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Table 3 Cox Proportional Multivariate Analysis for Baseline Characteristics of Patients with or without Severe Hepatotoxicity

From: Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon

Characteristics of the study population Level Univariate analysis Multivariate analysis
OR (95% CI) P OR (95% CI) P
Age group (Years) < 30 1 0.02 1  
30–40 0.15 (0.03–0.65) 0.16 (0.04–0.72) 0.03
> 40 0.40 (0.11–1.47) 0.32 (0.08–1.24) 0.1
Gender Male 1 0.04 1  
Female 0.26 (0.895.28) 1.78 (0.58–5.49) 0.32
Body Mass Index Normal 1 0.02 1  
Low 0.38 (0.04–3.35) 0.33 (0.11-0.99) 0.04
Overweight 0.30 (0.11-0.78) 0.35 (0.21–4.59) 0.11
Monthly income < 50,000 1 0.01 1  
> 50,000 0.18 (0.04–0.86) 0.14 (0.030.79) 0.02
Alcohol intake No 1 0.07 1  
Yes 0.40 (0.11-0.47) 0.42 (0.09–1.64) 0.1
Cigarette or tobacco intake No 1 0.09 1  
Yes 2.26 (0.885.80) 1.68 (0.51–5.60) 0.39
CD4 Count values < 200 1 0.06 1  
> 200 0.42 (0.16–1.08) 0.65 (0.34–2.37) 0.16
Name of ARV regimen TDF + 3TC + EFV 1 0.01 1  
AZT + 3TC + EFV 0.25 (0.05–1.18) 0.18 (0.03–0.99) 0.22
AZT + 3TC + NVP 2.86 (0.90–9.04) 2.44 (0.58–10.26) 0.03
  1. 3TC: Lamivudine, AZT: Zidovudine, BMI: Body mass index, EFV: Efavirenz, NVP: Nevirapine; TDF: Tenofovir