Table 2 Clinicopathological characteristics according to HER2 protein expression status
Item | HER2 negative N = 181 | HER2 overexpression N = 30 | P value |
|---|---|---|---|
Age (year, Mean ± SD) | 61.4 ± 9.7 | 62.3 ± 10.3 | 0.737 |
Sex (Male, %) | 138 (76.2) | 24 (80.0) | 0.652 |
Tumor location (n/%)a | 0.033 | ||
Upper 1/3 | 49 (27.1) | 14 (46.7) | |
Middle 1/3 | 26 (14.4) | 6 (20.0) | |
Lower 1/3 | 106 (58.6) | 10 (33.3) | |
Gross type (n/%) | 0.183 | ||
Elevated | 79 (43.6) | 14 (46.7) | |
Flat | 58 (32.0) | 13 (43.3) | |
Depressed | 44 (24.3) | 3 (6.4) | |
Depth of invasion (n/%) a | 0.147 | ||
Mucous layer | 168 (92.8) | 25 (83.3) | |
Submucosa | 13 (7.2) | 5 (16.7) | |
Differentiated types (n/%)a | 0.371 | ||
Differentiated | 170 (93.9) | 30 (100.0) | |
Undifferentiated | 11 (6.1) | 0 (0.0) | |
Tumor size (n/%) a | 0.775 | ||
≤ 2 cm | 155 (85.6) | 27 (90.0) | |
> 2 cm | 26 (14.4) | 3 (10.0) | |
Lymphovascular infiltration (n/%)a | 0.461 | ||
Present | 3 (1.7) | 1 (3.3) | |
Absent | 178 (98.3) | 29 (96.7) | |
Resection margin (n/%)a | 1.000 | ||
Positive | 6 (3.3) | 1 (3.3) | |
Negative | 175 (96.7) | 29 (96.7) | |
Current gastric ulcera | 26 (14.4) | 4 (13.3) | 1.000 |
Current HP infectiona | 24 (13.3) | 2 (6.7) | 0.547 |