Common laboratory blood test immune panel markers are useful for grading ulcerative colitis endoscopic severity

BMC Gastroenterology

Table 4 Intra-group comparisons of laboratory parameters of UC patients in MES-E3

Parameters	0–1 point	2 point	3 point	p Value	Intra-group
Parameters	0–1 point	2 point	3 point	p Value	1 versus 2	1 versus 3	2 versus 3
Age (years)	47.8 ± 14.3	45.2 ± 14.4	45.5 ± 14.0	0.560
Gender (F/M)*	21/27	42/56	43/57	0.995
Smoking (Y/N)*	8/40	18/80	11/89	0.329
BMI (kg/m²)	22.90 ± 4.42	21.55 ± 3.75	21.30 ± 3.76	0.059
Duration (month)	42.00 (108)	30.00 (76)	30.00 (72)	0.186
hs-CRP (mg/L)	2.34 (2.60)	10.10 (15.64)	32.20 (61.00)	< 0.001	< 0.001	< 0.001	< 0.001
IL-6 (pg/ml)	5.39 (4.41)	10.68 (16.05)	27.60 (34.64)	< 0.001	< 0.001	< 0.001	< 0.001
ESR (mm/h)	12.50(15.50)	28.00(33.30)	45.50(29.00)	< 0.001	< 0.001	< 0.001	< 0.001
ALB (g/L)	40.49 (5.22)	37.80 (7.43)	31.63 (8.20)	< 0.001	< 0.001	< 0.001	0.007
CAR	0.06 (0.07)	0.27 (0.47)	1.07 (1.97)	< 0.001	< 0.001	< 0.001	< 0.001
WBC (10⁹/L)	5.92 ± 1.87	7.81 ± 3.07	8.55 ± 3.69	< 0.001	0.002	< 0.001	0.300
Hb (g/L)	139.5 (34.0)	124.0 (32.0)	106.5 (38.0)	< 0.001	< 0.001	< 0.001	0.082
PLT (10⁹/L)	236.4 ± 82.2	314.5 ± 102.9	391.0 ± 106.6	< 0.001	< 0.001	< 0.001	< 0.001
Neutrophil (10⁹/L)	3.28 ± 1.19	4.53 ± 1.79	5.09 ± 1.82	< 0.001	< 0.001	< 0.001	0.066
Lymphocyte (10⁹/L)	1.87 (0.93)	1.86 (0.74)	1.68 (0.97)	0.021	1.000	0.059	0.061
Monocyte (10⁹/L)	0.40 (0.18)	0.60 (0.35)	0.69 (0.36)	< 0.001	< 0.001	< 0.001	0.526
MPV (fL)	10.69 ± 1.18	9.50 ± 0.95	8.94 ± 1.16	< 0.001	< 0.001	< 0.001	< 0.001
NLR	1.50 (1.33)	2.26 (1.65)	3.01 (2.00)	< 0.001	0.001	< 0.001	0.003
LMR	4.86 (3.00)	3.30 (1.93)	2.59 (1.54)	< 0.001	< 0.001	< 0.001	0.013
PLR	122.1 (69.0)	161.2 (66.8)	231.8 (120.5)	< 0.001	0.001	< 0.001	< 0.001

UC ulcerative colitis, BMI body mass index, hs-CRP high sensitivity C-reactive protein, IL-6 interleukin 6, ESR erythrocyte sedimentation rate, ALB albumin, CAR C reactive protein to albumin ratio, WBC white blood cells, Hb hemoglobin, PLT platelet, MPV mean platelet volume, NLR neutrophil to lymphocyte ratio, LMR lymphocyte to monocyte ratio, PLR platelet to lymphocyte ratio. Values are expressed as mean ± SD or median (IQR). 1 versus 2: 0–1 point group versus 2 ponit group. 1 versus 3: 0–1 point group versus 3 ponit group. 2 versus 3: 2 point group versus 3 ponit group. There is no statistical difference between the 0 point and 1 point group (p > 0.05)

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