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Table 1 Comparison of measurement results from different patient subgroups

From: A comparison of NAFLD and MAFLD diagnostic criteria in contemporary urban healthy adults in China: a cross-sectional study

 

NAFLD-, MAFLD-

NAFLD + , MAFLD-

NAFLD-, MAFLD + 

NAFLD + , MAFLD + 

P value

Number

53.71% (427/795)

1.51% (12/795)

2.89% (23/795)

41.89% (333/795)

 < 0.001

Sex (female/male)

217/210

2/10

5/18

88/245

 < 0.001

Overweight (presence/absence)

192/235

0/12

20/3

307/26

 < 0.001

Type 2 diabetes mellitus (presence/absence)

25/402

0/12

5/18

77/256

 < 0.001

Hypertension (presence/absence)

190/237

1/11

16/7

232/101

 < 0.001

Dyslipidemia (presence/absence)

272/155

5/7

20/3

279/54

 < 0.001

Age (y)

45 (37, 51)

44 (33.75, 55.5)

53 (40, 57)

46 (39, 53)

0.006

Body weight (Kg)

62 (55, 70)

60 (57, 63)

72 (68, 85) ***##

76 (71, 84) ***###

 < 0.001

Body mass index (Kg/m2)

23 (21, 25)

22.5 (22, 23)

27 (25, 30) ***###

27 (25, 30) ***###

 < 0.001

Waist circumference (cm)

80 (75, 85)

79 (75, 83)

89 (83, 97) ***#

90 (85, 98) ***###

 < 0.001

Systolic blood pressure (mmHg)

125 (113, 137)

118.5 (115.25, 126.75)

139 (123, 154) **##

135 (123, 150) ***##

 < 0.001

Diastolic blood pressure (mmHg)

74 (67, 82)

70 (65.5, 73.75)

81 (73, 91) **##

82 (74, 90) ***###

 < 0.001

Average number of metabolic disorders

1.83 ± 1.36

0.41 ± 0.52

3.34 ± 1.50***###

3.81 ± 1.48***###

 < 0.001

Fasting glucose (mg/dL)

5.2 (4.8, 5.5)

4.75 (4.53, 5.23)

5.5 (5, 5.9) ##

5.5 (5.1, 5.9) ***###

 < 0.001

HbA1c (%)

5.6 (5.4, 5.9)

5.35 (5.2, 5.6)

5.9 (5.5, 6.2) ##

5.8 (5.6, 6.3) ***###

 < 0.001

Fasting insulin (mU/L)

6.78 (4.64, 9.52)

5.89 (5.06, 7.22)

12.74 (8.5, 19.7) ***##

12.1 (8.12, 17.6) ***##

 < 0.001

HOMA-IR

1.55 (1.07, 2.22)

1.32 (1.16, 1.68)

2.9 (2.15, 5.31) ***##

2.93 (1.95, 4.52) ***###

 < 0.001

Uric acid (mmol/L)

284 (242, 348)

324.5 (283.75, 388)

381 (331, 448) ***

365 (300, 423.5) ***

 < 0.001

Creatinine (mmol/L)

65 (53, 76)

72.5 (61.75, 79)

75 (67, 84) **

72 (61, 82) ***

 < 0.001

Total cholesterol (mmol/L)

5.11 (4.48, 5.73)

4.64 (4.28, 5.9)

5.1 (4.34, 5.43)

5.33 (4.74, 6.07) ***

 < 0.001

LDL cholesterol (mmol/L)

2.94 (2.47, 3.5)

2.74 (2.5, 3.98)

3.01 (2.49, 3.47)

3.36 (2.92, 3.93) ***&

 < 0.001

Triglyceride (mmol/L)

0.96 (0.72, 1.33)

0.99 (0.85, 1.31)

1.49 (1.27, 2.23) ***

1.71 (1.2, 2.35) ***##

 < 0.001

HDL cholesterol (mmol/L)

1.37 (1.17, 1.57)

1.2 (1.08, 1.37)

1.26 (1.04, 1.44)

1.12 (0.99, 1.31) ***

 < 0.001

Albumin (g/L)

45.4 ± 2.57

46.23 ± 2.33

45.6 ± 2.22

45.68 ± 2.46

0.343

Globulin (g/L)

29.2 (27.3, 31.6)

27.55 (26.65, 28.83)

29.3 (27.6, 31.5)

29.4 (27.25, 31.85)

0.382

A/G

1.6 (1.4, 1.7)

1.7 (1.53, 1.78)

1.5 (1.3, 1.7)

1.6 (1.4, 1.7)

0.338

Aspartate aminotransferase (U/L)

20 (17, 25)

22.5 (21, 23.75)

23 (20, 34)

23 (19, 28) ***

 < 0.001

Alanine aminotransferase (U/L)

16 (12, 21)

24 (19, 30.5)

24 (17, 44) **

27 (20, 38) ***

 < 0.001

γ-glutamyl transpeptidase (U/L)

18 (14, 27)

26 (20.25, 32.75)

47 (31, 75) ***

35 (23, 53) ***

 < 0.001

Alkaline phosphatase (U/L)

70 (57, 85)

89.5 (69.25, 98.25)

85 (71, 93)

76 (66, 92) ***

 < 0.001

AST/ALT

1.29 (1.05, 1.53)

0.91 (0.7, 1.21)

1 (0.71, 1.15) **

0.86 (0.65, 1.09) ***

 < 0.001

Red blood cell count (× 1012/L)

4.95 (4.59, 5.27)

5.22 (4.48, 5.42)

5.29 (4.81, 5.63) *

5.28 (4.93, 5.57) ***

 < 0.001

Hemoglobin (g/L)

146 (136, 158)

158.5 (142.5, 161)

163 (148, 168) **

157 (145.5, 165) ***

 < 0.001

White blood cell count (× 109/L)

5.5 (4.6, 6.3)

5.5 (5.03, 6.35)

6.2 (5.8, 7) *

6.4 (5.3, 7.4) ***

 < 0.001

Percentage of neutrophils (%)

57.85 ± 7.45

54.33 ± 6.33

58.69 ± 7.27

59.12 ± 7.68

0.032

Neutrophil count (× 109/L)

3.14 (2.56, 3.86)

2.93 (2.33, 3.65)

3.75 (3.44, 4.27)

3.69 (3.01, 4.59) ***#

 < 0.001

Platelet (× 109/L)

232 (195, 266)

229 (213.5, 243.25)

218 (197, 242)

237 (198, 276.5)

0.272

NFS

-2.05 (-2.92, -1.17)

-2.7 (-3.77, -2.23)

-1.27 (-2.42, -0.67)#

-1.64 (-2.61, -0.88)**

 < 0.001

FIB-4

0.95 (0.73, 1.29)

1.04 (0.56, 1.24)

1.07 (0.68, 1.61)

0.87 (0.62, 1.21) *

0.040

NFS (< -1.455)

287/427

10/12

10/23

189/333

 

NFS (-1.455 <  = NFS < 0.676)

137/427

2/12

13/23

140/333

 

NFS (> = 0.676)

3/427

0/12

0/23

4/333

 

FIB-4 (< 1.30)

325/427

10/12

15/23

267/333

 

FIB-4 (1.30 <  = FIB-4 < 1.45)

28/427

1/12

1/23

18/333

 

FIB-4 (1.45 <  = FIB-4 < 2.67)

71/427

1/12

7/23

45/333

 

FIB-4 (2.67 <  = FIB-4 < 3.25)

2/427

0/12

0/23

2/333

 

FIB-4 (> = 3.25)

1/427

0/12

0/23

1/333

 
  1. All data are expressed as the mean ± SD, medians (interquartile range), or n (%), as appropriate. *Difference from NAFLD- MAFLD- group (P<0.05), **P<0.01, ***P<0.001. #Difference from NAFLD+ MAFLD- group (P<0.05), ##P<0.01, ###P<0.001. &Difference from NAFLD- MAFLD+ group (P<0.05), &&P<0.01, &&&P<0.001.