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Table 5 (A) Univariate Cox regression in Training-Validation dataset (N = 258). (B) Univariate Cox regression in the whole ACRG cohort (N = 300)

From: A 9‑gene expression signature to predict stage development in resectable stomach adenocarcinoma

Variables

Overall survival

Disease free survival

Hazard ratio

P value

Hazard ratio

P value

(A) N = 258

    

Male

0.98 (0.67–1.45)

0.940

1.01 (0.66–1.54)

0.977

Age (per 1 year increase)

1.01 (0.99–1.03)

0.255

1.00 (0.98–1.02)

0.893

Tumor location

    

Upper

1.00

1.000

1.00

1.000

Middle

0.61 (0.34–1.08)

0.089

0.76 (0.40–1.44)

0.397

Lower

0.56 (0.32–0.99)

0.045

0.56 (0.30–1.07)

0.082

Whole

2.91 (0.66–12.82)

0.158

3.33 (0.74–15.02)

0.117

Total resection

0.34 (0.23–0.50)

< 0.001

0.31 (0.21–0.48)

< 0.001

T stage

    

T2-3

1.00

1.000

1.00

1.000

T4a

2.48 (1.70–3.61)

< 0.001

2.73 (1.81–4.13)

< 0.001

T4b

1.73 (0.79–3.78)

0.169

1.69 (0.72–3.94)

0.229

 N stage

    

N0

1.00

1.000

1.00

1.000

N1

2.79 (1.06–7.37)

0.039

2.73 (0.92–8.13)

0.070

N2

2.08 (0.79–5.54)

0.140

1.71 (0.56–5.20)

0.344

N3a

4.82 (1.90–12.25)

0.001

5.60 (1.98–15.83)

0.001

N3b

10.09 (3.91–26.03)

< 0.001

11.81 (4.13–33.77)

< 0.001

T4 stage

2.35 (1.64–3.38)

< 0.001

2.54 (1.71–3.79)

< 0.001

 N + stage

3.87 (1.58–9.48)

0.003

4.04 (1.48–10.99)

0.006

High stage

2.18 (1.36–3.50)

0.001

2.35 (1.37–4.02)

0.002

MLH1 positivity

1.76 (1.09–2.85)

0.021

1.86 (1.07–3.23)

0.027

Lauren classification

    

Intestinal

1.00

1.000

1.00

1.000

Mixed

2.18 (1.13–4.19)

0.020

1.89 (0.85–4.23)

0.120

Diffused

1.59 (1.09–2.33)

0.017

1.49 (0.98–2.25)

0.062

Poor differentiation

1.50 (1.03–2.17)

0.035

1.40 (0.93–2.11)

0.106

ACRG subtype

    

TP53 negative

1.00

1.000

1.00

1.000

TP53positive

0.85 (0.53–1.36)

0.496

0.97 (0.58–1.63)

0.904

MSI

0.65 (0.39–1.09)

0.107

0.63 (0.34–1.16)

0.134

EMT

1.86 (1.14–3.06)

0.014

2.08 (1.23–3.51)

0.007

Chemotherapy

0.55 (0.35–0.85)

0.007

0.55 (0.34–0.88)

0.012

Mesenchymal phenotype

1.93 (1.32–2.81)

0.001

2.09 (1.38–3.15)

< 0.001

9-gene score

1.28 (1.08–1.50)

0.003

1.30 (1.10–1.55)

0.003

MYOCD

1.38 (1.23–1.55)

< 0.001

1.42 (1.25–1.61)

< 0.001

GHRL

1.03 (0.93–1.14)

0.585

1.04 (0.94–1.16)

0.399

SCRG1

1.27 (1.18–1.38)

< 0.001

1.30 (1.19–1.41)

< 0.001

TYRP1

1.20 (1.08–1.33)

0.001

1.22 (1.09–1.36)

0.001

LYPD6B

1.00 (0.89–1.13)

0.982

0.96 (0.85–1.09)

0.557

THBS4

1.27 (1.15–1.40)

< 0.001

1.29 (1.16–1.44)

< 0.001

TNFRSF17

0.95 (0.85–1.05)

0.298

0.95 (0.85–1.06)

0.388

SERPINB2

1.00 (0.90–1.10)

0.955

0.94 (0.84–1.06)

0.34

NEBL

1.01 (0.92–1.11)

0.865

1.01 (0.91–1.12)

0.854

Borrmann type

    

