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Table 3 Comparative analysis between clinical and endoscopic remission between the Adalimumab and Infliximab groups at baseline and at weeks 8, 26 and 52 of treatment

From: Anti-TNF therapy for ulcerative colitis in Brazil: a comparative real-world national retrospective multicentric study from the Brazilian study group of IBD (GEDIIB)

  Baseline Week 8 Week 26 Week 52
  Infliximab (n=271) P-value Adalimumab (n=101) Infliximab (n=251) P value Adalimumab (n=83) Infliximab (n=213) P value Adalimumab (n=76) Infliximab (n=215) P-value Adalimumab (n=103)  
Mayo partial score 5.42 ± 2.50 5.88 ± 2.25 0.0885 3.16 ± 2.56 3.45 ± 2.29 0.1831 2.72 ± 2.51 2.35 ± 2.15 0.0455 2.25 ± 2.58 1.75 ± 2.10 0.0049
Mayo endoscopic score 2.50 ± 0.70 2.54 ± 0.58 0.8312 - - - 1.50 ± 0.92 1.40 ± 0.99 0.5801 1.22 ± 1.14 1.03 ± 1.08 0.1584
Mayo total score 8.06 ± 2.64 8.49 ± 2.41 0.1929 - - - 4.34 ± 2.72 3.72 ± 2.77 0.0162 3.46 ± 3.21 2.68 ± 2.71 0.0006
Clinical remission 20 (19.42) 34 (12.55) 0.057 69 (68.32) 166 (66.14) <0.0001 52 (62.65) 160 (75.12) <0.0001 57 (51.35) 184 (65.24) <0.0001
Clinical response - - - 56 (56.00) 159 (63.35) 0.2022 66 (82.50) 178 (84.36) 0.7002 62 (84.93) 182 (88.35) 0.4487
Mayo endoscopic subscore
0 - remission 3 (2.91) -      10 (16.13) 37 (22.84)   26 (34.21) 94 (43.72)  
1 - mild 7 (6.79) 8 (2.94)      19 (30.65) 46 (28.40)   23 (30.26) 49 (22.79) 0.114
2 - moderate 27(26.20) 109 (40.07) 0.002 - - - 25 (40.32) 56 (34.57) 0.681 11 (14.47) 44 (20.79)  
3 - severe 66(64.08) 155 (56.98)      8 (12.90) 23 (14.20)   16 (21.05) 28 (13.02)  
Hematocrit (%) 36.18 ± 5.60 35.62 ± 5.82 0.4225 36.47 ± 5.44 36.88 ± 4.87 0.5440 37.54 ± 5.59 38.15 ± 4.72 0.3670 38.98 ± 5.11 38.45 ± 4.52 0.4435
Hemoglobin (g/dl) 11.95 ± 2.01 11.64 ± 2.10 0.2082 12.10 ± 2.08 12.16 ± 1.79 0.8106 12.29 ± 2.04 12.67 ± 1.72 0.1219 12.81 ± 1.82 12.73 ± 1.60 0.7655
Albumin (g/dl) 3.59 ± 0.66 3.59 ± 0.60 0.9821 3.84 ± 0.56 3.76 ± 0.47 0.3826 3.79 ± 0.44 3.88 ± 0.48 0.2484 3.88 ± 0.50 4.03 ± 0.47 0.0885
C-reactive protein (mg/dl) 19.94 ± 37.99 20.33 ± 34.29 0.8725 10.49 ± 19.55 8.98 ± 21.46 0.3807 9.25 ± 20.33 6.22 ± 15.63 0.0181 8.59 ± 15.68 4.50 ± 13.68 0.0008
Calprotectin (μg/g) 1084.27 ± 929.60 1500.49 ± 2172.67 0.1790 520.60 ±447.67 616.84 ±995.01 0.5533 320.77 ±406.86 405.50 ±580.11 0.4439 489.02 ±777.18 178.21 ±272.71 0.0047
  1. Data presented as mean ± SD and n (%). Calculated by Student’s t test or Pearson, χ2 or Fisher’s exact test