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Fig. 3 | BMC Gastroenterology

Fig. 3

From: Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein

Fig. 3

Inhibition of exosome secretion suppresses the aggressive phenotype of HCC cells. A The effects of conditioned medium of PAFs (PAFs-CM), CAFs-CM, and CAFs-CM + GW4869 on HCC cell proliferation were evaluated by CCK-8 assay. B The effects of PAFs-CM, CAFs-CM, and CAFs-CM + GW4869 on HCC cell migration were evaluated by wound healing assay. Scale bar: 100 μm. C The effects of PAFs-CM, CAFs-CM, and CAFs-CM + GW4869 on HCC cell invasion were evaluated by transwell assay. Scale bar: 50 μm. D The protein expression levels of EMT-related markers in HCC cells treated with PAFs-CM, CAFs-CM, and CAFs-CM + GW4869 were detected by WB assay

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BMC Gastroenterology

ISSN: 1471-230X

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