Fig. 4

STAG3 overexpression inhibited HCC proliferation and promoted apoptosis in vivo. A The image shows mice with tumor xenografts inoculated with STAG3-OE BEL-7404 and STAG3-NC BEL-7404 cells. Xenograft tumor growth was monitored. B HCC tissues from mice with tumor xenografts inoculated with STAG3-OE BEL-7404 and STAG3-NC BEL-7404 cells. Representative mice and tumor images are included. C The category graph (symbols and lines) shows the results from the quantitative analysis of the HCC volume of the NC and STAG3-OE groups at 1–4 weeks. D The scatter plot (vertical) shows the results from the quantitative analysis of the HCC weight in the NC and STAG3-OE groups. E The expression of Ki-67 in xenograft tumor tissues from the NC and STAG3-OE groups was detected by IHC. Representative images of HE staining and IHC staining of Ki-67 are shown. F The percentages of Ki-67-positive cells are indicated. G A TUNEL assay was used to verify the apoptosis of xenograft tumor tissues from the NC and STAG3-OE groups. Representative images are shown. H The percentages of TUNEL-positive cells are indicated. *P < 0.05; **P < 0.01; ***P < 0.001