Fig. 4

Profile of transcriptional alterations of stage I hepatocellular carcinoma (HCC). A The heatmap shows the transcriptional status of the top 100 differentially transcripted genes. Blue bars represent normal tissues while pink bars represent cancer tissues. B Volcano plot shows the significantly up-regulated (red) or down-regulated (green) genes, with the names of the most significant ones labeled. C–E The results for GO (C), KEGG (D) and Reactome (E) enrichment analyses. The significantly altered functions or pathways are shown as indicated. GO, gene ontology; KEGG, Kyoto encyclopedia of genes and genomes; BP, biological process; CC, cellular compartment; MF, molecular function; FC, fold change; p.adjust, adjusted p value