The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways

Table 2 Correlation between the expression of STAG3 and clinicopathological features in 126 HCC patients

Clinicopathological features	Number (n = 126)	Low expression (n = 90)	High expression (n = 36)	χ2	P value
Age, year
≤ 60	69	50	19	0.080	0.777
> 60	57	40	17	0.080	0.777
Gender
Male	103	76	27	1.537	0.215
Female	23	14	9	1.537	0.215
AFP, ng/ml
≤ 20	52	31	21	6.054	0.014*
> 20	74	59	15	6.054	0.014*
Cirrhosis
Negative	71	45	26	5.163	0.023*
Positive	55	45	10	5.163	0.023*
HBV
Negative	12	6	6	2.761	0.097
Positive	111	81	30		0.097
HCV	3	3	0
Tumor size, cm
≤ 5	65	39	26	8.593	0.003**
> 5	61	51	10	8.593	0.003**
Pathological stage
I-II	41	24	17	4.950	0.026*
III-IV	85	66	19	4.950	0.026*
Intrahepatic metastasis
Negative	114	81	33	0.083	0.773
Positive	12	9	3	0.083	0.773

ISSN: 1471-230X