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Table 1 Descriptive characteristics of clinical trials

From: Assessing clinical trial failure risk factors and reasons in gastric cancer

 

Failed (N = 42)

Completed (N = 247)

Active (N = 262)

Good terminated (N = 16)

P-value

Phase

    

0.463

 Phase II

33 (78.57%)

184 (74.49%)

192 (73.38%)

11 (68.75%)

 

 Phase III

9 (21.43%)

63 (25.51%)

70 (26.72%)

5 (31.25%)

 

Start year

    

< 0.001

 2007

2 (4.76%)

25 (10.12%)

1 (0.38%)

1 (6.25%)

 

 2008

3 (7.14%)

31 (12.55%)

1 (0.38%)

1 (6.25%)

 

 2009

4 (9.52%)

28 (11.34%)

1 (0.38%)

0

 

 2010

2 (4.76%)

23 (9.31%)

1 (0.38%)

0

 

 2011

5 (11.90%)

28 (11.34%)

2 (0.76%)

3 (18.75%)

 

 2012

7 (16.67%)

27 (10.93%)

2 (0.76%)

3 (18.75%)

 

 2013

4 (9.52%)

21 (8.50%)

11 (4.20%)

2 (12.50%)

 

 2014

3 (7.14%)

17 (6.88%)

7 (2.67%)

3 (18.75%)

 

 2015

4 (9.52%)

22 (8.91%)

12 (4.58%)

0

 

 2016

1 (2.38%)

3 (1.21%)

23 (8.78%)

0

 

 2017

5 (11.90%)

14 (5.67%)

38 (14.50%)

2 (12.50%)

 

 2018

2 (4.76%)

6 (2.43%)

43 (16.41%)

1 (6.25%)

 

 2019

0

2 (0.81%)

59 (22.52%)

0

 

 2020

0

0

61 (23.28%)

0

 

Treatment

    

< 0.001

 Drug

30 (71.43%)

186 (75.30%)

153 (58.40%)

14 (87.50%)

 

 Device

4 (9.52%)

20 (8.10%)

19 (7.25%)

0

 

 Genetic

8 (19.05%)

32 (12.96%)

71 (27.10%)

1 (6.25%)

 

 Radiation

0

8 (3.24%)

8 (3.05%)

1 (6.25%)

 

 Other

0

1 (0.4%)

11 (4.20%)

0

 

Sponsor

    

0.356

 NIH

2 (4.76%)

21 (8.54%)

11 (4.20%)

0

 

 Industry

20 (47.62%)

106 (42.91%)

125 (47.71%)

6 (37.50%)

 

 Other

20 (47.62%)

120 (48.58%)

126 (48.09%)

10 (62.50%)

 

Multi-centre

    

0.062

 No

15 (35.71%)

132 (53.44%)

123 (46.95%)

5 (31.25%)

 

 Yes

27 (64.29%)

115 (46.56%)

139 (53.05%)

11 (68.75%)

 

Multi-country

    

0.093

 No

29 (69.05%)

205 (83.00%)

202 (77.10%)

11 (68.75%)

 

 Yes

13 (30.95%)

42 (17.00%)

60 (23.90%)

5 (31.25%)

 

Anticipated accrual

123.21 (132.80)

159.67 (202.20)

237.57 (268.70)

209.94 (207.19)

0.001

Duration

36.36 (24.34)

46.48 (23.41)

43.40 (26.10)

34.38 (15.25)

0.363