Anticoagulant drugs with or without proton pump inhibitor and colorectal cancer risk: a population-based, case–control study

Table 4 Relationship between PPI combination therapy and CRC risk

Variable	Univariate logistic regression model			Multivariate logistic regression model^a
Variable	OR	95%CI	p Value	OR	95%CI	p Value
PPI + Low-dose aspirin	0.799	0.540–1.184	0.2635	0.483	0.321–0.728	0.0005***
PPI + Clopidogrel	1.800	1.279–2.532	0.0007***	1.009	0.701–1.453	0.9607
PPI + DOAC	5.002	1.974–12.676	0.0007***	3.906	1.485–10.273	0.0058**

^aModel was adjusted for the following variables: age, gender, and year of index date; comorbidities and risk factors, including smoking, alcohol usage, hypertension, diabetes mellitus, cardiovascular disease, stroke, inflammatory bowel disease, GI bleeding
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 1471-230X