Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma

Table 3 Univariate analysis of the sensitivity of bile duct biopsy

Factor		Sensitivity of bile duct biopsy	P-value
Tumor localization	Perihilar Distal	56.6% (357/631) 71.4% (115/161)	0.001
Macroscopic type	Papillary/nodular Flat	68.4% (234/342) 47.7% (213/447)	< 0.001
History of EST	Yes No (untreated papilla)	59.1% (182/308) 58.9% (272/462)	0.952
EBS	Yes No	62.1% (295/475) 55.4% (168/303)	0.065
Jaundice ^a	Yes No	67.9% (129/190) 57.0% (336/589)	0.008
Cholangitis ^b	Yes No	51.8% (42/81) 60.4% (429/710)	0.136

EST endoscopic sphincterotomy, EBS endoscopic biliary stenting
^aTotal bilirubin level ≥ 3.0 mg/dL. Cases without data were excluded, ^bCholangitis was diagnosed according to the Tokyo Guidelines 2018

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