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Fig. 4 | BMC Gastroenterology

Fig. 4

From: Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein

Fig. 4

MicroRNAs (miRNAs) in the DLK1-DIO3 imprinted region derived from CAFs-exo inhibit HHIP expression in HCC cells. A The expression levels of miRNAs in the DLK1-DIO3 imprinted region derived from PAFs-exo and CAFs-exo were detected by RT-PCR assay. B The expression levels of miRNAs in the DLK1-DIO3 imprinted region in HCC cells co-cultured with PAFs-exo and CAFs-exo were detected by RT-PCR assay. C The target genes of miR-329-3p, miR-380-3p, miR-410-5p, and miR-431-5p were predicted using the TargetScan database. D The mRNA expression levels of KLF12, KDM5A, and HHIP in HCC cells were detected by RT-PCR assay. E, F The mRNA and protein expression levels of HHIP in HCC cells transfected with 4 miRNA mimics were detected by RT-PCR and WB assays

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BMC Gastroenterology

ISSN: 1471-230X

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