Correlation between serum liver fibrosis markers and early gastroesophageal varices among patients with compensated liver cirrhosis: a cross-sectional analysis

Table 3 Correlations between serum fibrosis markers and clinical characteristics of patients with negative EGD

Variables statistics	Hyaluronic acid (ng/ml)		Laminin (ng/ml)		Type III pro-collagen (ng/ml)		Collagen type IV (ng/ml)
	r	P	r	P	r	P	r	P
Age (years)	0.168	<0.001	0.006	0.895	−0.131	0.004	−0.116	0.011
Child class (A/B)	0.273	<0.001	0.216	<0.001	0.301	<0.001	0.291	<0.001
ALT(U/L)	0.210	<0.001	0.254	<0.001	0.439	<0.001	0.420	<0.001
AST(U/L)	0.331	<0.001	0.352	<0.001	0.518	<0.001	0.529	<0.001
TBIL (μmol/L)	0.266	<0.001	0.290	<0.001	0.289	<0.001	0.256	<0.001
ALB(g/L)	−0.401	<0.001	−0.302	<0.001	−0.431	<0.001	−0.494	<0.001
PLT(×10⁹/L)	−0.314	<0.001	−0.249	<0.001	−0.150	<0.001	−0.267	<0.001
PT(s)	0.212	<0.001	0.217	<0.001	0.300	<0.001	0.339	<0.001
LS (kPa)	0.484	<0.001	0.430	<0.001	0.469	<0.001	0.568	<0.001
Splenic diameter (mm)	0.149	0.001	0.088	0.059	0.159	0.001	0.204	<0.001
APRI	0.404	<0.001	0.397	<0.001	0.357	<0.001	0.565	<0.001
FIB-4	0.496	<0.001	0.387	<0.001	0.521	<0.001	0.445	<0.001
EGD(−)EUS(−/+)	0.142	0.002	0.253	<0.001	0.130	0.004	0.127	0.006

ALT Alanine aminotransferase, AST Aspartate aminotransferase, TBIL Total bilirubin, ALB Albumin, PLT Platelet, PT Prothrombin time, LS Liver stiffness, APRI Aspartate aminotransferase-to-Platelet Ratio Index, FIB-4: Fibrosis 4 Score
EGD (−)Esophagogastroduodenoscopy negative， EUS(−/+) Endoscopic ultrasound negative or positive

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