BMC Gastroenterology

Table 2 Results of cytokine measurements comparing LTR to HC and patients in remission with relapse during the first year after anti-TNF discontinuation

From: Prediction of long-term remission in patients following discontinuation of anti-TNF therapy in ulcerative colitis: a 10 year follow up study

Cytokine	LTR vs. HC		LTR vs. Early relapse
Cytokine	P value	ΔΔCT FC	P value	ΔΔCT FC
IL17	0.026	3.31↑	0.044	5.14↓
IL23	0.000	10.20↑	0.024	2.17↓
IL4	0.024	2.77↑	0.890	ns
IL5	0.329	ns	0.997	ns
IL6	0.001	7.46↑	0.192	ns
IL10	0.000	6.82↑	0.038	2.45↓
IL21	0.062	ns	0.264	ns
IL33	0.001	3.77↑	0.011	2.42↓
TGF	0.007	2.39↑	0.009	1.70↓
GATA	0.000	12.47↑	0.212	ns
TLR4	0.001	3.89↑	0.023	1.69↓
IL1RL1	0.111	ns	0.049	1.93↓
RORC	0.000	6.41↑	0.089	ns
FOX	0.000	8.88↑	0.470	ns
TBX	0.000	5.28↑	0.181	ns
TNF	0.103	ns	0.542	ns

↑ ↓Up or down regulated mucosal gene expression in LTR group
CT FC Cycle threshold fold change, ns not significant, LTR Long-term remission, HC Healthy control

Back to article page

ISSN: 1471-230X

Contact us

Submission enquiries: bmcgastroenterology@biomedcentral.com
General enquiries: ORSupport@springernature.com