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Table 2 Univariate COX analysis for the potential predictors of ICU death in liver cirrhosis patients

From: Establishment of MELD-lactate clearance scoring system in predicting death risk of critically ill cirrhotic patients

Variables β SE χ2 P HR 95% CI
Lower Upper
Age 0.007 0.005 1.668 0.196 1.007 0.997 1.017
Gender (Male)  − 0.133 0.131 1.021 0.312 0.876 0.677 1.133
Insurance        
Medicare      Ref   
Others 0.062 0.159 0.151 0.697 1.064 0.779 1.453
Private 0.045 0.147 0.093 0.761 1.046 0.784 1.394
ICU type        
MICU      Ref   
CCU/CSRU  − 0.219 0.202 1.175 0.278 0.803 0.540 1.194
SICU/TSICU  − 0.368 0.147 6.215 0.013 0.692 0.519 0.924
Marital status        
Married      Ref   
Single 0.087 0.141 0.383 0.536 1.091 0.827 1.440
Widowed 0.049 0.284 0.030 0.863 1.050 0.602 1.831
Divorced/separated 0.061 0.200 0.092 0.761 1.063 0.717 1.574
Race        
White      Ref   
Black 0.236 0.206 1.319 0.251 1.267 0.846 1.896
Asian 0.759 0.343 4.890 0.027 2.136 1.090 4.187
Hispanic  − 0.443 0.361 1.506 0.220 0.642 0.316 1.303
Others  − 0.286 0.310 0.851 0.356 0.751 0.409 1.380
ACLF (Yes) 0.704 0.171 17.032  < 0.001 2.021 1.447 2.823
Pathogenesis        
Alcoholic      Ref   
No alcoholic 0.233 0.389 0.360 0.549 1.263 0.589 2.705
Biliary 0.127 0.129 0.979 0.322 1.136 0.883 1.462
Hepatic encephalopathy (Yes)  − 0.135 0.144 0.880 0.348 0.874 0.659 1.159
Ascites (Yes)  − 0.026 0.135 0.036 0.849 0.975 0.748 1.270
Hepatocerebral syndrome (Yes) 0.159 0.155 1.050 0.306 1.172 0.865 1.587
RRT (Yes) 0.389 0.183 4.541 0.033 1.476 1.032 2.111
Vasopressors (Yes) 1.175 0.133 77.955  < 0.001 3.239 2.495 4.205
Ventilation (Yes)  − 0.128 0.127 1.012 0.314 0.880 0.685 1.129
Transplantation (Yes)  − 2.511 0.710 12.494  < 0.001 0.081 0.020 0.327
Temperature  − 0.216 0.076 8.147 0.004 0.806 0.695 0.935
Heart rate 0.003 0.003 1.061 0.303 1.003 0.997 1.009
SBP  − 0.008 0.003 5.315 0.021 0.992 0.986 0.999
DBP  < 0.001 0.000 5.498 0.019 1.000 1.000 1.001
MAP  − 0.008 0.004 4.727 0.030 0.992 0.985 0.999
SPO2/FiO2  − 0.002 0.001 4.847 0.028 0.998 0.996 1.000
PaO2/FiO2  − 0.002 0.000 19.165  < 0.001 0.998 0.997 0.999
Bilirubin 0.027 0.006 23.490  < 0.001 1.028 1.016 1.039
Creatinine 0.124 0.031 15.708  < 0.001 1.132 1.065 1.203
INR 0.156 0.028 30.121  < 0.001 1.169 1.105 1.235
PT 0.028 0.005 29.509  < 0.001 1.028 1.018 1.039
Albumin  − 0.362 0.094 14.827  < 0.001 0.696 0.579 0.837
Glucose  < 0.001 0.001 0.253 0.615 1.001 0.998 1.003
PH  − 2.608 0.526 24.571  < 0.001 0.074 0.026 0.207
Sodium  − 0.043 0.009 22.916  < 0.001 0.958 0.941 0.975
Potassium 0.173 0.062 7.936 0.005 1.189 1.054 1.342
Hemoglobin  − 0.018 0.027 0.469 0.493 0.982 0.931 1.035
WBC 0.022 0.008 7.180 0.007 1.023 1.006 1.040
Chloride  − 0.032 0.008 15.679  < 0.001 0.969 0.954 0.984
PLT  − 0.001 0.001 2.599 0.107 0.999 0.997 1.000
Lactate last 0.263 0.015 328.456  < 0.001 1.301 1.265 1.339
Lactate first 0.117 0.018 43.252  < 0.001 1.124 1.086 1.164
ΔLA  − 0.350 0.038 85.886  < 0.001 0.704 0.654 0.759
  1. ICU, intensive care unit; MICU, medical intensive care unit; CCU, coronary care unit; CSRU, cardiac surgery care unit; ICU, surgical intensive care unit; TSICU, traumatic surgical intensive care unit; ACLF, acute chronic liver failure; RRT, renal replacement therapy; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PaO2, arterial oxygen partial pressure; FiO2, fraction of inspired oxygen; SPO2, pulse oxygen saturation; INR, international normalized ratio; PT, prothrombin time; PLT, platelet count; WBC, white blood cell count; ΔLA, lactate clearance;