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Table 3 Low HDL-C in infants with liver manifestations

From: Neonatal cholestasis is an early liver manifestation of children with acid sphingomyelinase deficiency

 

Infants with cholestatic jaundice

Infants with other liver presentations

Total (n = 111)

Within 6 months of age (n = 97)

Beyond 6 months of age (n = 14)

Total (n = 49)

Within 6 months of age (n = 19)

Beyond 6 months of age (n = 30)

Sex (male/female)

74/37

64/33

10/4

36/13

16/3

20/10

Age (months)

3 [2, 4]

2.0 [2.0, 4.0]

8.5 [7.0, 9.0]

6 [4, 8]*

3.0 [3.0, 4.0]

8.0 [6.0, 9.0]

HDL-C levels (mmol/L)#

0.70 [0.56, 0.85]

0.70 [0.59, 0.86]

0.56 [0.49, 0.75]

1.02 [0.82, 1.22]*

0.96 [0.82, 1.18]*

1.03 [0.90, 1.23]*

Low HDL-C (%)

100 (90.1%)

88 (90.7%)

12 (85.7%)

25 (51.0%)*

11 (57.9%)*

14 (46.7)*

With splenomegaly

48

44

4

6

3

3

Without splenomegaly

52

44

8

19

8

11

ASMD

0

0

0

1

0

1

  1. Interquartile range in square brackets
  2. HDL-C, high-density lipoprotein cholesterol; ASMD, acid sphingomyelinase deficiency
  3. #Normal reference: 1.03–1.55 mmol/L
  4. *Infants with cholestatic jaundice vs. infants with other liver presentation, P < 0.05