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Table 3 Chronological changes in liver function tests before and after endoscopic injection sclerotherapy

From: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function

Parameter

 

Before EIS

1 W after EIS

P*

1 M after EIS

p*

6 M after EIS

p*

12 M after EIS

p*

Albumin (g/dL)

IG

3.60 (3.30–4.10)

3.60 (3.30–4.00)

0.8993

3.70 (3.50–4.00)

0.3287

3.85 (3.63–4.10)

0.1165

3.90 (3.68–4.13)

0.0036

 

DG

3.30 (3.10–3.50)

3.35 (3.15–3.55)

0.9471

3.60 (3.13–3.83)

0.1715

3.40 (3.00–3.90)

0.8317

3.60 (3.05–3.70)

0.4347

PT (%)

IG

70.0 (65.5–74.0)

71.0 (66.0–76.0)

0.2148

69.0 (64.5–79.0)

0.0234

74.0 (66.0–85.0)

0.0907

74.0 (67.0–79.0)

0.0333

 

DG

71.0 (65.0–78.0)

67.5 (65.0–78.0)

0.1243

73.5 (66.8–81.8)

0.5898

69.5 (62.3–80.3)

0.8867

63.0 (56.0–84.5)

0.7315

Tbil (mg/dL)

IG

0.9 (0.8–1.0)

0.8 (0.6–1.0)

0.0084

1.0 (0.7–0.4)

0.4970

0.9 (0.7–1.2)

0.9418

1.1 (0.8–1.5)

0.8687

 

DG

1.1 (0.9–2.0)

0.9 (0.7–1.8)

0.6021

1.2 (0.8–2.4)

0.4895

1.2 (0.9–1.8)

0.4725

1.3 (1.0–1.8)

0.4885

NH3 (μg/dL)

IG

64.5 (51.0–73.8)

32.0 (18.0–42.0)

0.0045

46.0 (37.5–61.0)

0.0209

43.0 (37.5–61.0)

0.0075

51.0 (37.5–64.0)

0.1133

 

DG

59.0 (49.0–118.0)

46.0 (33.0–56.0)

0.0778

36.0 (24.0–78.0)

0.2062

92.0 (80.0–115.5)

0.8486

64.0 (31.5–92.8)

0.3215

Child–Pugh score

IG

6.00 (5.00–6.00)

6.00 (5.00–6.00)

0.3332

6.00 (5.00–6.00)

0.3343

5.50 (5.00–6.00)

0.1110

5.00 (5.00–5.75)

0.0475

 

DG

7.00 (6.00–7.00)

6.50 (6.00–7.00)

0.6305

5.50 (5.00–7.00)

0.2360

6.50 (5.00–7.00)

0.6776

7.00 (5.00–7.00)

1.000

MELD score

IG

15.1 (13.9–15.9)

14.9 (13.5–15.8)

0.0215

15.0 (13.5–15.9)

0.3572

14.7 (13.2–15.7)

0.1025

14.7 (13.6–16.0)

0.0321

 

DG

14.6 (13.5–17.0)

 14.2 (13.4–15.9)

 0.8705

 14.8 (13.5–17.2)

 0.8830

 14.8 (13.3–16.6)

 0.8574

 14.4 (13.0–15.3)

 0.9077

ICG-R15 (%)

IG

27.0 (18.5–33.0)

22.5 (16.0–28.8)

0.0024

 

DG

36.0 (26.5–42.0)

29.0 (25.0–41.0)

0.2711

  1. All data are expressed as median (first quartile-third quartile)
  2. *Before EIS vs 1 W, 1 M, 6 M, 12 M (paired-t test)
  3. EIS, endoscopic injection sclerotherapy; W, week; M, months; PT, prothrombin time; Tbil, total bilirubin; NH3, ammonia; MELD, Model for End-Stage Liver Disease; ICG-R15, indocyanine green retention at 15 min
  4. IG, increased group; and DG, decreased group