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Table 2 Comparison of baseline characteristics according to FIB-4 index

From: Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease

Variables

FIB-4 < 2.67

(Low-intermediate risk of advanced liver fibrosis)

N = 6011

FIB-4 ≥ 2.67

(High risk of advanced liver fibrosis)

N = 76

P value

Age (year)

47 (11-89)

72 (41-88)

 < 0.001

Male (%)

50.4

57.9

0.120

Smoking (%)

21.2

7.9

0.002

Habitual drinking (%)

12.7

25.7

0.002

BMI (kg/m2)

22.4 (10.6-61.1)

22.4 (16.8-31.2)

0.948

Obesity (%)

25.7

26.3

0.493

Waist circumference (cm)

80.0 (54.1-152.5)

79.8 (57.5-112.5)

0.229

Large waist circumference (%)

26.3

34.2

0.080

Systolic blood pressure (mmHg)

124 (77-244)

138 (105-174)

 < 0.001

Diastolic blood pressure (mmHg)

74 (34-140)

78 (51-106)

0.019

Fasting plasma glucose (mg/dL)

92 (57-295)

104 (79-321)

 < 0.001

HbA1c (%)

5.6 (4.4-14.6)

5.7 (5.1-8.6)

0.001

Triglyceride (mg/dL)

80 (16-1,454)

87 (30-432)

0.280

HDL cholesterol (mg/dL)

63 (11-158)

38 (38-103)

0.364

LDL cholesterol (mg/dL)

122 (25-335)

121 (61-178)

0.148

Uric acid (mg/dL)

5.2 (0.4-11.6)

5.2 (2.5-8.4)

0.627

Albumin (g/dL)

4.4 (3.4-5.3)

4.3 (3.7-4.9)

0.040

AST (IU/L)

20 (5-203)

28 (16-233)

 < 0.001

ALT (IU/L)

18 (3-561)

20 (7-212)

0.009

GGT (mg/dL)

22 (5-1,086)

27 (10-313)

 < 0.001

Platelet counts (× 104/μL)

25.0 (8.5-59.5)

14.8 (2.9-28.6)

 < 0.001

Hemoglobin (g/dL)

14.2 (7.0-19.7)

14.0 (8.1-17.0)

0.152

White blood cell (/μL)

5,400 (1,900-17,800)

4,500 (1,100-13,900)

 < 0.001

Creatinine (mg/dL)

0.76 (0.30-14.1)

0.79 (0.50-1.30)

0.010

Hypertension (%)

31.3

78.9

 < 0.001

Diabetes mellitus (%)

5.0

23.7

 < 0.001

Dyslipidemia (%)

45.1

52.6

0.115

Hyperuricemia (%)

11.5

9.1

0.352

  1. Data are expressed as median (range), †Mann-Whitney U-test, ‡Chi-squared test. ALT Alanine aminotransferase, AST Aspartate aminotransferase, BMI Body mass index, Fib-4 Fibrosis-4, GGT Gamma-glutamyl transpeptidase, HbA1c Hemoglobin A1c, HDL High-density lipoprotein, LDL Low-density lipoprotein