Table 1 Comparison of characteristics between patients with and without AKI, CA-AKI and HA-AKI
Variables | Non-AKI N = 357 | AKI N = 217 | P value | AKI | ||
|---|---|---|---|---|---|---|
CA-AKI N = 56 | HA-AKI N = 161 | P value | ||||
Age (years) | 49.6 ± 11.9 | 53.6 ± 12.1 |  < 0.001 | 54.1 ± 11.8 | 53.5 ± 12.2 | 0.728 |
Male-n (%) | 265 (74.2) | 169 (77.9) | 0.323 | 45 (80.4) | 124 (77.0) | 0.604 |
Death-n(%) | 77 (21.6) | 120 (55.3) |  < 0.001 | 33 (58.9) | 87 (54.0) | 0.0526 |
Hypertension-n(%) | 42 (11.8) | 41 (18.9) | 0.019 | 10 (17.9) | 31 (19.3) | 0.818 |
Diabetes mellitus-n(%) | 56 (9.8) | 43 (19.8) | 0.204 | 10 (17.9) | 33 (20.5) | 0.669 |
Baseline Cr (μmol/L) | 60.5 ± 18.4 | 84.9 ± 49.1 |  < 0.001 | 128.2 ± 70.8 | 69.9 ± 25.5 |  < 0.001 |
Baseline eGFR (ml/min/1.73m2)* | 134.6 ± 43.1 | 109.5 ± 61.1 |  < 0.001 | 73.4 ± 45.6 | 122.0 ± 60.9 |  < 0.001 |
Peak Cr (μmol/L) | – | 214.2 ± 139.9 |  | 276.4 ± 158.8 | 192.6 ± 126.1 |  < 0.001 |
Etiology of liver disease-n (%) | Â | Â | 0.013 | Â | Â | 0.793 |
Hepatitis B | 195 (54.6) | 102 (47.0) | Â | 25 (44.6) | 77 (47.8) | Â |
Alcohol | 92 (25.8) | 81 (37.3) | Â | 23 (41.1) | 58 (36.0) | Â |
Other causes | 70 (19.6) | 34 (15.7) | Â | 8 (14.3) | 26 (16.1) | Â |
Complications at admission-n (%) | ||||||
Ascites | 182 (51.0) | 118 (54.4) | 0.429 | 30 (53.6) | 88 (54.7) | 0.888 |
HE | 32 (9.0) | 22 (10.1) | 0.640 | 7 (12.5) | 15 (9.3) | 0.497 |
GI bleeding | 51 (14.3) | 63 (29.0) |  < 0.001 | 19 (33.9) | 44 (27.3) | 0.349 |
Bacterial infection | 46 (12.9) | 54 (24.9) |  < 0.001 | 11 (19.6) | 43 (26.7) | 0.292 |
Admission parameters | ||||||
MAP (mmHg) | 90 ± 11.5 | 88.7 ± 14.9 | 0.117 | 82.8 ± 15.0 | 90.7 ± 14.4 |  < 0.001 |
Heart rate (bpm) | 82.6 ± 14 | 87.2 ± 14.9 |  < 0.001 | 91.2 ± 18 | 85.8 ± 13.5 | 0.010 |
WBC (× 109/L) | 7.0 ± 4.4 | 9.8 ± 6.5 |  < 0.001 | 12.2 ± 7.2 | 9.0 ± 6.1 |  < 0.001 |
PLT (× 109/L) | 99.3 ± 62.3 | 104.3 ± 69.6 | 0.186 | 111.4 ± 77.5 | 101.9 ± 66.7 | 0.190 |
ALB (g/L) | 29.4 ± 5.1 | 27.3 ± 5.1 |  < 0.001 | 26.6 ± 4.5 | 27.5 ± 5.3 | 0.140 |
TBIL (μmol/L) | 233.1 ± 129.3 | 263.1 ± 156.7 | 0.009 | 261.3 ± 154.4 | 263.7 ± 157.9 | 0.462 |
INR | 2.3 ± 0.9 | 2.4 ± 1.1 | 0.034 | 2.6 ± 1.4 | 2.4 ± 1.0 | 0.077 |
PT (s) | 33.8 ± 10.9 | 35.7 ± 13.3 | 0.033 | 36.1 ± 13.2 | 35.5 ± 13.3 | 0.391 |
BUN (mmol/L) | 5.3 ± 3.1 | 10.4 ± 7.3 |  < 0.001 | 17.7 ± 7.9 | 7.9 ± 5.1 |  < 0.001 |
sCr (μmol/L) | 60.6 ± 18.4 | 110.8 ± 80.7 |  < 0.001 | 213.1 ± 91.7 | 75.2 ± 31.1 |  < 0.001 |
Serum Na+ (mmol/L) | 134.3 ± 5.8 | 132.3 ± 6.1 |  < 0.001 | 130.9 ± 7.2 | 132.8 ± 5.6 | 0.021 |
Serum K+ (mmol/L) | 3.8 ± 0.6 | 4.0 ± 0.7 | 0.004 | 4.1 ± 0.9 | 3.9 ± 0.6 | 0.029 |
eGFR (ml/min/1.73m2)* | 134.6 ± 43.1 | 105.2 ± 62.9 |  < 0.001 | 62.2 ± 45.7 | 120.2 ± 61.2 |  < 0.001 |
CTP | 11.1 ± 1.7 | 11.5 ± 1.8 | 0.006 | 11.8 ± 1.7 | 11.4 ± 1.8 | 0.118 |
MELD | 18.2 ± 5.7 | 22.6 ± 8.5 |  < 0.001 | 30.4 ± 7.1 | 20.0 ± 7.2 |  < 0.001 |
MELD-Na | 22.5 ± 8.5 | 29.3 ± 10.9 |  < 0.001 | 38.9 ± 9.8 | 26.0 ± 9.2 |  < 0.001 |
Initial ICA-AKI stage-n | ||||||
Stage 1/2/3 | Â | 132/58/27 | Â | 30/14/12 | 102/44/15 | 0.060 |
Peak ICA-AKI stage-n | ||||||
Stage 1/2/3 | Â | 84/60/73 | Â | 25/9/22 | 59/51/51 | 0.080 |