Fig. 1

Patient populations. ^*All patients randomly assigned to treatment for whom patient diary data could not rule out that they received at least one dose of NER1006. ^†Patients included in the safety population who had a normal sodium concentration at baseline and an increase from baseline to above the upper limit of normal (ULN) for sodium (143–148 mmol/L). ^‡Reported as an adverse event based on test results on the day of colonoscopy; medical intervention was not required, and sodium levels returned to normal range within 2 ± 1 days post-colonoscopy. DAYB Day Before Arm MORA Morning Arm NOCT Nocturnal Pause Arm