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Table 1 Histological assessment score in PBC patients

From: Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis

Feature

Score

Fibrosis

 Fibres were not seen or confined to the portal tracts

1

 Fibres extended from the portal tracts, but there was no bridging

2

 Fibres were bridging, but lobules were still clear

3

 Liver cirrhosis and pseudo lobules were noted

4

Interface activity

 No: the boundary plate was complete

0

 Mild: the inflammatory damage involved less than 30% of the interface

1

 Moderate: -the inflammatory damage involved 30%-50% of the interface

2

 Severe: the inflammatory lesions involved more than 50% of the interface

3

Ductopenia grade

 The proportion of missing bile ducts in the theoretical number of bile ducts in the portal area was less than 25%

1

 The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 25% but less than 50%

2

 The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 50% but less than 75%

3

 The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 75%

4

Plasma cells (CD38 staining)

 No: absence

0

 Few: isolated cells were positive

1

 Middle: clustered cells were positive

2

 Many: diffuse cells were positive

3

Ductular reaction (DR, CK7 staining)

 No: absence

0

 Few: less than 50% of the portal tracts

1

 Many: more than 50% of the portal tracts

2

Aberrant CK7 expression by hepatocytes

 Absence

0

 Isolated hepatocytes were positive

1

 Clustered/diffuse hepatocytes were positive

2