Feature | Score |
---|---|
Fibrosis | |
Fibres were not seen or confined to the portal tracts | 1 |
Fibres extended from the portal tracts, but there was no bridging | 2 |
Fibres were bridging, but lobules were still clear | 3 |
Liver cirrhosis and pseudo lobules were noted | 4 |
Interface activity | |
No: the boundary plate was complete | 0 |
Mild: the inflammatory damage involved less than 30% of the interface | 1 |
Moderate: -the inflammatory damage involved 30%-50% of the interface | 2 |
Severe: the inflammatory lesions involved more than 50% of the interface | 3 |
Ductopenia grade | |
The proportion of missing bile ducts in the theoretical number of bile ducts in the portal area was less than 25% | 1 |
The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 25% but less than 50% | 2 |
The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 50% but less than 75% | 3 |
The proportion of missing bile ducts in the number of theoretical bile ducts in the portal area was greater than or equal to 75% | 4 |
Plasma cells (CD38 staining) | |
No: absence | 0 |
Few: isolated cells were positive | 1 |
Middle: clustered cells were positive | 2 |
Many: diffuse cells were positive | 3 |
Ductular reaction (DR, CK7 staining) | |
No: absence | 0 |
Few: less than 50% of the portal tracts | 1 |
Many: more than 50% of the portal tracts | 2 |
Aberrant CK7 expression by hepatocytes | |
Absence | 0 |
Isolated hepatocytes were positive | 1 |
Clustered/diffuse hepatocytes were positive | 2 |