Common laboratory blood test immune panel markers are useful for grading ulcerative colitis endoscopic severity

BMC Gastroenterology

Table 3 Intra-group comparisons of laboratory parameters of UC patients in MES-All

Parameters	0–1 Point	2 Point	3 Point	p Value	Intra-group
Parameters	0–1 Point	2 Point	3 Point	p Value	1 versus 2	1 versus 3	2 versus 3
Age (years)	47.4 ± 13.9	45.6 ± 13.0	44.8 ± 14.1	0.355
Gender (F/M)	48/57	72/92	47/70	0.691
Smoking (Y/N)	14/91	25/139	13/104	0.606
BMI (kg/m²)	22.38 ± 4.27	22.13 ± 3.85	21.45 ± 3.73	0.181
Duration (month)	36 (72)	36 (69)	36 (60)	0.568
hs-CRP (mg/L)	2.64 (3.18)	8.42 (8.80)	29.80 (49.22)	< 0.001	< 0.001	< 0.001	< 0.001
IL-6 (pg/ml)	5.69 (5.36)	9.56 (11.02)	26.42 (37.00)	< 0.001	< 0.001	< 0.001	< 0.001
ESR (mm/h)	11.00 (12.00)	24.00 (25.50)	42.00 (30.00)	< 0.001	< 0.001	< 0.001	< 0.001
ALB (g/L)	40.26 (5.81)	39.32 (7.65)	32.69 (9.16)	< 0.001	< 0.001	< 0.001	0.021
CAR	0.06 (0.08)	0.22 (0.26)	0.97 (2.00)	< 0.001	< 0.001	< 0.001	< 0.001
WBC (10⁹/L)	6.03 ± 2.00	7.25 ± 2.72	8.44 ± 3.54	< 0.001	0.002	< 0.001	0.002
Hb (g/L)	135.0 (30.0)	127.0 (36.0)	109.0 (43.0)	< 0.001	< 0.001	< 0.001	0.025
PLT (10⁹/L)	239.6 ± 79.2	306.4 ± 96.3	382.4 ± 106.1	< 0.001	< 0.001	< 0.001	< 0.001
Neutrophil (10⁹/L)	3.24 ± 1.15	4.21 ± 1.63	5.02 ± 1.78	< 0.001	< 0.001	< 0.001	< 0.001
Lymphocyte (10⁹/L)	1.90 (0.82)	1.79 (0.89)	1.68 (0.94)	0.004	0.128	0.003	0.360
Monocyte (10⁹/L)	0.40 (0.19)	0.56 (0.30)	0.68 (0.35)	< 0.001	< 0.001	< 0.001	0.007
MPV (fL)	10.39 ± 1.24	9.70 ± 0.93	9.01 ± 1.14	< 0.001	< 0.001	< 0.001	< 0.001
NLR	1.52 (1.02)	2.20 (1.44)	2.98 (2.08)	< 0.001	< 0.001	< 0.001	< 0.001
LMR	4.77 (2.32)	3.52 (1.78)	2.60 (1.53)	< 0.001	< 0.001	< 0.001	< 0.001
PLR	117.9 (61.4)	161.9 (74.3)	228.1 (128.2)	< 0.001	< 0.001	< 0.001	< 0.001

UC ulcerative colitis, BMI body mass index, hs-CRP high sensitivity C-reactive protein, IL-6 interleukin 6, ESR erythrocyte sedimentation rate, ALB albumin, CAR C reactive protein to albumin ratio, WBC white blood cells, Hb hemoglobin, PLT platelet, MPV mean platelet volume, NLR neutrophil to lymphocyte ratio, LMR lymphocyte to monocyte ratio, PLR platelet to lymphocyte ratio. Values are expressed as mean ± SD or median (IQR). 1 versus 2: 0–1 point group versus 2 ponit group. 1 versus 3: 0–1 point group versus 3 ponit group. 2 versus 3: 2 point group versus 3 ponit group. There is no statistical difference between the 0 point and 1 point group (p > 0.05)

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