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Table 3 Univariable and multivariable analyses to identify independent prognostic indicators of disease-free survival in patients with HCC

From: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with hepatocellular carcinoma subjected to hepatectomy

Variables Disease-free survival
Univariable Multivariable
HR (95% CI) p value HR (95% CI) p value
Age (years) 0.988 (0.982, 0.994)  < 0.001 0.994 (0.987, 1.001) 0.078
Male sex 1.292 (1.033, 1.616) 0.025 1.170 (0.927, 1.478) 0.187
Positive HBsAg 1.603 (1.259, 2.041)  < 0.001 1.509 (1.167, 1.951) 0.002
Positive anti-HCV 0.775 (0.415, 1.447) 0.424   
Child–Pugh grade B 1.167 (0.870, 1.565) 0.302   
AFP ≥ 400 ng/mL 1.560 (1.351, 1.801)  < 0.001 1.277 (1.095, 1.489) 0.002
FAR 1.534 (1.311, 1.796)  < 0.001 1.211 (1.014, 1.445) 0.035
NLR 1.542 (1.318, 1.803)  < 0.001 1.086 (0.866, 1.362) 0.474
PLR 1.646 (1.350, 2.008)  < 0.001 0.970 (0.744, 1.265) 0.821
MLR 1.453 (1.257, 1.679)  < 0.001 1.055 (0.878, 1.267) 0.568
SII 1.676 (1.402, 2.005)  < 0.001 1.143 (0.857, 1.524) 0.364
CSPH 1.306 (1.033, 1.652) 0.026 1.319 (1.030, 1.689) 0.028
Ascites 1.303 (1.054, 1.610) 0.014 1.129 (0.903, 1.411) 0.287
Cirrhosis 1.150 (0.996, 1.328) 0.056   
Tumor size ≥ 5 cm 2.024 (1.732, 2.364)  < 0.001 1.348 (1.121, 1.620) 0.001
Multiple number 1.057 (0.876, 1.275) 0.565   
MVI 2.222 (1.910, 2.584)  < 0.001 0.829 (0.424, 1.622) 0.584
BCLC stage C 4.951 (2.835, 8.646)  < 0.001 3.109 (1.303, 7.416) 0.011
Blood loss ≥ 400 ml 1.860 (1.609, 2.149)  < 0.001 1.338 (1.136, 1.575)  < 0.001
Blood transfusion 1.312 (1.056, 1.629) 0.014 0.951 (0.755, 1.200) 0.674
Major hepatectomy 1.663 (1.438, 1.924)  < 0.001 1.144 (0.972, 1.346) 0.106
  1. HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; AFP, alpha-fetoprotein; FAR, fibrinogen-albumin ratio; NLR, neutrophil–lymphocyte ratio; MLR, monocyte-lymphocyte ratio; PLR, platelet–lymphocyte ratio; SII, systemic immune–inflammation index; CSPH, clinically significant portal hypertension; MVI, macrovascular invasion; BCLC, Barcelona Clinical Liver Cancer