Table 4 Clinical characteristics of LRP5 rs556442 A allele carriers and non-carriers in the study population

Sex (M/F)

835 (501/334)

69 (34/35)

228 (130/98)

19 (9/10)

104 (71/33)

14 (10/4)

Age, years

53.61 ± 14.37

52.71 ± 14.37

48.31 ± 11.90

49.26 ± 13.15

61.5 ± 8.07

62.29 ± 8.22

BMI, kg/m²

24.84 ± 3.23

23.41 ± 4.17

26.59 ± 2.93

25.44 ± 1.88

25.21 ± 2.45

24.25 ± 2.34

FPG, mmol/L

4.84 (4.37–5.56)

4.74 (4.39–5.20)

4.77 (4.40–5.28)

4.74 (4.46–5.28)

5.43 (4.77–6.49)

4.95 (4.33–6.39)

TC, mmol/L

4.46 ± 1.64

4.68 ± 1.60

5.32 ± 1.17

5.16 ± 1.15

4.41 ± 1.36

4.37 ± 1.22

TG, mmol/L

1.45 (1.01–2.23)

1.25 (0.87–1.94)

1.57 (1.15–2.19)

1.22 (0.99–1.90)

1.49 (0.97–2.32)

1.38 (1.18–2.18)

HDL, mmol/L

1.17 (1.00–1.38)

1.20 (1.01–1.48)

1.20 (1.05–1.32)

1.20 (1.08–1.45)

1.02 (0.87–1.16)

0.96 (0.83–1.19)

LDL, mmol/L

3.11 ± 0.99

3.12 ± 1.19

3.48 ± 1.71

3.06 ± 0.70

2.71 ± 0.91

2.73 ± 0.83

ALT, U/L

20.98 (15.00–31.16)

17.93 (12.92–28.62)

24.83 (17.63–39.02)

22.67 (13.85–37.13)

22.71 (15.62–33.51)

18.69 (10.93–29.73)

AST, U/L

21.47 (17.95–27.67)

20.71 (16.02–25.62)

22.87 (18.67–28.29)

21.55 (18.24–28.09)

23.30 (16.94–34.48)

18.63 (14.41–25.24)

ALT/AST

0.97 (0.75–1.27)

0.92 (0.68–1.10)

1.15 (0.88–1.46)

1.07 (0.81–1.24)

0.94 (0.68–1.24)

1.01 (0.69–1.25)

GGT, U/L

27.10 ± 21.15

37.88 ± 57.47

47.66 ± 82.71

29.30 ± 14.66

48.31 ± 81.49

38.49 ± 40.38

ALP, U/L

74.80 (59.82–91.52)

74.33 (59.55–97.60)

77.38 (62.55–93.59)

63.86 (51.98–105.33)

82.26 (69.75–99.42)

81.44 (73.38–98.63)

TB, μmol/L

14.69 ± 6.86

14.21 ± 6.11

13.31 ± 5.14

13.04 ± 5.15

15.14 ± 8.27

13.77 ± 5.03