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Table 2 Characteristics of gastroesophageal varices of different severities

From: Correlation between serum liver fibrosis markers and early gastroesophageal varices among patients with compensated liver cirrhosis: a cross-sectional analysis

Variables

EUS-EGD-(n = 198)

EUS + EGD-(n = 279)

EUS + EGD+(n = 314)

P

Age (years)

50 (39.75, 56.5)

51 (40, 57)

54 (44, 60)

<0.001

Male, n(%)

105 (53)

158 (60)

205 (65)

0.013

Aetiology of cirrhosis (HBV/HCV/other)

145/26/27

217/34/28

199/51/64

0.002

Child category (A/B)

189/9

253/26

274/40

0.009*

ALT(U/L)

46 (24, 116)

57 (28, 164)

47 (26, 116)

0.231

AST(U/L)

42.5 (24, 86)

45 (28, 120)

53 (28, 108)

0.095

TBIL (umol/L)

15.2 (11.6, 20.725)

16.1 (13, 23.8)

18.8 (14.4, 27.8)

<0.001*

ALB(g/L)

43.8 (39.5, 46.425)

42.7 (39.3, 46.4)

41.4 (37.8, 45.2)

<0.001

PLT(×109/L)

152 (120.5, 180.5)

137 (105, 176)

115 (81, 161)

<0.001**

PT(s)

13.4 (12.7, 14.0)

13.5 (12.8, 14.4)

13.9 (12.8, 15.1)

<0.001*

Hyaluronic acid (ng/ml)

106.5 (87, 192.25)

141 (93, 322)

201 (98, 430)

<0.001**

Laminin (ng/ml)

91 (68.75, 98.0)

97 (89, 130)

102 (91.8, 146)

<0.001***

type III pro-collagen (ng/ml)

6.5 (9.0, 12.0)

9.7 (7.2, 16)

10 (7, 16)

0.001*

Collagen type IV (ng/ml)

55 (68, 114.75)

72 (62, 137)

102 (65, 183.3)

<0.001**

LS (kPa)

11.55 (7.675, 17.35)

14.2 (8.8, 23.2)

19.4 (10.8, 29.1)

<0.001**

Splenic diameter (mm)

110.5 (99.25, 120.75)

114 (99, 125)

118 (105, 133)

<0.001

APRI

0.79 (0.39, 1.49)

0.86 (0.5, 2.5)

1.27 (0.61, 2.91)

<0.001*

FIB-4

2.07 (1.23, 3.53)

2.36 (1.56, 4.51)

3.62 (2.03, 7.03)

<0.001**

  1. Data are expressed as median (quartile 25, quartile 75) or number (proportion)
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin, ALB albumin, PLT platelet, PT prothrombin time, LS liver stiffness, APRI: Aspartate aminotransferase-to-Platelet Ratio Index, FIB-4: Fibrosis 4 Score
  3. * P< 0.05, ** P< 0.01, *** P<0.001, between EUS-EGD- group and EUS + EGD- group