Table 3 Comparative analysis between clinical and endoscopic remission between the Adalimumab and Infliximab groups at baseline and at weeks 8, 26 and 52 of treatment
Baseline | Week 8 | Week 26 | Week 52 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Infliximab (n=271) | P-value | Adalimumab (n=101) | Infliximab (n=251) | P value | Adalimumab (n=83) | Infliximab (n=213) | P value | Adalimumab (n=76) | Infliximab (n=215) | P-value Adalimumab (n=103) | ||
Mayo partial score | 5.42 ± 2.50 | 5.88 ± 2.25 | 0.0885 | 3.16 ± 2.56 | 3.45 ± 2.29 | 0.1831 | 2.72 ± 2.51 | 2.35 ± 2.15 | 0.0455 | 2.25 ± 2.58 | 1.75 ± 2.10 | 0.0049 |
Mayo endoscopic score | 2.50 ± 0.70 | 2.54 ± 0.58 | 0.8312 | - | - | - | 1.50 ± 0.92 | 1.40 ± 0.99 | 0.5801 | 1.22 ± 1.14 | 1.03 ± 1.08 | 0.1584 |
Mayo total score | 8.06 ± 2.64 | 8.49 ± 2.41 | 0.1929 | - | - | - | 4.34 ± 2.72 | 3.72 ± 2.77 | 0.0162 | 3.46 ± 3.21 | 2.68 ± 2.71 | 0.0006 |
Clinical remission | 20 (19.42) | 34 (12.55) | 0.057 | 69 (68.32) | 166 (66.14) | <0.0001 | 52 (62.65) | 160 (75.12) | <0.0001 | 57 (51.35) | 184 (65.24) | <0.0001 |
Clinical response | - | - | - | 56 (56.00) | 159 (63.35) | 0.2022 | 66 (82.50) | 178 (84.36) | 0.7002 | 62 (84.93) | 182 (88.35) | 0.4487 |
Mayo endoscopic subscore | ||||||||||||
0 - remission | 3 (2.91) | - | 10 (16.13) | 37 (22.84) | 26 (34.21) | 94 (43.72) | ||||||
1 - mild | 7 (6.79) | 8 (2.94) | 19 (30.65) | 46 (28.40) | 23 (30.26) | 49 (22.79) | 0.114 | |||||
2 - moderate | 27(26.20) | 109 (40.07) | 0.002 | - | - | - | 25 (40.32) | 56 (34.57) | 0.681 | 11 (14.47) | 44 (20.79) | |
3 - severe | 66(64.08) | 155 (56.98) | 8 (12.90) | 23 (14.20) | 16 (21.05) | 28 (13.02) | ||||||
Hematocrit (%) | 36.18 ± 5.60 | 35.62 ± 5.82 | 0.4225 | 36.47 ± 5.44 | 36.88 ± 4.87 | 0.5440 | 37.54 ± 5.59 | 38.15 ± 4.72 | 0.3670 | 38.98 ± 5.11 | 38.45 ± 4.52 | 0.4435 |
Hemoglobin (g/dl) | 11.95 ± 2.01 | 11.64 ± 2.10 | 0.2082 | 12.10 ± 2.08 | 12.16 ± 1.79 | 0.8106 | 12.29 ± 2.04 | 12.67 ± 1.72 | 0.1219 | 12.81 ± 1.82 | 12.73 ± 1.60 | 0.7655 |
Albumin (g/dl) | 3.59 ± 0.66 | 3.59 ± 0.60 | 0.9821 | 3.84 ± 0.56 | 3.76 ± 0.47 | 0.3826 | 3.79 ± 0.44 | 3.88 ± 0.48 | 0.2484 | 3.88 ± 0.50 | 4.03 ± 0.47 | 0.0885 |
C-reactive protein (mg/dl) | 19.94 ± 37.99 | 20.33 ± 34.29 | 0.8725 | 10.49 ± 19.55 | 8.98 ± 21.46 | 0.3807 | 9.25 ± 20.33 | 6.22 ± 15.63 | 0.0181 | 8.59 ± 15.68 | 4.50 ± 13.68 | 0.0008 |
Calprotectin (μg/g) | 1084.27 ± 929.60 | 1500.49 ± 2172.67 | 0.1790 | 520.60 ±447.67 | 616.84 ±995.01 | 0.5533 | 320.77 ±406.86 | 405.50 ±580.11 | 0.4439 | 489.02 ±777.18 | 178.21 ±272.71 | 0.0047 |