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Table 2 Clinicopathological comparisons of patients with cytokeratin 7-expressing hepatocytes

From: Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis

Index

Patients with CK7+Hs(n = 44)

Patients with CK7−Hs (n = 45)

P1

P2

Patients with CK7+Hs (2 +) (n = 15)

Patients with CK7+Hs (1 +) (n = 29)

Age mean ± SD

50.79 ± 5.75

50.67 ± 9.45

53.24 ± 10.47

0.521‡

0.258†

Sex (female⁄ male)

15/0*

19/10*

39/6

0.010††

0.249

Diagnosis PBC/OS

4/11

12/17

24/21

0.178††

0.108

AMA ( ±)

12/3

19/10

19/22 (n = 41)

0.051††

0. 024

AMA-M2 ( ±)

12/3

19/10

20/21 (n = 41)

0.081††

0.042

Anti-gp210 ( ±)

6/9

9/20

6/35 (n = 41)

0.093††

0.038

Anti-sp100 ( ±)

2/13

8/21

5/36 (n = 41)

0.223††

0.203

ANA ( ±)

8/7

13/16

24/17 (n = 41)

0.527††

0.318

TB range (median) umol/L

9.9–277.1 (24.0)*

7.3–337.6 (18.1) (n = 28)

8.1–341.1 (13.2)*

(n = 41)

0.005 §

0.005 §

DB range (median) umol/L

2.8–196.7 (13.0)*

(n = 14)

2.2–249.8 (7.7) (n = 28)

2.1–254.6 (4.4)*

(n = 41)

0.004 §

0.004 §

Alb mean ± SD g/L

39.40 ± 6.17 (n = 14)

38.08 ± 5.77 (n = 28)

40.51 ± 4.71 (n = 40)

0.246‡

0.112†

ALT range (median) IU/L

20.0–846.3 (58.7)

13–664.4 (64.9) (n = 28)

15.7–1062.3 (61.1) (n = 41)

0.772§

0.421 §

AST range (median) IU/L

38.4–646.1 (92.3)

20.8–473.1 (68.05) (n = 28)

17.4–1392 (58.7) (n = 41)

0.152 §

0.134 §

ALP range (median) IU/L

117.6–766.3 (347.5)*

(n = 14)

77.2–750.6 (205) (n = 27)

73.7–684.1 (168.25)*

(n = 40)

0.002 §

0.005 §

γ-GT range (median) U/L

27.9–1840.8 (323.3) (n = 14)

22.4–638.8 (214.5) (n = 27)

22.5–799.1 (188.85) (n = 40)

0.084 §

0.054 §

TA range (median) umol/L

2.4–369.9 (45.4)*

(n = 14)

3.7–389.1 (26.5) (n = 28)

1.1–244.1 (15.9)*

(n = 40)

0.006 §

0.005 §

IgA mean ± SD g/L

2.84 ± 1.39

3.07 ± 1.25 (n = 25)

2.80 ± 0.93 (n = 40)

0.856‡

0.641†

IgG mean ± SD g/L

16.54 ± 5.13

15.48 ± 4.62 (n = 25)

16.06 ± 4.90 (n = 40)

0.631‡

0.961†

IgM mean ± SD g/L

3.47 ± 1.83*

3.13 ± 1.56 (n = 25)

2.31 ± 1.42* (n = 40)

0.026‡

0.011†

Fibrosis (1/2/3/4)

2/6/4/3

5/11/9/4

17/14/13/1

0.056 §

0.018 §

IA (0/1/2/3)

1/3/5/6*

1/11/12/5

11/17/14/3*

0.003 §

0.002 §

D grade (1/2/3/4)

3/3/7/2*#

9/8/11/1*

26/13/5/1#

0.001 §

 < 0.001§

DR (0/1/2)

3/8/4

4/18/7

19/13/13

0.354 §

0.152 §

Plasma cells (0/1/2/3)

0/8/6/1

0/13/12/4

4/24/12/5

0.255§

0.125 §

  1. CK7+Hs (2 +) Cytokeratin 7-positive hepatocytes grade 2, CK7+Hs (1 +) Cytokeratin 7-positive hepatocytes grade 1, CK7+Hs Cytokeratin 7-positive hepatocytes, CK7−Hs Cytokeratin 7-negative hepatocytes, PBC Primary biliary cholangitis, OS Overlap syndrome, AMA Anti-mitochondrial antibody, AMA-M2 Anti-mitochondrial antibody-M2, anti-gp210 Anti-glycoprotein 210(immunoblotting), anti-sp100 Anti-soluble protein 100(immunoblotting), TB Total bilirubin, DB Direct bilirubin, Alb Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, ALP Alkaline phosphatase, γ-GT γ-glutamyl transferase, TA Total bile acid, IgA Immunoglobulin A, IgG Immunoglobulin G, IgM Immunoglobulin M, IA Interface activity, D grade Ductopenia grade, DR Ductular reaction
  2. P1: P value in CK7 + (2, 1, 0), P2: P value in CK7 (+ , -)
  3. † unpaired t test
  4. ‡ one-way-ANOVA
  5. § Kruskal‒Wallis test
  6. Mann‒Whitney U test
  7. †† chi-square test
  8. #* indicates a significant difference between two groups
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BMC Gastroenterology

ISSN: 1471-230X

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