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Table 3 Risk Factors for concomitant PDAC with all of 547 patients with pancreatic cyst

From: Long-standing diabetes mellitus increases concomitant pancreatic cancer risk in patients with intraductal papillary mucinous neoplasms

 

Concomitant PDAC

(N = 14)

Exception of Concomitant PDAC

(N = 533)

Univariate Analysis

(P-value)

Multivariate Analysis

Odds ratio

(95% CI)

(P-value)

Follow-up Period, median (range), months

45 (14-119)

59 (13-177)

0.30

  

Sex, M:F

7:7

197:336

0.4

  

Age at Cyst Diagnosis, median (range), years

73 (56-80)

71 (31-93)

0.79

  

Age at Cyst Diagnosis ≥65 years old

12:2

385:149

0.37

1.98 (0.24-16.29)

0.52

Age at Final Observation, median (range), years

76.5 (60-86)

76 (32-99)

0.79

  

Age at Final Observation ≥70 years old

12:2

391:142

0.37

  

Cyst Number (1,2, ≥3)

2:4:8

222:118:193

   

Cyst Number (1, ≥2)

2:12

222:312

0.05

0.37 (0.05-2.43)

0.30

Cyst Diameter, median (range), mm

17.0 (6.4-27.6)

14.5 (2-68)

0.17

  

Cyst Diameter (mm) ≥14.6, <14.6

10:14

263:270

0.11

2.38 (0.43-13.27)

0.32

Diameter of MPD, median (range), mm

3.1 (1-7.7)

2.5 (1-9.8)

0.06

  

MPD (mm) ≥2.5, <2.5

11:3

192:213

0.03

2.88 (0.45-18.27)

0.26

IPMN: non-IPMN

14:0

425:108

0.08

 

Diabetes Mellitus at Cyst Diagnosis, yes : no

9:5

103:430

<0.01

304.58 (51.01-1818.74)

<0.001

Hypertension at Cyst Diagnosis, yes : no

9:5

237:296

0.18

  

Hyperlipidemia at Cyst Diagnosis, yes : no

7:7

138:395

0.06

3.61 (0.77-16.88)

0.10

Cancer History, yes : no

2:12

150:537

0.75

  

Usual Alcohol Consumption ethanol (ethanol ≥20g/day

5:9

156:378

0.56

  

Smoking (BI ≥400), yes : no

3:11

135:398

1.00

  

Family History of Pancreatic Cancer (≤1nd grade), yes : no

1:12

39:491

1.00

  

BMI ≥25(kg/m2), yes : no

1:13

114:419

0.32

  
  1. PDAC Pancreatic ductal adenocarcinoma, CI Confidence interval, M male, F female, MPD main pancreatic duct, IPMN intraductal papillary mucinous neoplasm, HT hypertension, HL hyperlipidemia, BMI body mass index
  2. 14.6 mm in cyst diameter and 2.5mm in MPD diameter were overall median
  3. There were 4 data deficiencies in family history of pancreatic cancer