halima Abahssain, Saber Boutayeb, Samira El Fakir, Chakib Nejjari, Abdellatif Benider, Nawfel Mellas, Omar El Mesbahi, Maria Bennani, Rachid Bekkali, Ahmed Zidouh and Hassan Errihani

    Citation: BMC Gastroenterology 2016 16:131

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  28. Content type: Research article

    The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adul...

    Authors: Eugenia Shmidt, Vandana Nehra, Val Lowe and Amy S. Oxentenko

    Citation: BMC Gastroenterology 2016 16:125

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  29. Content type: Research article

    To assess public preferences for colorectal cancer (CRC) surveillance tests for intermediate-risk adenomas, using a hypothetical scenario.

    Authors: Bernardette Bonello, Alex Ghanouni, Harriet L. Bowyer, Eilidh MacRae, Wendy Atkin, Stephen P. Halloran, Jane Wardle and Christian von Wagner

    Citation: BMC Gastroenterology 2016 16:113

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  30. Content type: Research article

    Increasing morbidity and mortality from colorectal cancer is evident in recent years in the developing Asian nations. Particularly in Thailand and most neighbouring low-income countries, screening colonoscopy ...

    Authors: Bunchorn Siripongpreeda, Chulabhorn Mahidol, Navara Dusitanond, Tassanee Sriprayoon, Bunlung Muyphuag, Thaniya Sricharunrat, Narongchai Teerayatanakul, Watanya Chaiwong, Wipra Worasawate, Prassanee Sattayarungsee, Juthamas Sangthongdee, Jirapa Prarom, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak and Chirayu U. Auewarakul

    Citation: BMC Gastroenterology 2016 16:101

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  31. Content type: Study protocol

    Molecular studies suggest inhibition of colorectal mucosal polyamines (PAs) may be a promising approach to prevent colorectal cancer (CRC). Inhibition of ornithine decarboxylase (ODC) using low-dose eflornithi...

    Authors: Carol A. Burke, Evelien Dekker, N. Jewel Samadder, Elena Stoffel and Alfred Cohen

    Citation: BMC Gastroenterology 2016 16:87

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  32. Content type: Research article

    High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in bowel preparation quality through patient education. However, the effect of patient ...

    Authors: Jin-Seok Park, Min Su Kim, HyungKil Kim, Shin Il Kim, Chun Ho Shin, Hyun Jung Lee, Won Seop Lee and Soyoung Moon

    Citation: BMC Gastroenterology 2016 16:64

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  33. Content type: Research article

    Colorectal cancer (CRC) is the fourth leading cause of cancer-related death in Europe and the United States. Detecting the disease at an early stage improves outcomes. Risk prediction models which combine mult...

    Authors: Tom G. S. Williams, Joaquín Cubiella, Simon J. Griffin, Fiona M. Walter and Juliet A. Usher-Smith

    Citation: BMC Gastroenterology 2016 16:63

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  34. Content type: Study protocol

    Endoscopic mucosal resection (EMR) is currently the most used technique for resection of large distal colorectal polyps. However, in large lesions EMR can often only be performed in a piecemeal fashion resulti...

    Authors: Y. Backes, L. M. G. Moons, J. D. van Bergeijk, L. Berk, F. ter Borg, P. C. J. ter Borg, S. G. Elias, J. M. J. Geesing, J. N. Groen, M. Hadithi, J. C. H. Hardwick, M. Kerkhof, M. J. J. Mangen, J. W. A. Straathof, R. Schröder, M. P. Schwartz…

    Citation: BMC Gastroenterology 2016 16:56

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  35. Content type: Research article

    Incidence of anal carcinoma (AC) is increasing and timely diagnosis is critical for efficient therapy. However, there is a paucity of recent studies addressing clinical symptoms and physical findings of anal c...

    Authors: Matthias Sauter, Georg Keilholz, Helmut Kranzbühler, Norbert Lombriser, Meher Prakash, Stephan R. Vavricka and Benjamin Misselwitz

    Citation: BMC Gastroenterology 2016 16:46

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  36. Content type: Research article

    A clinical risk index employing age, sex, family history of colorectal cancer (CRC), smoking history and body mass index (BMI) may be useful for prioritizing screening with colonoscopy. The aim of this study w...

    Authors: Arlinda Ruco, David Stock, Robert J. Hilsden, S. Elizabeth McGregor, Lawrence F. Paszat, Refik Saskin and Linda Rabeneck

    Citation: BMC Gastroenterology 2015 15:162

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  37. Content type: Research article

    The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treat...

    Authors: Beatrix Bencsikova, Zbynek Bortlicek, Jana Halamkova, Lenka Ostrizkova, Igor Kiss, Bohuslav Melichar, Tomas Pavlik, Ladislav Dusek, Dalibor Valik, Rostislav Vyzula and Lenka Zdrazilova-Dubska

    Citation: BMC Gastroenterology 2015 15:37

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  38. Content type: Research article

    Colonoscopy offers limited protection against right-sided colon cancer, a significant proportion of which arise from the serrated pathway of carcinogenesis. The aim of this study was to compare cap-assisted co...

