Table 6 Effect size of SUA/Scr on NAFLD in prespecified and exploratory subgroups

Age, years

 < 30

30 to 40

40 to 50

50 to 60

60 to 70

42,177

56,690

41,167

22,149

10,007

 < 0.0001

1.553 (1.469, 1.642) < 0.0001

1.539 (1.484, 1.596) < 0.0001

1.436 (1.387, 1.487) < 0.0001

1.405 (1.350, 1.463) < 0.0001

1.341 (1.267, 1.420) < 0.0001

 ≥ 70

10,130

1.381 (1.297, 1.471) < 0.0001

Gender

 < 0.0001

Male

90,305

1.321 (1.290, 1.353) < 0.0001

Female

92,015

1.653 (1.597, 1.712) < 0.0001

BMI (kg/m²)

 < 0.0001

 < 18.5

18,085

2.032 (1.449, 2.848) < 0.0001

 ≥ 18.5, < 24

140,638

1.543 (1.508, 1.579) < 0.0001

 ≥ 24

23,597

1.344 (1.297, 1.394) < 0.0001

FPG (mmol/L)

 < 0.0001

 ≤ 6.1

171,532

1.435 (1.404, 1.466) < 0.0001

 > 6.1

10,788

1.199 (1.136, 1.266) < 0.0001

HDL-c (mmol/L)

 < 0.0001

 < 1

14,221

1.247 (1.186, 1.311) < 0.0001

 ≥ 1

168,099

1.460 (1.429, 1.492) < 0.0001

ALT (U/L)

0.8957

 ≤ 40

169,898

1.406 (1.377, 1.436) < 0.0001

 > 40

12,422

1.401 (1.332, 1.474) < 0.0001

GLB (g/L)

0.2555

 < 30

107,345

1.414 (1.379, 1.449) < 0.0001

 ≥ 30

74,975

1.443 (1.402, 1.485) < 0.0001

eGFR (ml/min/1.73m²)

0.0804

 < 60

3839

1.235 (1.099, 1.388) 0.0004

 ≥ 60

178,481

1.373 (1.348, 1.398) < 0.0001