Table 3  Adjusted and stratified CRC incidence and all-cause mortality in patients with 3–4 MetS components versus 1–2 MetS components

Overall

119,843

1,318

1.28 (1.15–1.43)

< 0.001

10,728

1.13 (1.08–1.17)

< 0.001

Age, years

0.731

< 0.001

  < 65

70,299

526

1.29 (1.09–1.54)

0.004

3,028

1.35 (1.25–1.45)

< 0.001

  ≥ 65

49,544

792

1.24 (1.07–1.43)

0.003

7,700

0.99 (0.94–1.04)

0.600

Gender

0.314

0.005

  Female

59,862

604

1.37 (1.16–1.61)

< 0.001

4,886

1.2 (1.13–1.27)

< 0.001

  Male

59,981

714

1.22 (1.05–1.42)

0.011

5,842

1.06 (1.01–1.12)

0.024

History of CHD

0.011

0.020

  Without

78,844

824

1.41 (1.23–1.62)

< 0.001

6,261

1.13 (1.08–1.19)

< 0.001

  With

40,999

494

1.08 (0.90–1.31)

0.398

4,467

1.13 (1.06–1.20)

< 0.001

History of CKD

0.587

0.300

  Without

115,741

1266

1.27 (1.14–1.43)

< 0.001

9,998

1.13 (1.09–1.18)

< 0.001

  With

4,102

52

1.50 (0.86–2.61)

0.151

730

0.97 (0.83–1.13)

0.706

Aspirin

0.118

0.420

  Non-user

83,282

869

1.35 (1.18–1.54)

< 0.001

5,201

1.06 (1.00-1.12)

0.045

  User

36,561

449

1.17 (0.97–1.42)

0.105

5,527

1.24 (1.17–1.31)

< 0.001

NSAIDs

0.839

< 0.001

  Non-user

43,008

450

1.32 (1.09–1.6)

0.004

2,422

1.02 (0.93–1.11)

0.727

  User

76,835

868

1.27 (1.11–1.45)

< 0.001

8,306

1.18 (1.13–1.23)

< 0.001

Statins

0.399

< 0.001

  Non-user

82,610

956

1.26 (1.11–1.44)

< 0.001

7,807

1.00 (0.95–1.05)

0.945

  User

37,233

362

1.31 (1.07–1.62)

0.010

2,921

1.54 (1.43–1.66)

< 0.001

Significant values (p < 0.05) between outcome and the stratified covariate are showing in bold.

^a Adjusted for age, sex, index year, smoking, alcohol drinking, comorbidities, renal transplantation and concurrent medications, except for the stratified covariate.

^b Not available (NA) due to a low sample size.

Abbreviations: CHD, coronary heart disease; CKD, chronic kidney disease; HR, hazard ratio; NSAID, nonsteroidal anti-inflammatory drugs.