Table 1 Immune gene signatures in the protein–protein interaction network of differentially expressed genes of the small intestine from young (5–6 weeks old) germ-free mouse hosts following 8 weeks after transplantation with either old (~ 24-month old) or young (5–6 weeks old) mouse donor gut microbiota
Gene ID | Name | − log10(P)* | Log2(FC) |
|---|---|---|---|
Highly interacting | Â | Â | Â |
ATP7A | ATPase copper transporting alpha | 3.87 | − 0.46 |
BIRC3 | Baculoviral IAP repeat containing 3 | 3.90 | − 0.79 |
CASP1 | Caspase 1 | 4.34 | − 0.69 |
CD74 | CD74 molecule | 4.25 | − 0.57 |
CXCL9 | C-X-C motif chemokine ligand 9 | 5.33 | − 1.85 |
ERAP1 | Endoplasmic reticulum aminopeptidase 1 | 4.06 | − 0.68 |
FAS | Fas cell surface death receptor | 5.51 | − 1.31 |
GBP2 | Guanylate binding protein 2 | 4.02 | − 2.03 |
GBP6 | Guanylate binding protein family member 6 | 3.94 | − 1.11 |
HLA-DMA | Major histocompatibility complex, class II, DM alpha | 3.98 | − 0.89 |
HLA-DMB | Major histocompatibility complex, class II, DM beta | 3.91 | − 0.66 |
HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 2 | 4.48 | − 0.79 |
IDO1 | Indoleamine 2,3-dioxygenase 1 | 5.77 | − 1.89 |
NR1D1 | Nuclear receptor subfamily 1 group D member 1 | 5.60 | − 2.01 |
PSMB10 | Proteasome 20S subunit beta 10 | 5.18 | − 0.97 |
RORC | RAR related orphan receptor C | 4.28 | 1.03 |
XCL1 | X-C motif chemokine ligand 1 | 4.03 | − 0.74 |
Low interacting | Â | Â | Â |
TCIRG1 | T cell immune regulator 1, ATPase H + transporting V0 subunit a3 | 4.00 | − 0.48 |
Non interacting | Â | Â | Â |
DOCK11 | Dedicator of cytokinesis 11 | − 0.82 | − 0.82 |
EMP2 | Epithelial membrane protein 2 | − 1.00 | − 1.00 |
FER | FER tyrosine kinase | − 0.59 | − 0.59 |
GRN | Granulin precursor | − 1.08 | − 1.08 |
GSDMC | Gasdermin C | − 3.35 | − 3.35 |
GSDMC | Gasdermin C | − 4.04 | − 4.04 |
LGR4 | Leucine rich repeat containing G protein-coupled receptor 4 | − 0.75 | − 0.75 |
RNASET2 | Ribonuclease T2 | − 0.46 | − 0.46 |
RNASET2 | Ribonuclease T2 | − 0.46 | − 0.46 |
SLC26A6 | Solute carrier family 26 member 6 | − 0.69 | − 0.69 |
DOCK11 | Dedicator of cytokinesis 11 | − 0.82 | − 0.82 |
EMP2 | Epithelial membrane protein 2 | − 1.00 | − 1.00 |
FER | FER tyrosine kinase | − 0.59 | − 0.59 |
GRN | Granulin precursor | − 1.08 | − 1.08 |
GSDMC | Gasdermin C | − 3.35 | − 3.35 |
GSDMC | Gasdermin C | − 4.04 | − 4.04 |
LGR4 | Leucine rich repeat containing G protein-coupled receptor 4 | − 0.75 | − 0.75 |
RNASET2 | Ribonuclease T2 | − 0.46 | − 0.46 |
RNASET2 | Ribonuclease T2 | − 0.46 | − 0.46 |
SLC26A6 | Solute carrier family 26 member 6 | − 0.69 | − 0.69 |