Skip to main content

Table 3 Univariable and multivariable analyses to identify independent prognostic indicators of disease-free survival in patients with HCC

From: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with hepatocellular carcinoma subjected to hepatectomy

Variables

Disease-free survival

Univariable

Multivariable

HR (95% CI)

p value

HR (95% CI)

p value

Age (years)

0.988 (0.982, 0.994)

 < 0.001

0.994 (0.987, 1.001)

0.078

Male sex

1.292 (1.033, 1.616)

0.025

1.170 (0.927, 1.478)

0.187

Positive HBsAg

1.603 (1.259, 2.041)

 < 0.001

1.509 (1.167, 1.951)

0.002

Positive anti-HCV

0.775 (0.415, 1.447)

0.424

  

Child–Pugh grade B

1.167 (0.870, 1.565)

0.302

  

AFP ≥ 400 ng/mL

1.560 (1.351, 1.801)

 < 0.001

1.277 (1.095, 1.489)

0.002

FAR

1.534 (1.311, 1.796)

 < 0.001

1.211 (1.014, 1.445)

0.035

NLR

1.542 (1.318, 1.803)

 < 0.001

1.086 (0.866, 1.362)

0.474

PLR

1.646 (1.350, 2.008)

 < 0.001

0.970 (0.744, 1.265)

0.821

MLR

1.453 (1.257, 1.679)

 < 0.001

1.055 (0.878, 1.267)

0.568

SII

1.676 (1.402, 2.005)

 < 0.001

1.143 (0.857, 1.524)

0.364

CSPH

1.306 (1.033, 1.652)

0.026

1.319 (1.030, 1.689)

0.028

Ascites

1.303 (1.054, 1.610)

0.014

1.129 (0.903, 1.411)

0.287

Cirrhosis

1.150 (0.996, 1.328)

0.056

  

Tumor size ≥ 5 cm

2.024 (1.732, 2.364)

 < 0.001

1.348 (1.121, 1.620)

0.001

Multiple number

1.057 (0.876, 1.275)

0.565

  

MVI

2.222 (1.910, 2.584)

 < 0.001

0.829 (0.424, 1.622)

0.584

BCLC stage C

4.951 (2.835, 8.646)

 < 0.001

3.109 (1.303, 7.416)

0.011

Blood loss ≥ 400 ml

1.860 (1.609, 2.149)

 < 0.001

1.338 (1.136, 1.575)

 < 0.001

Blood transfusion

1.312 (1.056, 1.629)

0.014

0.951 (0.755, 1.200)

0.674

Major hepatectomy

1.663 (1.438, 1.924)

 < 0.001

1.144 (0.972, 1.346)

0.106

  1. HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; AFP, alpha-fetoprotein; FAR, fibrinogen-albumin ratio; NLR, neutrophil–lymphocyte ratio; MLR, monocyte-lymphocyte ratio; PLR, platelet–lymphocyte ratio; SII, systemic immune–inflammation index; CSPH, clinically significant portal hypertension; MVI, macrovascular invasion; BCLC, Barcelona Clinical Liver Cancer