Table 2 The incidence of grade1-2 TRAEs and grade ≥ 3 TRAEs
TRAE Name | Studies | Grade1-2 | Grade ≥ 3 |
|---|---|---|---|
Heterogeneity rate (95% CI) % | Heterogeneity rate (95% CI) % | ||
Diarrhoea | 15–21,23,24,26–28,30 | Random 28 (18, 38) | Random 4 (2, 6) |
Rash | 15–20,21,23,24,27,28,30 | Random 15 (9, 21) | Random 2 (1, 3) |
Fatigue | 15–20,21,23,24,26–28,30 | Random 26 (17, 35) | Random 4 (2, 6) |
Nausea | 15–20,23,24,26–28 | Random 21 (14, 28) | Random 1 (0, 2) |
Poor appetite | 18–20,23,24,26–28,30 | Random 23 (14, 33) | Random 2 (0, 4) |
Abdominal pain | 15,17,20,24,26,28,30 | Random 15 (8, 23) | Random 3 (1, 5) |
Pyrexia | 15–17,20,23,24,26,27,30 | Random 16 (11, 21) | Random 2 (0, 3) |
Increased AST | 16,17,20,23,27,28 | Random 16 (5, 27) | Random 4 (2, 6) |
Increased ALT | 15–17,20,27,28 | Random 12 (5, 19) | Random 3 (2, 5) |
Hypothyroidism | 15–17,20,23,27,30 | Random 11 (7, 16) | Random 1 (− 1, 2) |
Pancreatitis | 13,14,16,17,24,25 | Random 7 (2, 12) | Random 5 (1, 9) |