Table 1 Clinical and demographic characteristics of the patient cohort
Characteristic | All patients | Patients with lung metastasis | Patients without lung metastasis | Patients with lung-only metastasis |
|---|---|---|---|---|
N = 129,143 | N = 6977 | N = 122,166 | N = 1065 | |
Age | ||||
 < 65 | 63,024 (48.8) | 3724 (53.4) | 59,300 (48.5) | 479 (45.0) |
 ≥ 65 | 66,119 (51.2) | 3253 (46.6) | 62,866 (51.5) | 586 (55.0) |
Race | ||||
 White | 100,788 (78.0) | 5124 (73.4) | 95,664 (78.3) | 798 (74.9) |
 Black | 15,650 (12.2) | 1101 (15.8) | 14,549 (11.9) | 159 (14.9) |
 Others | 12,705 (9.8) | 752 (10.8) | 11,953 (9.8) | 108 (10.2) |
Gender | ||||
 Female | 61,569 (47.7) | 3146 (45.1) | 58,423 (47.8) | 518 (48.6) |
 Male | 67,574 (52.3) | 3831 (54.9) | 63,743 (52.2) | 547 (51.4) |
Grade | ||||
 Grade I | 10,168 (7.9) | 313 (4.5) | 9855 (8.1) | 51 (4.8) |
 Grade II | 84,526 (65.5) | 3715 (53.2) | 80,811 (66.1) | 626 (58.8) |
 Grade III | 19,129 (14.8) | 1034 (14.8) | 18,095 (14.8) | 140 (13.1) |
 Grade IV | 3679 (2.8) | 171 (2.5) | 3508 (2.9) | 23 (2.2) |
 Unknown | 11,641 (9.0) | 1744 (25.0) | 9897 (8.1) | 225 (21.1) |
AJCC TNM stage | ||||
 I | 30,460 (23.6) | 0 (0.0) | 30,460 (24.9) | 0 (0.0) |
 II | 33,081 (25.6) | 0 (0.0) | 33,081 (27.1) | 0 (0.0) |
 III | 37,915 (29.4) | 0 (0.0) | 37,915 (31.0) | 0 (0.0) |
 IV | 27,687 (21.4) | 6977 (100.0) | 20,710 (17.0) | 1065 (100.0) |
AJCC T stage | ||||
 T0 | 56 (0.0) | 9 (0.1) | 47 (0.0) | 3 (0.3) |
 T1 | 22,947 (17.8) | 904 (13.0) | 22,043 (18.0) | 125 (11.7) |
 T2 | 16,173 (12.5) | 130 (1.9) | 16,043 (13.2) | 37 (3.5) |
 T3 | 62,061 (48.1) | 2028 (29.0) | 60,033 (49.1) | 492 (46.2) |
 T4 | 21,021 (16.3) | 1606 (23.0) | 19,415 (15.9) | 242 (22.7) |
 TX | 6885 (5.3) | 2300 (33.0) | 4585 (3.8) | 166 (15.6) |
AJCC N stage | ||||
 N0 | 71,956 (55.7) | 2317 (33.2) | 69,639 (57.0) | 471 (44.2) |
 N1 | 35,029 (27.2) | 2369 (34.0) | 32,660 (26.7) | 394 (37.0) |
 N2 | 19,388 (15.0) | 1293 (18.5) | 18,095 (14.8) | 200 (18.8) |
 N3 | 2770 (2.1) | 998 (14.3) | 1772 (1.5) | 0 (0.0) |
AJCC M stage | ||||
 M0 | 101,456 (78.6) | 0 (0) | 101,456 (83.0) | 0 (0.0) |
 M1 | 27,687 (21.4) | 6977 (100.0) | 20,710 (17.0) | 1065 (100.0) |
Marital status | ||||
 Married | 67,504 (52.3) | 3299 (47.3) | 64,205 (52.6) | 489 (45.9) |
 Single | 53,026 (41.0) | 3203 (45.9) | 49,823 (40.8) | 521 (48.9) |
 Unknown | 8613 (6.7) | 475 (6.8) | 8138 (6.6) | 55 (5.2) |
Insurance status | ||||
 Insured | 84,167 (65.2) | 4002 (57.4) | 80,165 (65.6) | 1006 (94.5) |
 Uninsured | 4693 (3.6) | 401 (5.7) | 4292 (3.5) | 45 (4.2) |
 Unknown | 40,283 (31.2) | 2574 (36.9) | 37,709 (30.9) | 14 (1.3) |
Chemotherapy | ||||
 Yes | 57,583 (44.6) | 4700 (67.4) | 52,883 (43.3) | 730 (68.5) |
 No/Unknown | 71,560 (55.4) | 2277 (32.6) | 69,283 (56.7) | 335 (31.5) |
Site | ||||
 Right-sided colon | 52,861 (40.9) | 2168 (31.1) | 50,693 (41.5) | 304 (28.5) |
 Left-sided colon | 36,085 (27.9) | 1854 (26.6) | 34,231 (28.0) | 219 (20.6) |
 Rectum | 29,231 (22.6) | 2165 (31.0) | 27,066 (22.2) | 431 (40.5) |
 Rectosigmoid | 10,966 (8.6) | 790 (11.3) | 10,176 (8.3) | 111 (10.4) |
Surgery | ||||
 No | 16,789 (13.0) | 4305 (61.7) | 12,461 (10.2) | 475 (44.6) |
 Yes | 111,450 (86.3) | 2595 (37.2) | 108,850 (89.1) | 586 (55.0) |
 Unknown | 904 (0.7) | 77 (1.1) | 855 (0.7) | 4 (0.4) |
Radiotherapy | ||||
 Yes | 21,396 (16.6) | 1164 (16.7) | 20,232 (16.6) | 267 (25.1) |
 No/Unknown | 107,747 (83.4) | 5813 (83.3) | 101,934 (83.4) | 798 (74.9) |
Osseous metastasis |  |  |  | – |
 No | 127,287 (98.6) | 6107 (87.6) | 121,180 (99.2) |  |
 Yes | 1511 (1.1) | 672 (9.6) | 839 (0.7) |  |
 Unknown | 345 (0.3) | 198 (2.8) | 147 (0.1) |  |
Brain metastasis |  |  |  | – |
 No | 128,368 (99.4) | 6564 (94.0) | 121,804 (99.8) |  |
 Yes | 367 (0.3) | 185 (2.7) | 182 (0.1) |  |
 Unknown | 408 (0.3) | 228 (3.3) | 180 (0.1) |  |
Liver metastasis |  |  |  | – |
 No | 108,363 (83.9) | 1892 (27.2) | 106,471 (87.2) |  |
 Yes | 20,641 (16.0) | 5019 (71.9) | 15,622 (12.7) |  |
 Unknown | 139 (0.1) | 66 (0.9) | 73 (0.1) |  |