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Table 2 Univariate and multivariate analyses of clinicopathological factors

From: Mutational and transcriptional alterations and clinicopathological factors predict the prognosis of stage I hepatocellular carcinoma

 

Univariate

Multivariate

 

HR (95% CI)

P value

HR (95% CI)

P value

Neoplasm histologic grade

    

G1

Reference

 

Reference

 

G2

1.07 (0.42–2.70)

0.886

1.38 (0.29–6.50)

0.681

G3

0.84 (0.31–2.26)

0.723

2.74 (0.49–15.33)

0.252

G4

2.08 (0.57–7.54)

0.266

10.78 (1.30–89.59)

0.028

Child Pugh classification grade

    

A

Reference

 

Reference

 

B or C

1.85 (0.64–5.36)

0.255

10.28 (1.82–57.98)

0.008

BMI

    

Normal

Reference

 

Reference

 

High

1.36 (0.70–2.67)

0.363

0.30 (0.10–0.89)

0.029

Low

0.00 (0.00-Inf)

0.997

0.00 (0.00-Inf)

0.998

Age

    

Age

1.04 (1.02–1.07)

0.003

1.08 (1.02–1.14)

0.007

Sex

    

Female

Reference

 

Reference

 

Male

0.49 (0.27–0.92)

0.025

0.76 (0.24–2.38)

0.639

Race

    

Asia

Reference

 

Reference

 

Black or African American

5.95 (1.62–21.88)

0.007

25.53 (3.97–164.23)

0.001

White

3.05 (1.47–6.33)

0.003

3.86 (0.86–17.35)

0.078

TMB

    

Low

Reference

 

Reference

 

High

2.69 (1.10–6.58)

0.030

1.97 (0.30–12.88)

0.480

Fibrosis Ishak score

    

0: No fibrosis

Reference

 

Reference

 

1, 2: Portal fibrosis

1.46 (0.41–5.17)

0.556

1.18 (0.15–9.43)

0.877

3, 4: Fibrous speta

1.49 (0.43–5.14)

0.530

1.86 (0.44–7.79)

0.397

5, 6: Incomplete or established cirrhosis

0.79 (0.30–2.07)

0.634

1.89 (0.51–7.08)

0.344

  1. P < 0.05 for bold P values
  2. HR, hazard ratio; CI, confidence interval; G, grade; BMI, body mass index; TMB, tumor mutational burden