Table 1 Major characteristics of included studies
Author | Year | Country | Sample source | Methylated SDC2 detection methods | Cut-off | colorectal cancer case | Control | Sample size | ACTB for reference | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Age (y) | M/F | N | Age (y) | M/F | ||||||||
TaeJeong Oh | 2013 | South Korea | Blood | qMSP | PMR > 0.936 | 131 | 58.4 (33–84) | 69/62 | 125 | 51.0 (40–61) | 64/61 | 256 | Yes |
Barbara Kinga Barták | 2017 | Hungary | Blood | MethyLight PCR | NR | 37 | NR | NR | 47 | NR | NR | 121 | No |
Tae Jeong Oh | 2017 | South Korea | Stool | LTE-qMSP | CT < 40 | 50 | 61.9 (41–84) | 30/20 | 22 | 58.8 (36–77) | 12/10 | 72 | No |
Feng Niu | 2017 | China | Stool | qMSP | NR | 196 | 61.0 (43–79) | 121/75 | 179 | 61.0 (45–76) | 70/109 | 375 | Yes |
Minghao Sun | 2019 | China | Stool | qPCR | CT < 42 | 105 | NR | NR | 108 | NR | NR | 213 | Yes |
Guodong Zhao | 2019 | China | Blood | qMSP | Cp < 50 | 117 | 61.8 (25–89) | 64/53 | 166 | 36.6 (21–69) | 87/79 | 283 | Yes |
Ying Chen | 2019 | China | Blood | qMSP | Cp < 50 | 111 | 61.0 (25–89) | NR | 114 | 33.2 (19–60) | NR | 225 | Yes |
Yoon Dae Han | 2019 | South Korea | Stool | LTE-qMSP | CT < 40 | 245 | NR | 133/122 | 245 | NR | 114/131 | 490 | No |
Guodong Zhao I | 2020 | China | Blood | qMSP | Cp < 44 | 122 | 61.8 (30–88) | 64/58 | 91 | 39.3 (23–69) | 56/35 | 213 | Yes |
Guodong Zhao II | 2020 | China | Stool | qPCR | CT < 50 | 39 | 59.0 (27–83) | 21/18 | 59 | 47.9 (24–83) | 31/28 | 98 | Yes |
Jianping Wang | 2020 | China | Stool | qMSP | CT < 38 | 359 | NR | 234/125 | 713 | NR | NR | 1072 | Yes |
Wei-Chih Su | 2021 | China | Stool | qPCR | CT < 39 | 62 | NR | 33/29 | 76 | NR | 37/39 | 138 | No |