Fig. 2

Immune microenvironment status of the 25-genes signature of immune-associated differentially expressed genes in the small intestine of young germ-free mice transplanted with old donor gut microbiota. Expression levels of this signature was positively correlated with naïve T-cell (A), effector memory T-cell (B), central memory T-cell (C), resident memory T-cell (D), exhausted T-cell (E), resting Treg T-cell (F), effector Treg T-cell (G) and Th1-like (H) gene signatures in normal colorectal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression project