| NAFLD-, MAFLD- | NAFLD + , MAFLD- | NAFLD-, MAFLD +  | NAFLD + , MAFLD +  | P value |
---|---|---|---|---|---|
Number | 53.71% (427/795) | 1.51% (12/795) | 2.89% (23/795) | 41.89% (333/795) |  < 0.001 |
Sex (female/male) | 217/210 | 2/10 | 5/18 | 88/245 |  < 0.001 |
Overweight (presence/absence) | 192/235 | 0/12 | 20/3 | 307/26 |  < 0.001 |
Type 2 diabetes mellitus (presence/absence) | 25/402 | 0/12 | 5/18 | 77/256 |  < 0.001 |
Hypertension (presence/absence) | 190/237 | 1/11 | 16/7 | 232/101 |  < 0.001 |
Dyslipidemia (presence/absence) | 272/155 | 5/7 | 20/3 | 279/54 |  < 0.001 |
Age (y) | 45 (37, 51) | 44 (33.75, 55.5) | 53 (40, 57) | 46 (39, 53) | 0.006 |
Body weight (Kg) | 62 (55, 70) | 60 (57, 63) | 72 (68, 85) ***## | 76 (71, 84) ***### |  < 0.001 |
Body mass index (Kg/m2) | 23 (21, 25) | 22.5 (22, 23) | 27 (25, 30) ***### | 27 (25, 30) ***### |  < 0.001 |
Waist circumference (cm) | 80 (75, 85) | 79 (75, 83) | 89 (83, 97) ***# | 90 (85, 98) ***### |  < 0.001 |
Systolic blood pressure (mmHg) | 125 (113, 137) | 118.5 (115.25, 126.75) | 139 (123, 154) **## | 135 (123, 150) ***## |  < 0.001 |
Diastolic blood pressure (mmHg) | 74 (67, 82) | 70 (65.5, 73.75) | 81 (73, 91) **## | 82 (74, 90) ***### |  < 0.001 |
Average number of metabolic disorders | 1.83 ± 1.36 | 0.41 ± 0.52 | 3.34 ± 1.50***### | 3.81 ± 1.48***### |  < 0.001 |
Fasting glucose (mg/dL) | 5.2 (4.8, 5.5) | 4.75 (4.53, 5.23) | 5.5 (5, 5.9) ## | 5.5 (5.1, 5.9) ***### |  < 0.001 |
HbA1c (%) | 5.6 (5.4, 5.9) | 5.35 (5.2, 5.6) | 5.9 (5.5, 6.2) ## | 5.8 (5.6, 6.3) ***### |  < 0.001 |
Fasting insulin (mU/L) | 6.78 (4.64, 9.52) | 5.89 (5.06, 7.22) | 12.74 (8.5, 19.7) ***## | 12.1 (8.12, 17.6) ***## |  < 0.001 |
HOMA-IR | 1.55 (1.07, 2.22) | 1.32 (1.16, 1.68) | 2.9 (2.15, 5.31) ***## | 2.93 (1.95, 4.52) ***### |  < 0.001 |
Uric acid (mmol/L) | 284 (242, 348) | 324.5 (283.75, 388) | 381 (331, 448) *** | 365 (300, 423.5) *** |  < 0.001 |
Creatinine (mmol/L) | 65 (53, 76) | 72.5 (61.75, 79) | 75 (67, 84) ** | 72 (61, 82) *** |  < 0.001 |
Total cholesterol (mmol/L) | 5.11 (4.48, 5.73) | 4.64 (4.28, 5.9) | 5.1 (4.34, 5.43) | 5.33 (4.74, 6.07) *** |  < 0.001 |
LDL cholesterol (mmol/L) | 2.94 (2.47, 3.5) | 2.74 (2.5, 3.98) | 3.01 (2.49, 3.47) | 3.36 (2.92, 3.93) ***& |  < 0.001 |
Triglyceride (mmol/L) | 0.96 (0.72, 1.33) | 0.99 (0.85, 1.31) | 1.49 (1.27, 2.23) *** | 1.71 (1.2, 2.35) ***## |  < 0.001 |
HDL cholesterol (mmol/L) | 1.37 (1.17, 1.57) | 1.2 (1.08, 1.37) | 1.26 (1.04, 1.44) | 1.12 (0.99, 1.31) *** |  < 0.001 |
Albumin (g/L) | 45.4 ± 2.57 | 46.23 ± 2.33 | 45.6 ± 2.22 | 45.68 ± 2.46 | 0.343 |
Globulin (g/L) | 29.2 (27.3, 31.6) | 27.55 (26.65, 28.83) | 29.3 (27.6, 31.5) | 29.4 (27.25, 31.85) | 0.382 |
A/G | 1.6 (1.4, 1.7) | 1.7 (1.53, 1.78) | 1.5 (1.3, 1.7) | 1.6 (1.4, 1.7) | 0.338 |
Aspartate aminotransferase (U/L) | 20 (17, 25) | 22.5 (21, 23.75) | 23 (20, 34) | 23 (19, 28) *** |  < 0.001 |
Alanine aminotransferase (U/L) | 16 (12, 21) | 24 (19, 30.5) | 24 (17, 44) ** | 27 (20, 38) *** |  < 0.001 |
γ-glutamyl transpeptidase (U/L) | 18 (14, 27) | 26 (20.25, 32.75) | 47 (31, 75) *** | 35 (23, 53) *** |  < 0.001 |
Alkaline phosphatase (U/L) | 70 (57, 85) | 89.5 (69.25, 98.25) | 85 (71, 93) | 76 (66, 92) *** |  < 0.001 |
AST/ALT | 1.29 (1.05, 1.53) | 0.91 (0.7, 1.21) | 1 (0.71, 1.15) ** | 0.86 (0.65, 1.09) *** |  < 0.001 |
Red blood cell count (× 1012/L) | 4.95 (4.59, 5.27) | 5.22 (4.48, 5.42) | 5.29 (4.81, 5.63) * | 5.28 (4.93, 5.57) *** |  < 0.001 |
Hemoglobin (g/L) | 146 (136, 158) | 158.5 (142.5, 161) | 163 (148, 168) ** | 157 (145.5, 165) *** |  < 0.001 |
White blood cell count (× 109/L) | 5.5 (4.6, 6.3) | 5.5 (5.03, 6.35) | 6.2 (5.8, 7) * | 6.4 (5.3, 7.4) *** |  < 0.001 |
Percentage of neutrophils (%) | 57.85 ± 7.45 | 54.33 ± 6.33 | 58.69 ± 7.27 | 59.12 ± 7.68 | 0.032 |
Neutrophil count (× 109/L) | 3.14 (2.56, 3.86) | 2.93 (2.33, 3.65) | 3.75 (3.44, 4.27) | 3.69 (3.01, 4.59) ***# |  < 0.001 |
Platelet (× 109/L) | 232 (195, 266) | 229 (213.5, 243.25) | 218 (197, 242) | 237 (198, 276.5) | 0.272 |
NFS | -2.05 (-2.92, -1.17) | -2.7 (-3.77, -2.23) | -1.27 (-2.42, -0.67)# | -1.64 (-2.61, -0.88)** |  < 0.001 |
FIB-4 | 0.95 (0.73, 1.29) | 1.04 (0.56, 1.24) | 1.07 (0.68, 1.61) | 0.87 (0.62, 1.21) * | 0.040 |
NFS (< -1.455) | 287/427 | 10/12 | 10/23 | 189/333 |  |
NFS (-1.455 <  = NFS < 0.676) | 137/427 | 2/12 | 13/23 | 140/333 |  |
NFS (> = 0.676) | 3/427 | 0/12 | 0/23 | 4/333 |  |
FIB-4 (< 1.30) | 325/427 | 10/12 | 15/23 | 267/333 |  |
FIB-4 (1.30 <  = FIB-4 < 1.45) | 28/427 | 1/12 | 1/23 | 18/333 |  |
FIB-4 (1.45 <  = FIB-4 < 2.67) | 71/427 | 1/12 | 7/23 | 45/333 |  |
FIB-4 (2.67 <  = FIB-4 < 3.25) | 2/427 | 0/12 | 0/23 | 2/333 |  |
FIB-4 (> = 3.25) | 1/427 | 0/12 | 0/23 | 1/333 |  |