Borrmann I or EGC

1.00

1.000

1.00

1.000

Borrmann II

0.71 (0.29–1.73)

0.455

0.62 (0.25–1.54)

0.302

Borrmann III

1.49 (0.64–3.44)

0.352

1.24 (0.53–2.90)

0.615

Borrmann IV

3.62 (1.48–8.89)

0.005

3.31 (1.33–8.25)

0.010

(B) N = 300

    

Male

0.90 (0.65–1.27)

0.559

0.96 (0.66–1.39)

0.825

Age (per 1 year increase)

1.01 (1.00–1.03)

0.181

1.00 (0.99–1.02)

0.715

Tumor location

    

Upper

1.00

1.000

1.00

1.000

Middle

1.09 (0.76–1.56)

0.631

1.21 (0.82–1.78)

0.330

Lower

1.66 (1.02–2.70)

0.041

1.62 (0.93–2.83)

0.087

Whole

3.27 (1.42–7.56)

0.006

2.21 (0.80–6.11)

0.127

Subtotal resection

0.38 (0.27–0.52)

< 0.001

0.38 (0.27–0.55)

< 0.001

T stage

    

T2-3

1.00

1.000

1.00

1.000

T4a

2.37 (1.69–3.32)

< 0.001

2.52 (1.73–3.67)

< 0.001

T4b

2.51 (1.46–4.32)

< 0.001

2.71 (1.53–4.79)

0.001

 N stage

    

N0

1.00

1.000

1.00

1.000

N1

1.74 (0.86–3.54)

0.124

1.71 (0.76–3.83)

0.191

N2

3.37 (1.65–6.85)

< 0.001

3.94 (1.77–8.79)

0.001

N3

6.94 (3.36–14.33)

< 0.001

7.46 (3.31–16.83)

< 0.001

MLH1 positivity

2.03 (1.28–3.22)

0.003

2.10 (1.25–3.56)

0.005

Lauren classification

    

Intestinal

1.00

1.000

1.00

1.000

Diffused

1.69 (0.68–4.20)

0.260

2.70 (0.97–7.50)

0.057

Mixed

1.75 (1.26–2.42)

< 0.001

1.63 (1.13–2.34)

0.009

Poor differentiation

1.60 (1.14–2.24)

0.006

1.51 (1.05–2.19)

0.028

ACRG subtype

    

TP53 negative

1.00

1.000

1.00

1.000

TP53positive

0.78 (0.52–1.18)

0.246

0.82 (0.52–1.29)

0.391

MSI

0.52 (0.32–0.84)

0.008

0.48 (0.27–0.85)

0.012

EMT

1.56 (1.02–2.40)

0.041

1.62 (1.03–2.55)

0.037

Chemotherapy

0.48 (0.32–0.73)

< 0.001

0.49 (0.31–0.76)

0.001

Mesenchymal phenotype

1.79 (1.29–2.50)

< 0.001

1.92 (1.34–2.76)

< 0.001

9-gene score

1.29 (1.12–1.49)

< 0.001

1.31 (1.13–1.52)

< 0.001

MYOCD

1.34 (1.21–1.48)

< 0.001

1.37 (1.23–1.52)

< 0.001

GHRL

1.05 (0.97–1.14)

0.193

1.07 (0.98–1.16)

0.148

SCRG1

1.23 (1.15–1.32)

< 0.001

1.24 (1.15–1.34)

< 0.001

TYRP1

1.18 (1.08–1.30)

< 0.001

1.19 (1.08–1.31)

< 0.001

LYPD6B

1.02 (0.92–1.13)

0.760

0.99 (0.89–1.11)

0.896

THBS4

1.23 (1.13–1.34)

< 0.001

1.24 (1.14–1.36)

< 0.001

TNFRSF17

0.95 (0.87–1.04)

0.240

0.94 (0.86–1.04)

0.218

SERPINB2

0.98 (0.89–1.07)

0.653

0.94 (0.84–1.04)

0.225

NEBL

1.00 (0.92–1.09)

0.985

1.01 (0.92–1.11)

0.882

Borrmann type

    

Borrmann I or EGC

1.00

1.000

1.00

1.000

Borrmann II

0.87 (0.37–2.08)

0.757

0.83 (0.34–1.99)

0.670

Borrmann III

1.70 (0.74–3.91)

0.209

1.42 (0.61–3.27)

0.417

Borrmann IV

4.07 (1.70–9.76)

0.002

3.33 (1.37–8.11)

0.008

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