Variable | Patients with lung metastasis (N = 6278) | Patients with lung-only metastasis (N = 1065) | ||||||
---|---|---|---|---|---|---|---|---|
1-yearOS (%) | 3-year OS (%) | Median survival time (months) | p value | 1-yearOS (%) | 3-year OS (%) | Median survival time (months) | p value | |
Total case | 49.2 ± 0.6 | 15.9 ± 0.5 | 12.0 (11.4–12.6) |  | 68.5 ± 1.4 | 36.1 ± 1.6 | 24.0 (21.8–26.1) |  |
Age |  |  |  | < 0.001 |  |  |  | < 0.001 |
 < 65 | 57.8 ± 0.9 | 18.8 ± 0.8 | 17.0 (16.2–17.8) |  | 81.1 ± 1.8 | 49.6 ± 2.6 | 35.0 (29.7–40.2) |  |
 ≥ 65 | 38.5 ± 0.9 | 11.5 ± 0.7 | 8.0 (7.3–8.7) |  | 58.2 ± 0.2 | 25.0 ± 2.0 | 17.0 (14.8–19.2) |  |
Grade |  |  |  | < 0.001 |  |  |  | < 0.001 |
 Grade I | 54.8 ± 3.1 | 19.3 ± 2.8 | 15.0 (11.9–18.1) |  | 61.1 ± 8.1 | 28.5 ± 8.6 | 25.0 (21.2–28.8) |  |
 Grade II | 56.3 ± 0.9 | 19.5 ± 0.8 | 15.0 (14.1–15.9) |  | 75.1 ± 2.1 | 41.4 ± 2.7 | 31.0 (27.4–34.6) |  |
 Grade III | 36.9 ± 1.6 | 11.2 ± 1.2 | 7.0 (5.9–8.1) |  | 58.3 ± 5.0 | 35.2 ± 5.2 | 18.0 (10.9–25.0) |  |
 Grade IV | 36.5 ± 4.0 | 13.8 ± 2.3 | 7.0 (4.2–9.8) |  | 74.0 ± 1.2 | – | 24.0 (2.6–45.4) |  |
 Unknown | 41.7 ± 1.2 | 10.2 ± 0.9 | 9.0 (8.0–9.9) |  | 51.3 ± 3.8 | – | 14.0 (10.0–18.0) |  |
AJCC T stage |  |  |  | < 0.001 |  |  |  | < 0.001 |
 T0 | 43.9 ± 1.8 | 11.1 ± 1.3 | 1.0 (0–2.5) |  | – | – | 6.0 (3.1–10.2) |  |
 T1 | 66.4 ± 4.3 | 29.5 ± 4.7 | 10.0 (8.6–11.4) |  | 57.5 ± 5.3 | – | 21.0 (11.2–30.8) |  |
 T2 | 62.5 ± 1.1 | 26.0 ± 1.2 | 21.0 (14.9–27.1) |  | 67.9 ± 8.8 | 57.8 ± 1.0 | 41.0 (29.7–52.3) |  |
 T3 | 26.6 ± 1.2 | 12.0 ± 1.0 | 19.0 (17.9–20.1) |  | 78.2 ± 2.2 | 46.6 ± 3.0 | 33.0 (27.8–38.2) |  |
 T4 | 15.4 ± 1.1 | 5.3 ± 0.9 | 12.0 (10.9–13.0) |  | 58.1 ± 3.9 | 28.2 ± 3.0 | 19.0 (12.9–25.0) |  |
 TX | – | – | 8.0 (7.2–8.8) |  | 46.9 ± 4.7 | 11.8 ± 3.8 | 11.0 (6.0–16.0) |  |
AJCC N stage |  |  |  | < 0.001 |  |  |  | < 0.001 |
 N0 | 47.7 ± 1.1 | 15.5 ± 0.9 | 12.0 (11.0–13.0) |  | 61.4 ± 2.3 | 28.4 ± 2.3 | 19.0 (16.0–22.0) |  |
 N1 | 53.0 ± 1.1 | 18.9 ± 1.0 | 14.0 (12.9–15.1) |  | 74.7 ± 2.2 | 43.0 ± 2.8 | 29.0 (24.2–34.0) |  |
 N2 | 54.6 ± 1.5 | 17.3 ± 1.0 | 14.0 (12.6–15.4) |  | 73.3 ± 3.1 | 39.6 ± 3.0 | 26.0 (21.9–26.1) |  |
 N3 | 36.7 ± 1.6 | 7.9 ± 1.0 | 7.0 (5.8–8.2) |  | – | – | – |  |
Marital status |  |  |  | < 0.001 |  |  |  | < 0.001 |
 Married | 54.2 ± 0.9 | 18.7 ± 0.8 | 14.0 (13.2–14.8) |  | 60.4 ± 2.2 | 29.6 ± 2.2 | 19.0 (16.4–21.6) |  |
 Single | 44.1 ± 0.9 | 12.6 ± 0.7 | 10.0 (9.3–10.7) |  | 77.7 ± 1.9 | 42.7 ± 2.5 | 31.0 (27.1–34.9) |  |
 Other | 48.5 ± 2.5 | 17.9 ± 2.1 | 12.0 (9.5–14.5) |  | 63.6 ± 6.5 | 29.7 ± 6.5 | 22.0 (21.9–26.1) |  |
Chemotherapy |  |  |  | < 0.001 |  |  |  | < 0.001 |
 Yes | 63.7 ± 0.7 | 21.0 ± 0.7 | 18.0 (17.3–18.7) |  | 83.0 ± 1.4 | 47.6 ± 2.2 | 33.0 (29.8–36.2) |  |