    Authors: Fadi Rzouq, Neil Gupta, Sachin Wani, Prateek Sharma, Ajay Bansal and Amit Rastogi

    Citation: BMC Gastroenterology 2015 15:11

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  39. Content type: Research article

    MicroRNA-21 (miR-21) is an oncogenic microRNA that regulates the expression of multiple cancer-related target genes. miR-21 has been associated with progression of some types of cancer. Metastasis-associated p...

    Authors: Won Kyung Kang, Jin Kwon Lee, Seong Taek Oh, Sung Hak Lee and Chan Kwon Jung

    Citation: BMC Gastroenterology 2015 15:2

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  40. Content type: Research article

    Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in a...

    Authors: Li-Chun Chang, Han-Mo Chiu, Chia-Tung Shun, Jin-Tung Liang, Jaw-Town Lin, Chien-Chuan Chen, Yi-Chia Lee and Ming-Shiang Wu

    Citation: BMC Gastroenterology 2014 14:221

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  41. Content type: Research article

    Faecal immunochemical tests (FITs) are commonly used in colorectal cancer (CRC) screening. Diagnostic accuracy of FIT differs between males and females. This so far unexplained difference could result in a dis...

    Authors: Sietze T van Turenhout, Frank A Oort, René WM van der Hulst, Arjen P Visscher, Jochim S Terhaar sive Droste, Pieter Scholten, Anneke A Bouman, Gerrit A Meijer, Chris JJ Mulder, Leo GM van Rossum and Veerle MH Coupé

    Citation: BMC Gastroenterology 2014 14:217

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  42. Content type: Research article

    Obesity and related metabolic abnormalities, including excess oxidative stress and chronic inflammation, are associated with colorectal carcinogenesis. Astaxanthin, a xanthophyll carotenoid found in aquatic an...

    Authors: Takahiro Kochi, Masahito Shimizu, Takafumi Sumi, Masaya Kubota, Yohei Shirakami, Takuji Tanaka and Hisataka Moriwaki

    Citation: BMC Gastroenterology 2014 14:212

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  43. Content type: Research article

    The incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations ...

    Authors: Tomohiro Miwata, Toru Hiyama, Duc Trong Quach, Huy Minh Le, Ha Ngoc Thi Hua, Shiro Oka, Shinji Tanaka, Koji Arihiro and Kazuaki Chayama

    Citation: BMC Gastroenterology 2014 14:203

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  44. Content type: Research article

    Data on the quality of colonoscopies in populations with rising colorectal cancer (CRC) incidence is scarce. We aimed to calculate the adenoma detection rates (ADR), and assess the quality of colonoscopies in ...

    Authors: Alireza Delavari, Faraz Bishehsari, Hamideh Salimzadeh, Pejman Khosravi, Farnaz Delavari, Siavosh Nasseri-Moghaddam, Shahin Merat, Reza Ansari, Homayoon Vahedi, Bijan Shahbazkhani, Mehdi Saberifiroozi, Masoud Sotoudeh and Reza Malekzadeh

    Citation: BMC Gastroenterology 2014 14:196

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  45. Content type: Research article

    Metabolic factors have been reported to increase the prevalence of colorectal adenomas, however, whether metabolic factors might also accelerate the recurrence after removal of adenomas has not yet been discus...

    Authors: Leo Taniguchi, Takuma Higurashi, Takashi Uchiyama, Yoshinobu Kondo, Eri Uchida, Shiori Uchiyama, Fumitake Jono, Jun Hamanaka, Hitoshi Kuriyama, Yasuo Hata, Hiroki Endo, Hirokazu Takahashi, Hajime Nagase, Nobuyuki Matsuhashi and Atsushi Nakajima

    Citation: BMC Gastroenterology 2014 14:187

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  46. Content type: Research article

    Despite strong recommendations for colorectal cancer (CRC) screening, participation rates are low. Understanding factors that affect screening choices is essential to developing future screening strategies. Th...

    Authors: Andreas Adler, Sebastian Geiger, Anne Keil, Harald Bias, Philipp Schatz, Theo deVos, Jens Dhein, Mathias Zimmermann, Rudolf Tauber and Bertram Wiedenmann

    Citation: BMC Gastroenterology 2014 14:183

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  47. Content type: Research article

    Laparoscopy-assisted low anterior resection (LAR) of colorectal cancer, using a posterior surgical approach, is a difficult and controversial procedure to perform. We report successful operations on 13 patient...

    Authors: Hao Qu, Yan-Fu Du, Min-Zhe Li, Yu-Dong Zhang and Jian Shen

    Citation: BMC Gastroenterology 2014 14:158

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