Fig. 5

Forest plots showing the proportion of patients with Crohn’s disease achieving clinical remission during A the induction phase and B the maintenance phase with infliximab (upper plot) or vedolizumab (lower plot). Panel A SONIC (a): IFX IV (corticosteroid free); SONIC (b): combination therapy; PLANET CD (a): patients with CT-P13 IV only; PLANET CD (b): patients with CT-P13 IV and IFX IV; GEMINI 2 (a): VDZ before TNFi; GEMINI 2 (b): VDZ after TNFi failure; GEMINI 3 (a): VDZ IV before TNFi; GEMINI 3 (b): VDZ IV after TNFi failure. Abbreviation: CI, confidence interval; IFX, infliximab; IV, intravenous; TNFi, tumour necrosis factor-α inhibitor; VDZ, vedolizumab. Panel B SONIC (a): IFX IV (corticosteroid free); SONIC (b): combination therapy; PLANET CD (a): CT-P13 IV only; PLANET CD (b): CT-P13 IV switch to IFX IV; PLANET CD (c): IFX IV only; PLANET CD (d): IFX IV switch to CT-P13 IV; CT-P13 SC trial (a): CT-P13 SC only; CT-P13 SC trial (b): CT-P13 IV switch to CT-P13 SC; GEMINI 2 (a): VDZ before TNFi; GEMINI 2 (b): VDZ after TNFi failure. Abbreviation: CI, confidence interval; IFX, infliximab; IV, intravenous; SC, subcutaneous; TNFi, tumour necrosis factor-α inhibitor; VDZ, vedolizumab