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Table 5 Diagnostic value of FIT and mSEPT9 in CRC

From: Methylated Septin9 has moderate diagnostic value in colorectal cancer detection in Chinese population: a multicenter study

 

mSEPT9

FIT

Colon cancer

Rectal cancer

Colon cancer

Rectal cancer

Sensitivity

0.87 (0.79, 0.92)

0.93 (0.76, 0.99)

0.82 (0.74, 0.89)

0.68 (0.48, 0.84)

Specificity

0.74 (0.64, 0.83)

0.79 (0.69, 0.87)

0.81 (0.71, 0.89)

0.94 (0.87, 0.98)

PPV

0.81 (0.73, 0.87)

0.58 (0.42, 0.72)

0.85 (0.77, 0.91)

0.79 (0.58, 0.93)

NPV

0.81 (0.71, 0.89)

0.97 (0.90, 1.00)

0.78 (0.68, 0.86)

0.90 (0.82, 0.95)

Accuracy

0.81(0.75, 0.86)

0.82(0.74, 0.89)

0.82(0.76, 0.87)

0.88(0.81, 0.93)

AUC

0.81(0.75, 0.86)

0.81(0.75, 0.86)

0.82 (0.76, 0.87)

0.81 (0.72, 0.90)

  1. PPV Positive predictive value, NPV negative predictive value, AUC area under the curve