 No/Unknown | 18.6 ± 0.9 | 5.0 ± 0.6 | 2.0 (1.7–2.3) |  | 36.7 ± 2.7 | 11.2 ± 1.9 | 8.0 (6.3–9.7) |  |
Radiotherapy |  |  |  | < 0.001 |  |  |  | < 0.001 |
 Yes | 58.5 ± 1.5 | 21.9 ± 1.4 | 16.0 (14.8–17.2) |  | 78.6 ± 2.5 | 43.6 ± 3.3 | 31.0 (25.1–36.9) |  |
 No/Unknown | 46.9 ± 0.7 | 14.1 ± 0.6 | 11.0 (10.4–11.6) |  | 65.2 ± 1.7 | 33.1 ± 1.9 | 21.0 (18.8–23.2) |  |
Surgery |  |  |  | < 0.001 |  |  |  | < 0.001 |
 Yes | 61.7 ± 1.0 | 25.7 ± 1.0 | 19.0 (17.8–20.2) |  | 79.4 ± 1.7 | 50.1 ± 2.3 | 37.0 (33.0–40.9) |  |
 No/Unknown | 41.7 ± 0.8 | 9.7 ± 0.6 | 9.0 (8.4–9.6) |  | 55.3 ± 2.3 | 17.9 ± 2.1 | 14.0 (11.9–16.1) |  |
Site |  |  |  | < 0.001 |  |  |  | 0.002 |
 Right-sided colon | 39.1 ± 1.1 | 9.7 ± 0.8 | 8.0 (7.2–8.8) |  | 58.8 ± 2.8 | 29.3 ± 2.8 | 19.0 (16.4–21.6) |  |
 Left-sided colon | 51.2 ± 1.2 | 17.8 ± 1.1 | 13.0 (11.9–14.1) |  | 72.1 ± 3.1 | 40.2 ± 3.7 | 27.0 (22.4–31.6) |  |
 Rectum | 56.4 ± 1.1 | 19.4 ± 1.0 | 15.0 (13.9–16.1) |  | 71.1 ± 4.3 | 41.2 ± 5.6 | 31.0 (21.4–40.6) |  |
 Rectosigmoid | 52.3 ± 1.9 | 18.8 ± 1.7 | 14.0 (12.1–15.9) |  | 72.9 ± 2.1 | 37.0 ± 2.6 | 25.0 (21.4–28.6) |  |
Insurance status |  |  |  | < 0.001 |  |  |  | 0.042 |
 Insured | 52.6 ± 0.8 | 18.1 ± 0.7 | 14.0 (13.2–14.8) |  | 72.8 ± 6.7 | 24.7 ± 7.2 | 21.0 (16.3–25.7) |  |
 Uninsured | 48.0 ± 2.7 | 14.1 ± 2.1 | 12.0 (9.8–14.2) |  | 68.4 ± 1.5 | 36.7 ± 1.7 | 24.0 (21.6–26.4) |  |
 Unknown | 44.1 ± 1.0 | 12.7 ± 12.8 | 10.0 (9.2–10.8) |  | 64.3 ± 12 | – | 22.0 (21.9–26.1) |  |
Race | Â | Â | Â | 0.027 | Â | Â | Â | 0.218 |
 White | 49.4 ± 0.7 | 16.3 ± 0.6 | 12.0 (11.3–12.7) |  | 73.3 ± 3.5 | 33.7 ± 3.5 | 23.0 (20.6–25.2) |  |
 Black | 46.1 ± 1.6 | 12.4 ± 1.2 | 11.0 (9.8–12.2) |  | 67.2 ± 1.7 | 35.5 ± 1.9 | 25.0 (20.0–30.0) |  |
 Others | 48.3 ± 1.9 | 6.0 ± 1.4 | 12.0 (10.2–13.7) |  | 71.3 ± 0.4 | 36.5 ± 5.7 | 29.0 (21.8–36.2) |  |
Gender | Â | Â | Â | 0.946 | Â | Â | Â | 0.271 |
 Female | 48.2 ± 0.9 | 16.1 ± 0.8 | 12.0 (11.112.9) |  | 65.3 ± 2.5 | 34.6 ± 2.8 | 23.0 (19.8–26.2) |  |
 Male | 49.4 ± 0.9 | 14.5 ± 0.7 | 12.0 (11.3–12.7) |  | 68.3 ± 2.4 | 36.6 ± 2.7 | 24.0 (20.5–27.5) |  |
Osseous metastasis |  |  |  | < 0.001 | – | – | – |  |
 No | 51.4 ± 0.7 | 17.1 ± 0.6 | 13.0 (12.4–13.6) |  |  |  |  |  |
 Yes | 31.0 ± 0.9 | 6.4 ± 1.2 | 6.0 (4.9–7.1) |  |  |  |  |  |
 Unknown | 41.8 ± 3.8 | 10.6 ± 2.5 | 7.0 (5.3–8.7) |  |  |  |  |  |
Brain metastasis |  |  |  | < 0.001 | – | – | – |  |
 No | 17.1 ± 0.6 | 16.4 ± 0.6 | 13.0 (12.4–13.6) |  |  |  |  |  |
 Yes | 25.6 ± 3.4 | 11.1 ± 1.3 | 4.0 (2.4–5.6) |  |  |  |  |  |
 Unknown | 60..9 ± 6.4 | 19.0 ± 5.4 | 17.0 (12.7–21.3) |  |  |  |  |  |
Liver metastasis |  |  |  | < 0.001 | – | – | – |  |
 No | 49.7 ± 0.7 | 15.9 ± 0.5 | 20.0 (18.5–21.5) |  |  |  |  |  |
 Yes | 24.9 ± 3.4 | – | 10.0 (9.4–10.6) |  |  |  |  |  |
 Unknown | 41.2 ± 3.5 | 11.3 ± 2.4 | 17.0 (12.7–21.3) |  |  |  |  |  |