| |
Baseline
|
Week 8
|
Week 26
|
Week 52
|
|---|
| |
Infliximab (n=271)
|
P-value
|
Adalimumab (n=101)
|
Infliximab (n=251)
|
P value
|
Adalimumab (n=83)
|
Infliximab (n=213)
|
P value
|
Adalimumab (n=76)
|
Infliximab (n=215)
|
P-value Adalimumab (n=103)
| |
|---|
|
Mayo partial score
|
5.42 ± 2.50
|
5.88 ± 2.25
|
0.0885
|
3.16 ± 2.56
|
3.45 ± 2.29
|
0.1831
|
2.72 ± 2.51
|
2.35 ± 2.15
|
0.0455
|
2.25 ± 2.58
|
1.75 ± 2.10
|
0.0049
|
|
Mayo endoscopic score
|
2.50 ± 0.70
|
2.54 ± 0.58
|
0.8312
|
-
|
-
|
-
|
1.50 ± 0.92
|
1.40 ± 0.99
|
0.5801
|
1.22 ± 1.14
|
1.03 ± 1.08
|
0.1584
|
|
Mayo total score
|
8.06 ± 2.64
|
8.49 ± 2.41
|
0.1929
|
-
|
-
|
-
|
4.34 ± 2.72
|
3.72 ± 2.77
|
0.0162
|
3.46 ± 3.21
|
2.68 ± 2.71
|
0.0006
|
|
Clinical remission
|
20 (19.42)
|
34 (12.55)
|
0.057
|
69 (68.32)
|
166 (66.14)
|
<0.0001
|
52 (62.65)
|
160 (75.12)
|
<0.0001
|
57 (51.35)
|
184 (65.24)
|
<0.0001
|
|
Clinical response
|
-
|
-
|
-
|
56 (56.00)
|
159 (63.35)
|
0.2022
|
66 (82.50)
|
178 (84.36)
|
0.7002
|
62 (84.93)
|
182 (88.35)
|
0.4487
|
|
Mayo endoscopic subscore
|
|
0 - remission
|
3 (2.91)
|
-
| | | | |
10 (16.13)
|
37 (22.84)
| |
26 (34.21)
|
94 (43.72)
| |
|
1 - mild
|
7 (6.79)
|
8 (2.94)
| | | | |
19 (30.65)
|
46 (28.40)
| |
23 (30.26)
|
49 (22.79)
|
0.114
|
|
2 - moderate
|
27(26.20)
|
109 (40.07)
|
0.002
|
-
|
-
|
-
|
25 (40.32)
|
56 (34.57)
|
0.681
|
11 (14.47)
|
44 (20.79)
| |
|
3 - severe
|
66(64.08)
|
155 (56.98)
| | | | |
8 (12.90)
|
23 (14.20)
| |
16 (21.05)
|
28 (13.02)
| |
|
Hematocrit (%)
|
36.18 ± 5.60
|
35.62 ± 5.82
|
0.4225
|
36.47 ± 5.44
|
36.88 ± 4.87
|
0.5440
|
37.54 ± 5.59
|
38.15 ± 4.72
|
0.3670
|
38.98 ± 5.11
|
38.45 ± 4.52
|
0.4435
|
|
Hemoglobin (g/dl)
|
11.95 ± 2.01
|
11.64 ± 2.10
|
0.2082
|
12.10 ± 2.08
|
12.16 ± 1.79
|
0.8106
|
12.29 ± 2.04
|
12.67 ± 1.72
|
0.1219
|
12.81 ± 1.82
|
12.73 ± 1.60
|
0.7655
|
|
Albumin (g/dl)
|
3.59 ± 0.66
|
3.59 ± 0.60
|
0.9821
|
3.84 ± 0.56
|
3.76 ± 0.47
|
0.3826
|
3.79 ± 0.44
|
3.88 ± 0.48
|
0.2484
|
3.88 ± 0.50
|
4.03 ± 0.47
|
0.0885
|
|
C-reactive protein (mg/dl)
|
19.94 ± 37.99
|
20.33 ± 34.29
|
0.8725
|
10.49 ± 19.55
|
8.98 ± 21.46
|
0.3807
|
9.25 ± 20.33
|
6.22 ± 15.63
|
0.0181
|
8.59 ± 15.68
|
4.50 ± 13.68
|
0.0008
|
|
Calprotectin (μg/g)
|
1084.27 ± 929.60
|
1500.49 ± 2172.67
|
0.1790
|
520.60 ±447.67
|
616.84 ±995.01
|
0.5533
|
320.77 ±406.86
|
405.50 ±580.11
|
0.4439
|
489.02 ±777.18
|
178.21 ±272.71
|
0.0047
|
- Data presented as mean ± SD and n (%). Calculated by Student’s t test or Pearson, χ2 or Fisher’s exact test
