Table 5 Univariate and multivariate regression analysis of overall survival (OS) in patients with pancreatic signet ring cell carcinoma (PSRCC)

Age at diagnosis

<=67

1

1

> 67

1.27 (1.07–1.50)

0.005

1.22 (0.87–1.71)

0.244

Sex

Female

1

Male

1 (0.84–1.18)

0.982

/

/

Race

Black

Other

1.15 (0.76–1.73)

0.507

/

/

White

0.93 (0.71–1.23)

0.616

/

/

Year of diagnosis

2000–2009

1

1

2010–2018

0.80 (0.67–0.95)

0.009

0.71 (0.50–1.00)

0.052

Marital status at diagnosis

Married

1

1

Unmarried

1.31 (1.10–1.56)

0.002

1.32 (0.93–1.86)

0.120

Differentiation grade

I/II

1

1

III/IV

1.84 (1.25–2.72)

0.002

1.41 (0.85–2.35)

0.183

Tumour size

<=4

1

1

> 4

1.37 (1.11–1.69)

0.003

1.02 (0.72–1.45)

0.913

Primary site

Head

1

1

Body

1.47 (1.10–1.97)

0.009

1.38 (0.78–2.43)

0.272

Tail

1.29 (1.00–1.66)

0.048

1.45 (0.88–2.38)

0.140

Other

1.39 (1.01–1.93)

0.045

1.27 (0.72–2.22)

0.412

Regional nodes status

Positive

1

1

Negative

0.71 (0.48–1.06)

0.097

0.58 (0.35–0.95)

0.031

No nodes examined

2.53 (1.98–3.24)

< 0.001

0.74 (0.35–1.57)

0.440

Summary stage

Distant

1

1

Localised/Regional

0.44 (0.36–0.53)

< 0.001

0.66 (0.45–0.97)

0.034

Surgery

No

1

1

Yes

0.31 (0.24–0.40)

< 0.001

0.30 (0.14–0.65)

0.002

Chemotherapy

No/Unknown

1

1

Yes

0.41 (0.35–0.49)

< 0.001

0.42 (0.28–0.63)

< 0.001

Radiation

No/Unknown

1

1

Yes

0.45 (0.35–0.58)

< 0.001

1.07 (0.66–1.74)

0.782