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Table 3 Univariate and multivariate Cox regression analysis of overall survival in 126 HCC patients

From: The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways

 

Overall survival

Variables

HR

95% CI

P value

Univariate analysis

Age (y, ≤ 60/ > 60)

3.385

1.829–2.264

 < 0.001***

Gender

1.197

0.662–1.162

0.552

AFP (ng/ml, ≤ 20/ > 20)

2.378

1.334–4.238

0.003**

Cirrhosis

2.906

1.608–5.251

 < 0.001***

HBV

1.132

0.512–2.502

0.760

Tumor size (cm, ≤ 5/ > 5)

2.998

1.596–5.633

0.001**

Pathological stage

0.309

0.167–0.570

 < 0.001***

Intrahepatic metastasis

2.942

0.867–9.984

0.084

STAG3 expression

0.114

0.048–0.272

 < 0.001***

Multivariate analysis

Age (y, ≤ 60/ > 60)

1.994

0.972–4.090

0.060

AFP (ng/mL, ≤ 20/ > 20)

1.000

0.516–1.940

1.000

Cirrhosis

1.398

0.670–2.916

0.372

Tumor size (cm, ≤ 5/ > 5)

1.025

0.511–2.055

0.944

Pathological stage

0.394

0.195–0.797

0.010*

STAG3 expression

0.174

0.063–0.483

0.001**

  1. CI confidence interval, HR hazard ratio, HCC hepatocellular carcinoma.
  2. *P < 0.05, **P < 0.01, ***P < 0.001.
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BMC Gastroenterology

ISSN: 1471-230X

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